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PTPRN (protein tyrosine phosphatase receptor type N)

Identity

Alias (NCBI)IA-2
IA-2/PTP
IA2
ICA512
R-PTP-N
HGNC (Hugo) PTPRN
HGNC Alias symbIA-2
ICA512
HGNC Alias nameinsulinoma-associated tyrosine-phosphatase-like protein
 islet cell antigen 512
LocusID (NCBI) 5798
Atlas_Id 41935
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 219289623 and ends at 219309401 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HELZ (17q24.2)::PTPRN (2q35)PTPRN (2q35)::GNAS (20q13.32)PTPRN (2q35)::PTPRN (2q35)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PTPRN   9676
Cards
Entrez_Gene (NCBI)PTPRN    protein tyrosine phosphatase receptor type N
AliasesIA-2; IA-2/PTP; IA2; ICA512; 
R-PTP-N
GeneCards (Weizmann)PTPRN
Ensembl hg19 (Hinxton)ENSG00000054356 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000054356 [Gene_View]  ENSG00000054356 [Sequence]  chr2:219289623-219309401 [Contig_View]  PTPRN [Vega]
ICGC DataPortalENSG00000054356
TCGA cBioPortalPTPRN
AceView (NCBI)PTPRN
Genatlas (Paris)PTPRN
SOURCE (Princeton)PTPRN
Genetics Home Reference (NIH)PTPRN
Genomic and cartography
GoldenPath hg38 (UCSC)PTPRN  -     chr2:219289623-219309401 -  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPRN  -     2q35   [Description]    (hg19-Feb_2009)
GoldenPathPTPRN - 2q35 [CytoView hg19]  PTPRN - 2q35 [CytoView hg38]
ImmunoBaseENSG00000054356
Genome Data Viewer NCBIPTPRN [Mapview hg19]  
OMIM601773   
Gene and transcription
Genbank (Entrez)AB209368 AK054765 AK122679 AK291469 AK294490
RefSeq transcript (Entrez)NM_001199763 NM_001199764 NM_002846
Consensus coding sequences : CCDS (NCBI)PTPRN
Gene ExpressionPTPRN [ NCBI-GEO ]   PTPRN [ EBI - ARRAY_EXPRESS ]   PTPRN [ SEEK ]   PTPRN [ MEM ]
Gene Expression Viewer (FireBrowse)PTPRN [ Firebrowse - Broad ]
GenevisibleExpression of PTPRN in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5798
GTEX Portal (Tissue expression)PTPRN
Human Protein AtlasENSG00000054356-PTPRN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16849   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16849  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16849
PhosPhoSitePlusQ16849
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)IA-2/IA-2_beta    Prot-tyrosine_phosphatase-like    PTPase_domain    Receptor_IA-2_dom    Receptor_IA-2_ectodomain_sf    RESP18_dom    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)Receptor_IA-2 (PF11548)    RESP18 (PF14948)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam11548    pfam14948    pfam00102   
Domain families : Smart (EMBL)PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPRN
PDB (RSDB)2I1Y    2QT7    3N01    3N4W    3NG8    3NP5   
PDB Europe2I1Y    2QT7    3N01    3N4W    3NG8    3NP5   
PDB (PDBSum)2I1Y    2QT7    3N01    3N4W    3NG8    3NP5   
PDB (IMB)2I1Y    2QT7    3N01    3N4W    3NG8    3NP5   
Structural Biology KnowledgeBase2I1Y    2QT7    3N01    3N4W    3NG8    3NP5   
SCOP (Structural Classification of Proteins)2I1Y    2QT7    3N01    3N4W    3NG8    3NP5   
CATH (Classification of proteins structures)2I1Y    2QT7    3N01    3N4W    3NG8    3NP5   
SuperfamilyQ16849
AlphaFold pdb e-kbQ16849   
Human Protein Atlas [tissue]ENSG00000054356-PTPRN [tissue]
HPRD03466
Protein Interaction databases
DIP (DOE-UCLA)Q16849
IntAct (EBI)Q16849
BioGRIDPTPRN
STRING (EMBL)PTPRN
ZODIACPTPRN
Ontologies - Pathways
QuickGOQ16849
