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PTPRN2 (protein tyrosine phosphatase receptor type N2)

Identity

Alias (NCBI)IA-2beta
IAR
ICAAR
PTPRP
R-PTP-N2
HGNC (Hugo) PTPRN2
HGNC Alias symbKIAA0387
phogrin
ICAAR
IA-2beta
HGNC Alias nameIAR PTPRP
HGNC Previous nameprotein tyrosine phosphatase, receptor type, N polypeptide 2
LocusID (NCBI) 5799
Atlas_Id 41936
Location 7q36.3  [Link to chromosome band 7q36]
Location_base_pair Starts at 157539056 and ends at 158587823 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACIN1 (14q11.2)::PTPRN2 (7q36.3)ACTR3B (7q36.1)::PTPRN2 (7q36.3)ANKIB1 (7q21.2)::PTPRN2 (7q36.3)
BLCAP (20q11.23)::PTPRN2 (7q36.3)ESYT2 (7q36.3)::PTPRN2 (7q36.3)FNBP1L (1p22.1)::PTPRN2 (7q36.3)
LMBR1 (7q36.3)::PTPRN2 (7q36.3)PTPRN2 (7q36.3)::ANKRD13A (12q24.11)PTPRN2 (7q36.3)::CADM2 (3p12.1)
PTPRN2 (7q36.3)::FGF3 (11q13.3)PTPRN2 (7q36.3)::GALNT11 (7q36.1)PTPRN2 (7q36.3)::PRKAR1B (7p22.3)
PTPRN2 (7q36.3)::PTPRN2 (7q36.3)PTPRN2 (7q36.3)::SSBP3 (1p32.3)TMEM87A (15q15.1)::PTPRN2 (7q36.3)
UBE3C (7q36.3)::PTPRN2 (7q36.3)LMBR1 7q36.3::PTPRN2 7q36.3PTPRN2 7q36.3::GALNT11 7q36.1
TMEM87A 15q15.1::PTPRN2 7q36.3UBE3C 7q36.3::PTPRN2 7q36.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PTPRN2   9677
Cards
Entrez_Gene (NCBI)PTPRN2    protein tyrosine phosphatase receptor type N2
AliasesIA-2beta; IAR; ICAAR; PTPRP; 
R-PTP-N2
GeneCards (Weizmann)PTPRN2
Ensembl hg19 (Hinxton)ENSG00000155093 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000155093 [Gene_View]  ENSG00000155093 [Sequence]  chr7:157539056-158587823 [Contig_View]  PTPRN2 [Vega]
ICGC DataPortalENSG00000155093
TCGA cBioPortalPTPRN2
AceView (NCBI)PTPRN2
Genatlas (Paris)PTPRN2
SOURCE (Princeton)PTPRN2
Genetics Home Reference (NIH)PTPRN2
Genomic and cartography
GoldenPath hg38 (UCSC)PTPRN2  -     chr7:157539056-158587823 -  7q36.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPRN2  -     7q36.3   [Description]    (hg19-Feb_2009)
GoldenPathPTPRN2 - 7q36.3 [CytoView hg19]  PTPRN2 - 7q36.3 [CytoView hg38]
ImmunoBaseENSG00000155093
Genome Data Viewer NCBIPTPRN2 [Mapview hg19]  
OMIM601698   
Gene and transcription
Genbank (Entrez)AB002385 AF007555 AL157451 AW292950 BC034040
RefSeq transcript (Entrez)NM_001308267 NM_001308268 NM_002847 NM_130842 NM_130843
Consensus coding sequences : CCDS (NCBI)PTPRN2
Gene ExpressionPTPRN2 [ NCBI-GEO ]   PTPRN2 [ EBI - ARRAY_EXPRESS ]   PTPRN2 [ SEEK ]   PTPRN2 [ MEM ]
Gene Expression Viewer (FireBrowse)PTPRN2 [ Firebrowse - Broad ]
GenevisibleExpression of PTPRN2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5799
GTEX Portal (Tissue expression)PTPRN2
Human Protein AtlasENSG00000155093-PTPRN2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92932   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92932  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92932
Catalytic activity : Enzyme3.1.3.- [ Enzyme-Expasy ]   3.1.3.-3.1.3.- [ IntEnz-EBI ]   3.1.3.- [ BRENDA ]   3.1.3.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ92932
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)IA-2/IA-2_beta    Prot-tyrosine_phosphatase-like    PTPase_domain    Receptor_IA-2_dom    Receptor_IA-2_ectodomain_sf    RESP18_dom    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)Receptor_IA-2 (PF11548)    RESP18 (PF14948)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam11548    pfam14948    pfam00102   
Domain families : Smart (EMBL)PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPRN2
PDB (RSDB)2QEP    4HTI    4HTJ   
PDB Europe2QEP    4HTI    4HTJ   
