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PTPRN2 (protein tyrosine phosphatase, receptor type N2)

Identity

Alias_namesprotein tyrosine phosphatase
Alias_symbol (synonym)KIAA0387
phogrin
ICAAR
IA-2beta
Other aliasIAR
PTPRP
R-PTP-N2
HGNC (Hugo) PTPRN2
LocusID (NCBI) 5799
Atlas_Id 41936
Location 7q36.3  [Link to chromosome band 7q36]
Location_base_pair Starts at 157331746 and ends at 158380494 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACIN1 (14q11.2) / PTPRN2 (7q36.3)ACTR3B (7q36.1) / PTPRN2 (7q36.3)ANKIB1 (7q21.2) / PTPRN2 (7q36.3)
BLCAP (20q11.23) / PTPRN2 (7q36.3)ESYT2 (7q36.3) / PTPRN2 (7q36.3)FNBP1L (1p22.1) / PTPRN2 (7q36.3)
LMBR1 (7q36.3) / PTPRN2 (7q36.3)PTPRN2 (7q36.3) / ANKRD13A (12q24.11)PTPRN2 (7q36.3) / CADM2 (3p12.1)
PTPRN2 (7q36.3) / FGF3 (11q13.3)PTPRN2 (7q36.3) / GALNT11 (7q36.1)PTPRN2 (7q36.3) / PRKAR1B (7p22.3)
PTPRN2 (7q36.3) / PTPRN2 (7q36.3)PTPRN2 (7q36.3) / SSBP3 (1p32.3)TMEM87A (15q15.1) / PTPRN2 (7q36.3)
UBE3C (7q36.3) / PTPRN2 (7q36.3)LMBR1 7q36.3 / PTPRN2 7q36.3PTPRN2 7q36.3 / GALNT11 7q36.1
TMEM87A 15q15.1 / PTPRN2 7q36.3UBE3C 7q36.3 / PTPRN2 7q36.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTPRN2   9677
Cards
Entrez_Gene (NCBI)PTPRN2  5799  protein tyrosine phosphatase, receptor type N2
AliasesIA-2beta; IAR; ICAAR; PTPRP; 
R-PTP-N2
GeneCards (Weizmann)PTPRN2
Ensembl hg19 (Hinxton)ENSG00000155093 [Gene_View]  chr7:157331746-158380494 [Contig_View]  PTPRN2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000155093 [Gene_View]  chr7:157331746-158380494 [Contig_View]  PTPRN2 [Vega]
ICGC DataPortalENSG00000155093
TCGA cBioPortalPTPRN2
AceView (NCBI)PTPRN2
Genatlas (Paris)PTPRN2
WikiGenes5799
SOURCE (Princeton)PTPRN2
Genetics Home Reference (NIH)PTPRN2
Genomic and cartography
GoldenPath hg19 (UCSC)PTPRN2  -     chr7:157331746-158380494 -  7q36.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PTPRN2  -     7q36.3   [Description]    (hg38-Dec_2013)
EnsemblPTPRN2 - 7q36.3 [CytoView hg19]  PTPRN2 - 7q36.3 [CytoView hg38]
Mapping of homologs : NCBIPTPRN2 [Mapview hg19]  PTPRN2 [Mapview hg38]
OMIM601698   
Gene and transcription
Genbank (Entrez)AB002385 AB383870 AF007555 AL157451 AW292950
RefSeq transcript (Entrez)NM_001308267 NM_001308268 NM_002847 NM_130842 NM_130843
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_029966 NT_007933 NW_004929334
Consensus coding sequences : CCDS (NCBI)PTPRN2
Cluster EST : UnigeneHs.490789 [ NCBI ]
CGAP (NCI)Hs.490789
Alternative Splicing GalleryENSG00000155093
Gene ExpressionPTPRN2 [ NCBI-GEO ]   PTPRN2 [ EBI - ARRAY_EXPRESS ]   PTPRN2 [ SEEK ]   PTPRN2 [ MEM ]
Gene Expression Viewer (FireBrowse)PTPRN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5799
GTEX Portal (Tissue expression)PTPRN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92932   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92932  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92932
Splice isoforms : SwissVarQ92932
PhosPhoSitePlusQ92932
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)Prot-tyrosine_phosphatase-like    PTPase_domain    Receptor_IA-2_dom    RESP18_dom    Tyr_Pase_AS    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)Receptor_IA-2 (PF11548)    RESP18 (PF14948)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam11548    pfam14948    pfam00102   
Domain families : Smart (EMBL)PTPc (SM00194)  
Conserved Domain (NCBI)PTPRN2
DMDM Disease mutations5799
Blocks (Seattle)PTPRN2
PDB (SRS)2QEP    4HTI    4HTJ   
PDB (PDBSum)2QEP    4HTI    4HTJ   
PDB (IMB)2QEP    4HTI    4HTJ   
PDB (RSDB)2QEP    4HTI    4HTJ   
Structural Biology KnowledgeBase2QEP    4HTI    4HTJ   
SCOP (Structural Classification of Proteins)2QEP    4HTI    4HTJ   
