QTRT1 (queuine tRNA-ribosyltransferase catalytic subunit 1)

2014-11-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
FP3235,TGT,TGUT
FUSION GENES

Other Information

Locus ID:

NCBI: 81890
MIM: 609615
HGNC: 23797
Ensembl: ENSG00000213339

Variants:

dbSNP: 81890
ClinVar: 81890
TCGA: ENSG00000213339
COSMIC: QTRT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213339ENST00000250237Q9BXR0
ENSG00000213339ENST00000421333Q9BXR0
ENSG00000213339ENST00000587599K7EJ21
ENSG00000213339ENST00000591643K7EPI1
ENSG00000213339ENST00000592254K7ESP6
ENSG00000213339ENST00000592376K7EL95

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
tRNA processingREACTOMER-HSA-72306
tRNA modification in the nucleus and cytosolREACTOMER-HSA-6782315

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203541542010Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure.17
211312772011Evolution of eukaryal tRNA-guanine transglycosylase: insight gained from the heterocyclic substrate recognition by the wild-type and mutant human and Escherichia coli tRNA-guanine transglycosylases.8
237049822013Investigation of specificity determinants in bacterial tRNA-guanine transglycosylase reveals queuine, the substrate of its eucaryotic counterpart, as inhibitor.6
216400762011Differential heterocyclic substrate recognition by, and pteridine inhibition of E. coli and human tRNA-guanine transglycosylases.2

Citation

Dessen P

QTRT1 (queuine tRNA-ribosyltransferase catalytic subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72445/qtrt1