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PUM2 (pumilio RNA binding family member 2)

Identity

Alias (NCBI)PUMH2
PUML2
HGNC (Hugo) PUM2
HGNC Alias symbPUMH2
KIAA0235
HGNC Previous namepumilio homolog 2 (Drosophila)
LocusID (NCBI) 23369
Atlas_Id 41950
Location 2p24.1  [Link to chromosome band 2p24]
Location_base_pair Starts at 20248738 and ends at 20350844 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CD74 (5q32)::PUM2 (2p24.1)IDS (Xq28)::PUM2 (2p24.1)PUM2 (2p24.1)::ATF5 (19q13.33)
PUM2 (2p24.1)::HS1BP3 (2p24.1)PUM2 (2p24.1)::IL1RN (2q13)PUM2 (2p24.1)::LDAH (2p24.1)
PUM2 (2p24.1)::PPM1H (12q14.1)PUM2 (2p24.1)::VPS35 (16q11.2)PUM2 (2p24.1)::ZNF334 (20q13.12)
UBFD1 (16p12.2)::PUM2 (2p24.1)UHRF2 (9p24.1)::PUM2 (2p24.1)WDR35 (2p24.1)::PUM2 (2p24.1)
PUM2 2p24.1 C2orf43PUM2 2p24.1::HS1BP3 2p24.1PUM2 2p24.1::IL1RN 2q13
WDR35 2p24.1::PUM2 2p24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PUM2   14958
Cards
Entrez_Gene (NCBI)PUM2    pumilio RNA binding family member 2
AliasesPUMH2; PUML2
GeneCards (Weizmann)PUM2
Ensembl hg19 (Hinxton)ENSG00000055917 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000055917 [Gene_View]  ENSG00000055917 [Sequence]  chr2:20248738-20350844 [Contig_View]  PUM2 [Vega]
ICGC DataPortalENSG00000055917
TCGA cBioPortalPUM2
AceView (NCBI)PUM2
Genatlas (Paris)PUM2
SOURCE (Princeton)PUM2
Genetics Home Reference (NIH)PUM2
Genomic and cartography
GoldenPath hg38 (UCSC)PUM2  -     chr2:20248738-20350844 -  2p24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PUM2  -     2p24.1   [Description]    (hg19-Feb_2009)
GoldenPathPUM2 - 2p24.1 [CytoView hg19]  PUM2 - 2p24.1 [CytoView hg38]
ImmunoBaseENSG00000055917
Genome Data Viewer NCBIPUM2 [Mapview hg19]  
OMIM607205   
Gene and transcription
Genbank (Entrez)AF272350 AF315591 AK093847 AK304198 BC024218
RefSeq transcript (Entrez)NM_001282752 NM_001282790 NM_001282791 NM_001352917 NM_001352918 NM_001352919 NM_001352920 NM_001352923 NM_001352925 NM_001352926 NM_001352927 NM_001352928 NM_001352929 NM_001352930 NM_015317
Consensus coding sequences : CCDS (NCBI)PUM2
Gene ExpressionPUM2 [ NCBI-GEO ]   PUM2 [ EBI - ARRAY_EXPRESS ]   PUM2 [ SEEK ]   PUM2 [ MEM ]
Gene Expression Viewer (FireBrowse)PUM2 [ Firebrowse - Broad ]
GenevisibleExpression of PUM2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23369
GTEX Portal (Tissue expression)PUM2
Human Protein AtlasENSG00000055917-PUM2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TB72   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TB72  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TB72
PhosPhoSitePlusQ8TB72
Domaine pattern : Prosite (Expaxy)PUM (PS50302)    PUM_HD (PS50303)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    PUM-HD    Pumilio_RNA-bd    Pumilio_RNA-bd_rpt   
Domain families : Pfam (Sanger)PUF (PF00806)   
Domain families : Pfam (NCBI)pfam00806   
Domain families : Smart (EMBL)Pumilio (SM00025)  
Conserved Domain (NCBI)PUM2
PDB (RSDB)3Q0Q    3Q0R    3Q0S   
PDB Europe3Q0Q    3Q0R    3Q0S   
PDB (PDBSum)3Q0Q    3Q0R    3Q0S   
PDB (IMB)3Q0Q    3Q0R    3Q0S   
Structural Biology KnowledgeBase3Q0Q    3Q0R    3Q0S   
SCOP (Structural Classification of Proteins)3Q0Q    3Q0R    3Q0S   
CATH (Classification of proteins structures)3Q0Q    3Q0R    3Q0S   
SuperfamilyQ8TB72
AlphaFold pdb e-kbQ8TB72   
Human Protein Atlas [tissue]ENSG00000055917-PUM2 [tissue]
HPRD09527
Protein Interaction databases
DIP (DOE-UCLA)Q8TB72
IntAct (EBI)Q8TB72
BioGRIDPUM2
STRING (EMBL)PUM2
ZODIACPUM2
Ontologies - Pathways
QuickGOQ8TB72
