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PUM1 (pumilio RNA binding family member 1)

Identity

Alias_namespumilio homolog 1 (Drosophila)
Alias_symbol (synonym)PUMH1
KIAA0099
Other aliasHSPUM
PUMH
PUML1
HGNC (Hugo) PUM1
LocusID (NCBI) 9698
Atlas_Id 41949
Location 1p35.2  [Link to chromosome band 1p35]
Location_base_pair Starts at 31404353 and ends at 31538564 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CD63 (12q13.2) / PUM1 (1p35.2)DYNC2H1 (11q22.3) / PUM1 (1p35.2)NLRC5 (16q13) / PUM1 (1p35.2)
PUM1 (1p35.2) / ADGRG3 (16q21)PUM1 (1p35.2) / ARV1 (1q42.2)PUM1 (1p35.2) / ATP5C1 (10p14)
PUM1 (1p35.2) / EIF4G3 (1p36.12)PUM1 (1p35.2) / EPC2 (2q23.1)PUM1 (1p35.2) / KIAA1211 (4q12)
PUM1 (1p35.2) / NKAIN1 (1p35.2)PUM1 (1p35.2) / NLRC5 (16q13)PUM1 (1p35.2) / PTPRK (6q22.33)
PUM1 (1p35.2) / PUM1 (1p35.2)PUM1 (1p35.2) / RALGPS1 (9q33.3)PUM1 (1p35.2) / RPH3AL (17p13.3)
PUM1 (1p35.2) / SFPQ (16q24.1)PUM1 (1p35.2) / TRERF1 (6p21.1)PUM1 1p35.2 / EIF4G3 1p36.12
PUM1 1p35.2 / KIAA1211 4q12PUM1 1p35.2 / NKAIN1 1p35.2PUM1 1p35.2 / PTPRK 6q22.33
PUM1 1p35.2 / RPH3AL 17p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PUM1   14957
Cards
Entrez_Gene (NCBI)PUM1  9698  pumilio RNA binding family member 1
AliasesHSPUM; PUMH; PUMH1; PUML1
GeneCards (Weizmann)PUM1
Ensembl hg19 (Hinxton)ENSG00000134644 [Gene_View]  chr1:31404353-31538564 [Contig_View]  PUM1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000134644 [Gene_View]  chr1:31404353-31538564 [Contig_View]  PUM1 [Vega]
ICGC DataPortalENSG00000134644
TCGA cBioPortalPUM1
AceView (NCBI)PUM1
Genatlas (Paris)PUM1
WikiGenes9698
SOURCE (Princeton)PUM1
Genetics Home Reference (NIH)PUM1
Genomic and cartography
GoldenPath hg19 (UCSC)PUM1  -     chr1:31404353-31538564 -  1p35.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PUM1  -     1p35.2   [Description]    (hg38-Dec_2013)
EnsemblPUM1 - 1p35.2 [CytoView hg19]  PUM1 - 1p35.2 [CytoView hg38]
Mapping of homologs : NCBIPUM1 [Mapview hg19]  PUM1 [Mapview hg38]
OMIM607204   
Gene and transcription
Genbank (Entrez)AF315592 AK056662 AK096476 AK222605 AK291779
RefSeq transcript (Entrez)NM_001020658 NM_014676
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)PUM1
Cluster EST : UnigeneHs.281707 [ NCBI ]
CGAP (NCI)Hs.281707
Alternative Splicing GalleryENSG00000134644
Gene ExpressionPUM1 [ NCBI-GEO ]   PUM1 [ EBI - ARRAY_EXPRESS ]   PUM1 [ SEEK ]   PUM1 [ MEM ]
Gene Expression Viewer (FireBrowse)PUM1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9698
GTEX Portal (Tissue expression)PUM1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14671   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14671  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14671
Splice isoforms : SwissVarQ14671
PhosPhoSitePlusQ14671
Domaine pattern : Prosite (Expaxy)PUM (PS50302)    PUM_HD (PS50303)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Pumilio_RNA-bd_rpt   
Domain families : Pfam (Sanger)PUF (PF00806)   
Domain families : Pfam (NCBI)pfam00806   
Domain families : Smart (EMBL)Pumilio (SM00025)  
Conserved Domain (NCBI)PUM1
DMDM Disease mutations9698
Blocks (Seattle)PUM1
PDB (SRS)1IB2    1M8W    1M8X    1M8Y    1M8Z    2YJY    3BSB    3BSX    3Q0L    3Q0M    3Q0N    3Q0O    3Q0P   
PDB (PDBSum)1IB2    1M8W    1M8X    1M8Y    1M8Z    2YJY    3BSB    3BSX    3Q0L    3Q0M    3Q0N    3Q0O    3Q0P   
PDB (IMB)1IB2    1M8W    1M8X    1M8Y    1M8Z    2YJY    3BSB    3BSX    3Q0L    3Q0M    3Q0N    3Q0O    3Q0P   
PDB (RSDB)1IB2    1M8W    1M8X    1M8Y    1M8Z    2YJY    3BSB    3BSX    3Q0L    3Q0M    3Q0N    3Q0O    3Q0P   
Structural Biology KnowledgeBase1IB2    1M8W    1M8X    1M8Y    1M8Z    2YJY    3BSB    3BSX    3Q0L    3Q0M    3Q0N    3Q0O    3Q0P   
SCOP (Structural Classification of Proteins)1IB2    1M8W    1M8X    1M8Y    1M8Z    2YJY    3BSB    3BSX    3Q0L    3Q0M    3Q0N    3Q0O    3Q0P   
CATH (Classification of proteins structures)1IB2    1M8W    1M8X    1M8Y    1M8Z    2YJY    3BSB    3BSX    3Q0L    3Q0M    3Q0N    3Q0O    3Q0P   
