Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PTPRS (protein tyrosine phosphatase receptor type S)

Identity

Other aliasPTPSIGMA
R-PTP-S
R-PTP-sigma
HGNC (Hugo) PTPRS
LocusID (NCBI) 5802
Atlas_Id 41938
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 5205508 and ends at 5340803 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PTPRS (19p13.3) / FN1 (2q35)PTPRS (19p13.3) / PDHB (3p14.3)PTPRS (19p13.3) / POU2F2 (19q13.2)
RAD54L2 (3p21.2) / PTPRS (19p13.3)TICAM1 (19p13.3) / PTPRS (19p13.3)PTPRS 19p13.3 / POU2F2 19q13.2
TICAM1 19p13.3 / PTPRS 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]

Solid Tumors TT_t1919p13p13ID103249 TT_t1919p13q13ID103285

External links

Nomenclature
HGNC (Hugo)PTPRS   9681
Cards
Entrez_Gene (NCBI)PTPRS  5802  protein tyrosine phosphatase receptor type S
AliasesPTPSIGMA; R-PTP-S; R-PTP-sigma
GeneCards (Weizmann)PTPRS
Ensembl hg19 (Hinxton)ENSG00000105426 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105426 [Gene_View]  ENSG00000105426 [Sequence]  chr19:5205508-5340803 [Contig_View]  PTPRS [Vega]
ICGC DataPortalENSG00000105426
TCGA cBioPortalPTPRS
AceView (NCBI)PTPRS
Genatlas (Paris)PTPRS
WikiGenes5802
SOURCE (Princeton)PTPRS
Genetics Home Reference (NIH)PTPRS
Genomic and cartography
GoldenPath hg38 (UCSC)PTPRS  -     chr19:5205508-5340803 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPRS  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathPTPRS - 19p13.3 [CytoView hg19]  PTPRS - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000105426
Mapping of homologs : NCBIPTPRS [Mapview hg19]  PTPRS [Mapview hg38]
OMIM601576   
Gene and transcription
Genbank (Entrez)AB209333 BC029496 BC104812 BC143286 BC143287
RefSeq transcript (Entrez)NM_002850 NM_130853 NM_130854 NM_130855
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTPRS
Alternative Splicing GalleryENSG00000105426
Gene ExpressionPTPRS [ NCBI-GEO ]   PTPRS [ EBI - ARRAY_EXPRESS ]   PTPRS [ SEEK ]   PTPRS [ MEM ]
Gene Expression Viewer (FireBrowse)PTPRS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5802
GTEX Portal (Tissue expression)PTPRS
Human Protein AtlasENSG00000105426-PTPRS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13332   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13332  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13332
Splice isoforms : SwissVarQ13332
PhosPhoSitePlusQ13332
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    IG_LIKE (PS50835)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)FN3_dom    FN3_sf    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    Prot-tyrosine_phosphatase-like    PTPase_domain    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)fn3 (PF00041)    I-set (PF07679)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00041    pfam07679    pfam00102   
Domain families : Smart (EMBL)FN3 (SM00060)  IG (SM00409)  IGc2 (SM00408)  PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPRS
DMDM Disease mutations5802
Blocks (Seattle)PTPRS
PDB (RSDB)2FH7    2YD2    2YD3    2YD9    4BPC    4PBX   
PDB Europe2FH7    2YD2    2YD3    2YD9    4BPC    4PBX   
PDB (PDBSum)2FH7    2YD2    2YD3    2YD9    4BPC    4PBX   
PDB (IMB)2FH7    2YD2    2YD3    2YD9    4BPC    4PBX   
Structural Biology KnowledgeBase2FH7    2YD2    2YD3    2YD9    4BPC    4PBX   
SCOP (Structural Classification of Proteins)2FH7    2YD2    2YD3    2YD9    4BPC    4PBX   
CATH (Classification of proteins structures)2FH7    2YD2    2YD3    2YD9    4BPC    4PBX   
SuperfamilyQ13332
Human Protein Atlas [tissue]ENSG00000105426-PTPRS [tissue]
Peptide AtlasQ13332
HPRD03344
IPIIPI00289831   IPI00332271   IPI00332272   IPI00332273   IPI00299590   IPI00743517   IPI00293275   IPI00642154   IPI01026204   IPI01011587   IPI01012408   IPI01010138   
Protein Interaction databases
DIP (DOE-UCLA)Q13332
IntAct (EBI)Q13332
FunCoupENSG00000105426
BioGRIDPTPRS
STRING (EMBL)PTPRS
ZODIACPTPRS
Ontologies - Pathways
QuickGOQ13332
