Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PTPRK (protein tyrosine phosphatase receptor type K)

Identity

Alias (NCBI)R-PTP-kappa
HGNC (Hugo) PTPRK
HGNC Alias symbR-PTP-kappa
LocusID (NCBI) 5796
Atlas_Id 41933
Location 6q22.33  [Link to chromosome band 6q22]
Location_base_pair Starts at 127968785 and ends at 128520599 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AL137003.1 () / PTPRK (6q22.33)ANKRD36B (2q11.2) / PTPRK (6q22.33)KIF13A (6p22.3) / PTPRK (6q22.33)
L3MBTL3 (6q23.1) / PTPRK (6q22.33)PTPRK (6q22.33) / C6orf203 (6q21)PTPRK (6q22.33) / CACNB2 (10p12.33)
PTPRK (6q22.33) / CHMP1A (16q24.3)PTPRK (6q22.33) / HECA (6q24.1)PTPRK (6q22.33) / NHSL1 (6q23.3)
PTPRK (6q22.33) / OXR1 (8q23.1)PTPRK (6q22.33) / PKP2 (12p11.21)PTPRK (6q22.33) / PLN (6q22.31)
PTPRK (6q22.33) / PTPRK (6q22.33)PTPRK (6q22.33) / RSPO3 (6q22.33)PTPRK (6q22.33) / STAG3 (7q22.1)
PTPRK (6q22.33) / STXBP6 (14q12)PTPRK (6q22.33) / TAOK3 (12q24.23)PTPRK (6q22.33) / THEMIS (6q22.33)
PTPRK (6q22.33) / UACA (15q23)PUM1 (1p35.2) / PTPRK (6q22.33)PTPRK 6q22.33 / RSPO3 6q22.33
AL137003.1 PTPRK 6q22.33KIF13A 6p22.3 / PTPRK 6q22.33PTPRK 6q22.33 / C6orf203 6q21
PTPRK 6q22.33 / HECA 6q24.1PTPRK 6q22.33 / OXR1 8q23.1PTPRK 6q22.33 / PLN 6q22.31
PTPRK 6q22.33 / STXBP6 14q12PUM1 1p35.2 / PTPRK 6q22.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(q22;q23) L3MBTL3/PTPRK


External links

 

