RAB11FIP2 (RAB11 family interacting protein 2)

2016-08-01  

Identity

HGNC
RAB11FIP2
LOCATION
10q26.11
LOCUSID
22841
ALIAS
Rab11-FIP2,nRip11
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22841
MIM: 608599
HGNC: 29152
Ensembl: ENSG00000107560

Variants:

dbSNP: 22841
ClinVar: 22841
TCGA: ENSG00000107560
COSMIC: RAB11FIP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107560ENST00000355624Q7L804
ENSG00000107560ENST00000369199Q7L804

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Aquaporin-mediated transportREACTOMER-HSA-445717
Vasopressin regulates renal water homeostasis via AquaporinsREACTOMER-HSA-432040

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
186216832008Respiratory syncytial virus uses a Vps4-independent budding mechanism controlled by Rab11-FIP2.72
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
119942792002Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain.41
167750132006MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells.34
243729662014Rab11-FIP2 interaction with MYO5B regulates movement of Rab11a-containing recycling vesicles.25
224206462012A Rab11A/myosin Vb/Rab11-FIP2 complex frames two late recycling steps of langerin from the ERC to the plasma membrane.20
176262442007Rab11-FIP2 regulates differentiable steps in transcytosis.18
267927222016Rab11-FIP2 promotes colorectal cancer migration and invasion by regulating PI3K/AKT/MMP7 signaling pathway.15
280738332017Exosomal miR-142-3p is increased during cardiac allograft rejection and augments vascular permeability through down-regulation of endothelial RAB11FIP2 expression.15
265020902016Rab11-FIP2 promotes the metastasis of gastric cancer cells.10

Citation

Dessen P

RAB11FIP2 (RAB11 family interacting protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55843/rab11fip2