Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RAB10 (RAB10, member RAS oncogene family)

Identity

Other alias-
HGNC (Hugo) RAB10
LocusID (NCBI) 10890
Atlas_Id 41955
Location 2p23.3  [Link to chromosome band 2p23]
Location_base_pair Starts at 26033860 and ends at 26137454 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DPP10 (2q14.1) / RAB10 (2p23.3)FEZ2 (2p22.2) / RAB10 (2p23.3)PSME2 (14q12) / RAB10 (2p23.3)
RAB10 (2p23.3) / NCOA1 (2p23.3)RAB10 (2p23.3) / SDC1 (2p24.1)SLIT1 (10q24.1) / RAB10 (2p23.3)
FEZ2 2p22.2 / RAB10 2p23.3RAB10 2p23.3 / NCOA1 2p23.3RAB10 2p23.3 / SDC1 2p24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RAB10   9759
Cards
Entrez_Gene (NCBI)RAB10  10890  RAB10, member RAS oncogene family
Aliases
GeneCards (Weizmann)RAB10
Ensembl hg19 (Hinxton)ENSG00000084733 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000084733 [Gene_View]  chr2:26033860-26137454 [Contig_View]  RAB10 [Vega]
ICGC DataPortalENSG00000084733
TCGA cBioPortalRAB10
AceView (NCBI)RAB10
Genatlas (Paris)RAB10
WikiGenes10890
SOURCE (Princeton)RAB10
Genetics Home Reference (NIH)RAB10
Genomic and cartography
GoldenPath hg38 (UCSC)RAB10  -     chr2:26033860-26137454 +  2p23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAB10  -     2p23.3   [Description]    (hg19-Feb_2009)
EnsemblRAB10 - 2p23.3 [CytoView hg19]  RAB10 - 2p23.3 [CytoView hg38]
Mapping of homologs : NCBIRAB10 [Mapview hg19]  RAB10 [Mapview hg38]
OMIM612672   
Gene and transcription
Genbank (Entrez)AF086917 AF091032 AF106681 AF297660 AF498945
RefSeq transcript (Entrez)NM_016131
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RAB10
Cluster EST : UnigeneHs.467960 [ NCBI ]
CGAP (NCI)Hs.467960
Alternative Splicing GalleryENSG00000084733
Gene ExpressionRAB10 [ NCBI-GEO ]   RAB10 [ EBI - ARRAY_EXPRESS ]   RAB10 [ SEEK ]   RAB10 [ MEM ]
Gene Expression Viewer (FireBrowse)RAB10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10890
GTEX Portal (Tissue expression)RAB10
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61026   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61026  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61026
Splice isoforms : SwissVarP61026
PhosPhoSitePlusP61026
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)RAB10
DMDM Disease mutations10890
Blocks (Seattle)RAB10
PDB (SRS)5LPN    5SZJ   
PDB (PDBSum)5LPN    5SZJ   
PDB (IMB)5LPN    5SZJ   
PDB (RSDB)5LPN    5SZJ   
Structural Biology KnowledgeBase5LPN    5SZJ   
SCOP (Structural Classification of Proteins)5LPN    5SZJ   
CATH (Classification of proteins structures)5LPN    5SZJ   
SuperfamilyP61026
Human Protein AtlasENSG00000084733
Peptide AtlasP61026
HPRD06692
IPIIPI00016513   
Protein Interaction databases
DIP (DOE-UCLA)P61026
IntAct (EBI)P61026
FunCoupENSG00000084733
BioGRIDRAB10
STRING (EMBL)RAB10
ZODIACRAB10
Ontologies - Pathways
QuickGOP61026
Ontology : AmiGOGolgi membrane  exocyst  GTPase activity  protein binding  GTP binding  endosome  endoplasmic reticulum membrane  Golgi apparatus  trans-Golgi network  cytosol  plasma membrane  plasma membrane  cell-cell adherens junction  focal adhesion  cilium  Golgi to plasma membrane transport  vesicle docking involved in exocytosis  axonogenesis  protein secretion  vesicle-mediated transport  endosomal transport  GDP binding  antigen processing and presentation  cytoplasmic vesicle membrane  secretory granule membrane  phagocytic vesicle membrane  polarized epithelial cell differentiation  myosin V binding  insulin-responsive compartment  cellular response to insulin stimulus  cellular response to insulin stimulus  Golgi to plasma membrane protein transport  neutrophil degranulation  establishment of neuroblast polarity  recycling endosome  recycling endosome membrane  membrane organization  basolateral protein localization  extracellular exosome  exocytic vesicle  endoplasmic reticulum tubular network  endoplasmic reticulum tubular network organization  protein localization to plasma membrane  establishment of protein localization to membrane  establishment of protein localization to endoplasmic reticulum membrane  cell-cell adhesion  cadherin binding involved in cell-cell adhesion  
