Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PTPRU (protein tyrosine phosphatase receptor type U)

Identity

Alias (NCBI)FMI
PCP-2
PTP
PTP-J
PTP-PI
PTP-RO
PTPPSI
PTPRO
PTPU2
R-PTP-PSI
R-PTP-U
hPTP-J
HGNC (Hugo) PTPRU
HGNC Alias symbPTPRO
hPTP-J
PCP-2
FMI
PTP
HGNC Alias namepi R-PTP-Psi
LocusID (NCBI) 10076
Atlas_Id 41940
Location 1p35.3  [Link to chromosome band 1p35]
Location_base_pair Starts at 29236522 and ends at 29326800 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALPP (2q37.1)::PTPRU (1p35.3)MACF1 (1p34.3)::PTPRU (1p35.3)PTPRU (1p35.3)::GAB1 (4q31.21)
PTPRU (1p35.3)::NOS1AP (1q23.3)PTPRU (1p35.3)::SBSPON (8q21.11)MACF1 1p34.3::PTPRU 1p35.3
PTPRU 1p35.3 C8orf84PTPRU 1p35.3::NOS1AP 1q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PTPRU   9683
Cards
Entrez_Gene (NCBI)PTPRU    protein tyrosine phosphatase receptor type U
AliasesFMI; PCP-2; PTP; PTP-J; 
PTP-PI; PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U; hPTP-J
GeneCards (Weizmann)PTPRU
Ensembl hg19 (Hinxton)ENSG00000060656 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000060656 [Gene_View]  ENSG00000060656 [Sequence]  chr1:29236522-29326800 [Contig_View]  PTPRU [Vega]
ICGC DataPortalENSG00000060656
TCGA cBioPortalPTPRU
AceView (NCBI)PTPRU
Genatlas (Paris)PTPRU
SOURCE (Princeton)PTPRU
Genetics Home Reference (NIH)PTPRU
Genomic and cartography
GoldenPath hg38 (UCSC)PTPRU  -     chr1:29236522-29326800 +  1p35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTPRU  -     1p35.3   [Description]    (hg19-Feb_2009)
GoldenPathPTPRU - 1p35.3 [CytoView hg19]  PTPRU - 1p35.3 [CytoView hg38]
ImmunoBaseENSG00000060656
Genome Data Viewer NCBIPTPRU [Mapview hg19]  
OMIM602454   
Gene and transcription
Genbank (Entrez)AB208855 AK094849 BC033131 BC146655 BM799833
RefSeq transcript (Entrez)NM_001195001 NM_005704 NM_133177 NM_133178
Consensus coding sequences : CCDS (NCBI)PTPRU
Gene ExpressionPTPRU [ NCBI-GEO ]   PTPRU [ EBI - ARRAY_EXPRESS ]   PTPRU [ SEEK ]   PTPRU [ MEM ]
Gene Expression Viewer (FireBrowse)PTPRU [ Firebrowse - Broad ]
GenevisibleExpression of PTPRU in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10076
GTEX Portal (Tissue expression)PTPRU
Human Protein AtlasENSG00000060656-PTPRU [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92729   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92729  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92729
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ92729
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    MAM_1 (PS00740)    MAM_2 (PS50060)    TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)    TYR_PHOSPHATASE_PTP (PS50055)   
Domains : Interpro (EBI)ConA-like_dom_sf    FN3_dom    FN3_sf    Ig-like_dom_sf    Ig-like_fold    MAM_dom    Prot-tyrosine_phosphatase-like    PTPase_domain    Tyr_Pase_AS    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)fn3 (PF00041)    MAM (PF00629)    Y_phosphatase (PF00102)   
Domain families : Pfam (NCBI)pfam00041    pfam00629    pfam00102   
Domain families : Smart (EMBL)FN3 (SM00060)  MAM (SM00137)  PTPc (SM00194)  PTPc_motif (SM00404)  
Conserved Domain (NCBI)PTPRU
PDB (RSDB)6SUB    6SUC   
PDB Europe6SUB    6SUC   
PDB (PDBSum)6SUB    6SUC   
PDB (IMB)6SUB    6SUC   
Structural Biology KnowledgeBase6SUB    6SUC   
SCOP (Structural Classification of Proteins)6SUB    6SUC   
CATH (Classification of proteins structures)6SUB    6SUC   
SuperfamilyQ92729
AlphaFold pdb e-kbQ92729   
Human Protein Atlas [tissue]ENSG00000060656-PTPRU [tissue]
HPRD03908
Protein Interaction databases
DIP (DOE-UCLA)Q92729
IntAct (EBI)Q92729
BioGRIDPTPRU
STRING (EMBL)PTPRU