CATH (Classification of proteins structures)2QEP    4HTI    4HTJ   
SuperfamilyQ92932
Human Protein AtlasENSG00000155093
Peptide AtlasQ92932
HPRD03413
IPIIPI00334666   IPI00334667   IPI00902906   IPI00917684   IPI00472249   
Protein Interaction databases
DIP (DOE-UCLA)Q92932
IntAct (EBI)Q92932
FunCoupENSG00000155093
BioGRIDPTPRN2
STRING (EMBL)PTPRN2
ZODIACPTPRN2
Ontologies - Pathways
QuickGOQ92932
Ontology : AmiGOtransmembrane receptor protein tyrosine phosphatase activity  endoplasmic reticulum lumen  integral component of plasma membrane  protein dephosphorylation  neurotransmitter secretion  cell junction  secretory granule membrane  synaptic vesicle membrane  negative regulation of GTPase activity  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  insulin secretion involved in cellular response to glucose stimulus  terminal bouton  receptor complex  
Ontology : EGO-EBItransmembrane receptor protein tyrosine phosphatase activity  endoplasmic reticulum lumen  integral component of plasma membrane  protein dephosphorylation  neurotransmitter secretion  cell junction  secretory granule membrane  synaptic vesicle membrane  negative regulation of GTPase activity  peptidyl-tyrosine dephosphorylation  peptidyl-tyrosine dephosphorylation  insulin secretion involved in cellular response to glucose stimulus  terminal bouton  receptor complex  
Pathways : KEGGType I diabetes mellitus   
NDEx NetworkPTPRN2
Atlas of Cancer Signalling NetworkPTPRN2
Wikipedia pathwaysPTPRN2
Orthology - Evolution
OrthoDB5799
GeneTree (enSembl)ENSG00000155093
Phylogenetic Trees/Animal Genes : TreeFamPTPRN2
HOVERGENQ92932
HOGENOMQ92932
Homologs : HomoloGenePTPRN2
Homology/Alignments : Family Browser (UCSC)PTPRN2
Gene fusions - Rearrangements
Fusion : MitelmanACTR3B/PTPRN2 [7q36.1/7q36.3]  [t(7;7)(q36;q36)]  
Fusion : MitelmanLMBR1/PTPRN2 [7q36.3/7q36.3]  [t(7;7)(q36;q36)]  
Fusion : MitelmanPTPRN2/GALNT11 [7q36.3/7q36.1]  [t(7;7)(q36;q36)]  
Fusion : MitelmanTMEM87A/PTPRN2 [15q15.1/7q36.3]  [t(7;15)(q36;q15)]  
Fusion : MitelmanUBE3C/PTPRN2 [7q36.3/7q36.3]  [t(7;7)(q36;q36)]  
Fusion: TCGALMBR1 7q36.3 PTPRN2 7q36.3 BRCA PRAD
Fusion: TCGAPTPRN2 7q36.3 GALNT11 7q36.1 BRCA
Fusion: TCGATMEM87A 15q15.1 PTPRN2 7q36.3 LUSC
Fusion: TCGAUBE3C 7q36.3 PTPRN2 7q36.3 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPRN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPRN2
dbVarPTPRN2
ClinVarPTPRN2
1000_GenomesPTPRN2 
Exome Variant ServerPTPRN2
ExAC (Exome Aggregation Consortium)PTPRN2 (select the gene name)
Genetic variants : HAPMAP5799
Genomic Variants (DGV)PTPRN2 [DGVbeta]
DECIPHER (Syndromes)7:157331746-158380494  ENSG00000155093
CONAN: Copy Number AnalysisPTPRN2 
Mutations
ICGC Data PortalPTPRN2 
TCGA Data PortalPTPRN2 
Broad Tumor PortalPTPRN2
OASIS PortalPTPRN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPRN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTPRN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTPRN2
DgiDB (Drug Gene Interaction Database)PTPRN2
DoCM (Curated mutations)PTPRN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPRN2 (select a term)
intoGenPTPRN2
Cancer3DPTPRN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601698   
Orphanet
MedgenPTPRN2
Genetic Testing Registry PTPRN2
NextProtQ92932 [Medical]
TSGene5799
GENETestsPTPRN2
Huge Navigator PTPRN2 [HugePedia]
snp3D : Map Gene to Disease5799
BioCentury BCIQPTPRN2
ClinGenPTPRN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5799
Chemical/Pharm GKB GenePA34022
Clinical trialPTPRN2
Miscellaneous
canSAR (ICR)PTPRN2 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPRN2
EVEXPTPRN2
GoPubMedPTPRN2
iHOPPTPRN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:16:15 CEST 2017

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