Ontology : AmiGORNA binding  RNA binding  mRNA binding  mRNA 3'-UTR binding  mRNA 3'-UTR binding  protein binding  cytoplasm  cytosol  cytosol  regulation of translation  cytoplasmic stress granule  cytoplasmic stress granule  posttranscriptional regulation of gene expression  posttranscriptional regulation of gene expression  posttranscriptional regulation of gene expression  nuclear membrane  stress granule assembly  production of miRNAs involved in gene silencing by miRNA  production of miRNAs involved in gene silencing by miRNA  miRNA binding  regulation of mRNA stability  regulation of mRNA stability  perinuclear region of cytoplasm  regulation of chromosome segregation  regulation of gene silencing by miRNA  positive regulation of RIG-I signaling pathway  positive regulation of gene silencing by miRNA  
Ontology : EGO-EBIRNA binding  RNA binding  mRNA binding  mRNA 3'-UTR binding  mRNA 3'-UTR binding  protein binding  cytoplasm  cytosol  cytosol  regulation of translation  cytoplasmic stress granule  cytoplasmic stress granule  posttranscriptional regulation of gene expression  posttranscriptional regulation of gene expression  posttranscriptional regulation of gene expression  nuclear membrane  stress granule assembly  production of miRNAs involved in gene silencing by miRNA  production of miRNAs involved in gene silencing by miRNA  miRNA binding  regulation of mRNA stability  regulation of mRNA stability  perinuclear region of cytoplasm  regulation of chromosome segregation  regulation of gene silencing by miRNA  positive regulation of RIG-I signaling pathway  positive regulation of gene silencing by miRNA  
NDEx NetworkPUM2
Atlas of Cancer Signalling NetworkPUM2
Wikipedia pathwaysPUM2
Orthology - Evolution
OrthoDB23369
GeneTree (enSembl)ENSG00000055917
Phylogenetic Trees/Animal Genes : TreeFamPUM2
Homologs : HomoloGenePUM2
Homology/Alignments : Family Browser (UCSC)PUM2
Gene fusions - Rearrangements
Fusion : MitelmanPUM2::C2orf43 [2p24.1/]  
Fusion : MitelmanPUM2::HS1BP3 [2p24.1/2p24.1]  
Fusion : MitelmanPUM2::IL1RN [2p24.1/2q13]  
Fusion : MitelmanPUM2::LDAH [2p24.1/2p24.1]  
Fusion : MitelmanWDR35::PUM2 [2p24.1/2p24.1]  
Fusion : QuiverPUM2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPUM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PUM2
dbVarPUM2
ClinVarPUM2
MonarchPUM2
1000_GenomesPUM2 
Exome Variant ServerPUM2
GNOMAD BrowserENSG00000055917
Varsome BrowserPUM2
ACMGPUM2 variants
VarityQ8TB72
Genomic Variants (DGV)PUM2 [DGVbeta]
DECIPHERPUM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPUM2 
Mutations
ICGC Data PortalPUM2 
TCGA Data PortalPUM2 
Broad Tumor PortalPUM2
OASIS PortalPUM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPUM2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPUM2
Mutations and Diseases : HGMDPUM2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPUM2
DgiDB (Drug Gene Interaction Database)PUM2
DoCM (Curated mutations)PUM2
CIViC (Clinical Interpretations of Variants in Cancer)PUM2
Cancer3DPUM2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607205   
Orphanet
DisGeNETPUM2
MedgenPUM2
Genetic Testing Registry PUM2
NextProtQ8TB72 [Medical]
GENETestsPUM2
Target ValidationPUM2
Huge Navigator PUM2 [HugePedia]
ClinGenPUM2
Clinical trials, drugs, therapy
MyCancerGenomePUM2
Protein Interactions : CTDPUM2
Pharm GKB GenePA34043
PharosQ8TB72
Clinical trialPUM2
Miscellaneous
canSAR (ICR)PUM2
HarmonizomePUM2
ARCHS4PUM2
DataMed IndexPUM2
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPUM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:54:40 CET 2022

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