SuperfamilyQ14671
Human Protein AtlasENSG00000134644
Peptide AtlasQ14671
HPRD06230
IPIIPI00551014   IPI00941189   IPI00978073   IPI00032355   IPI00646054   IPI00909786   IPI00941275   IPI00982610   IPI00939543   IPI00978276   IPI00984621   IPI00981986   IPI00980957   IPI00978924   IPI00978721   IPI00979329   IPI00985256   
Protein Interaction databases
DIP (DOE-UCLA)Q14671
IntAct (EBI)Q14671
FunCoupENSG00000134644
BioGRIDPUM1
STRING (EMBL)PUM1
ZODIACPUM1
Ontologies - Pathways
QuickGOQ14671
Ontology : AmiGOcytoplasmic mRNA processing body  RNA binding  mRNA 3'-UTR binding  protein binding  cytosol  spermatogenesis  adult locomotory behavior  cytoplasmic stress granule  posttranscriptional gene silencing  regulation of mRNA stability  poly(A) RNA binding  stem cell differentiation  regulation of cell cycle  regulation of chromosome segregation  regulation of gene silencing by miRNA  mRNA destabilization  positive regulation of RIG-I signaling pathway  positive regulation of gene silencing by miRNA  
Ontology : EGO-EBIcytoplasmic mRNA processing body  RNA binding  mRNA 3'-UTR binding  protein binding  cytosol  spermatogenesis  adult locomotory behavior  cytoplasmic stress granule  posttranscriptional gene silencing  regulation of mRNA stability  poly(A) RNA binding  stem cell differentiation  regulation of cell cycle  regulation of chromosome segregation  regulation of gene silencing by miRNA  mRNA destabilization  positive regulation of RIG-I signaling pathway  positive regulation of gene silencing by miRNA  
NDEx NetworkPUM1
Atlas of Cancer Signalling NetworkPUM1
Wikipedia pathwaysPUM1
Orthology - Evolution
OrthoDB9698
GeneTree (enSembl)ENSG00000134644
Phylogenetic Trees/Animal Genes : TreeFamPUM1
HOVERGENQ14671
HOGENOMQ14671
Homologs : HomoloGenePUM1
Homology/Alignments : Family Browser (UCSC)PUM1
Gene fusions - Rearrangements
Fusion : MitelmanPUM1/EIF4G3 [1p35.2/1p36.12]  
Fusion : MitelmanPUM1/KIAA1211 [1p35.2/4q12]  [t(1;4)(p35;q12)]  
Fusion : MitelmanPUM1/NKAIN1 [1p35.2/1p35.2]  [dup(1)(p35p35)]  [t(1;1)(p35;p35)]  
Fusion : MitelmanPUM1/PTPRK [1p35.2/6q22.33]  [t(1;6)(p35;q22)]  
Fusion : MitelmanPUM1/RPH3AL [1p35.2/17p13.3]  [t(1;17)(p35;p13)]  
Fusion : MitelmanPUM1/TRERF1 [1p35.2/6p21.1]  [t(1;6)(p35;p21)]  
Fusion: TCGAPUM1 1p35.2 EIF4G3 1p36.12 LUSC
Fusion: TCGAPUM1 1p35.2 KIAA1211 4q12 HNSC
Fusion: TCGAPUM1 1p35.2 NKAIN1 1p35.2 BRCA LUAD
Fusion: TCGAPUM1 1p35.2 PTPRK 6q22.33 BRCA
Fusion: TCGAPUM1 1p35.2 RPH3AL 17p13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPUM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PUM1
dbVarPUM1
ClinVarPUM1
1000_GenomesPUM1 
Exome Variant ServerPUM1
ExAC (Exome Aggregation Consortium)PUM1 (select the gene name)
Genetic variants : HAPMAP9698
Genomic Variants (DGV)PUM1 [DGVbeta]
DECIPHER (Syndromes)1:31404353-31538564  ENSG00000134644
CONAN: Copy Number AnalysisPUM1 
Mutations
ICGC Data PortalPUM1 
TCGA Data PortalPUM1 
Broad Tumor PortalPUM1
OASIS PortalPUM1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPUM1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPUM1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PUM1
DgiDB (Drug Gene Interaction Database)PUM1
DoCM (Curated mutations)PUM1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PUM1 (select a term)
intoGenPUM1
Cancer3DPUM1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607204   
Orphanet
MedgenPUM1
Genetic Testing Registry PUM1
NextProtQ14671 [Medical]
TSGene9698
GENETestsPUM1
Huge Navigator PUM1 [HugePedia]
snp3D : Map Gene to Disease9698
BioCentury BCIQPUM1
ClinGenPUM1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9698
Chemical/Pharm GKB GenePA34042
Clinical trialPUM1
Miscellaneous
canSAR (ICR)PUM1 (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePUM1
EVEXPUM1
GoPubMedPUM1
iHOPPUM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:16:19 CEST 2017

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