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QARS (glutaminyl-tRNA synthetase)

Identity

Other aliasGLNRS
MSCCA
PRO2195
HGNC (Hugo) QARS
LocusID (NCBI) 5859
Atlas_Id 72437
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 49095932 and ends at 49105129 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CNIH1 (14q22.2) / QARS (3p21.31)MINOS1 (1p36.13) / QARS (3p21.31)QARS (3p21.31) / AP2A1 (19q13.33)
QARS (3p21.31) / QARS (3p21.31)QARS (3p21.31) / USP19 (3p21.31)TRAPPC1 (17p13.1) / QARS (3p21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)QARS   9751
Cards
Entrez_Gene (NCBI)QARS  5859  glutaminyl-tRNA synthetase
AliasesGLNRS; MSCCA; PRO2195
GeneCards (Weizmann)QARS
Ensembl hg19 (Hinxton)ENSG00000172053 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172053 [Gene_View]  chr3:49095932-49105129 [Contig_View]  QARS [Vega]
ICGC DataPortalENSG00000172053
TCGA cBioPortalQARS
AceView (NCBI)QARS
Genatlas (Paris)QARS
WikiGenes5859
SOURCE (Princeton)QARS
Genetics Home Reference (NIH)QARS
Genomic and cartography
GoldenPath hg38 (UCSC)QARS  -     chr3:49095932-49105129 -  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)QARS  -     3p21.31   [Description]    (hg19-Feb_2009)
EnsemblQARS - 3p21.31 [CytoView hg19]  QARS - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBIQARS [Mapview hg19]  QARS [Mapview hg38]
OMIM603727   615760   
Gene and transcription
Genbank (Entrez)AF130067 AK056815 AK222510 AK290523 AK293260
RefSeq transcript (Entrez)NM_001272073 NM_005051
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)QARS
Cluster EST : UnigeneHs.79322 [ NCBI ]
CGAP (NCI)Hs.79322
Alternative Splicing GalleryENSG00000172053
Gene ExpressionQARS [ NCBI-GEO ]   QARS [ EBI - ARRAY_EXPRESS ]   QARS [ SEEK ]   QARS [ MEM ]
Gene Expression Viewer (FireBrowse)QARS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5859
GTEX Portal (Tissue expression)QARS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP47897   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP47897  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP47897
Splice isoforms : SwissVarP47897
Catalytic activity : Enzyme6.1.1.18 [ Enzyme-Expasy ]   6.1.1.186.1.1.18 [ IntEnz-EBI ]   6.1.1.18 [ BRENDA ]   6.1.1.18 [ KEGG ]   
PhosPhoSitePlusP47897
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)   
Domains : Interpro (EBI)aa-tRNA-synth_I_CS    Gln-tRNA-synth    Gln-tRNA-synth_Ib_RNA-bd_2    Gln-tRNA-synth_Ib_RNA-bd_N    Glu/Gln-tRNA-synth    Glu/Gln-tRNA-synth_Ib_a-bdl    Glu/Gln-tRNA-synth_Ib_cat-dom    Glu/Gln-tRNA-synth_Ib_codon-bd    Rbsml_L25/Gln-tRNA_synth_b-brl    Ribosomal_L25/Gln-tRNA_synth    Rossmann-like_a/b/a_fold   
Domain families : Pfam (Sanger)tRNA-synt_1c (PF00749)    tRNA-synt_1c_C (PF03950)    tRNA_synt_1c_R1 (PF04558)    tRNA_synt_1c_R2 (PF04557)   
Domain families : Pfam (NCBI)pfam00749    pfam03950    pfam04558    pfam04557   
Conserved Domain (NCBI)QARS
DMDM Disease mutations5859
Blocks (Seattle)QARS
PDB (SRS)4R3Z    4YE6    4YE8    4YE9   
PDB (PDBSum)4R3Z    4YE6    4YE8    4YE9   
PDB (IMB)4R3Z    4YE6    4YE8    4YE9   
PDB (RSDB)4R3Z    4YE6    4YE8    4YE9   
Structural Biology KnowledgeBase4R3Z    4YE6    4YE8    4YE9   
SCOP (Structural Classification of Proteins)4R3Z    4YE6    4YE8    4YE9   
CATH (Classification of proteins structures)4R3Z    4YE6    4YE8    4YE9   
