Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PTPRO (protein tyrosine phosphatase, receptor type O)

Identity

Alias_symbol (synonym)PTPU2
GLEPP1
PTP-U2
PTP-oc
NPHS6
Other aliasPTP-OC
PTPROT
R-PTP-O
HGNC (Hugo) PTPRO
LocusID (NCBI) 5800
Atlas_Id 45721
Location 12p12.3  [Link to chromosome band 12p12]
Location_base_pair Starts at 15322257 and ends at 15598331 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BAX (19q13.33) / PTPRO (12p12.3)ETV6 (12p13.2) / PTPRO (12p12.3)PTPRO (12p12.3) / NBAS (2p24.3)
PTPRO (12p12.3) / PTPRO (12p12.3)UIMC1 (5q35.2) / PTPRO (12p12.3)UIMC1 5q35.2 / PTPRO 12p12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTPRO   9678
Cards
Entrez_Gene (NCBI)PTPRO  5800  protein tyrosine phosphatase, receptor type O
AliasesGLEPP1; NPHS6; PTP-OC; PTP-U2; 
PTPROT; PTPU2; R-PTP-O
GeneCards (Weizmann)PTPRO
Ensembl hg19 (Hinxton)ENSG00000151490 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151490 [Gene_View]  chr12:15322257-15598331 [Contig_View]  PTPRO [Vega]
ICGC DataPortalENSG00000151490
TCGA cBioPortalPTPRO
AceView (NCBI)PTPRO
Genatlas (Paris)PTPRO
WikiGenes5800
SOURCE (Princeton)PTPRO
Genetics Home Reference (NIH)PTPRO
Genomic and cartography
GoldenPath hg38 (UCSC)PTPRO  -     chr12:15322257-15598331 +  12p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPRO  -     12p12.3   [Description]    (hg19-Feb_2009)
EnsemblPTPRO - 12p12.3 [CytoView hg19]  PTPRO - 12p12.3 [CytoView hg38]
Mapping of homologs : NCBIPTPRO [Mapview hg19]  PTPRO [Mapview hg38]
OMIM600579   614196   
Gene and transcription
Genbank (Entrez)AB209729 AF152378 AF187042 AF187043 AF187044
RefSeq transcript (Entrez)NM_002848 NM_030667 NM_030668 NM_030669 NM_030670 NM_030671
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTPRO
Cluster EST : UnigeneHs.160871 [ NCBI ]
CGAP (NCI)Hs.160871
Alternative Splicing GalleryENSG00000151490
Gene ExpressionPTPRO [ NCBI-GEO ]   PTPRO [ EBI - ARRAY_EXPRESS ]   PTPRO [ SEEK ]   PTPRO [ MEM ]
Gene Expression Viewer (FireBrowse)PTPRO [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5800
GTEX Portal (Tissue expression)PTPRO
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16827   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16827  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16827
Splice isoforms : SwissVarQ16827
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
PhosPhoSitePlusQ16827
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)FN3_dom    Ig-like_fold    Prot-tyrosine_phosphatase-like    PTPase_domain    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)fn3 (PF00041)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00041    pfam00102   
Domain families : Smart (EMBL)FN3 (SM00060)  PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPRO
DMDM Disease mutations5800
Blocks (Seattle)PTPRO
PDB (SRS)2G59    2GJT   
PDB (PDBSum)2G59    2GJT   
PDB (IMB)2G59    2GJT   
PDB (RSDB)2G59    2GJT   
Structural Biology KnowledgeBase2G59    2GJT   
SCOP (Structural Classification of Proteins)2G59    2GJT   
CATH (Classification of proteins structures)2G59    2GJT   
SuperfamilyQ16827
Human Protein AtlasENSG00000151490
Peptide AtlasQ16827
HPRD02784
IPIIPI00001767   IPI00884189   IPI00791982   IPI01014755   IPI00001772   IPI00001769   IPI01013126   IPI01011006   
Protein Interaction databases
DIP (DOE-UCLA)Q16827
IntAct (EBI)Q16827
FunCoupENSG00000151490
BioGRIDPTPRO
STRING (EMBL)PTPRO
ZODIACPTPRO
Ontologies - Pathways
QuickGOQ16827
