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PTX3 (pentraxin 3)

Identity

Alias (NCBI)TNFAIP5
TSG-14
HGNC (Hugo) PTX3
HGNC Alias symbTSG-14
HGNC Alias namelong pentraxin 3
HGNC Previous nameTNFAIP5
HGNC Previous namepentaxin-related gene, rapidly induced by IL-1 beta
 tumor necrosis factor, alpha-induced protein 5
 pentraxin-related gene, rapidly induced by IL-1 beta
 pentraxin 3, long
LocusID (NCBI) 5806
Atlas_Id 41948
Location 3q25.32  [Link to chromosome band 3q25]
Location_base_pair Starts at 157436850 and ends at 157443632 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PTX3   9692
Cards
Entrez_Gene (NCBI)PTX3    pentraxin 3
AliasesTNFAIP5; TSG-14
GeneCards (Weizmann)PTX3
Ensembl hg19 (Hinxton)ENSG00000163661 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163661 [Gene_View]  ENSG00000163661 [Sequence]  chr3:157436850-157443632 [Contig_View]  PTX3 [Vega]
ICGC DataPortalENSG00000163661
TCGA cBioPortalPTX3
AceView (NCBI)PTX3
Genatlas (Paris)PTX3
SOURCE (Princeton)PTX3
Genetics Home Reference (NIH)PTX3
Genomic and cartography
GoldenPath hg38 (UCSC)PTX3  -     chr3:157436850-157443632 +  3q25.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PTX3  -     3q25.32   [Description]    (hg19-Feb_2009)
GoldenPathPTX3 - 3q25.32 [CytoView hg19]  PTX3 - 3q25.32 [CytoView hg38]
ImmunoBaseENSG00000163661
Genome Data Viewer NCBIPTX3 [Mapview hg19]  
OMIM602492   
Gene and transcription
Genbank (Entrez)AK312705 BC027887 BC039733 BQ010272 DA716533
RefSeq transcript (Entrez)NM_002852
Consensus coding sequences : CCDS (NCBI)PTX3
Gene ExpressionPTX3 [ NCBI-GEO ]   PTX3 [ EBI - ARRAY_EXPRESS ]   PTX3 [ SEEK ]   PTX3 [ MEM ]
Gene Expression Viewer (FireBrowse)PTX3 [ Firebrowse - Broad ]
GenevisibleExpression of PTX3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5806
GTEX Portal (Tissue expression)PTX3
Human Protein AtlasENSG00000163661-PTX3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26022   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26022  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26022
PhosPhoSitePlusP26022
Domaine pattern : Prosite (Expaxy)PTX_1 (PS00289)    PTX_2 (PS51828)   
Domains : Interpro (EBI)ConA-like_dom_sf    LamG-like    Pentaxin_CS    Pentraxin-related    PTX3   
Domain families : Pfam (Sanger)Pentaxin (PF00354)   
Domain families : Pfam (NCBI)pfam00354   
Domain families : Smart (EMBL)LamGL (SM00560)  PTX (SM00159)  
Conserved Domain (NCBI)PTX3
SuperfamilyP26022
AlphaFold pdb e-kbP26022   
Human Protein Atlas [tissue]ENSG00000163661-PTX3 [tissue]
HPRD03928
Protein Interaction databases
DIP (DOE-UCLA)P26022
IntAct (EBI)P26022
BioGRIDPTX3
STRING (EMBL)PTX3
ZODIACPTX3
Ontologies - Pathways
QuickGOP26022
Ontology : AmiGOovarian cumulus expansion  complement component C1q complex binding  complement component C1q complex binding  (1->3)-beta-D-glucan binding  response to yeast  protein binding  extracellular region  extracellular space  extracellular space  inflammatory response  opsonization  extracellular matrix organization  extracellular matrix  specific granule lumen  identical protein binding  neutrophil degranulation  negative regulation by host of viral process  negative regulation by host of viral exo-alpha-sialidase activity  negative regulation by host of viral glycoprotein metabolic process  innate immune response  innate immune response  positive regulation of nitric oxide biosynthetic process  negative regulation of viral entry into host cell  virion binding  positive regulation of phagocytosis  negative regulation of exo-alpha-sialidase activity  negative regulation of glycoprotein metabolic process  tertiary granule lumen  
Ontology : EGO-EBIovarian cumulus expansion  complement component C1q complex binding  complement component C1q complex binding  (1->3)-beta-D-glucan binding  response to yeast  protein binding  extracellular region  extracellular space  extracellular space  inflammatory response  opsonization  extracellular matrix organization  extracellular matrix  specific granule lumen  identical protein binding  neutrophil degranulation  negative regulation by host of viral process  negative regulation by host of viral exo-alpha-sialidase activity  negative regulation by host of viral glycoprotein metabolic process  innate immune response  innate immune response  positive regulation of nitric oxide biosynthetic process  negative regulation of viral entry into host cell  virion binding  positive regulation of phagocytosis  negative regulation of exo-alpha-sialidase activity  negative regulation of glycoprotein metabolic process  tertiary granule lumen  
NDEx NetworkPTX3
Atlas of Cancer Signalling NetworkPTX3
Wikipedia pathwaysPTX3
Orthology - Evolution
OrthoDB5806
GeneTree (enSembl)ENSG00000163661
Phylogenetic Trees/Animal Genes : TreeFamPTX3
Homologs : HomoloGenePTX3
Homology/Alignments : Family Browser (UCSC)PTX3
Gene fusions - Rearrangements
Fusion : QuiverPTX3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTX3
dbVarPTX3
ClinVarPTX3
MonarchPTX3
1000_GenomesPTX3 
Exome Variant ServerPTX3
GNOMAD BrowserENSG00000163661
Varsome BrowserPTX3
ACMGPTX3 variants
VarityP26022
Genomic Variants (DGV)PTX3 [DGVbeta]
DECIPHERPTX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPTX3 
Mutations
ICGC Data PortalPTX3 
TCGA Data PortalPTX3 
Broad Tumor PortalPTX3
OASIS PortalPTX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTX3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPTX3
Mutations and Diseases : HGMDPTX3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPTX3
DgiDB (Drug Gene Interaction Database)PTX3
DoCM (Curated mutations)PTX3
CIViC (Clinical Interpretations of Variants in Cancer)PTX3
Cancer3DPTX3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602492   
Orphanet
DisGeNETPTX3
MedgenPTX3
Genetic Testing Registry PTX3
NextProtP26022 [Medical]
GENETestsPTX3
Target ValidationPTX3
Huge Navigator PTX3 [HugePedia]
ClinGenPTX3
Clinical trials, drugs, therapy
MyCancerGenomePTX3
Protein Interactions : CTDPTX3
Pharm GKB GenePA34036
PharosP26022
Clinical trialPTX3
Miscellaneous
canSAR (ICR)PTX3
HarmonizomePTX3
DataMed IndexPTX3
Probes
Litterature
PubMed412 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPTX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:27:35 CEST 2021

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