SuperfamilyP47897
Human Protein AtlasENSG00000172053
Peptide AtlasP47897
HPRD07223
IPIIPI00925046   IPI00910548   IPI00792753   IPI00925735   IPI00925511   IPI00925203   IPI00925012   IPI00924591   
Protein Interaction databases
DIP (DOE-UCLA)P47897
IntAct (EBI)P47897
FunCoupENSG00000172053
BioGRIDQARS
STRING (EMBL)QARS
ZODIACQARS
Ontologies - Pathways
QuickGOP47897
Ontology : AmiGOglutamine-tRNA ligase activity  protein kinase inhibitor activity  protein binding  ATP binding  cytoplasm  mitochondrial matrix  cytosol  cytosol  tRNA aminoacylation for protein translation  glutaminyl-tRNA aminoacylation  negative regulation of protein kinase activity  brain development  aminoacyl-tRNA synthetase multienzyme complex  protein kinase binding  negative regulation of stress-activated MAPK cascade  protein complex  negative regulation of transcription, DNA-templated  negative regulation of apoptotic signaling pathway  
Ontology : EGO-EBIglutamine-tRNA ligase activity  protein kinase inhibitor activity  protein binding  ATP binding  cytoplasm  mitochondrial matrix  cytosol  cytosol  tRNA aminoacylation for protein translation  glutaminyl-tRNA aminoacylation  negative regulation of protein kinase activity  brain development  aminoacyl-tRNA synthetase multienzyme complex  protein kinase binding  negative regulation of stress-activated MAPK cascade  protein complex  negative regulation of transcription, DNA-templated  negative regulation of apoptotic signaling pathway  
Pathways : KEGGAminoacyl-tRNA biosynthesis   
NDEx NetworkQARS
Atlas of Cancer Signalling NetworkQARS
Wikipedia pathwaysQARS
Orthology - Evolution
OrthoDB5859
GeneTree (enSembl)ENSG00000172053
Phylogenetic Trees/Animal Genes : TreeFamQARS
HOVERGENP47897
HOGENOMP47897
Homologs : HomoloGeneQARS
Homology/Alignments : Family Browser (UCSC)QARS
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerQARS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)QARS
dbVarQARS
ClinVarQARS
1000_GenomesQARS 
Exome Variant ServerQARS
ExAC (Exome Aggregation Consortium)QARS (select the gene name)
Genetic variants : HAPMAP5859
Genomic Variants (DGV)QARS [DGVbeta]
DECIPHERQARS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisQARS 
Mutations
ICGC Data PortalQARS 
TCGA Data PortalQARS 
Broad Tumor PortalQARS
OASIS PortalQARS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICQARS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDQARS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch QARS
DgiDB (Drug Gene Interaction Database)QARS
DoCM (Curated mutations)QARS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)QARS (select a term)
intoGenQARS
Cancer3DQARS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603727    615760   
Orphanet22918   
MedgenQARS
Genetic Testing Registry QARS
NextProtP47897 [Medical]
TSGene5859
GENETestsQARS
Huge Navigator QARS [HugePedia]
snp3D : Map Gene to Disease5859
BioCentury BCIQQARS
ClinGenQARS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5859
Chemical/Pharm GKB GenePA34093
Clinical trialQARS
Miscellaneous
canSAR (ICR)QARS (select the gene name)
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineQARS
EVEXQARS
GoPubMedQARS
iHOPQARS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 11:50:19 CEST 2017

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