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PTPRK (protein tyrosine phosphatase, receptor type K)

Identity

Alias_symbol (synonym)R-PTP-kappa
Other alias
HGNC (Hugo) PTPRK
LocusID (NCBI) 5796
Atlas_Id 41933
Location 6q22.33  [Link to chromosome band 6q22]
Location_base_pair Starts at 127968779 and ends at 128520674 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AL137003.1 () / PTPRK (6q22.33)ANKRD36B (2q11.2) / PTPRK (6q22.33)KIF13A (6p22.3) / PTPRK (6q22.33)
L3MBTL3 (6q23.1) / PTPRK (6q22.33)PTPRK (6q22.33) / C6orf203 (6q21)PTPRK (6q22.33) / CACNB2 (10p12.33)
PTPRK (6q22.33) / CHMP1A (16q24.3)PTPRK (6q22.33) / HECA (6q24.1)PTPRK (6q22.33) / NHSL1 (6q23.3)
PTPRK (6q22.33) / OXR1 (8q23.1)PTPRK (6q22.33) / PKP2 (12p11.21)PTPRK (6q22.33) / PLN (6q22.31)
PTPRK (6q22.33) / PTPRK (6q22.33)PTPRK (6q22.33) / RSPO3 (6q22.33)PTPRK (6q22.33) / STAG3 (7q22.1)
PTPRK (6q22.33) / STXBP6 (14q12)PTPRK (6q22.33) / TAOK3 (12q24.23)PTPRK (6q22.33) / THEMIS (6q22.33)
PTPRK (6q22.33) / UACA (15q23)PUM1 (1p35.2) / PTPRK (6q22.33)PTPRK RSPO3
AL137003.1 PTPRK 6q22.33KIF13A 6p22.3 / PTPRK 6q22.33PTPRK 6q22.33 / C6orf203 6q21
PTPRK 6q22.33 / HECA 6q24.1PTPRK 6q22.33 / OXR1 8q23.1PTPRK 6q22.33 / PLN 6q22.31
PTPRK 6q22.33 / STXBP6 14q12PUM1 1p35.2 / PTPRK 6q22.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(q22;q23) L3MBTL3/PTPRK


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 8 ]
  t(1;6)(p35;q22) PUM1/PTPRK
t(6;6)(p22;q22) KIF13A/PTPRK
t(6;6)(q21;q22) PTPRK/C6orf203
PTPRK/PLN (6q22)
PTPRK/RSPO3 (6q22)
t(6;6)(q22;q24) PTPRK/HECA
t(6;8)(q22;q23) PTPRK/OXR1
t(6;14)(q22;q12) PTPRK/STXBP6


