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PWWP2B (PWWP domain containing 2B)

Identity

Alias_namesPWWP2
PWWP domain containing 2
Alias_symbol (synonym)bA432J24.1
FLJ46823
Other aliaspp8607
HGNC (Hugo) PWWP2B
LocusID (NCBI) 170394
Atlas_Id 72417
Location 10q26.3  [Link to chromosome band 10q26]
Location_base_pair Starts at 132397198 and ends at 132417854 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PWWP2B (10q26.3) / LBH (2p23.1)PWWP2B (10q26.3) / LYST (1q42.3)RIMBP2 (12q24.33) / PWWP2B (10q26.3)
STK32C (10q26.3) / PWWP2B (10q26.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;10)(q26;q26) STK32C/PWWP2B

External links

Nomenclature
HGNC (Hugo)PWWP2B   25150
Cards
Entrez_Gene (NCBI)PWWP2B  170394  PWWP domain containing 2B
AliasesPWWP2; bA432J24.1; pp8607
GeneCards (Weizmann)PWWP2B
Ensembl hg19 (Hinxton)ENSG00000171813 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171813 [Gene_View]  ENSG00000171813 [Sequence]  chr10:132397198-132417854 [Contig_View]  PWWP2B [Vega]
ICGC DataPortalENSG00000171813
TCGA cBioPortalPWWP2B
AceView (NCBI)PWWP2B
Genatlas (Paris)PWWP2B
WikiGenes170394
SOURCE (Princeton)PWWP2B
Genetics Home Reference (NIH)PWWP2B
Genomic and cartography
GoldenPath hg38 (UCSC)PWWP2B  -     chr10:132397198-132417854 +  10q26.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PWWP2B  -     10q26.3   [Description]    (hg19-Feb_2009)
EnsemblPWWP2B - 10q26.3 [CytoView hg19]  PWWP2B - 10q26.3 [CytoView hg38]
Mapping of homologs : NCBIPWWP2B [Mapview hg19]  PWWP2B [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF318365 AK096940 AK128663 AW166547 BC011630
RefSeq transcript (Entrez)NM_001098637 NM_138499
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PWWP2B
Cluster EST : UnigeneHs.527751 [ NCBI ]
CGAP (NCI)Hs.527751
Alternative Splicing GalleryENSG00000171813
Gene ExpressionPWWP2B [ NCBI-GEO ]   PWWP2B [ EBI - ARRAY_EXPRESS ]   PWWP2B [ SEEK ]   PWWP2B [ MEM ]
Gene Expression Viewer (FireBrowse)PWWP2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)170394
GTEX Portal (Tissue expression)PWWP2B
Human Protein AtlasENSG00000171813-PWWP2B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6NUJ5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6NUJ5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6NUJ5
Splice isoforms : SwissVarQ6NUJ5
PhosPhoSitePlusQ6NUJ5
Domaine pattern : Prosite (Expaxy)PWWP (PS50812)   
Domains : Interpro (EBI)PWWP_dom   
Domain families : Pfam (Sanger)PWWP (PF00855)   
Domain families : Pfam (NCBI)pfam00855   
Domain families : Smart (EMBL)PWWP (SM00293)  
Conserved Domain (NCBI)PWWP2B
DMDM Disease mutations170394
Blocks (Seattle)PWWP2B
PDB (SRS)4LD6   
PDB (PDBSum)4LD6   
PDB (IMB)4LD6   
PDB (RSDB)4LD6   
Structural Biology KnowledgeBase4LD6   
SCOP (Structural Classification of Proteins)4LD6   
CATH (Classification of proteins structures)4LD6   
SuperfamilyQ6NUJ5
Human Protein Atlas [tissue]ENSG00000171813-PWWP2B [tissue]
Peptide AtlasQ6NUJ5
HPRD11465
IPIIPI00103812   IPI00383286   IPI00848105   
Protein Interaction databases
DIP (DOE-UCLA)Q6NUJ5
IntAct (EBI)Q6NUJ5
FunCoupENSG00000171813
BioGRIDPWWP2B
STRING (EMBL)PWWP2B
ZODIACPWWP2B
Ontologies - Pathways
QuickGOQ6NUJ5
Ontology : AmiGOprotein binding  nucleoplasm  
Ontology : EGO-EBIprotein binding  nucleoplasm  
NDEx NetworkPWWP2B
Atlas of Cancer Signalling NetworkPWWP2B
Wikipedia pathwaysPWWP2B
Orthology - Evolution
OrthoDB170394
GeneTree (enSembl)ENSG00000171813
Phylogenetic Trees/Animal Genes : TreeFamPWWP2B
HOVERGENQ6NUJ5
HOGENOMQ6NUJ5
Homologs : HomoloGenePWWP2B
Homology/Alignments : Family Browser (UCSC)PWWP2B
Gene fusions - Rearrangements
Fusion : QuiverPWWP2B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPWWP2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PWWP2B
dbVarPWWP2B
ClinVarPWWP2B
1000_GenomesPWWP2B 
Exome Variant ServerPWWP2B
ExAC (Exome Aggregation Consortium)ENSG00000171813
GNOMAD BrowserENSG00000171813
Varsome BrowserPWWP2B
Genetic variants : HAPMAP170394
Genomic Variants (DGV)PWWP2B [DGVbeta]
DECIPHERPWWP2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPWWP2B 
Mutations
ICGC Data PortalPWWP2B 
TCGA Data PortalPWWP2B 
Broad Tumor PortalPWWP2B
OASIS PortalPWWP2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPWWP2B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPWWP2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PWWP2B
DgiDB (Drug Gene Interaction Database)PWWP2B
DoCM (Curated mutations)PWWP2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PWWP2B (select a term)
intoGenPWWP2B
Cancer3DPWWP2B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETPWWP2B
MedgenPWWP2B
Genetic Testing Registry PWWP2B
NextProtQ6NUJ5 [Medical]
TSGene170394
GENETestsPWWP2B
Target ValidationPWWP2B
Huge Navigator PWWP2B [HugePedia]
snp3D : Map Gene to Disease170394
BioCentury BCIQPWWP2B
ClinGenPWWP2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD170394
Chemical/Pharm GKB GenePA162400513
Clinical trialPWWP2B
Miscellaneous
canSAR (ICR)PWWP2B (select the gene name)
Probes
Litterature
PubMed8 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePWWP2B
EVEXPWWP2B
GoPubMedPWWP2B
iHOPPWWP2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 14:25:45 CEST 2018
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