Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RAB12 (RAB12, member RAS oncogene family)

Identity

Alias (NCBI)-
HGNC (Hugo) RAB12
LocusID (NCBI) 201475
Atlas_Id 43038
Location 18p11.22  [Link to chromosome band 18p11]
Location_base_pair Starts at 8609445 and ends at 8639382 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C20orf96 (20p13) / RAB12 (18p11.22)JADE1 (4q28.2) / RAB12 (18p11.22)PPP1R1B (17q12) / RAB12 (18p11.22)
RAB12 (18p11.22) / FAM19A2 (12q14.1)RAB12 18p11.22 / FAM19A2 12q14.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;18)(q14;p11) RAB12/FAM19A2


External links

Nomenclature
HGNC (Hugo)RAB12   31332
Cards
Entrez_Gene (NCBI)RAB12    RAB12, member RAS oncogene family
Aliases
GeneCards (Weizmann)RAB12
Ensembl hg19 (Hinxton)ENSG00000206418 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000206418 [Gene_View]  ENSG00000206418 [Sequence]  chr18:8609445-8639382 [Contig_View]  RAB12 [Vega]
ICGC DataPortalENSG00000206418
TCGA cBioPortalRAB12
AceView (NCBI)RAB12
Genatlas (Paris)RAB12
SOURCE (Princeton)RAB12
Genetics Home Reference (NIH)RAB12
Genomic and cartography
GoldenPath hg38 (UCSC)RAB12  -     chr18:8609445-8639382 +  18p11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAB12  -     18p11.22   [Description]    (hg19-Feb_2009)
GoldenPathRAB12 - 18p11.22 [CytoView hg19]  RAB12 - 18p11.22 [CytoView hg38]
ImmunoBaseENSG00000206418
genome Data Viewer NCBIRAB12 [Mapview hg19]  
OMIM616448   
Gene and transcription
Genbank (Entrez)AK127824 BC050338 BC071600 BC098407
RefSeq transcript (Entrez)NM_001025300
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RAB12
Alternative Splicing GalleryENSG00000206418
Gene ExpressionRAB12 [ NCBI-GEO ]   RAB12 [ EBI - ARRAY_EXPRESS ]   RAB12 [ SEEK ]   RAB12 [ MEM ]
Gene Expression Viewer (FireBrowse)RAB12 [ Firebrowse - Broad ]
GenevisibleExpression of RAB12 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)201475
GTEX Portal (Tissue expression)RAB12
Human Protein AtlasENSG00000206418-RAB12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6IQ22   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6IQ22  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6IQ22
Splice isoforms : SwissVarQ6IQ22
PhosPhoSitePlusQ6IQ22
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Rab12    Small_GTP-bd_dom    Small_GTPase   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)RAB12
Blocks (Seattle)RAB12
PDB (RSDB)2IL1   
PDB Europe2IL1   
PDB (PDBSum)2IL1   
PDB (IMB)2IL1   
Structural Biology KnowledgeBase2IL1   
SCOP (Structural Classification of Proteins)2IL1   
CATH (Classification of proteins structures)2IL1   
SuperfamilyQ6IQ22
Human Protein Atlas [tissue]ENSG00000206418-RAB12 [tissue]
Peptide AtlasQ6IQ22
IPIIPI00419932   
Protein Interaction databases
DIP (DOE-UCLA)Q6IQ22
IntAct (EBI)Q6IQ22
BioGRIDRAB12
STRING (EMBL)RAB12
ZODIACRAB12
Ontologies - Pathways
QuickGOQ6IQ22
Ontology : AmiGOGolgi membrane  protein binding  GTP binding  lysosome  lysosomal membrane  endosome  autophagosome  Golgi apparatus  cytosol  plasma membrane  vesicle docking involved in exocytosis  autophagy  synaptic vesicle  endosome to lysosome transport  protein secretion  positive regulation of macroautophagy  regulation of exocytosis  GDP binding  insulin-responsive compartment  cellular response to insulin stimulus  cellular protein catabolic process  phagocytic vesicle  recycling endosome  recycling endosome membrane  recycling endosome membrane  cellular response to interferon-gamma  protein localization to plasma membrane  
Ontology : EGO-EBIGolgi membrane  protein binding  GTP binding  lysosome  lysosomal membrane  endosome  autophagosome  Golgi apparatus  cytosol  plasma membrane  vesicle docking involved in exocytosis  autophagy  synaptic vesicle  endosome to lysosome transport  protein secretion  positive regulation of macroautophagy  regulation of exocytosis  GDP binding  insulin-responsive compartment  cellular response to insulin stimulus  cellular protein catabolic process  phagocytic vesicle  recycling endosome  recycling endosome membrane  recycling endosome membrane  cellular response to interferon-gamma  protein localization to plasma membrane  
NDEx NetworkRAB12
Atlas of Cancer Signalling NetworkRAB12
Wikipedia pathwaysRAB12
Orthology - Evolution
OrthoDB201475
GeneTree (enSembl)ENSG00000206418
Phylogenetic Trees/Animal Genes : TreeFamRAB12
HOGENOMQ6IQ22
Homologs : HomoloGeneRAB12
Homology/Alignments : Family Browser (UCSC)RAB12
Gene fusions - Rearrangements
Fusion : MitelmanRAB12/FAM19A2 [18p11.22/12q14.1]  
Fusion PortalRAB12 18p11.22 FAM19A2 12q14.1 BRCA
Fusion : QuiverRAB12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAB12 [hg38]
dbVarRAB12
ClinVarRAB12
MonarchRAB12
1000_GenomesRAB12 
Exome Variant ServerRAB12
GNOMAD BrowserENSG00000206418
Varsome BrowserRAB12
Genomic Variants (DGV)RAB12 [DGVbeta]
DECIPHERRAB12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAB12 
Mutations
ICGC Data PortalRAB12 
TCGA Data PortalRAB12 
Broad Tumor PortalRAB12
OASIS PortalRAB12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAB12  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRAB12
Mutations and Diseases : HGMDRAB12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAB12
DgiDB (Drug Gene Interaction Database)RAB12
DoCM (Curated mutations)RAB12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAB12 (select a term)
intoGenRAB12
Cancer3DRAB12(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616448   
Orphanet
DisGeNETRAB12
MedgenRAB12
Genetic Testing Registry RAB12
NextProtQ6IQ22 [Medical]
GENETestsRAB12
Target ValidationRAB12
Huge Navigator RAB12 [HugePedia]
ClinGenRAB12
Clinical trials, drugs, therapy
MyCancerGenomeRAB12
Protein Interactions : CTD
Pharm GKB GenePA142671102
PharosQ6IQ22
Clinical trialRAB12
Miscellaneous
canSAR (ICR)RAB12 (select the gene name)
HarmonizomeRAB12
DataMed IndexRAB12
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRAB12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:33:52 CET 2021

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