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PTPRU (protein tyrosine phosphatase, receptor type U)

Identity

Alias_symbol (synonym)PTPRO
hPTP-J
PCP-2
FMI
PTP
Other aliasPTP-J
PTP-PI
PTP-RO
PTPPSI
PTPU2
R-PTP-PSI
R-PTP-U
HGNC (Hugo) PTPRU
LocusID (NCBI) 10076
Atlas_Id 41940
Location 1p35.3  [Link to chromosome band 1p35]
Location_base_pair Starts at 29236516 and ends at 29326813 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ALPP (2q37.1) / PTPRU (1p35.3)MACF1 (1p34.3) / PTPRU (1p35.3)PTPRU (1p35.3) / GAB1 (4q31.21)
PTPRU (1p35.3) / NOS1AP (1q23.3)PTPRU (1p35.3) / SBSPON (8q21.11)MACF1 1p34.3 / PTPRU 1p35.3
PTPRU 1p35.3 C8orf84PTPRU 1p35.3 / NOS1AP 1q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTPRU   9683
Cards
Entrez_Gene (NCBI)PTPRU  10076  protein tyrosine phosphatase, receptor type U
AliasesFMI; PCP-2; PTP; PTP-J; 
PTP-PI; PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U; hPTP-J
GeneCards (Weizmann)PTPRU
Ensembl hg19 (Hinxton)ENSG00000060656 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000060656 [Gene_View]  chr1:29236516-29326813 [Contig_View]  PTPRU [Vega]
ICGC DataPortalENSG00000060656
TCGA cBioPortalPTPRU
AceView (NCBI)PTPRU
Genatlas (Paris)PTPRU
WikiGenes10076
SOURCE (Princeton)PTPRU
Genetics Home Reference (NIH)PTPRU
Genomic and cartography
GoldenPath hg38 (UCSC)PTPRU  -     chr1:29236516-29326813 +  1p35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPRU  -     1p35.3   [Description]    (hg19-Feb_2009)
EnsemblPTPRU - 1p35.3 [CytoView hg19]  PTPRU - 1p35.3 [CytoView hg38]
Mapping of homologs : NCBIPTPRU [Mapview hg19]  PTPRU [Mapview hg38]
OMIM602454   
Gene and transcription
Genbank (Entrez)AB208855 AK094849 BC033131 BC146655 BM799833
RefSeq transcript (Entrez)NM_001195001 NM_005704 NM_133177 NM_133178
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTPRU
Cluster EST : UnigeneHs.19718 [ NCBI ]
CGAP (NCI)Hs.19718
Alternative Splicing GalleryENSG00000060656
Gene ExpressionPTPRU [ NCBI-GEO ]   PTPRU [ EBI - ARRAY_EXPRESS ]   PTPRU [ SEEK ]   PTPRU [ MEM ]
Gene Expression Viewer (FireBrowse)PTPRU [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10076
GTEX Portal (Tissue expression)PTPRU
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92729   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92729  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92729
Splice isoforms : SwissVarQ92729
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
PhosPhoSitePlusQ92729
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    MAM_1 (PS00740)    MAM_2 (PS50060)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)ConA-like_dom    FN3_dom    Ig-like_dom    Ig-like_fold    MAM_dom    Prot-tyrosine_phosphatase-like    PTPase_domain    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)fn3 (PF00041)    MAM (PF00629)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00041    pfam00629    pfam00102   
Domain families : Smart (EMBL)FN3 (SM00060)  MAM (SM00137)  PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPRU
DMDM Disease mutations10076
Blocks (Seattle)PTPRU
SuperfamilyQ92729
Human Protein AtlasENSG00000060656
Peptide AtlasQ92729
HPRD03908
IPIIPI00107472   IPI00023197   IPI00943208   IPI00384563   IPI00843858   
Protein Interaction databases
DIP (DOE-UCLA)Q92729
IntAct (EBI)Q92729
FunCoupENSG00000060656
BioGRIDPTPRU
STRING (EMBL)PTPRU
ZODIACPTPRU
Ontologies - Pathways
QuickGOQ92729
