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PURA (purine rich element binding protein A)

Identity

Alias_symbol (synonym)PURALPHA
PUR1
PUR-ALPHA
Other aliasMRD31
HGNC (Hugo) PURA
LocusID (NCBI) 5813
Atlas_Id 41951
Location 5q31.3  [Link to chromosome band 5q31]
Location_base_pair Starts at 140114123 and ends at 140119416 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PURA   9701
Cards
Entrez_Gene (NCBI)PURA  5813  purine rich element binding protein A
AliasesMRD31; PUR-ALPHA; PUR1; PURALPHA
GeneCards (Weizmann)PURA
Ensembl hg19 (Hinxton)ENSG00000185129 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185129 [Gene_View]  chr5:140114123-140119416 [Contig_View]  PURA [Vega]
ICGC DataPortalENSG00000185129
TCGA cBioPortalPURA
AceView (NCBI)PURA
Genatlas (Paris)PURA
WikiGenes5813
SOURCE (Princeton)PURA
Genetics Home Reference (NIH)PURA
Genomic and cartography
GoldenPath hg38 (UCSC)PURA  -     chr5:140114123-140119416 +  5q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PURA  -     5q31.3   [Description]    (hg19-Feb_2009)
EnsemblPURA - 5q31.3 [CytoView hg19]  PURA - 5q31.3 [CytoView hg38]
Mapping of homologs : NCBIPURA [Mapview hg19]  PURA [Mapview hg38]
OMIM600473   616158   
Gene and transcription
Genbank (Entrez)BC036087 BC110574 BC110594 BT019388 CK819077
RefSeq transcript (Entrez)NM_005859
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PURA
Cluster EST : UnigeneHs.733524 [ NCBI ]
CGAP (NCI)Hs.733524
Alternative Splicing GalleryENSG00000185129
Gene ExpressionPURA [ NCBI-GEO ]   PURA [ EBI - ARRAY_EXPRESS ]   PURA [ SEEK ]   PURA [ MEM ]
Gene Expression Viewer (FireBrowse)PURA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5813
GTEX Portal (Tissue expression)PURA
Human Protein AtlasENSG00000185129-PURA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ00577   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ00577  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ00577
Splice isoforms : SwissVarQ00577
PhosPhoSitePlusQ00577
Domains : Interpro (EBI)PUR-bd_fam    PURalpha   
Domain families : Pfam (Sanger)PurA (PF04845)   
Domain families : Pfam (NCBI)pfam04845   
Domain families : Smart (EMBL)PUR (SM00712)  
Conserved Domain (NCBI)PURA
DMDM Disease mutations5813
Blocks (Seattle)PURA
SuperfamilyQ00577
Human Protein Atlas [tissue]ENSG00000185129-PURA [tissue]
Peptide AtlasQ00577
HPRD02721
IPIIPI00023591   
Protein Interaction databases
DIP (DOE-UCLA)Q00577
IntAct (EBI)Q00577
FunCoupENSG00000185129
BioGRIDPURA
STRING (EMBL)PURA
ZODIACPURA
Ontologies - Pathways
QuickGOQ00577
Ontology : AmiGOnuclear chromosome, telomeric region  translation repressor activity, nucleic acid binding  double-stranded telomeric DNA binding  single-stranded DNA binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  RNA binding  protein binding  nucleus  DNA replication factor A complex  cytoplasm  DNA unwinding involved in DNA replication  DNA replication initiation  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  nervous system development  transcription factor binding  positive regulation of cell proliferation  negative regulation of translation  cell differentiation  dendrite  purine-rich negative regulatory element binding  neuronal cell body  negative regulation of transcription, DNA-templated  SMAD binding  
Ontology : EGO-EBInuclear chromosome, telomeric region  translation repressor activity, nucleic acid binding  double-stranded telomeric DNA binding  single-stranded DNA binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  RNA binding  protein binding  nucleus  DNA replication factor A complex  cytoplasm  DNA unwinding involved in DNA replication  DNA replication initiation  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  nervous system development  transcription factor binding  positive regulation of cell proliferation  negative regulation of translation  cell differentiation  dendrite  purine-rich negative regulatory element binding  neuronal cell body  negative regulation of transcription, DNA-templated  SMAD binding  
NDEx NetworkPURA
Atlas of Cancer Signalling NetworkPURA
Wikipedia pathwaysPURA
Orthology - Evolution
OrthoDB5813
GeneTree (enSembl)ENSG00000185129
Phylogenetic Trees/Animal Genes : TreeFamPURA
HOVERGENQ00577
HOGENOMQ00577
Homologs : HomoloGenePURA
Homology/Alignments : Family Browser (UCSC)PURA
Gene fusions - Rearrangements
Tumor Fusion PortalPURA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPURA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PURA
dbVarPURA
ClinVarPURA
1000_GenomesPURA 
Exome Variant ServerPURA
ExAC (Exome Aggregation Consortium)ENSG00000185129
GNOMAD BrowserENSG00000185129
Genetic variants : HAPMAP5813
Genomic Variants (DGV)PURA [DGVbeta]
DECIPHERPURA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPURA 
Mutations
ICGC Data PortalPURA 
TCGA Data PortalPURA 
Broad Tumor PortalPURA
OASIS PortalPURA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPURA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPURA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PURA
DgiDB (Drug Gene Interaction Database)PURA
DoCM (Curated mutations)PURA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PURA (select a term)
intoGenPURA
Cancer3DPURA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600473    616158   
Orphanet21510    23370   
DisGeNETPURA
MedgenPURA
Genetic Testing Registry PURA
NextProtQ00577 [Medical]
TSGene5813
GENETestsPURA
Target ValidationPURA
Huge Navigator PURA [HugePedia]
snp3D : Map Gene to Disease5813
BioCentury BCIQPURA
ClinGenPURA (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5813
Chemical/Pharm GKB GenePA34045
Clinical trialPURA
Miscellaneous
canSAR (ICR)PURA (select the gene name)
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePURA
EVEXPURA
GoPubMedPURA
iHOPPURA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:31:05 CET 2017

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