PYGB (glycogen phosphorylase B)

2007-05-01  

Identity

HGNC
LOCATION
20p11.21
LOCUSID
ALIAS
GPBB
FUSION GENES

Other Information

Locus ID:

NCBI: 5834
MIM: 138550
HGNC: 9723
Ensembl: ENSG00000100994

Variants:

dbSNP: 5834
ClinVar: 5834
TCGA: ENSG00000100994
COSMIC: PYGB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100994ENST00000216962P11216
ENSG00000100994ENST00000428458H0Y4Z6

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
Starch and sucrose metabolismKEGGko00500
Insulin signaling pathwayKEGGko04910
Starch and sucrose metabolismKEGGhsa00500
Insulin signaling pathwayKEGGhsa04910
Metabolic pathwaysKEGGhsa01100
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
Glycogen breakdown (glycogenolysis)REACTOMER-HSA-70221
Insulin resistanceKEGGhsa04931
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192047262009Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.63
204710302010Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.42
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.11
274028522016Insights into Brain Glycogen Metabolism: THE STRUCTURE OF HUMAN BRAIN GLYCOGEN PHOSPHORYLASE.6
228381882012Diagnostic accuracy of heart fatty acid binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) in diagnosis of acute myocardial infarction in patients with acute coronary syndrome.5
173939852006Clinicopathological significance of BGP expression in non-small-cell lung carcinoma: relationship with histological type, microvessel density and patients' survival.4
276603932016An Isozyme-specific Redox Switch in Human Brain Glycogen Phosphorylase Modulates Its Allosteric Activation by AMP.4
301061102018Silencing of PYGB suppresses growth and promotes the apoptosis of prostate cancer cells via the NF‑κB/Nrf2 signaling pathway.4
316270922019Glycogen phosphorylase B promotes ovarian cancer progression via Wnt/β-catenin signaling and is regulated by miR-133a-3p.4

Citation

Dessen P

PYGB (glycogen phosphorylase B)

Atlas Genet Cytogenet Oncol Haematol. 2007-05-01

Online version: http://atlasgeneticsoncology.org/gene/47533/pygb