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RAB10 (RAB10, member RAS oncogene family)

Identity

Alias (NCBI)-
HGNC (Hugo) RAB10
HGNC Alias nameras-related GTP-binding protein
LocusID (NCBI) 10890
Atlas_Id 41955
Location 2p23.3  [Link to chromosome band 2p23]
Location_base_pair Starts at 26034084 and ends at 26137454 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DPP10 (2q14.1) / RAB10 (2p23.3)FEZ2 (2p22.2) / RAB10 (2p23.3)PSME2 (14q12) / RAB10 (2p23.3)
RAB10 (2p23.3) / NCOA1 (2p23.3)RAB10 (2p23.3) / SDC1 (2p24.1)SLIT1 (10q24.1) / RAB10 (2p23.3)
FEZ2 2p22.2 / RAB10 2p23.3RAB10 2p23.3 / NCOA1 2p23.3RAB10 2p23.3 / SDC1 2p24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RAB10   9759
Cards
Entrez_Gene (NCBI)RAB10    RAB10, member RAS oncogene family
Aliases
GeneCards (Weizmann)RAB10
Ensembl hg19 (Hinxton)ENSG00000084733 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000084733 [Gene_View]  ENSG00000084733 [Sequence]  chr2:26034084-26137454 [Contig_View]  RAB10 [Vega]
ICGC DataPortalENSG00000084733
TCGA cBioPortalRAB10
AceView (NCBI)RAB10
Genatlas (Paris)RAB10
SOURCE (Princeton)RAB10
Genetics Home Reference (NIH)RAB10
Genomic and cartography
GoldenPath hg38 (UCSC)RAB10  -     chr2:26034084-26137454 +  2p23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAB10  -     2p23.3   [Description]    (hg19-Feb_2009)
GoldenPathRAB10 - 2p23.3 [CytoView hg19]  RAB10 - 2p23.3 [CytoView hg38]
ImmunoBaseENSG00000084733
Genome Data Viewer NCBIRAB10 [Mapview hg19]  
OMIM612672   
Gene and transcription
Genbank (Entrez)AF086917 AF091032 AF106681 AF297660 AF498945
RefSeq transcript (Entrez)NM_016131
Consensus coding sequences : CCDS (NCBI)RAB10
Gene ExpressionRAB10 [ NCBI-GEO ]   RAB10 [ EBI - ARRAY_EXPRESS ]   RAB10 [ SEEK ]   RAB10 [ MEM ]
Gene Expression Viewer (FireBrowse)RAB10 [ Firebrowse - Broad ]
GenevisibleExpression of RAB10 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10890
GTEX Portal (Tissue expression)RAB10
Human Protein AtlasENSG00000084733-RAB10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61026   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61026  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61026
PhosPhoSitePlusP61026
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)RAB10
PDB (RSDB)5LPN    5SZJ   
PDB Europe5LPN    5SZJ   
PDB (PDBSum)5LPN    5SZJ   
PDB (IMB)5LPN    5SZJ   
Structural Biology KnowledgeBase5LPN    5SZJ   
SCOP (Structural Classification of Proteins)5LPN    5SZJ   
CATH (Classification of proteins structures)5LPN    5SZJ   
SuperfamilyP61026
AlphaFold pdb e-kbP61026   
Human Protein Atlas [tissue]ENSG00000084733-RAB10 [tissue]
HPRD06692
Protein Interaction databases
DIP (DOE-UCLA)P61026
IntAct (EBI)P61026
BioGRIDRAB10
STRING (EMBL)RAB10
ZODIACRAB10
Ontologies - Pathways
QuickGOP61026
Ontology : AmiGOGolgi membrane  G protein activity  protein binding  GTP binding  endosome  endosome  endoplasmic reticulum membrane  Golgi apparatus  Golgi apparatus  trans-Golgi network  cytosol  cytoskeleton  plasma membrane  plasma membrane  adherens junction  focal adhesion  cilium  Golgi to plasma membrane transport  vesicle docking involved in exocytosis  axonogenesis  synaptic vesicle  protein secretion  vesicle-mediated transport  endosomal transport  regulation of exocytosis  GDP binding  antigen processing and presentation  cytoplasmic vesicle membrane  secretory granule membrane  phagocytic vesicle membrane  polarized epithelial cell differentiation  myosin V binding  insulin-responsive compartment  insulin-responsive compartment  cellular response to insulin stimulus  cellular response to insulin stimulus  Golgi to plasma membrane protein transport  neutrophil degranulation  regulated exocytosis  establishment of neuroblast polarity  perinuclear region of cytoplasm  recycling endosome  recycling endosome  recycling endosome membrane  extracellular exosome  exocytic vesicle  endoplasmic reticulum tubular network  endoplasmic reticulum tubular network organization  protein localization to plasma membrane  protein localization to plasma membrane  establishment of protein localization to membrane  establishment of protein localization to endoplasmic reticulum membrane  cell-cell adhesion  cadherin binding involved in cell-cell adhesion  protein localization to basolateral plasma membrane  