Ontology : AmiGOprotein tyrosine phosphatase activity  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  protein binding  plasma membrane  integral component of plasma membrane  cell-cell junction  protein dephosphorylation  cell adhesion  transmembrane receptor protein tyrosine phosphatase signaling pathway  beta-catenin binding  negative regulation of cell proliferation  single organismal cell-cell adhesion  cell differentiation  negative regulation of cell migration  animal organ regeneration  homotypic cell-cell adhesion  protein localization to cell surface  peptidyl-tyrosine dephosphorylation  response to glucocorticoid  canonical Wnt signaling pathway  
Ontology : EGO-EBIprotein tyrosine phosphatase activity  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  protein binding  plasma membrane  integral component of plasma membrane  cell-cell junction  protein dephosphorylation  cell adhesion  transmembrane receptor protein tyrosine phosphatase signaling pathway  beta-catenin binding  negative regulation of cell proliferation  single organismal cell-cell adhesion  cell differentiation  negative regulation of cell migration  animal organ regeneration  homotypic cell-cell adhesion  protein localization to cell surface  peptidyl-tyrosine dephosphorylation  response to glucocorticoid  canonical Wnt signaling pathway  
NDEx NetworkPTPRU
Atlas of Cancer Signalling NetworkPTPRU
Wikipedia pathwaysPTPRU
Orthology - Evolution
OrthoDB10076
GeneTree (enSembl)ENSG00000060656
Phylogenetic Trees/Animal Genes : TreeFamPTPRU
HOVERGENQ92729
HOGENOMQ92729
Homologs : HomoloGenePTPRU
Homology/Alignments : Family Browser (UCSC)PTPRU
Gene fusions - Rearrangements
Fusion : MitelmanMACF1/PTPRU [1p34.3/1p35.3]  [t(1;1)(p34;p35)]  
Fusion : MitelmanPTPRU/NOS1AP [1p35.3/1q23.3]  [t(1;1)(p35;q23)]  
Fusion : MitelmanPTPRU/SBSPON [1p35.3/8q21.11]  [t(1;8)(p35;q21)]  
Fusion: TCGAMACF1 1p34.3 PTPRU 1p35.3 BRCA
Fusion: TCGAPTPRU 1p35.3 C8orf84 LUAD
Fusion: TCGAPTPRU 1p35.3 NOS1AP 1q23.3 KIRC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPRU [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPRU
dbVarPTPRU
ClinVarPTPRU
1000_GenomesPTPRU 
Exome Variant ServerPTPRU
ExAC (Exome Aggregation Consortium)PTPRU (select the gene name)
Genetic variants : HAPMAP10076
Genomic Variants (DGV)PTPRU [DGVbeta]
DECIPHERPTPRU [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPRU 
Mutations
ICGC Data PortalPTPRU 
TCGA Data PortalPTPRU 
Broad Tumor PortalPTPRU
OASIS PortalPTPRU [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPRU  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTPRU
intOGen PortalPTPRU
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTPRU
DgiDB (Drug Gene Interaction Database)PTPRU
DoCM (Curated mutations)PTPRU (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTPRU (select a term)
intoGenPTPRU
Cancer3DPTPRU(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602454   
Orphanet
MedgenPTPRU
Genetic Testing Registry PTPRU
NextProtQ92729 [Medical]
TSGene10076
GENETestsPTPRU
Huge Navigator PTPRU [HugePedia]
snp3D : Map Gene to Disease10076
BioCentury BCIQPTPRU
ClinGenPTPRU
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10076
Chemical/Pharm GKB GenePA34028
Clinical trialPTPRU
Miscellaneous
canSAR (ICR)PTPRU (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTPRU
EVEXPTPRU
GoPubMedPTPRU
iHOPPTPRU
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:33:33 CEST 2017

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