Nomenclature
HGNC (Hugo)PTPRK   9674
Cards
Entrez_Gene (NCBI)PTPRK    protein tyrosine phosphatase receptor type K
AliasesR-PTP-kappa
GeneCards (Weizmann)PTPRK
Ensembl hg19 (Hinxton)ENSG00000152894 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152894 [Gene_View]  ENSG00000152894 [Sequence]  chr6:127968785-128520599 [Contig_View]  PTPRK [Vega]
ICGC DataPortalENSG00000152894
TCGA cBioPortalPTPRK
AceView (NCBI)PTPRK
Genatlas (Paris)PTPRK
SOURCE (Princeton)PTPRK
Genetics Home Reference (NIH)PTPRK
Genomic and cartography
GoldenPath hg38 (UCSC)PTPRK  -     chr6:127968785-128520599 -  6q22.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPRK  -     6q22.33   [Description]    (hg19-Feb_2009)
GoldenPathPTPRK - 6q22.33 [CytoView hg19]  PTPRK - 6q22.33 [CytoView hg38]
ImmunoBaseENSG00000152894
Genome Data Viewer NCBIPTPRK [Mapview hg19]  
OMIM602545   
Gene and transcription
Genbank (Entrez)AB209670 AF533875 AK295028 BC063596 BC140775
RefSeq transcript (Entrez)NM_001135648 NM_001291981 NM_001291982 NM_001291983 NM_001291984 NM_002844
Consensus coding sequences : CCDS (NCBI)PTPRK
Gene ExpressionPTPRK [ NCBI-GEO ]   PTPRK [ EBI - ARRAY_EXPRESS ]   PTPRK [ SEEK ]   PTPRK [ MEM ]
Gene Expression Viewer (FireBrowse)PTPRK [ Firebrowse - Broad ]
GenevisibleExpression of PTPRK in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5796
GTEX Portal (Tissue expression)PTPRK
Human Protein AtlasENSG00000152894-PTPRK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15262   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15262  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15262
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ15262
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    IG_LIKE (PS50835)    MAM_1 (PS00740)    MAM_2 (PS50060)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)ConA-like_dom_sf    FN3_dom    FN3_sf    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_I-set    Ig_sub    MAM_dom    Prot-tyrosine_phosphatase-like    PTPase_domain    PTPRJ_TM    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)fn3 (PF00041)    I-set (PF07679)    MAM (PF00629)    PTP_tm (PF18861)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00041    pfam07679    pfam00629    pfam18861    pfam00102   
Domain families : Smart (EMBL)FN3 (SM00060)  IG (SM00409)  MAM (SM00137)  PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPRK
PDB (RSDB)2C7S   
PDB Europe2C7S   
PDB (PDBSum)2C7S   
PDB (IMB)2C7S   
Structural Biology KnowledgeBase2C7S   
SCOP (Structural Classification of Proteins)2C7S   
CATH (Classification of proteins structures)2C7S   
SuperfamilyQ15262
AlphaFold pdb e-kbQ15262   
Human Protein Atlas [tissue]ENSG00000152894-PTPRK [tissue]
HPRD03968
Protein Interaction databases
DIP (DOE-UCLA)Q15262
IntAct (EBI)Q15262
BioGRIDPTPRK
STRING (EMBL)PTPRK
ZODIACPTPRK
Ontologies - Pathways
QuickGOQ15262
Ontology : AmiGOprotein tyrosine phosphatase activity  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  protein binding  plasma membrane  integral component of plasma membrane  cell-cell junction  adherens junction  protein dephosphorylation  protein dephosphorylation  cell adhesion  signal transduction  transforming growth factor beta receptor signaling pathway  beta-catenin binding  negative regulation of cell population proliferation  cell surface  negative regulation of keratinocyte proliferation  integral component of membrane  cell migration  protein kinase binding  cell junction  T cell differentiation  negative regulation of cell migration  neuron projection development  leading edge membrane  protein localization to cell surface  cellular response to reactive oxygen species  cellular response to UV  peptidyl-tyrosine dephosphorylation  intracellular membrane-bounded organelle  gamma-catenin binding  negative regulation of cell cycle  negative regulation of transcription, DNA-templated  focal adhesion assembly  
Ontology : EGO-EBIprotein tyrosine phosphatase activity  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  protein binding  plasma membrane  integral component of plasma membrane  cell-cell junction  adherens junction  protein dephosphorylation  protein dephosphorylation  cell adhesion  signal transduction  transforming growth factor beta receptor signaling pathway  beta-catenin binding  negative regulation of cell population proliferation  cell surface  negative regulation of keratinocyte proliferation  integral component of membrane  cell migration  protein kinase binding  cell junction  T cell differentiation  negative regulation of cell migration  neuron projection development  leading edge membrane  protein localization to cell surface  cellular response to reactive oxygen species  cellular response to UV  peptidyl-tyrosine dephosphorylation  intracellular membrane-bounded organelle  gamma-catenin binding  negative regulation of cell cycle  negative regulation of transcription, DNA-templated  focal adhesion assembly  
NDEx NetworkPTPRK
Atlas of Cancer Signalling NetworkPTPRK
Wikipedia pathwaysPTPRK
Orthology - Evolution
OrthoDB5796
GeneTree (enSembl)ENSG00000152894
Phylogenetic Trees/Animal Genes : TreeFamPTPRK
Homologs : HomoloGenePTPRK
Homology/Alignments : Family Browser (UCSC)PTPRK
Gene fusions - Rearrangements
Fusion : MitelmanKIF13A/PTPRK [6p22.3/6q22.33]  
Fusion : MitelmanL3MBTL3/PTPRK [6q23.1/6q22.33]  
Fusion : MitelmanPTPRK/C6orf203 [6q22.33/6q21]  
Fusion : MitelmanPTPRK/HECA [6q22.33/6q24.1]  
Fusion : MitelmanPTPRK/OXR1 [6q22.33/8q23.1]  
Fusion : MitelmanPTPRK/PLN [6q22.33/6q22.31]  
Fusion : MitelmanPTPRK/RSPO3 [6q22.33/6q22.33]  
Fusion : MitelmanPTPRK/STXBP6 [6q22.33/14q12]  
Fusion : MitelmanPUM1/PTPRK [1p35.2/6q22.33]  
Fusion : QuiverPTPRK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPRK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPRK
dbVarPTPRK
ClinVarPTPRK
MonarchPTPRK
1000_GenomesPTPRK 
Exome Variant ServerPTPRK
GNOMAD BrowserENSG00000152894
Varsome BrowserPTPRK
ACMGPTPRK variants
VarityQ15262
Genomic Variants (DGV)PTPRK [DGVbeta]
DECIPHERPTPRK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPRK 
Mutations
ICGC Data PortalPTPRK 
TCGA Data PortalPTPRK 
Broad Tumor PortalPTPRK
OASIS PortalPTPRK [ Somatic mutations - Copy number]
Cancer Gene: CensusPTPRK 
Somatic Mutations in Cancer : COSMICPTPRK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPTPRK
Mutations and Diseases : HGMDPTPRK
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPTPRK
DgiDB (Drug Gene Interaction Database)PTPRK
DoCM (Curated mutations)PTPRK
CIViC (Clinical Interpretations of Variants in Cancer)PTPRK
Cancer3DPTPRK
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602545   
Orphanet
DisGeNETPTPRK
MedgenPTPRK
Genetic Testing Registry PTPRK
NextProtQ15262 [Medical]
GENETestsPTPRK
Target ValidationPTPRK
Huge Navigator PTPRK [HugePedia]
ClinGenPTPRK
Clinical trials, drugs, therapy
MyCancerGenomePTPRK
Protein Interactions : CTDPTPRK
Pharm GKB GenePA34019
PharosQ15262
Clinical trialPTPRK
Miscellaneous
canSAR (ICR)PTPRK
HarmonizomePTPRK
DataMed IndexPTPRK
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPTPRK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:27:32 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.