Ontology : EGO-EBIGolgi membrane  G protein activity  protein binding  GTP binding  endosome  endosome  endoplasmic reticulum membrane  Golgi apparatus  Golgi apparatus  trans-Golgi network  cytosol  cytoskeleton  plasma membrane  plasma membrane  adherens junction  focal adhesion  cilium  Golgi to plasma membrane transport  vesicle docking involved in exocytosis  axonogenesis  synaptic vesicle  protein secretion  vesicle-mediated transport  endosomal transport  regulation of exocytosis  GDP binding  antigen processing and presentation  cytoplasmic vesicle membrane  secretory granule membrane  phagocytic vesicle membrane  polarized epithelial cell differentiation  myosin V binding  insulin-responsive compartment  insulin-responsive compartment  cellular response to insulin stimulus  cellular response to insulin stimulus  Golgi to plasma membrane protein transport  neutrophil degranulation  regulated exocytosis  establishment of neuroblast polarity  perinuclear region of cytoplasm  recycling endosome  recycling endosome  recycling endosome membrane  extracellular exosome  exocytic vesicle  endoplasmic reticulum tubular network  endoplasmic reticulum tubular network organization  protein localization to plasma membrane  protein localization to plasma membrane  establishment of protein localization to membrane  establishment of protein localization to endoplasmic reticulum membrane  cell-cell adhesion  cadherin binding involved in cell-cell adhesion  protein localization to basolateral plasma membrane  
NDEx NetworkRAB10
Atlas of Cancer Signalling NetworkRAB10
Wikipedia pathwaysRAB10
Orthology - Evolution
OrthoDB10890
GeneTree (enSembl)ENSG00000084733
Phylogenetic Trees/Animal Genes : TreeFamRAB10
Homologs : HomoloGeneRAB10
Homology/Alignments : Family Browser (UCSC)RAB10
Gene fusions - Rearrangements
Fusion : MitelmanFEZ2/RAB10 [2p22.2/2p23.3]  
Fusion : MitelmanRAB10/NCOA1 [2p23.3/2p23.3]  
Fusion : MitelmanRAB10/SDC1 [2p23.3/2p24.1]  
Fusion : QuiverRAB10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAB10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAB10
dbVarRAB10
ClinVarRAB10
MonarchRAB10
1000_GenomesRAB10 
Exome Variant ServerRAB10
GNOMAD BrowserENSG00000084733
Varsome BrowserRAB10
ACMGRAB10 variants
VarityP61026
Genomic Variants (DGV)RAB10 [DGVbeta]
DECIPHERRAB10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAB10 
Mutations
ICGC Data PortalRAB10 
TCGA Data PortalRAB10 
Broad Tumor PortalRAB10
OASIS PortalRAB10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAB10  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRAB10
Mutations and Diseases : HGMDRAB10
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRAB10
DgiDB (Drug Gene Interaction Database)RAB10
DoCM (Curated mutations)RAB10
CIViC (Clinical Interpretations of Variants in Cancer)RAB10
Cancer3DRAB10
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612672   
Orphanet
DisGeNETRAB10
MedgenRAB10
Genetic Testing Registry RAB10
NextProtP61026 [Medical]
GENETestsRAB10
Target ValidationRAB10
Huge Navigator RAB10 [HugePedia]
ClinGenRAB10
Clinical trials, drugs, therapy
MyCancerGenomeRAB10
Protein Interactions : CTDRAB10
Pharm GKB GenePA34100
PharosP61026
Clinical trialRAB10
Miscellaneous
canSAR (ICR)RAB10
HarmonizomeRAB10
DataMed IndexRAB10
Probes
Litterature
PubMed129 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRAB10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:27:42 CEST 2021

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