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PTPRN (protein tyrosine phosphatase, receptor type N)

Identity

Alias_symbol (synonym)IA-2
Other aliasIA-2/PTP
IA2
ICA512
R-PTP-N
HGNC (Hugo) PTPRN
LocusID (NCBI) 5798
Atlas_Id 41935
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 219289623 and ends at 219309573 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HELZ (17q24.2) / PTPRN (2q35)PTPRN (2q35) / GNAS (20q13.32)PTPRN (2q35) / PTPRN (2q35)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTPRN   9676
Cards
Entrez_Gene (NCBI)PTPRN  5798  protein tyrosine phosphatase, receptor type N
AliasesIA-2; IA-2/PTP; IA2; ICA512; 
R-PTP-N
GeneCards (Weizmann)PTPRN
Ensembl hg19 (Hinxton)ENSG00000054356 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000054356 [Gene_View]  chr2:219289623-219309573 [Contig_View]  PTPRN [Vega]
ICGC DataPortalENSG00000054356
TCGA cBioPortalPTPRN
AceView (NCBI)PTPRN
Genatlas (Paris)PTPRN
WikiGenes5798
SOURCE (Princeton)PTPRN
Genetics Home Reference (NIH)PTPRN
Genomic and cartography
GoldenPath hg38 (UCSC)PTPRN  -     chr2:219289623-219309573 -  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPRN  -     2q35   [Description]    (hg19-Feb_2009)
EnsemblPTPRN - 2q35 [CytoView hg19]  PTPRN - 2q35 [CytoView hg38]
Mapping of homologs : NCBIPTPRN [Mapview hg19]  PTPRN [Mapview hg38]
OMIM601773   
Gene and transcription
Genbank (Entrez)AB209368 AK054765 AK122679 AK291469 AK294490
RefSeq transcript (Entrez)NM_001199763 NM_001199764 NM_002846
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTPRN
Cluster EST : UnigeneHs.89655 [ NCBI ]
CGAP (NCI)Hs.89655
Alternative Splicing GalleryENSG00000054356
Gene ExpressionPTPRN [ NCBI-GEO ]   PTPRN [ EBI - ARRAY_EXPRESS ]   PTPRN [ SEEK ]   PTPRN [ MEM ]
Gene Expression Viewer (FireBrowse)PTPRN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5798
GTEX Portal (Tissue expression)PTPRN
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16849   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16849  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16849
Splice isoforms : SwissVarQ16849
PhosPhoSitePlusQ16849
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)IA-2/IA-2_beta    Prot-tyrosine_phosphatase-like    PTPase_domain    Receptor_IA-2_dom    RESP18_dom    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)Receptor_IA-2 (PF11548)    RESP18 (PF14948)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam11548    pfam14948    pfam00102   
Domain families : Smart (EMBL)PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPRN
DMDM Disease mutations5798
Blocks (Seattle)PTPRN
PDB (SRS)2I1Y    2QT7    3N01    3N4W    3NG8    3NP5   
PDB (PDBSum)2I1Y    2QT7    3N01    3N4W    3NG8    3NP5   
PDB (IMB)2I1Y    2QT7    3N01    3N4W    3NG8    3NP5   
PDB (RSDB)2I1Y    2QT7    3N01    3N4W    3NG8    3NP5   
Structural Biology KnowledgeBase2I1Y    2QT7    3N01    3N4W    3NG8    3NP5   
SCOP (Structural Classification of Proteins)2I1Y    2QT7    3N01    3N4W    3NG8    3NP5   
CATH (Classification of proteins structures)2I1Y    2QT7    3N01    3N4W    3NG8    3NP5   
SuperfamilyQ16849
Human Protein AtlasENSG00000054356
Peptide AtlasQ16849
HPRD03466
IPIIPI00004440   IPI01013129   IPI00916379   IPI00917520   IPI00917612   IPI00917188   IPI00915873   IPI00916029   IPI00917996   
Protein Interaction databases
DIP (DOE-UCLA)Q16849
IntAct (EBI)Q16849
FunCoupENSG00000054356
BioGRIDPTPRN
STRING (EMBL)PTPRN
ZODIACPTPRN
Ontologies - Pathways
QuickGOQ16849
Ontology : AmiGOresponse to reactive oxygen species  luteinization  protein tyrosine phosphatase activity  protein binding  nucleus  endosome  Golgi apparatus  plasma membrane  transcription, DNA-templated  synaptic vesicle  transcription factor binding  integral component of membrane  cytokine-mediated signaling pathway  cell junction  insulin secretion  secretory granule  axon  spectrin binding  transport vesicle membrane  response to insulin  insulin secretion involved in cellular response to glucose stimulus  neuronal cell body  perikaryon  response to estrogen  axon terminus  ubiquitin-like protein ligase binding  synapse  positive regulation of transcription from RNA polymerase II promoter  GTPase binding  response to cAMP  positive regulation of type B pancreatic cell proliferation  dense core granule maturation  
Ontology : EGO-EBIresponse to reactive oxygen species  luteinization  protein tyrosine phosphatase activity  protein binding  nucleus  endosome  Golgi apparatus  plasma membrane  transcription, DNA-templated  synaptic vesicle  transcription factor binding  integral component of membrane  cytokine-mediated signaling pathway  cell junction  insulin secretion  secretory granule  axon  spectrin binding  transport vesicle membrane  response to insulin  insulin secretion involved in cellular response to glucose stimulus  neuronal cell body  perikaryon  response to estrogen  axon terminus  ubiquitin-like protein ligase binding  synapse  positive regulation of transcription from RNA polymerase II promoter  GTPase binding  response to cAMP  positive regulation of type B pancreatic cell proliferation  dense core granule maturation  
Pathways : KEGGType I diabetes mellitus   
NDEx NetworkPTPRN
Atlas of Cancer Signalling NetworkPTPRN
Wikipedia pathwaysPTPRN
Orthology - Evolution
OrthoDB5798
GeneTree (enSembl)ENSG00000054356
Phylogenetic Trees/Animal Genes : TreeFamPTPRN
HOVERGENQ16849
HOGENOMQ16849
Homologs : HomoloGenePTPRN
Homology/Alignments : Family Browser (UCSC)PTPRN
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPRN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPRN
dbVarPTPRN
ClinVarPTPRN
1000_GenomesPTPRN 
Exome Variant ServerPTPRN
ExAC (Exome Aggregation Consortium)PTPRN (select the gene name)
Genetic variants : HAPMAP5798
Genomic Variants (DGV)PTPRN [DGVbeta]
DECIPHERPTPRN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPRN 
Mutations
ICGC Data PortalPTPRN 
TCGA Data PortalPTPRN 
Broad Tumor PortalPTPRN
OASIS PortalPTPRN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPRN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTPRN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTPRN
DgiDB (Drug Gene Interaction Database)PTPRN
DoCM (Curated mutations)PTPRN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPRN (select a term)
intoGenPTPRN
Cancer3DPTPRN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601773   
Orphanet
MedgenPTPRN
Genetic Testing Registry PTPRN
NextProtQ16849 [Medical]
TSGene5798
GENETestsPTPRN
Target ValidationPTPRN
Huge Navigator PTPRN [HugePedia]
snp3D : Map Gene to Disease5798
BioCentury BCIQPTPRN
ClinGenPTPRN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5798
Chemical/Pharm GKB GenePA34021
Clinical trialPTPRN
Miscellaneous
canSAR (ICR)PTPRN (select the gene name)
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPRN
EVEXPTPRN
GoPubMedPTPRN
iHOPPTPRN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:51:50 CEST 2017

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