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PYCRL (pyrroline-5-carboxylate reductase-like)

Identity

Alias_symbol (synonym)FLJ13852
Other alias-
HGNC (Hugo) PYCRL
LocusID (NCBI) 65263
Atlas_Id 72428
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 144686083 and ends at 144691784 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ZC3H3 (8q24.3) / PYCRL (8q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PYCRL   25846
Cards
Entrez_Gene (NCBI)PYCRL  65263  pyrroline-5-carboxylate reductase-like
Aliases
GeneCards (Weizmann)PYCRL
Ensembl hg19 (Hinxton)ENSG00000104524 [Gene_View]  chr8:144686083-144691784 [Contig_View]  PYCRL [Vega]
Ensembl hg38 (Hinxton)ENSG00000104524 [Gene_View]  chr8:144686083-144691784 [Contig_View]  PYCRL [Vega]
ICGC DataPortalENSG00000104524
TCGA cBioPortalPYCRL
AceView (NCBI)PYCRL
Genatlas (Paris)PYCRL
WikiGenes65263
SOURCE (Princeton)PYCRL
Genetics Home Reference (NIH)PYCRL
Genomic and cartography
GoldenPath hg19 (UCSC)PYCRL  -     chr8:144686083-144691784 -  8q24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PYCRL  -     8q24.3   [Description]    (hg38-Dec_2013)
EnsemblPYCRL - 8q24.3 [CytoView hg19]  PYCRL - 8q24.3 [CytoView hg38]
Mapping of homologs : NCBIPYCRL [Mapview hg19]  PYCRL [Mapview hg38]
OMIM616408   
Gene and transcription
Genbank (Entrez)AF086378 AK001500 AK023914 AK222685 AK225404
RefSeq transcript (Entrez)NM_023078
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_008046 NT_187571 NW_004929340
Consensus coding sequences : CCDS (NCBI)PYCRL
Cluster EST : UnigeneHs.165186 [ NCBI ]
CGAP (NCI)Hs.165186
Alternative Splicing GalleryENSG00000104524
Gene ExpressionPYCRL [ NCBI-GEO ]   PYCRL [ EBI - ARRAY_EXPRESS ]   PYCRL [ SEEK ]   PYCRL [ MEM ]
Gene Expression Viewer (FireBrowse)PYCRL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)65263
GTEX Portal (Tissue expression)PYCRL
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ53H96   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ53H96  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ53H96
Splice isoforms : SwissVarQ53H96
Catalytic activity : Enzyme1.5.1.2 [ Enzyme-Expasy ]   1.5.1.21.5.1.2 [ IntEnz-EBI ]   1.5.1.2 [ BRENDA ]   1.5.1.2 [ KEGG ]   
PhosPhoSitePlusQ53H96
Domaine pattern : Prosite (Expaxy)P5CR (PS00521)   
Domains : Interpro (EBI)6-PGluconate_DH_C-like    NAD(P)-bd_dom    P5CR_dimer    ProC_N    Pyrroline-COOH_reductase   
Domain families : Pfam (Sanger)F420_oxidored (PF03807)    P5CR_dimer (PF14748)   
Domain families : Pfam (NCBI)pfam03807    pfam14748   
Conserved Domain (NCBI)PYCRL
DMDM Disease mutations65263
Blocks (Seattle)PYCRL
SuperfamilyQ53H96
Human Protein AtlasENSG00000104524
Peptide AtlasQ53H96
HPRD15196
IPIIPI00926788   IPI00646105   IPI00926996   
Protein Interaction databases
DIP (DOE-UCLA)Q53H96
IntAct (EBI)Q53H96
FunCoupENSG00000104524
BioGRIDPYCRL
STRING (EMBL)PYCRL
ZODIACPYCRL
Ontologies - Pathways
QuickGOQ53H96
Ontology : AmiGOpyrroline-5-carboxylate reductase activity  protein binding  oxidation-reduction process  L-proline biosynthetic process  
Ontology : EGO-EBIpyrroline-5-carboxylate reductase activity  protein binding  oxidation-reduction process  L-proline biosynthetic process  
Pathways : KEGGArginine and proline metabolism   
NDEx NetworkPYCRL
Atlas of Cancer Signalling NetworkPYCRL
Wikipedia pathwaysPYCRL
Orthology - Evolution
OrthoDB65263
GeneTree (enSembl)ENSG00000104524
Phylogenetic Trees/Animal Genes : TreeFamPYCRL
HOVERGENQ53H96
HOGENOMQ53H96
Homologs : HomoloGenePYCRL
Homology/Alignments : Family Browser (UCSC)PYCRL
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPYCRL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PYCRL
dbVarPYCRL
ClinVarPYCRL
1000_GenomesPYCRL 
Exome Variant ServerPYCRL
ExAC (Exome Aggregation Consortium)PYCRL (select the gene name)
Genetic variants : HAPMAP65263
Genomic Variants (DGV)PYCRL [DGVbeta]
DECIPHER (Syndromes)8:144686083-144691784  ENSG00000104524
CONAN: Copy Number AnalysisPYCRL 
Mutations
ICGC Data PortalPYCRL 
TCGA Data PortalPYCRL 
Broad Tumor PortalPYCRL
OASIS PortalPYCRL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPYCRL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPYCRL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PYCRL
DgiDB (Drug Gene Interaction Database)PYCRL
DoCM (Curated mutations)PYCRL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PYCRL (select a term)
intoGenPYCRL
Cancer3DPYCRL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616408   
Orphanet
MedgenPYCRL
Genetic Testing Registry PYCRL
NextProtQ53H96 [Medical]
TSGene65263
GENETestsPYCRL
Huge Navigator PYCRL [HugePedia]
snp3D : Map Gene to Disease65263
BioCentury BCIQPYCRL
ClinGenPYCRL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD65263
Chemical/Pharm GKB GenePA134889043
Clinical trialPYCRL
Miscellaneous
canSAR (ICR)PYCRL (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePYCRL
EVEXPYCRL
GoPubMedPYCRL
iHOPPYCRL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:40:21 CET 2017

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