Ontology : EGO-EBIGolgi membrane  exocyst  GTPase activity  protein binding  GTP binding  endosome  endoplasmic reticulum membrane  Golgi apparatus  trans-Golgi network  cytosol  plasma membrane  plasma membrane  cell-cell adherens junction  focal adhesion  cilium  Golgi to plasma membrane transport  vesicle docking involved in exocytosis  axonogenesis  protein secretion  vesicle-mediated transport  endosomal transport  GDP binding  antigen processing and presentation  cytoplasmic vesicle membrane  secretory granule membrane  phagocytic vesicle membrane  polarized epithelial cell differentiation  myosin V binding  insulin-responsive compartment  cellular response to insulin stimulus  cellular response to insulin stimulus  Golgi to plasma membrane protein transport  neutrophil degranulation  establishment of neuroblast polarity  recycling endosome  recycling endosome membrane  membrane organization  basolateral protein localization  extracellular exosome  exocytic vesicle  endoplasmic reticulum tubular network  endoplasmic reticulum tubular network organization  protein localization to plasma membrane  establishment of protein localization to membrane  establishment of protein localization to endoplasmic reticulum membrane  cell-cell adhesion  cadherin binding involved in cell-cell adhesion  
NDEx NetworkRAB10
Atlas of Cancer Signalling NetworkRAB10
Wikipedia pathwaysRAB10
Orthology - Evolution
OrthoDB10890
GeneTree (enSembl)ENSG00000084733
Phylogenetic Trees/Animal Genes : TreeFamRAB10
HOVERGENP61026
HOGENOMP61026
Homologs : HomoloGeneRAB10
Homology/Alignments : Family Browser (UCSC)RAB10
Gene fusions - Rearrangements
Fusion : MitelmanFEZ2/RAB10 [2p22.2/2p23.3]  [t(2;2)(p22;p23)]  
Fusion : MitelmanRAB10/NCOA1 [2p23.3/2p23.3]  [t(2;2)(p23;p23)]  
Fusion : MitelmanRAB10/SDC1 [2p23.3/2p24.1]  [t(2;2)(p23;p24)]  
Fusion: TCGAFEZ2 2p22.2 RAB10 2p23.3 LUAD
Fusion: TCGARAB10 2p23.3 NCOA1 2p23.3 BRCA
Fusion: TCGARAB10 2p23.3 SDC1 2p24.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAB10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAB10
dbVarRAB10
ClinVarRAB10
1000_GenomesRAB10 
Exome Variant ServerRAB10
ExAC (Exome Aggregation Consortium)RAB10 (select the gene name)
Genetic variants : HAPMAP10890
Genomic Variants (DGV)RAB10 [DGVbeta]
DECIPHERRAB10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAB10 
Mutations
ICGC Data PortalRAB10 
TCGA Data PortalRAB10 
Broad Tumor PortalRAB10
OASIS PortalRAB10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAB10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAB10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAB10
DgiDB (Drug Gene Interaction Database)RAB10
DoCM (Curated mutations)RAB10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAB10 (select a term)
intoGenRAB10
Cancer3DRAB10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612672   
Orphanet
MedgenRAB10
Genetic Testing Registry RAB10
NextProtP61026 [Medical]
TSGene10890
GENETestsRAB10
Target ValidationRAB10
Huge Navigator RAB10 [HugePedia]
snp3D : Map Gene to Disease10890
BioCentury BCIQRAB10
ClinGenRAB10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10890
Chemical/Pharm GKB GenePA34100
Clinical trialRAB10
Miscellaneous
canSAR (ICR)RAB10 (select the gene name)
Probes
Litterature
PubMed69 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAB10
EVEXRAB10
GoPubMedRAB10
iHOPRAB10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:12:13 CEST 2017

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