RAB11B (RAB11B, member RAS oncogene family)

2003-12-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
H-YPT3,NDAGSCW
FUSION GENES

Other Information

Locus ID:

NCBI: 9230
MIM: 604198
HGNC: 9761
Ensembl: ENSG00000185236

Variants:

dbSNP: 9230
ClinVar: 9230
TCGA: ENSG00000185236
COSMIC: RAB11B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185236ENST00000328024Q15907
ENSG00000185236ENST00000594216Q15907
ENSG00000185236ENST00000600719M0R377
ENSG00000185236ENST00000601897M0R2D0

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Vasopressin-regulated water reabsorptionKEGGko04962
Vasopressin-regulated water reabsorptionKEGGhsa04962
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
TBC/RABGAPsREACTOMER-HSA-8854214
RAB geranylgeranylationREACTOMER-HSA-8873719

References

Pubmed IDYearTitleCitations
192443462009Rab11b regulates the apical recycling of the cystic fibrosis transmembrane conductance regulator in polarized intestinal epithelial cells.58
206866662010Biogenesis of the inner membrane complex is dependent on vesicular transport by the alveolate specific GTPase Rab11B.27
241419072014Rab11b mediates melanin transfer between donor melanocytes and acceptor keratinocytes via coupled exo/endocytosis.21
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
212480792011Small GTPase Rab11b regulates degradation of surface membrane L-type Cav1.2 channels.15
165459622006The crystal structure of the small GTPase Rab11b reveals critical differences relative to the Rab11a isoform.13
207179562011Rab11b and its effector Rip11 regulate the acidosis-induced traffic of V-ATPase in salivary ducts.13
291068252017Recurrent De Novo Mutations Disturbing the GTP/GDP Binding Pocket of RAB11B Cause Intellectual Disability and a Distinctive Brain Phenotype.11
250708902014Crystal structure of the cGMP-dependent protein kinase II leucine zipper and Rab11b protein complex reveals molecular details of G-kinase-specific interactions.10
266353652016Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins.9

Citation

Dessen P

RAB11B (RAB11B, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41957/rab11b