PYHIN1 (pyrin and HIN domain family member 1)

2007-02-01  

Identity

HGNC
PYHIN1
LOCATION
1q23.1
LOCUSID
149628
ALIAS
IFIX

Other Information

Locus ID:

NCBI: 149628
MIM: 612677
HGNC: 28894
Ensembl: ENSG00000163564

Variants:

dbSNP: 149628
ClinVar: 149628
TCGA: ENSG00000163564
COSMIC: PYHIN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163564ENST00000368135Q6K0P9
ENSG00000163564ENST00000368138Q6K0P9
ENSG00000163564ENST00000368140Q6K0P9
ENSG00000163564ENST00000392252Q6K0P9
ENSG00000163564ENST00000392254Q6K0P9
ENSG00000163564ENST00000458222X6RHR0

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
164790152006Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.17
151223302004Antitumor activity of IFIX, a novel interferon-inducible HIN-200 gene, in breast cancer.15
280774452017Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.8
182473782008Interferon-inducible protein IFIXalpha inhibits cell invasion by upregulating the metastasis suppressor maspin.4
205952942010Association of IFI200 gene polymorphisms with susceptibility to systemic lupus erythematosus.3

Citation

Dessen P

PYHIN1 (pyrin and HIN domain family member 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43635/pyhin1