PYM1 (PYM homolog 1, exon junction complex associated factor)

2016-01-01  

Identity

HGNC
PYM1
LOCATION
12q13.2
LOCUSID
84305
ALIAS
PYM,WIBG
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84305
HGNC: 30258
Ensembl: ENSG00000170473

Variants:

dbSNP: 84305
ClinVar: 84305
TCGA: ENSG00000170473
COSMIC: PYM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170473ENST00000398213Q9BRP8
ENSG00000170473ENST00000408946Q9BRP8
ENSG00000170473ENST00000454792F8VT68
ENSG00000170473ENST00000547925F8VXH2
ENSG00000170473ENST00000549939H0YJW5
ENSG00000170473ENST00000557259G3V5P2

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
194105472009Disassembly of exon junction complexes by PYM.78
180261202007PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs.54

Citation

Dessen P

PYM1 (PYM homolog 1, exon junction complex associated factor)

Atlas Genet Cytogenet Oncol Haematol. 2016-01-01

Online version: http://atlasgeneticsoncology.org/gene/77963/pym1