ZODIACPTPRU
Ontologies - Pathways
QuickGOQ92729
Ontology : AmiGOprotein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  protein binding  plasma membrane  integral component of plasma membrane  cell-cell junction  protein dephosphorylation  protein dephosphorylation  cell adhesion  transmembrane receptor protein tyrosine phosphatase signaling pathway  beta-catenin binding  negative regulation of cell population proliferation  cell differentiation  negative regulation of cell migration  animal organ regeneration  homotypic cell-cell adhesion  protein localization to cell surface  peptidyl-tyrosine dephosphorylation  response to glucocorticoid  negative regulation of canonical Wnt signaling pathway  positive regulation of cell-cell adhesion mediated by cadherin  
Ontology : EGO-EBIprotein tyrosine phosphatase activity  protein tyrosine phosphatase activity  protein tyrosine phosphatase activity  transmembrane receptor protein tyrosine phosphatase activity  protein binding  plasma membrane  integral component of plasma membrane  cell-cell junction  protein dephosphorylation  protein dephosphorylation  cell adhesion  transmembrane receptor protein tyrosine phosphatase signaling pathway  beta-catenin binding  negative regulation of cell population proliferation  cell differentiation  negative regulation of cell migration  animal organ regeneration  homotypic cell-cell adhesion  protein localization to cell surface  peptidyl-tyrosine dephosphorylation  response to glucocorticoid  negative regulation of canonical Wnt signaling pathway  positive regulation of cell-cell adhesion mediated by cadherin  
NDEx NetworkPTPRU
Atlas of Cancer Signalling NetworkPTPRU
Wikipedia pathwaysPTPRU
Orthology - Evolution
OrthoDB10076
GeneTree (enSembl)ENSG00000060656
Phylogenetic Trees/Animal Genes : TreeFamPTPRU
Homologs : HomoloGenePTPRU
Homology/Alignments : Family Browser (UCSC)PTPRU
Gene fusions - Rearrangements
Fusion : MitelmanMACF1::PTPRU [1p34.3/1p35.3]  
Fusion : MitelmanPTPRU::NOS1AP [1p35.3/1q23.3]  
Fusion : MitelmanPTPRU::SBSPON [1p35.3/8q21.11]  
Fusion : QuiverPTPRU
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTPRU [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTPRU
dbVarPTPRU
ClinVarPTPRU
MonarchPTPRU
1000_GenomesPTPRU 
Exome Variant ServerPTPRU
GNOMAD BrowserENSG00000060656
Varsome BrowserPTPRU
ACMGPTPRU variants
VarityQ92729
Genomic Variants (DGV)PTPRU [DGVbeta]
DECIPHERPTPRU [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTPRU 
Mutations
ICGC Data PortalPTPRU 
TCGA Data PortalPTPRU 
Broad Tumor PortalPTPRU
OASIS PortalPTPRU [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTPRU  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPTPRU
Mutations and Diseases : HGMDPTPRU
intOGen PortalPTPRU
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPTPRU
DgiDB (Drug Gene Interaction Database)PTPRU
DoCM (Curated mutations)PTPRU
CIViC (Clinical Interpretations of Variants in Cancer)PTPRU
Cancer3DPTPRU
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602454   
Orphanet
DisGeNETPTPRU
MedgenPTPRU
Genetic Testing Registry PTPRU
NextProtQ92729 [Medical]
GENETestsPTPRU
Target ValidationPTPRU
Huge Navigator PTPRU [HugePedia]
ClinGenPTPRU
Clinical trials, drugs, therapy
MyCancerGenomePTPRU
Protein Interactions : CTDPTPRU
Pharm GKB GenePA34028
PharosQ92729
Clinical trialPTPRU
Miscellaneous
canSAR (ICR)PTPRU
HarmonizomePTPRU
ARCHS4PTPRU
DataMed IndexPTPRU
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPTPRU
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 20 12:54:37 CET 2022

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.