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PZP (PZP alpha-2-macroglobulin like)

Identity

Alias (NCBI)CPAMD6
HGNC (Hugo) PZP
HGNC Alias symbCPAMD6
HGNC Previous namepregnancy-zone protein
LocusID (NCBI) 5858
Atlas_Id 72436
Location 12p13.31  [Link to chromosome band 12p13]
Location_base_pair Starts at 9148840 and ends at 9208395 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
A2M (12p13.31) / PZP (12p13.31)CMC2 (16q23.2) / PZP (12p13.31)PZP (12p13.31) / CPNE4 (3q22.1)
TOP1 (20q12) / PZP (12p13.31)TOP1 PZPC16orf61 PZP

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PZP   9750
Cards
Entrez_Gene (NCBI)PZP    PZP alpha-2-macroglobulin like
AliasesCPAMD6
GeneCards (Weizmann)PZP
Ensembl hg19 (Hinxton)ENSG00000126838 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126838 [Gene_View]  ENSG00000126838 [Sequence]  chr12:9148840-9208395 [Contig_View]  PZP [Vega]
ICGC DataPortalENSG00000126838
TCGA cBioPortalPZP
AceView (NCBI)PZP
Genatlas (Paris)PZP
SOURCE (Princeton)PZP
Genetics Home Reference (NIH)PZP
Genomic and cartography
GoldenPath hg38 (UCSC)PZP  -     chr12:9148840-9208395 -  12p13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PZP  -     12p13.31   [Description]    (hg19-Feb_2009)
GoldenPathPZP - 12p13.31 [CytoView hg19]  PZP - 12p13.31 [CytoView hg38]
ImmunoBaseENSG00000126838
Genome Data Viewer NCBIPZP [Mapview hg19]  
OMIM176420   
Gene and transcription
Genbank (Entrez)AK302259 AK308724 AK313639 BC111756 DB040351
RefSeq transcript (Entrez)NM_002864
Consensus coding sequences : CCDS (NCBI)PZP
Gene ExpressionPZP [ NCBI-GEO ]   PZP [ EBI - ARRAY_EXPRESS ]   PZP [ SEEK ]   PZP [ MEM ]
Gene Expression Viewer (FireBrowse)PZP [ Firebrowse - Broad ]
GenevisibleExpression of PZP in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5858
GTEX Portal (Tissue expression)PZP
Human Protein AtlasENSG00000126838-PZP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20742   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20742  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20742
PhosPhoSitePlusP20742
Domaine pattern : Prosite (Expaxy)ALPHA_2_MACROGLOBULIN (PS00477)   
Domains : Interpro (EBI)A-macroglobulin_rcpt-bd    A-macroglobulin_rcpt-bd_sf    A2M_N_BRD    A2M_TED    Alpha-macroglobulin_TED    Ig-like_fold    Ig_E-set    Macroglobln_a2    MacrogloblnA2_CS    MG2    MG3    MG4    Terpenoid_cyclase/PrenylTrfase    TonB_box_CS   
Domain families : Pfam (Sanger)A2M (PF00207)    A2M_BRD (PF07703)    A2M_recep (PF07677)    MG2 (PF01835)    MG3 (PF17791)    MG4 (PF17789)    TED_complement (PF07678)   
Domain families : Pfam (NCBI)pfam00207    pfam07703    pfam07677    pfam01835    pfam17791    pfam17789    pfam07678   
Domain families : Smart (EMBL)A2M (SM01360)  A2M_N_2 (SM01359)  A2M_recep (SM01361)  
Conserved Domain (NCBI)PZP
SuperfamilyP20742
AlphaFold pdb e-kbP20742   
Human Protein Atlas [tissue]ENSG00000126838-PZP [tissue]
HPRD07178
Protein Interaction databases
DIP (DOE-UCLA)P20742
IntAct (EBI)P20742
BioGRIDPZP
STRING (EMBL)PZP
ZODIACPZP
Ontologies - Pathways
QuickGOP20742
Ontology : AmiGOprotease binding  endopeptidase inhibitor activity  endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  extracellular region  female pregnancy  negative regulation of endopeptidase activity  collagen-containing extracellular matrix  extracellular exosome  blood microparticle  
Ontology : EGO-EBIprotease binding  endopeptidase inhibitor activity  endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  extracellular region  female pregnancy  negative regulation of endopeptidase activity  collagen-containing extracellular matrix  extracellular exosome  blood microparticle  
NDEx NetworkPZP
Atlas of Cancer Signalling NetworkPZP
Wikipedia pathwaysPZP
Orthology - Evolution
OrthoDB5858
GeneTree (enSembl)ENSG00000126838
Phylogenetic Trees/Animal Genes : TreeFamPZP
Homologs : HomoloGenePZP
Homology/Alignments : Family Browser (UCSC)PZP
Gene fusions - Rearrangements
Fusion : QuiverPZP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPZP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PZP
dbVarPZP
ClinVarPZP
MonarchPZP
1000_GenomesPZP 
Exome Variant ServerPZP
GNOMAD BrowserENSG00000126838
Varsome BrowserPZP
ACMGPZP variants
VarityP20742
Genomic Variants (DGV)PZP [DGVbeta]
DECIPHERPZP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPZP 
Mutations
ICGC Data PortalPZP 
TCGA Data PortalPZP 
Broad Tumor PortalPZP
OASIS PortalPZP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPZP  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPZP
Mutations and Diseases : HGMDPZP
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPZP
DgiDB (Drug Gene Interaction Database)PZP
DoCM (Curated mutations)PZP
CIViC (Clinical Interpretations of Variants in Cancer)PZP
Cancer3DPZP
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176420   
Orphanet
DisGeNETPZP
MedgenPZP
Genetic Testing Registry PZP
NextProtP20742 [Medical]
GENETestsPZP
Target ValidationPZP
Huge Navigator PZP [HugePedia]
ClinGenPZP
Clinical trials, drugs, therapy
MyCancerGenomePZP
Protein Interactions : CTDPZP
Pharm GKB GenePA34092
PharosP20742
Clinical trialPZP
Miscellaneous
canSAR (ICR)PZP
HarmonizomePZP
DataMed IndexPZP
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPZP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:17:47 CEST 2021

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