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PUM2 (pumilio RNA binding family member 2)

Identity

Alias_namespumilio homolog 2 (Drosophila)
Alias_symbol (synonym)PUMH2
KIAA0235
Other aliasPUML2
HGNC (Hugo) PUM2
LocusID (NCBI) 23369
Atlas_Id 41950
Location 2p24.1  [Link to chromosome band 2p24]
Location_base_pair Starts at 20448453 and ends at 20550611 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CD74 (5q32) / PUM2 (2p24.1)IDS (Xq28) / PUM2 (2p24.1)PUM2 (2p24.1) / ATF5 (19q13.33)
PUM2 (2p24.1) / HS1BP3 (2p24.1)PUM2 (2p24.1) / IL1RN (2q13)PUM2 (2p24.1) / LDAH (2p24.1)
PUM2 (2p24.1) / PPM1H (12q14.1)PUM2 (2p24.1) / VPS35 (16q11.2)PUM2 (2p24.1) / ZNF334 (20q13.12)
UBFD1 (16p12.2) / PUM2 (2p24.1)UHRF2 (9p24.1) / PUM2 (2p24.1)WDR35 (2p24.1) / PUM2 (2p24.1)
PUM2 2p24.1 C2orf43PUM2 2p24.1 / HS1BP3 2p24.1PUM2 2p24.1 / IL1RN 2q13
WDR35 2p24.1 / PUM2 2p24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PUM2   14958
Cards
Entrez_Gene (NCBI)PUM2  23369  pumilio RNA binding family member 2
AliasesPUMH2; PUML2
GeneCards (Weizmann)PUM2
Ensembl hg19 (Hinxton)ENSG00000055917 [Gene_View]  chr2:20448453-20550611 [Contig_View]  PUM2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000055917 [Gene_View]  chr2:20448453-20550611 [Contig_View]  PUM2 [Vega]
ICGC DataPortalENSG00000055917
TCGA cBioPortalPUM2
AceView (NCBI)PUM2
Genatlas (Paris)PUM2
WikiGenes23369
SOURCE (Princeton)PUM2
Genetics Home Reference (NIH)PUM2
Genomic and cartography
GoldenPath hg19 (UCSC)PUM2  -     chr2:20448453-20550611 -  2p24.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PUM2  -     2p24.1   [Description]    (hg38-Dec_2013)
EnsemblPUM2 - 2p24.1 [CytoView hg19]  PUM2 - 2p24.1 [CytoView hg38]
Mapping of homologs : NCBIPUM2 [Mapview hg19]  PUM2 [Mapview hg38]
OMIM607205   
Gene and transcription
Genbank (Entrez)AF272350 AF315591 AK093847 AK304198 BC024218
RefSeq transcript (Entrez)NM_001282752 NM_001282790 NM_001282791 NM_015317
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_022184 NW_004929299
Consensus coding sequences : CCDS (NCBI)PUM2
Cluster EST : UnigeneHs.467824 [ NCBI ]
CGAP (NCI)Hs.467824
Alternative Splicing GalleryENSG00000055917
Gene ExpressionPUM2 [ NCBI-GEO ]   PUM2 [ EBI - ARRAY_EXPRESS ]   PUM2 [ SEEK ]   PUM2 [ MEM ]
Gene Expression Viewer (FireBrowse)PUM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23369
GTEX Portal (Tissue expression)PUM2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TB72   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TB72  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TB72
Splice isoforms : SwissVarQ8TB72
PhosPhoSitePlusQ8TB72
Domaine pattern : Prosite (Expaxy)PUM (PS50302)    PUM_HD (PS50303)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Pumilio_RNA-bd_rpt   
Domain families : Pfam (Sanger)PUF (PF00806)   
Domain families : Pfam (NCBI)pfam00806   
Domain families : Smart (EMBL)Pumilio (SM00025)  
Conserved Domain (NCBI)PUM2
DMDM Disease mutations23369
Blocks (Seattle)PUM2
PDB (SRS)3Q0Q    3Q0R    3Q0S   
PDB (PDBSum)3Q0Q    3Q0R    3Q0S   
PDB (IMB)3Q0Q    3Q0R    3Q0S   
PDB (RSDB)3Q0Q    3Q0R    3Q0S   
Structural Biology KnowledgeBase3Q0Q    3Q0R    3Q0S   
SCOP (Structural Classification of Proteins)3Q0Q    3Q0R    3Q0S   
CATH (Classification of proteins structures)3Q0Q    3Q0R    3Q0S   
SuperfamilyQ8TB72
Human Protein AtlasENSG00000055917
Peptide AtlasQ8TB72
