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PZP (PZP, alpha-2-macroglobulin like)

Identity

Alias_namespregnancy-zone protein
Alias_symbol (synonym)CPAMD6
Other alias
HGNC (Hugo) PZP
LocusID (NCBI) 5858
Atlas_Id 72436
Location 12p13.31  [Link to chromosome band 12p13]
Location_base_pair Starts at 9148840 and ends at 9208370 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
A2M (12p13.31) / PZP (12p13.31)CMC2 (16q23.2) / PZP (12p13.31)PZP (12p13.31) / CPNE4 (3q22.1)
TOP1 (20q12) / PZP (12p13.31)TOP1 PZPC16orf61 PZP

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PZP   9750
Cards
Entrez_Gene (NCBI)PZP  5858  PZP, alpha-2-macroglobulin like
AliasesCPAMD6
GeneCards (Weizmann)PZP
Ensembl hg19 (Hinxton)ENSG00000126838 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126838 [Gene_View]  chr12:9148840-9208370 [Contig_View]  PZP [Vega]
ICGC DataPortalENSG00000126838
TCGA cBioPortalPZP
AceView (NCBI)PZP
Genatlas (Paris)PZP
WikiGenes5858
SOURCE (Princeton)PZP
Genetics Home Reference (NIH)PZP
Genomic and cartography
GoldenPath hg38 (UCSC)PZP  -     chr12:9148840-9208370 -  12p13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PZP  -     12p13.31   [Description]    (hg19-Feb_2009)
EnsemblPZP - 12p13.31 [CytoView hg19]  PZP - 12p13.31 [CytoView hg38]
Mapping of homologs : NCBIPZP [Mapview hg19]  PZP [Mapview hg38]
OMIM176420   
Gene and transcription
Genbank (Entrez)AK302259 AK308724 AK313639 BC111756 DB040351
RefSeq transcript (Entrez)NM_002864
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PZP
Cluster EST : UnigeneHs.707491 [ NCBI ]
CGAP (NCI)Hs.707491
Alternative Splicing GalleryENSG00000126838
Gene ExpressionPZP [ NCBI-GEO ]   PZP [ EBI - ARRAY_EXPRESS ]   PZP [ SEEK ]   PZP [ MEM ]
Gene Expression Viewer (FireBrowse)PZP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5858
GTEX Portal (Tissue expression)PZP
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20742   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20742  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20742
Splice isoforms : SwissVarP20742
PhosPhoSitePlusP20742
Domaine pattern : Prosite (Expaxy)ALPHA_2_MACROGLOBULIN (PS00477)   
Domains : Interpro (EBI)A-macroglobulin_rcpt-bd    A2M_comp    A2M_N    A2M_N_2    Ig_E-set    Macroglobln_a2    MacrogloblnA2_CS    MacrogloblnA2_thiol-ester-bond    Terpenoid_cyclase/PrenylTrfase    TonB_box_CS   
Domain families : Pfam (Sanger)A2M (PF00207)    A2M_comp (PF07678)    A2M_N (PF01835)    A2M_N_2 (PF07703)    A2M_recep (PF07677)    Thiol-ester_cl (PF10569)   
Domain families : Pfam (NCBI)pfam00207    pfam07678    pfam01835    pfam07703    pfam07677    pfam10569   
Domain families : Smart (EMBL)A2M (SM01360)  A2M_N_2 (SM01359)  A2M_recep (SM01361)  
Conserved Domain (NCBI)PZP
DMDM Disease mutations5858
Blocks (Seattle)PZP
SuperfamilyP20742
Human Protein AtlasENSG00000126838
Peptide AtlasP20742
HPRD07178
IPIIPI00025426   IPI00884981   IPI00922117   IPI01012978   
Protein Interaction databases
DIP (DOE-UCLA)P20742
IntAct (EBI)P20742
FunCoupENSG00000126838
BioGRIDPZP
STRING (EMBL)PZP
ZODIACPZP
Ontologies - Pathways
QuickGOP20742
Ontology : AmiGOendopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  extracellular region  female pregnancy  negative regulation of endopeptidase activity  extracellular exosome  blood microparticle  
Ontology : EGO-EBIendopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  extracellular region  female pregnancy  negative regulation of endopeptidase activity  extracellular exosome  blood microparticle  
NDEx NetworkPZP
Atlas of Cancer Signalling NetworkPZP
Wikipedia pathwaysPZP
Orthology - Evolution
OrthoDB5858
GeneTree (enSembl)ENSG00000126838
Phylogenetic Trees/Animal Genes : TreeFamPZP
HOVERGENP20742
HOGENOMP20742
Homologs : HomoloGenePZP
Homology/Alignments : Family Browser (UCSC)PZP
Gene fusions - Rearrangements
Fusion: TCGATOP1 PZP
Fusion: TCGAC16orf61 PZP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPZP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PZP
dbVarPZP
ClinVarPZP
1000_GenomesPZP 
Exome Variant ServerPZP
ExAC (Exome Aggregation Consortium)PZP (select the gene name)
Genetic variants : HAPMAP5858
Genomic Variants (DGV)PZP [DGVbeta]
DECIPHERPZP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPZP 
Mutations
ICGC Data PortalPZP 
TCGA Data PortalPZP 
Broad Tumor PortalPZP
OASIS PortalPZP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPZP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPZP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PZP
DgiDB (Drug Gene Interaction Database)PZP
DoCM (Curated mutations)PZP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PZP (select a term)
intoGenPZP
Cancer3DPZP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176420   
Orphanet
MedgenPZP
Genetic Testing Registry PZP
NextProtP20742 [Medical]
TSGene5858
GENETestsPZP
Target ValidationPZP
Huge Navigator PZP [HugePedia]
snp3D : Map Gene to Disease5858
BioCentury BCIQPZP
ClinGenPZP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5858
Chemical/Pharm GKB GenePA34092
Clinical trialPZP
Miscellaneous
canSAR (ICR)PZP (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePZP
EVEXPZP
GoPubMedPZP
iHOPPZP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:35:44 CEST 2017

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