External links

Nomenclature
HGNC (Hugo)PTPRK   9674
Cards
Entrez_Gene (NCBI)PTPRK  5796  protein tyrosine phosphatase, receptor type K
AliasesR-PTP-kappa
GeneCards (Weizmann)PTPRK
Ensembl hg19 (Hinxton)ENSG00000152894 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152894 [Gene_View]  ENSG00000152894 [Sequence]  chr6:127968779-128520674 [Contig_View]  PTPRK [Vega]
ICGC DataPortalENSG00000152894
TCGA cBioPortalPTPRK
AceView (NCBI)PTPRK
Genatlas (Paris)PTPRK
WikiGenes5796
SOURCE (Princeton)PTPRK
Genetics Home Reference (NIH)PTPRK
Genomic and cartography
GoldenPath hg38 (UCSC)PTPRK  -     chr6:127968779-128520674 -  6q22.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPRK  -     6q22.33   [Description]    (hg19-Feb_2009)
EnsemblPTPRK - 6q22.33 [CytoView hg19]  PTPRK - 6q22.33 [CytoView hg38]
Mapping of homologs : NCBIPTPRK [Mapview hg19]  PTPRK [Mapview hg38]
OMIM602545   
Gene and transcription
Genbank (Entrez)AB209670 AF533875 AK295028 BC063596 BC140775
RefSeq transcript (Entrez)NM_001135648 NM_001291981 NM_001291982 NM_001291983 NM_001291984 NM_002844
RefSeq genomic (Entrez)NC_000006 NT_187556
Consensus coding sequences : CCDS (NCBI)PTPRK
Cluster EST : UnigeneHs.155919 [ NCBI ]
CGAP (NCI)Hs.155919
Alternative Splicing GalleryENSG00000152894
Gene ExpressionPTPRK [ NCBI-GEO ]   PTPRK [ EBI - ARRAY_EXPRESS ]   PTPRK [ SEEK ]   PTPRK [ MEM ]
Gene Expression Viewer (FireBrowse)PTPRK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5796
GTEX Portal (Tissue expression)PTPRK
Human Protein AtlasENSG00000152894-PTPRK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15262   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15262  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15262
Splice isoforms : SwissVarQ15262
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
PhosPhoSitePlusQ15262
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    IG_LIKE (PS50835)    MAM_1 (PS00740)    MAM_2 (PS50060)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)ConA-like_dom_sf    FN3_dom    FN3_sf    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_I-set    Ig_sub    MAM_dom    Prot-tyrosine_phosphatase-like    PTPase_domain    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)fn3 (PF00041)    I-set (PF07679)    MAM (PF00629)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00041    pfam07679    pfam00629    pfam00102   
Domain families : Smart (EMBL)FN3 (SM00060)  IG (SM00409)  MAM (SM00137)  PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPRK
DMDM Disease mutations5796
Blocks (Seattle)PTPRK
PDB (SRS)2C7S   
PDB (PDBSum)2C7S   
PDB (IMB)2C7S   
PDB (RSDB)2C7S   
Structural Biology KnowledgeBase2C7S   
SCOP (Structural Classification of Proteins)2C7S   
CATH (Classification of proteins structures)2C7S   
SuperfamilyQ15262
Human Protein Atlas [tissue]ENSG00000152894-PTPRK [tissue]
Peptide AtlasQ15262
HPRD03968
IPIIPI00015756   IPI00644648   IPI00555714   IPI00553030   IPI00979748   IPI00470937   IPI00552597   IPI00871253   IPI00973773   IPI00978169   IPI00976967   IPI00979124   IPI00552690   IPI00981585   IPI00980074   IPI01008910   
Protein Interaction databases
DIP (DOE-UCLA)Q15262
IntAct (EBI)Q15262
FunCoupENSG00000152894
BioGRIDPTPRK
STRING (EMBL)PTPRK
ZODIACPTPRK
Ontologies - Pathways
QuickGOQ15262
Ontology : AmiGOphotoreceptor outer segment  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  protein binding  plasma membrane  integral component of plasma membrane  cell-cell junction  adherens junction  protein dephosphorylation  cell adhesion  signal transduction  transforming growth factor beta receptor signaling pathway  beta-catenin binding  negative regulation of cell proliferation  cell surface  negative regulation of keratinocyte proliferation  integral component of membrane  cell migration  protein kinase binding  cell junction  negative regulation of cell migration  axon  dendrite  neuron projection development  leading edge membrane  protein localization to cell surface  cellular response to reactive oxygen species  cellular response to UV  peptidyl-tyrosine dephosphorylation  neuronal cell body  intracellular membrane-bounded organelle  gamma-catenin binding  negative regulation of cell cycle  negative regulation of transcription, DNA-templated  focal adhesion assembly  