Ontology : AmiGOphosphoprotein phosphatase activity  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein binding  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  protein dephosphorylation  protein dephosphorylation  heparin binding  negative regulation of neuron projection development  spinal cord development  cerebellum development  hippocampus development  cerebral cortex development  corpus callosum development  cell junction  integral component of synaptic vesicle membrane  axon  negative regulation of axon extension  negative regulation of interferon-alpha production  negative regulation of interferon-beta production  negative regulation of toll-like receptor 9 signaling pathway  peptidyl-tyrosine dephosphorylation  chondroitin sulfate binding  perikaryon  heparan sulfate proteoglycan binding  negative regulation of collateral sprouting  negative regulation of axon regeneration  modulation of chemical synaptic transmission  negative regulation of dendritic spine development  extracellular exosome  establishment of endothelial intestinal barrier  Schaffer collateral - CA1 synapse  glutamatergic synapse  integral component of presynaptic membrane  integral component of postsynaptic density membrane  regulation of postsynaptic density assembly  synaptic membrane adhesion  synaptic membrane adhesion  synaptic membrane adhesion  
Ontology : EGO-EBIphosphoprotein phosphatase activity  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein binding  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  protein dephosphorylation  protein dephosphorylation  heparin binding  negative regulation of neuron projection development  spinal cord development  cerebellum development  hippocampus development  cerebral cortex development  corpus callosum development  cell junction  integral component of synaptic vesicle membrane  axon  negative regulation of axon extension  negative regulation of interferon-alpha production  negative regulation of interferon-beta production  negative regulation of toll-like receptor 9 signaling pathway  peptidyl-tyrosine dephosphorylation  chondroitin sulfate binding  perikaryon  heparan sulfate proteoglycan binding  negative regulation of collateral sprouting  negative regulation of axon regeneration  modulation of chemical synaptic transmission  negative regulation of dendritic spine development  extracellular exosome  establishment of endothelial intestinal barrier  Schaffer collateral - CA1 synapse  glutamatergic synapse  integral component of presynaptic membrane  integral component of postsynaptic density membrane  regulation of postsynaptic density assembly  synaptic membrane adhesion  synaptic membrane adhesion  synaptic membrane adhesion  
NDEx NetworkPTPRS
Atlas of Cancer Signalling NetworkPTPRS
Wikipedia pathwaysPTPRS
Orthology - Evolution
OrthoDB5802
GeneTree (enSembl)ENSG00000105426
Phylogenetic Trees/Animal Genes : TreeFamPTPRS
HOGENOMQ13332
Homologs : HomoloGenePTPRS
Homology/Alignments : Family Browser (UCSC)PTPRS
Gene fusions - Rearrangements
Fusion : MitelmanPTPRS/POU2F2 [19p13.3/19q13.2]  
Fusion : MitelmanTICAM1/PTPRS [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion PortalPTPRS 19p13.3 POU2F2 19q13.2 LGG
Fusion PortalTICAM1 19p13.3 PTPRS 19p13.3 BRCA
Fusion Cancer (Beijing)PTPRS [19p13.3]  -  FN1 [2q35]  [FUSC003475]
Fusion : QuiverPTPRS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPRS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPRS
dbVarPTPRS
ClinVarPTPRS
1000_GenomesPTPRS 
Exome Variant ServerPTPRS
ExAC (Exome Aggregation Consortium)ENSG00000105426
GNOMAD BrowserENSG00000105426
Varsome BrowserPTPRS
Genetic variants : HAPMAP5802
Genomic Variants (DGV)PTPRS [DGVbeta]
DECIPHERPTPRS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPRS 
Mutations
ICGC Data PortalPTPRS 
TCGA Data PortalPTPRS 
Broad Tumor PortalPTPRS
OASIS PortalPTPRS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPRS  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPTPRS
Mutations and Diseases : HGMDPTPRS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTPRS
DgiDB (Drug Gene Interaction Database)PTPRS
DoCM (Curated mutations)PTPRS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPRS (select a term)
intoGenPTPRS
Cancer3DPTPRS(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601576   
Orphanet
DisGeNETPTPRS
MedgenPTPRS
Genetic Testing Registry PTPRS
NextProtQ13332 [Medical]
TSGene5802
GENETestsPTPRS
Target ValidationPTPRS
Huge Navigator PTPRS [HugePedia]
snp3D : Map Gene to Disease5802
BioCentury BCIQPTPRS
ClinGenPTPRS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5802
Chemical/Pharm GKB GenePA34026
Clinical trialPTPRS
Miscellaneous
canSAR (ICR)PTPRS (select the gene name)
DataMed IndexPTPRS
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPRS
EVEXPTPRS
GoPubMedPTPRS
iHOPPTPRS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Feb 19 17:04:26 CET 2020
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