PDB (PDBSum)2QEP    4HTI    4HTJ   
PDB (IMB)2QEP    4HTI    4HTJ   
Structural Biology KnowledgeBase2QEP    4HTI    4HTJ   
SCOP (Structural Classification of Proteins)2QEP    4HTI    4HTJ   
CATH (Classification of proteins structures)2QEP    4HTI    4HTJ   
SuperfamilyQ92932
AlphaFold pdb e-kbQ92932   
Human Protein Atlas [tissue]ENSG00000155093-PTPRN2 [tissue]
HPRD03413
Protein Interaction databases
DIP (DOE-UCLA)Q92932
IntAct (EBI)Q92932
BioGRIDPTPRN2
STRING (EMBL)PTPRN2
ZODIACPTPRN2
Ontologies - Pathways
QuickGOQ92932
Ontology : AmiGOtransmembrane receptor protein tyrosine phosphatase activity  plasma membrane  integral component of plasma membrane  protein dephosphorylation  lipid metabolic process  neurotransmitter secretion  secretory granule membrane  synaptic vesicle membrane  peptidyl-tyrosine dephosphorylation  insulin secretion involved in cellular response to glucose stimulus  receptor complex  ficolin-1-rich granule membrane  
Ontology : EGO-EBItransmembrane receptor protein tyrosine phosphatase activity  plasma membrane  integral component of plasma membrane  protein dephosphorylation  lipid metabolic process  neurotransmitter secretion  secretory granule membrane  synaptic vesicle membrane  peptidyl-tyrosine dephosphorylation  insulin secretion involved in cellular response to glucose stimulus  receptor complex  ficolin-1-rich granule membrane  
Pathways : KEGGKEGG_TYPE_I_DIABETES_MELLITUS   
NDEx NetworkPTPRN2
Atlas of Cancer Signalling NetworkPTPRN2
Wikipedia pathwaysPTPRN2
Orthology - Evolution
OrthoDB5799
GeneTree (enSembl)ENSG00000155093
Phylogenetic Trees/Animal Genes : TreeFamPTPRN2
Homologs : HomoloGenePTPRN2
Homology/Alignments : Family Browser (UCSC)PTPRN2
Gene fusions - Rearrangements
Fusion : MitelmanACTR3B::PTPRN2 [7q36.1/7q36.3]  
Fusion : MitelmanLMBR1::PTPRN2 [7q36.3/7q36.3]  
Fusion : MitelmanPTPRN2::GALNT11 [7q36.3/7q36.1]  
Fusion : MitelmanTMEM87A::PTPRN2 [15q15.1/7q36.3]  
Fusion : MitelmanUBE3C::PTPRN2 [7q36.3/7q36.3]  
Fusion : QuiverPTPRN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPRN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPRN2
dbVarPTPRN2
ClinVarPTPRN2
MonarchPTPRN2
1000_GenomesPTPRN2 
Exome Variant ServerPTPRN2
GNOMAD BrowserENSG00000155093
Varsome BrowserPTPRN2
ACMGPTPRN2 variants
VarityQ92932
Genomic Variants (DGV)PTPRN2 [DGVbeta]
DECIPHERPTPRN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPRN2 
Mutations
ICGC Data PortalPTPRN2 
TCGA Data PortalPTPRN2 
Broad Tumor PortalPTPRN2
OASIS PortalPTPRN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPRN2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPTPRN2
Mutations and Diseases : HGMDPTPRN2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPTPRN2
DgiDB (Drug Gene Interaction Database)PTPRN2
DoCM (Curated mutations)PTPRN2
CIViC (Clinical Interpretations of Variants in Cancer)PTPRN2
Cancer3DPTPRN2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601698   
Orphanet
DisGeNETPTPRN2
MedgenPTPRN2
Genetic Testing Registry PTPRN2
NextProtQ92932 [Medical]
GENETestsPTPRN2
Target ValidationPTPRN2
Huge Navigator PTPRN2 [HugePedia]
ClinGenPTPRN2
Clinical trials, drugs, therapy
MyCancerGenomePTPRN2
Protein Interactions : CTDPTPRN2
Pharm GKB GenePA34022
PharosQ92932
Clinical trialPTPRN2
Miscellaneous
canSAR (ICR)PTPRN2
HarmonizomePTPRN2
ARCHS4PTPRN2
DataMed IndexPTPRN2
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPTPRN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:54:36 CET 2022

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