Ontology : AmiGOresponse to reactive oxygen species  luteinization  protein tyrosine phosphatase activity  protein binding  nucleus  endosome  Golgi apparatus  plasma membrane  synaptic vesicle  transcription factor binding  integral component of membrane  cytokine-mediated signaling pathway  insulin secretion  secretory granule  spectrin binding  transport vesicle membrane  response to insulin  peptidyl-tyrosine dephosphorylation  insulin secretion involved in cellular response to glucose stimulus  neuronal cell body  perikaryon  response to estrogen  axon terminus  ubiquitin-like protein ligase binding  synapse  positive regulation of transcription by RNA polymerase II  GTPase binding  response to cAMP  positive regulation of type B pancreatic cell proliferation  dense core granule maturation  
Ontology : EGO-EBIresponse to reactive oxygen species  luteinization  protein tyrosine phosphatase activity  protein binding  nucleus  endosome  Golgi apparatus  plasma membrane  synaptic vesicle  transcription factor binding  integral component of membrane  cytokine-mediated signaling pathway  insulin secretion  secretory granule  spectrin binding  transport vesicle membrane  response to insulin  peptidyl-tyrosine dephosphorylation  insulin secretion involved in cellular response to glucose stimulus  neuronal cell body  perikaryon  response to estrogen  axon terminus  ubiquitin-like protein ligase binding  synapse  positive regulation of transcription by RNA polymerase II  GTPase binding  response to cAMP  positive regulation of type B pancreatic cell proliferation  dense core granule maturation  
Pathways : KEGGType I diabetes mellitus   
NDEx NetworkPTPRN
Atlas of Cancer Signalling NetworkPTPRN
Wikipedia pathwaysPTPRN
Orthology - Evolution
OrthoDB5798
GeneTree (enSembl)ENSG00000054356
Phylogenetic Trees/Animal Genes : TreeFamPTPRN
Homologs : HomoloGenePTPRN
Homology/Alignments : Family Browser (UCSC)PTPRN
Gene fusions - Rearrangements
Fusion : QuiverPTPRN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPRN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPRN
dbVarPTPRN
ClinVarPTPRN
MonarchPTPRN
1000_GenomesPTPRN 
Exome Variant ServerPTPRN
GNOMAD BrowserENSG00000054356
Varsome BrowserPTPRN
ACMGPTPRN variants
VarityQ16849
Genomic Variants (DGV)PTPRN [DGVbeta]
DECIPHERPTPRN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPRN 
Mutations
ICGC Data PortalPTPRN 
TCGA Data PortalPTPRN 
Broad Tumor PortalPTPRN
OASIS PortalPTPRN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPRN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPTPRN
Mutations and Diseases : HGMDPTPRN
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPTPRN
DgiDB (Drug Gene Interaction Database)PTPRN
DoCM (Curated mutations)PTPRN
CIViC (Clinical Interpretations of Variants in Cancer)PTPRN
Cancer3DPTPRN
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601773   
Orphanet
DisGeNETPTPRN
MedgenPTPRN
Genetic Testing Registry PTPRN
NextProtQ16849 [Medical]
GENETestsPTPRN
Target ValidationPTPRN
Huge Navigator PTPRN [HugePedia]
ClinGenPTPRN
Clinical trials, drugs, therapy
MyCancerGenomePTPRN
Protein Interactions : CTDPTPRN
Pharm GKB GenePA34021
PharosQ16849
Clinical trialPTPRN
Miscellaneous
canSAR (ICR)PTPRN
HarmonizomePTPRN
ARCHS4PTPRN
DataMed IndexPTPRN
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPTPRN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun Jan 16 18:29:46 CET 2022

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