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PYCR3 (pyrroline-5-carboxylate reductase 3)

Identity

Alias_namesPYCRL
pyrroline-5-carboxylate reductase-like
Alias_symbol (synonym)FLJ13852
Other alias
HGNC (Hugo) PYCR3
LocusID (NCBI) 65263
Atlas_Id 78864
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 143603224 and ends at 143609614 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PYCR3   25846
Cards
Entrez_Gene (NCBI)PYCR3  65263  pyrroline-5-carboxylate reductase 3
AliasesPYCRL
GeneCards (Weizmann)PYCR3
Ensembl hg19 (Hinxton)ENSG00000104524 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104524 [Gene_View]  chr8:143603224-143609614 [Contig_View]  PYCR3 [Vega]
ICGC DataPortalENSG00000104524
TCGA cBioPortalPYCR3
AceView (NCBI)PYCR3
Genatlas (Paris)PYCR3
WikiGenes65263
SOURCE (Princeton)PYCR3
Genetics Home Reference (NIH)PYCR3
Genomic and cartography
GoldenPath hg38 (UCSC)PYCR3  -     chr8:143603224-143609614 -  8q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PYCR3  -     8q24.3   [Description]    (hg19-Feb_2009)
EnsemblPYCR3 - 8q24.3 [CytoView hg19]  PYCR3 - 8q24.3 [CytoView hg38]
Mapping of homologs : NCBIPYCR3 [Mapview hg19]  PYCR3 [Mapview hg38]
OMIM616408   
Gene and transcription
Genbank (Entrez)AF086378 AK001500 AK023914 AK222685 AK225404
RefSeq transcript (Entrez)NM_001329866 NM_023078
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_051357 NT_187571
Consensus coding sequences : CCDS (NCBI)PYCR3
Cluster EST : UnigeneHs.165186 [ NCBI ]
CGAP (NCI)Hs.165186
Alternative Splicing GalleryENSG00000104524
Gene ExpressionPYCR3 [ NCBI-GEO ]   PYCR3 [ EBI - ARRAY_EXPRESS ]   PYCR3 [ SEEK ]   PYCR3 [ MEM ]
Gene Expression Viewer (FireBrowse)PYCR3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)65263
GTEX Portal (Tissue expression)PYCR3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ53H96   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ53H96  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ53H96
Splice isoforms : SwissVarQ53H96
PhosPhoSitePlusQ53H96
Domaine pattern : Prosite (Expaxy)P5CR (PS00521)   
Domains : Interpro (EBI)6-PGluconate_DH_C-like    NAD(P)-bd_dom    P5C_Rdtase_cat_N    P5CR_dimer    Pyrroline-COOH_reductase   
Domain families : Pfam (Sanger)F420_oxidored (PF03807)    P5CR_dimer (PF14748)   
Domain families : Pfam (NCBI)pfam03807    pfam14748   
Conserved Domain (NCBI)PYCR3
DMDM Disease mutations65263
Blocks (Seattle)PYCR3
SuperfamilyQ53H96
Human Protein AtlasENSG00000104524
Peptide AtlasQ53H96
IPIIPI00926788   IPI00646105   IPI00926996   
Protein Interaction databases
DIP (DOE-UCLA)Q53H96
IntAct (EBI)Q53H96
FunCoupENSG00000104524
BioGRIDPYCR3
STRING (EMBL)PYCR3
ZODIACPYCR3
Ontologies - Pathways
QuickGOQ53H96
Ontology : AmiGOpyrroline-5-carboxylate reductase activity  pyrroline-5-carboxylate reductase activity  protein binding  cytosol  cytosol  cellular amino acid biosynthetic process  oxidation-reduction process  L-proline biosynthetic process  L-proline biosynthetic process  
Ontology : EGO-EBIpyrroline-5-carboxylate reductase activity  pyrroline-5-carboxylate reductase activity  protein binding  cytosol  cytosol  cellular amino acid biosynthetic process  oxidation-reduction process  L-proline biosynthetic process  L-proline biosynthetic process  
NDEx NetworkPYCR3
Atlas of Cancer Signalling NetworkPYCR3
Wikipedia pathwaysPYCR3
Orthology - Evolution
OrthoDB65263
GeneTree (enSembl)ENSG00000104524
Phylogenetic Trees/Animal Genes : TreeFamPYCR3
HOVERGENQ53H96
HOGENOMQ53H96
Homologs : HomoloGenePYCR3
Homology/Alignments : Family Browser (UCSC)PYCR3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPYCR3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PYCR3
dbVarPYCR3
ClinVarPYCR3
1000_GenomesPYCR3 
Exome Variant ServerPYCR3
ExAC (Exome Aggregation Consortium)PYCR3 (select the gene name)
Genetic variants : HAPMAP65263
Genomic Variants (DGV)PYCR3 [DGVbeta]
DECIPHERPYCR3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPYCR3 
Mutations
ICGC Data PortalPYCR3 
TCGA Data PortalPYCR3 
Broad Tumor PortalPYCR3
OASIS PortalPYCR3 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPYCR3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PYCR3
DgiDB (Drug Gene Interaction Database)PYCR3
DoCM (Curated mutations)PYCR3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PYCR3 (select a term)
intoGenPYCR3
Cancer3DPYCR3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616408   
Orphanet
MedgenPYCR3
Genetic Testing Registry PYCR3
NextProtQ53H96 [Medical]
TSGene65263
GENETestsPYCR3
Target ValidationPYCR3
Huge Navigator PYCR3 [HugePedia]
snp3D : Map Gene to Disease65263
BioCentury BCIQPYCR3
ClinGenPYCR3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD65263
Chemical/Pharm GKB GenePA134889043
Clinical trialPYCR3
Miscellaneous
canSAR (ICR)PYCR3 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePYCR3
EVEXPYCR3
GoPubMedPYCR3
iHOPPYCR3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:35:43 CEST 2017

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