QRFPR (pyroglutamylated RFamide peptide receptor)

2014-11-01  

Identity

HGNC
LOCATION
4q27
LOCUSID
ALIAS
AQ27,GPR103,SP9155

Other Information

Locus ID:

NCBI: 84109
MIM: 606925
HGNC: 15565
Ensembl: ENSG00000186867

Variants:

dbSNP: 84109
ClinVar: 84109
TCGA: ENSG00000186867
COSMIC: QRFPR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186867ENST00000334383J3KNR3
ENSG00000186867ENST00000394427Q96P65
ENSG00000186867ENST00000507331F2Z3L3

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Orexin and neuropeptides FF and QRFP bind to their respective receptorsREACTOMER-HSA-389397
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
127145922003Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155.42
166482502006A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.35
205346932010GPR103b functions in the peripheral regulation of adipogenesis.10
262118942015Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103.2
306331252019Whole-exome sequencing in multiplex preeclampsia families identifies novel candidate susceptibility genes.1

Citation

Dessen P

QRFPR (pyroglutamylated RFamide peptide receptor)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72442/qrfpr