Ontology : EGO-EBIphotoreceptor outer segment  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  protein binding  plasma membrane  integral component of plasma membrane  cell-cell junction  adherens junction  protein dephosphorylation  cell adhesion  signal transduction  transforming growth factor beta receptor signaling pathway  beta-catenin binding  negative regulation of cell proliferation  cell surface  negative regulation of keratinocyte proliferation  integral component of membrane  cell migration  protein kinase binding  cell junction  negative regulation of cell migration  axon  dendrite  neuron projection development  leading edge membrane  protein localization to cell surface  cellular response to reactive oxygen species  cellular response to UV  peptidyl-tyrosine dephosphorylation  neuronal cell body  intracellular membrane-bounded organelle  gamma-catenin binding  negative regulation of cell cycle  negative regulation of transcription, DNA-templated  focal adhesion assembly  
NDEx NetworkPTPRK
Atlas of Cancer Signalling NetworkPTPRK
Wikipedia pathwaysPTPRK
Orthology - Evolution
OrthoDB5796
GeneTree (enSembl)ENSG00000152894
Phylogenetic Trees/Animal Genes : TreeFamPTPRK
HOVERGENQ15262
HOGENOMQ15262
Homologs : HomoloGenePTPRK
Homology/Alignments : Family Browser (UCSC)PTPRK
Gene fusions - Rearrangements
Fusion : MitelmanKIF13A/PTPRK [6p22.3/6q22.33]  [t(6;6)(p22;q22)]  
Fusion : MitelmanL3MBTL3/PTPRK [6q23.1/6q22.33]  [t(6;6)(q22;q23)]  
Fusion : MitelmanPTPRK/C6orf203 [6q22.33/6q21]  [t(6;6)(q21;q22)]  
Fusion : MitelmanPTPRK/HECA [6q22.33/6q24.1]  [t(6;6)(q22;q24)]  
Fusion : MitelmanPTPRK/OXR1 [6q22.33/8q23.1]  [t(6;8)(q22;q23)]  
Fusion : MitelmanPTPRK/PLN [6q22.33/6q22.31]  [t(6;6)(q22;q22)]  
Fusion : MitelmanPTPRK/RSPO3 [6q22.33/6q22.33]  [inv(6)(q22q22)]  
Fusion : MitelmanPTPRK/STXBP6 [6q22.33/14q12]  [t(6;14)(q22;q12)]  
Fusion : MitelmanPUM1/PTPRK [1p35.2/6q22.33]  [t(1;6)(p35;q22)]  
Fusion PortalAL137003.1 PTPRK 6q22.33 BRCA
Fusion PortalKIF13A 6p22.3 PTPRK 6q22.33 LUAD
Fusion PortalPTPRK 6q22.33 C6orf203 6q21 BRCA
Fusion PortalPTPRK 6q22.33 HECA 6q24.1 BRCA
Fusion PortalPTPRK 6q22.33 OXR1 8q23.1 BRCA
Fusion PortalPTPRK 6q22.33 PLN 6q22.31 BRCA
Fusion PortalPTPRK 6q22.33 STXBP6 14q12 BRCA
Fusion PortalPUM1 1p35.2 PTPRK 6q22.33 BRCA
Fusion : QuiverPTPRK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPRK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPRK
dbVarPTPRK
ClinVarPTPRK
1000_GenomesPTPRK 
Exome Variant ServerPTPRK
ExAC (Exome Aggregation Consortium)ENSG00000152894
GNOMAD BrowserENSG00000152894
Varsome BrowserPTPRK
Genetic variants : HAPMAP5796
Genomic Variants (DGV)PTPRK [DGVbeta]
DECIPHERPTPRK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPRK 
Mutations
ICGC Data PortalPTPRK 
TCGA Data PortalPTPRK 
Broad Tumor PortalPTPRK
OASIS PortalPTPRK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPRK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTPRK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTPRK
DgiDB (Drug Gene Interaction Database)PTPRK
DoCM (Curated mutations)PTPRK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPRK (select a term)
intoGenPTPRK
Cancer3DPTPRK(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602545   
Orphanet
DisGeNETPTPRK
MedgenPTPRK
Genetic Testing Registry PTPRK
NextProtQ15262 [Medical]
TSGene5796
GENETestsPTPRK
Target ValidationPTPRK
Huge Navigator PTPRK [HugePedia]
snp3D : Map Gene to Disease5796
BioCentury BCIQPTPRK
ClinGenPTPRK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5796
Chemical/Pharm GKB GenePA34019
Clinical trialPTPRK
Miscellaneous
canSAR (ICR)PTPRK (select the gene name)
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPRK
EVEXPTPRK
GoPubMedPTPRK
iHOPPTPRK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:33:22 CET 2018

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