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PURB (purine rich element binding protein B)

Identity

Alias_symbol (synonym)PURBETA
Other alias
HGNC (Hugo) PURB
LocusID (NCBI) 5814
Atlas_Id 41952
Location 7p13  [Link to chromosome band 7p13]
Location_base_pair Starts at 44876293 and ends at 44885385 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PRKCSH (19p13.2) / PURB (7p13)PURB (7p13) / PURB (7p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PURB   9702
Cards
Entrez_Gene (NCBI)PURB  5814  purine rich element binding protein B
AliasesPURBETA
GeneCards (Weizmann)PURB
Ensembl hg19 (Hinxton)ENSG00000146676 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146676 [Gene_View]  chr7:44876293-44885385 [Contig_View]  PURB [Vega]
ICGC DataPortalENSG00000146676
TCGA cBioPortalPURB
AceView (NCBI)PURB
Genatlas (Paris)PURB
WikiGenes5814
SOURCE (Princeton)PURB
Genetics Home Reference (NIH)PURB
Genomic and cartography
GoldenPath hg38 (UCSC)PURB  -     chr7:44876293-44885385 -  7p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PURB  -     7p13   [Description]    (hg19-Feb_2009)
EnsemblPURB - 7p13 [CytoView hg19]  PURB - 7p13 [CytoView hg38]
Mapping of homologs : NCBIPURB [Mapview hg19]  PURB [Mapview hg38]
OMIM608887   
Gene and transcription
Genbank (Entrez)AA016115 AI042138 AI050971 AI209043 AI912557
RefSeq transcript (Entrez)NM_033224
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PURB
Cluster EST : UnigeneHs.596321 [ NCBI ]
CGAP (NCI)Hs.596321
Alternative Splicing GalleryENSG00000146676
Gene ExpressionPURB [ NCBI-GEO ]   PURB [ EBI - ARRAY_EXPRESS ]   PURB [ SEEK ]   PURB [ MEM ]
Gene Expression Viewer (FireBrowse)PURB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5814
GTEX Portal (Tissue expression)PURB
Human Protein AtlasENSG00000146676-PURB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96QR8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96QR8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96QR8
Splice isoforms : SwissVarQ96QR8
PhosPhoSitePlusQ96QR8
Domains : Interpro (EBI)PUR-bd_fam    PURbeta   
Domain families : Pfam (Sanger)PurA (PF04845)   
Domain families : Pfam (NCBI)pfam04845   
Domain families : Smart (EMBL)PUR (SM00712)  
Conserved Domain (NCBI)PURB
DMDM Disease mutations5814
Blocks (Seattle)PURB
SuperfamilyQ96QR8
Human Protein Atlas [tissue]ENSG00000146676-PURB [tissue]
Peptide AtlasQ96QR8
HPRD12325
IPIIPI00045051   
Protein Interaction databases
DIP (DOE-UCLA)Q96QR8
IntAct (EBI)Q96QR8
FunCoupENSG00000146676
BioGRIDPURB
STRING (EMBL)PURB
ZODIACPURB
Ontologies - Pathways
QuickGOQ96QR8
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  single-stranded DNA binding  RNA binding  mRNA binding  nucleus  DNA replication factor A complex  transcription, DNA-templated  transcription factor binding  cell proliferation  cell differentiation  regulation of myeloid cell differentiation  SMAD binding  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  single-stranded DNA binding  RNA binding  mRNA binding  nucleus  DNA replication factor A complex  transcription, DNA-templated  transcription factor binding  cell proliferation  cell differentiation  regulation of myeloid cell differentiation  SMAD binding  
NDEx NetworkPURB
Atlas of Cancer Signalling NetworkPURB
Wikipedia pathwaysPURB
Orthology - Evolution
OrthoDB5814
GeneTree (enSembl)ENSG00000146676
Phylogenetic Trees/Animal Genes : TreeFamPURB
HOVERGENQ96QR8
HOGENOMQ96QR8
Homologs : HomoloGenePURB
Homology/Alignments : Family Browser (UCSC)PURB
Gene fusions - Rearrangements
Tumor Fusion PortalPURB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPURB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PURB
dbVarPURB
ClinVarPURB
1000_GenomesPURB 
Exome Variant ServerPURB
ExAC (Exome Aggregation Consortium)ENSG00000146676
GNOMAD BrowserENSG00000146676
Genetic variants : HAPMAP5814
Genomic Variants (DGV)PURB [DGVbeta]
DECIPHERPURB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPURB 
Mutations
ICGC Data PortalPURB 
TCGA Data PortalPURB 
Broad Tumor PortalPURB
OASIS PortalPURB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPURB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPURB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PURB
DgiDB (Drug Gene Interaction Database)PURB
DoCM (Curated mutations)PURB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PURB (select a term)
intoGenPURB
Cancer3DPURB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608887   
Orphanet
DisGeNETPURB
MedgenPURB
Genetic Testing Registry PURB
NextProtQ96QR8 [Medical]
TSGene5814
GENETestsPURB
Target ValidationPURB
Huge Navigator PURB [HugePedia]
snp3D : Map Gene to Disease5814
BioCentury BCIQPURB
ClinGenPURB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5814
Chemical/Pharm GKB GenePA34046
Clinical trialPURB
Miscellaneous
canSAR (ICR)PURB (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePURB
EVEXPURB
GoPubMedPURB
iHOPPURB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:31:06 CET 2017

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