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PTX3 (pentraxin 3)

Identity

Alias_namesTNFAIP5
pentaxin-related gene, rapidly induced by IL-1 beta
tumor necrosis factor, alpha-induced protein 5
pentraxin-related gene, rapidly induced by IL-1 beta
pentraxin 3, long
Alias_symbol (synonym)TSG-14
Other alias
HGNC (Hugo) PTX3
LocusID (NCBI) 5806
Atlas_Id 41948
Location 3q25.32  [Link to chromosome band 3q25]
Location_base_pair Starts at 157154580 and ends at 157161417 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PTX3   9692
Cards
Entrez_Gene (NCBI)PTX3  5806  pentraxin 3
AliasesTNFAIP5; TSG-14
GeneCards (Weizmann)PTX3
Ensembl hg19 (Hinxton)ENSG00000163661 [Gene_View]  chr3:157154580-157161417 [Contig_View]  PTX3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000163661 [Gene_View]  chr3:157154580-157161417 [Contig_View]  PTX3 [Vega]
ICGC DataPortalENSG00000163661
TCGA cBioPortalPTX3
AceView (NCBI)PTX3
Genatlas (Paris)PTX3
WikiGenes5806
SOURCE (Princeton)PTX3
Genetics Home Reference (NIH)PTX3
Genomic and cartography
GoldenPath hg19 (UCSC)PTX3  -     chr3:157154580-157161417 +  3q25.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PTX3  -     3q25.32   [Description]    (hg38-Dec_2013)
EnsemblPTX3 - 3q25.32 [CytoView hg19]  PTX3 - 3q25.32 [CytoView hg38]
Mapping of homologs : NCBIPTX3 [Mapview hg19]  PTX3 [Mapview hg38]
OMIM602492   
Gene and transcription
Genbank (Entrez)AK312705 BC027887 BC039733 BQ010272 DA716533
RefSeq transcript (Entrez)NM_002852
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)PTX3
Cluster EST : UnigeneHs.591286 [ NCBI ]
CGAP (NCI)Hs.591286
Alternative Splicing GalleryENSG00000163661
Gene ExpressionPTX3 [ NCBI-GEO ]   PTX3 [ EBI - ARRAY_EXPRESS ]   PTX3 [ SEEK ]   PTX3 [ MEM ]
Gene Expression Viewer (FireBrowse)PTX3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5806
GTEX Portal (Tissue expression)PTX3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26022   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26022  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26022
Splice isoforms : SwissVarP26022
PhosPhoSitePlusP26022
Domaine pattern : Prosite (Expaxy)PENTAXIN (PS00289)   
Domains : Interpro (EBI)ConA-like_dom    Pentaxin-related    Pentaxin_CS   
Domain families : Pfam (Sanger)Pentaxin (PF00354)   
Domain families : Pfam (NCBI)pfam00354   
Domain families : Smart (EMBL)PTX (SM00159)  
Conserved Domain (NCBI)PTX3
DMDM Disease mutations5806
Blocks (Seattle)PTX3
SuperfamilyP26022
Human Protein AtlasENSG00000163661
Peptide AtlasP26022
HPRD03928
IPIIPI00029568   
Protein Interaction databases
DIP (DOE-UCLA)P26022
IntAct (EBI)P26022
FunCoupENSG00000163661
BioGRIDPTX3
STRING (EMBL)PTX3
ZODIACPTX3
Ontologies - Pathways
QuickGOP26022
Ontology : AmiGOcomplement component C1q binding  (1->3)-beta-D-glucan binding  response to yeast  extracellular region  extracellular space  inflammatory response  opsonization  negative regulation by host of viral exo-alpha-sialidase activity  negative regulation by host of viral glycoprotein metabolic process  innate immune response  positive regulation of nitric oxide biosynthetic process  negative regulation of viral entry into host cell  virion binding  positive regulation of phagocytosis  negative regulation of exo-alpha-sialidase activity  negative regulation of glycoprotein metabolic process  
Ontology : EGO-EBIcomplement component C1q binding  (1->3)-beta-D-glucan binding  response to yeast  extracellular region  extracellular space  inflammatory response  opsonization  negative regulation by host of viral exo-alpha-sialidase activity  negative regulation by host of viral glycoprotein metabolic process  innate immune response  positive regulation of nitric oxide biosynthetic process  negative regulation of viral entry into host cell  virion binding  positive regulation of phagocytosis  negative regulation of exo-alpha-sialidase activity  negative regulation of glycoprotein metabolic process  
NDEx NetworkPTX3
Atlas of Cancer Signalling NetworkPTX3
Wikipedia pathwaysPTX3
Orthology - Evolution
OrthoDB5806
GeneTree (enSembl)ENSG00000163661
Phylogenetic Trees/Animal Genes : TreeFamPTX3
HOVERGENP26022
HOGENOMP26022
Homologs : HomoloGenePTX3
Homology/Alignments : Family Browser (UCSC)PTX3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPTX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PTX3
dbVarPTX3
ClinVarPTX3
1000_GenomesPTX3 
Exome Variant ServerPTX3
ExAC (Exome Aggregation Consortium)PTX3 (select the gene name)
Genetic variants : HAPMAP5806
Genomic Variants (DGV)PTX3 [DGVbeta]
DECIPHER (Syndromes)3:157154580-157161417  ENSG00000163661
CONAN: Copy Number AnalysisPTX3 
Mutations
ICGC Data PortalPTX3 
TCGA Data PortalPTX3 
Broad Tumor PortalPTX3
OASIS PortalPTX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPTX3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPTX3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PTX3
DgiDB (Drug Gene Interaction Database)PTX3
DoCM (Curated mutations)PTX3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PTX3 (select a term)
intoGenPTX3
Cancer3DPTX3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602492   
Orphanet
MedgenPTX3
Genetic Testing Registry PTX3
NextProtP26022 [Medical]
TSGene5806
GENETestsPTX3
Huge Navigator PTX3 [HugePedia]
snp3D : Map Gene to Disease5806
BioCentury BCIQPTX3
ClinGenPTX3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5806
Chemical/Pharm GKB GenePA34036
Clinical trialPTX3
Miscellaneous
canSAR (ICR)PTX3 (select the gene name)
Probes
Litterature
PubMed245 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePTX3
EVEXPTX3
GoPubMedPTX3
iHOPPTX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:23:43 CET 2017

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