Ontology : AmiGOcell morphogenesis  monocyte chemotaxis  regulation of glomerular filtration  negative regulation of glomerular filtration  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  protein binding  plasma membrane  integral component of plasma membrane  protein dephosphorylation  protein dephosphorylation  axon guidance  negative regulation of cell-substrate adhesion  negative regulation of neuron projection development  integral component of membrane  apical plasma membrane  lateral plasma membrane  phosphatase activity  Wnt-protein binding  lamellipodium  lamellipodium assembly  axon  growth cone  glomerulus development  peptidyl-tyrosine dephosphorylation  slit diaphragm assembly  slit diaphragm assembly  protein homodimerization activity  neuron projection  dendritic spine  extracellular exosome  glomerular visceral epithelial cell differentiation  negative regulation of canonical Wnt signaling pathway  negative regulation of retinal ganglion cell axon guidance  
Ontology : EGO-EBIcell morphogenesis  monocyte chemotaxis  regulation of glomerular filtration  negative regulation of glomerular filtration  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  protein binding  plasma membrane  integral component of plasma membrane  protein dephosphorylation  protein dephosphorylation  axon guidance  negative regulation of cell-substrate adhesion  negative regulation of neuron projection development  integral component of membrane  apical plasma membrane  lateral plasma membrane  phosphatase activity  Wnt-protein binding  lamellipodium  lamellipodium assembly  axon  growth cone  glomerulus development  peptidyl-tyrosine dephosphorylation  slit diaphragm assembly  slit diaphragm assembly  protein homodimerization activity  neuron projection  dendritic spine  extracellular exosome  glomerular visceral epithelial cell differentiation  negative regulation of canonical Wnt signaling pathway  negative regulation of retinal ganglion cell axon guidance  
NDEx NetworkPTPRO
Atlas of Cancer Signalling NetworkPTPRO
Wikipedia pathwaysPTPRO
Orthology - Evolution
OrthoDB5800
GeneTree (enSembl)ENSG00000151490
Phylogenetic Trees/Animal Genes : TreeFamPTPRO
HOVERGENQ16827
HOGENOMQ16827
Homologs : HomoloGenePTPRO
Homology/Alignments : Family Browser (UCSC)PTPRO
Gene fusions - Rearrangements
Fusion : MitelmanUIMC1/PTPRO [5q35.2/12p12.3]  [t(5;12)(q35;p12)]  
Fusion: TCGAUIMC1 5q35.2 PTPRO 12p12.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPRO [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPRO
dbVarPTPRO
ClinVarPTPRO
1000_GenomesPTPRO 
Exome Variant ServerPTPRO
ExAC (Exome Aggregation Consortium)PTPRO (select the gene name)
Genetic variants : HAPMAP5800
Genomic Variants (DGV)PTPRO [DGVbeta]
DECIPHERPTPRO [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPRO 
Mutations
ICGC Data PortalPTPRO 
TCGA Data PortalPTPRO 
Broad Tumor PortalPTPRO
OASIS PortalPTPRO [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPRO  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTPRO
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTPRO
DgiDB (Drug Gene Interaction Database)PTPRO
DoCM (Curated mutations)PTPRO (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPRO (select a term)
intoGenPTPRO
Cancer3DPTPRO(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600579    614196   
Orphanet12194    12193    12192    12191   
MedgenPTPRO
Genetic Testing Registry PTPRO
NextProtQ16827 [Medical]
TSGene5800
GENETestsPTPRO
Target ValidationPTPRO
Huge Navigator PTPRO [HugePedia]
snp3D : Map Gene to Disease5800
BioCentury BCIQPTPRO
ClinGenPTPRO
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5800
Chemical/Pharm GKB GenePA34023
Clinical trialPTPRO
Miscellaneous
canSAR (ICR)PTPRO (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPRO
EVEXPTPRO
GoPubMedPTPRO
iHOPPTPRO
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:27:17 CEST 2017

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