Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PTTG2 (pituitary tumor-transforming 2)

Identity

Other alias-
HGNC (Hugo) PTTG2
LocusID (NCBI) 10744
Atlas_Id 41945
Location 4p14  [Link to chromosome band 4p14]
Location_base_pair Starts at 37960435 and ends at 37961010 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTTG2   9691
Cards
Entrez_Gene (NCBI)PTTG2  10744  pituitary tumor-transforming 2
Aliases
GeneCards (Weizmann)PTTG2
Ensembl hg19 (Hinxton)ENSG00000250254 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000250254 [Gene_View]  chr4:37960435-37961010 [Contig_View]  PTTG2 [Vega]
ICGC DataPortalENSG00000250254
TCGA cBioPortalPTTG2
AceView (NCBI)PTTG2
Genatlas (Paris)PTTG2
WikiGenes10744
SOURCE (Princeton)PTTG2
Genetics Home Reference (NIH)PTTG2
Genomic and cartography
GoldenPath hg38 (UCSC)PTTG2  -     chr4:37960435-37961010 +  4p14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTTG2  -     4p14   [Description]    (hg19-Feb_2009)
EnsemblPTTG2 - 4p14 [CytoView hg19]  PTTG2 - 4p14 [CytoView hg38]
Mapping of homologs : NCBIPTTG2 [Mapview hg19]  PTTG2 [Mapview hg38]
OMIM604231   
Gene and transcription
Genbank (Entrez)AF095288 BC069114 BC069400
RefSeq transcript (Entrez)NM_006607
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PTTG2
Cluster EST : UnigeneHs.668806 [ NCBI ]
CGAP (NCI)Hs.668806
Alternative Splicing GalleryENSG00000250254
Gene ExpressionPTTG2 [ NCBI-GEO ]   PTTG2 [ EBI - ARRAY_EXPRESS ]   PTTG2 [ SEEK ]   PTTG2 [ MEM ]
Gene Expression Viewer (FireBrowse)PTTG2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10744
GTEX Portal (Tissue expression)PTTG2
Human Protein AtlasENSG00000250254-PTTG2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZH5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NZH5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NZH5
Splice isoforms : SwissVarQ9NZH5
PhosPhoSitePlusQ9NZH5
Domains : Interpro (EBI)Securin_separation_inhibitor   
Domain families : Pfam (Sanger)Securin (PF04856)   
Domain families : Pfam (NCBI)pfam04856   
Conserved Domain (NCBI)PTTG2
DMDM Disease mutations10744
Blocks (Seattle)PTTG2
SuperfamilyQ9NZH5
Human Protein Atlas [tissue]ENSG00000250254-PTTG2 [tissue]
Peptide AtlasQ9NZH5
HPRD09176
IPIIPI00021381   IPI00008631   
Protein Interaction databases
DIP (DOE-UCLA)Q9NZH5
IntAct (EBI)Q9NZH5
FunCoupENSG00000250254
BioGRIDPTTG2
STRING (EMBL)PTTG2
ZODIACPTTG2
Ontologies - Pathways
QuickGOQ9NZH5
Ontology : AmiGOmolecular_function  nucleus  cytoplasm  regulation of transcription, DNA-templated  negative regulation of peptidase activity  SH3 domain binding  peptidase inhibitor activity  homologous chromosome segregation  chromosome organization  
Ontology : EGO-EBImolecular_function  nucleus  cytoplasm  regulation of transcription, DNA-templated  negative regulation of peptidase activity  SH3 domain binding  peptidase inhibitor activity  homologous chromosome segregation  chromosome organization  
Pathways : KEGGCell cycle    Oocyte meiosis    HTLV-I infection   
NDEx NetworkPTTG2
Atlas of Cancer Signalling NetworkPTTG2
Wikipedia pathwaysPTTG2
Orthology - Evolution
OrthoDB10744
GeneTree (enSembl)ENSG00000250254
Phylogenetic Trees/Animal Genes : TreeFamPTTG2
HOVERGENQ9NZH5
HOGENOMQ9NZH5
Homologs : HomoloGenePTTG2
Homology/Alignments : Family Browser (UCSC)PTTG2
Gene fusions - Rearrangements
Fusion: Tumor Portal PTTG2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTTG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTTG2
dbVarPTTG2
ClinVarPTTG2
1000_GenomesPTTG2 
Exome Variant ServerPTTG2
ExAC (Exome Aggregation Consortium)ENSG00000250254
GNOMAD BrowserENSG00000250254
Genetic variants : HAPMAP10744
Genomic Variants (DGV)PTTG2 [DGVbeta]
DECIPHERPTTG2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTTG2 
Mutations
ICGC Data PortalPTTG2 
TCGA Data PortalPTTG2 
Broad Tumor PortalPTTG2
OASIS PortalPTTG2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTTG2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTTG2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTTG2
DgiDB (Drug Gene Interaction Database)PTTG2
DoCM (Curated mutations)PTTG2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTTG2 (select a term)
intoGenPTTG2
Cancer3DPTTG2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604231   
Orphanet
MedgenPTTG2
Genetic Testing Registry PTTG2
NextProtQ9NZH5 [Medical]
TSGene10744
GENETestsPTTG2
Target ValidationPTTG2
Huge Navigator PTTG2 [HugePedia]
snp3D : Map Gene to Disease10744
BioCentury BCIQPTTG2
ClinGenPTTG2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10744
Chemical/Pharm GKB GenePA34035
Clinical trialPTTG2
Miscellaneous
canSAR (ICR)PTTG2 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTTG2
EVEXPTTG2
GoPubMedPTTG2
iHOPPTTG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 13:07:22 CET 2017

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