HPRD09527
IPIIPI00398749   IPI00398750   IPI00022184   IPI01009448   IPI00892928   IPI00892704   IPI00893277   IPI00892647   
Protein Interaction databases
DIP (DOE-UCLA)Q8TB72
IntAct (EBI)Q8TB72
FunCoupENSG00000055917
BioGRIDPUM2
STRING (EMBL)PUM2
ZODIACPUM2
Ontologies - Pathways
QuickGOQ8TB72
Ontology : AmiGORNA binding  mRNA 3'-UTR binding  protein binding  cytoplasm  cytoplasmic stress granule  cytoplasmic stress granule  nuclear membrane  stress granule assembly  regulation of mRNA stability  poly(A) RNA binding  perinuclear region of cytoplasm  regulation of chromosome segregation  regulation of gene silencing by miRNA  positive regulation of RIG-I signaling pathway  positive regulation of gene silencing by miRNA  
Ontology : EGO-EBIRNA binding  mRNA 3'-UTR binding  protein binding  cytoplasm  cytoplasmic stress granule  cytoplasmic stress granule  nuclear membrane  stress granule assembly  regulation of mRNA stability  poly(A) RNA binding  perinuclear region of cytoplasm  regulation of chromosome segregation  regulation of gene silencing by miRNA  positive regulation of RIG-I signaling pathway  positive regulation of gene silencing by miRNA  
NDEx NetworkPUM2
Atlas of Cancer Signalling NetworkPUM2
Wikipedia pathwaysPUM2
Orthology - Evolution
OrthoDB23369
GeneTree (enSembl)ENSG00000055917
Phylogenetic Trees/Animal Genes : TreeFamPUM2
HOVERGENQ8TB72
HOGENOMQ8TB72
Homologs : HomoloGenePUM2
Homology/Alignments : Family Browser (UCSC)PUM2
Gene fusions - Rearrangements
Fusion : MitelmanPUM2/C2orf43 [2p24.1/]  
Fusion : MitelmanPUM2/HS1BP3 [2p24.1/2p24.1]  [t(2;2)(p24;p24)]  
Fusion : MitelmanPUM2/IL1RN [2p24.1/2q13]  [t(2;2)(p24;q13)]  
Fusion : MitelmanPUM2/LDAH [2p24.1/2p24.1]  [t(2;2)(p24;p24)]  
Fusion : MitelmanWDR35/PUM2 [2p24.1/2p24.1]  [t(2;2)(p24;p24)]  
Fusion: TCGAPUM2 2p24.1 C2orf43 GBM
Fusion: TCGAPUM2 2p24.1 HS1BP3 2p24.1 BRCA
Fusion: TCGAPUM2 2p24.1 IL1RN 2q13 BRCA
Fusion: TCGAWDR35 2p24.1 PUM2 2p24.1 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPUM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PUM2
dbVarPUM2
ClinVarPUM2
1000_GenomesPUM2 
Exome Variant ServerPUM2
ExAC (Exome Aggregation Consortium)PUM2 (select the gene name)
Genetic variants : HAPMAP23369
Genomic Variants (DGV)PUM2 [DGVbeta]
DECIPHER (Syndromes)2:20448453-20550611  ENSG00000055917
CONAN: Copy Number AnalysisPUM2 
Mutations
ICGC Data PortalPUM2 
TCGA Data PortalPUM2 
Broad Tumor PortalPUM2
OASIS PortalPUM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPUM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPUM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PUM2
DgiDB (Drug Gene Interaction Database)PUM2
DoCM (Curated mutations)PUM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PUM2 (select a term)
intoGenPUM2
Cancer3DPUM2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607205   
Orphanet
MedgenPUM2
Genetic Testing Registry PUM2
NextProtQ8TB72 [Medical]
TSGene23369
GENETestsPUM2
Huge Navigator PUM2 [HugePedia]
snp3D : Map Gene to Disease23369
BioCentury BCIQPUM2
ClinGenPUM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23369
Chemical/Pharm GKB GenePA34043
Clinical trialPUM2
Miscellaneous
canSAR (ICR)PUM2 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePUM2
EVEXPUM2
GoPubMedPUM2
iHOPPUM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:16:19 CEST 2017

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