QSOX1 (quiescin sulfhydryl oxidase 1)

2010-02-01  

Identity

HGNC
LOCATION
1q25.2
LOCUSID
ALIAS
Q6,QSCN6
FUSION GENES

Other Information

Locus ID:

NCBI: 5768
MIM: 603120
HGNC: 9756
Ensembl: ENSG00000116260

Variants:

dbSNP: 5768
ClinVar: 5768
TCGA: ENSG00000116260
COSMIC: QSOX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116260ENST00000367600O00391
ENSG00000116260ENST00000367600A0A140VKE5
ENSG00000116260ENST00000367602O00391
ENSG00000116260ENST00000392029A8MXT8
ENSG00000116260ENST00000443059H0Y5Z8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
371613882023Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer.16
371613882023Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer.16
337705212021Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation.64
337705212021Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation.64
328630022020QSOX1 promotes mitochondrial apoptosis of hepatocellular carcinoma cells during anchorage-independent growth by inhibiting lipid synthesis.0
328630022020QSOX1 promotes mitochondrial apoptosis of hepatocellular carcinoma cells during anchorage-independent growth by inhibiting lipid synthesis.0
297125362019QSOX1 regulates trophoblastic apoptosis in preeclampsia through hydrogen peroxide production.6
303675602019cis-Proline mutants of quiescin sulfhydryl oxidase 1 with altered redox properties undermine extracellular matrix integrity and cell adhesion in fibroblast cultures.8
297125362019QSOX1 regulates trophoblastic apoptosis in preeclampsia through hydrogen peroxide production.6
303675602019cis-Proline mutants of quiescin sulfhydryl oxidase 1 with altered redox properties undermine extracellular matrix integrity and cell adhesion in fibroblast cultures.8
297573792018Quiescin sulfhydryl oxidase 1 (QSOX1) glycosite mutation perturbs secretion but not Golgi localization.7
298047172018High expression of QSOX1 is associated with tumor invasiveness and high grades groups in prostate cancer.15
303366362018Quiescin Sulfhydryl Oxidase 1 (QSOX1) Secreted by Lung Cancer Cells Promotes Cancer Metastasis.23
297573792018Quiescin sulfhydryl oxidase 1 (QSOX1) glycosite mutation perturbs secretion but not Golgi localization.7
298047172018High expression of QSOX1 is associated with tumor invasiveness and high grades groups in prostate cancer.15

Citation

Dessen P

QSOX1 (quiescin sulfhydryl oxidase 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51357/qsox1