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RAB1A (RAB1A, member RAS oncogene family)

Identity

Alias_namesRAB1
Alias_symbol (synonym)YPT1
Other alias
HGNC (Hugo) RAB1A
LocusID (NCBI) 5861
Atlas_Id 41962
Location 2p14  [Link to chromosome band 2p14]
Location_base_pair Starts at 65086854 and ends at 65130301 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CGA (6q14.3) / RAB1A (2p14)ENOSF1 (18p11.32) / RAB1A (2p14)PHTF2 (7q11.23) / RAB1A (2p14)
RAB1A (2p14) / BCL11A (2p16.1)RAB1A (2p14) / COL1A1 (17q21.33)RAB1A (2p14) / LUC7L3 (17q21.33)
RAB1A (2p14) / MFF (2q36.3)RAB1A (2p14) / PHTF2 (7q11.23)RAB1A (2p14) / SLC35D1 (1p31.3)
SPRED2 (2p14) / RAB1A (2p14)ZMYM2 (13q12.11) / RAB1A (2p14)PHTF2 7q11.23 / RAB1A 2p14
RAB1A 2p14 / PHTF2 7q11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RAB1A   9758
Cards
Entrez_Gene (NCBI)RAB1A  5861  RAB1A, member RAS oncogene family
AliasesRAB1; YPT1
GeneCards (Weizmann)RAB1A
Ensembl hg19 (Hinxton)ENSG00000138069 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138069 [Gene_View]  chr2:65086854-65130301 [Contig_View]  RAB1A [Vega]
ICGC DataPortalENSG00000138069
TCGA cBioPortalRAB1A
AceView (NCBI)RAB1A
Genatlas (Paris)RAB1A
WikiGenes5861
SOURCE (Princeton)RAB1A
Genetics Home Reference (NIH)RAB1A
Genomic and cartography
GoldenPath hg38 (UCSC)RAB1A  -     chr2:65086854-65130301 -  2p14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAB1A  -     2p14   [Description]    (hg19-Feb_2009)
EnsemblRAB1A - 2p14 [CytoView hg19]  RAB1A - 2p14 [CytoView hg38]
Mapping of homologs : NCBIRAB1A [Mapview hg19]  RAB1A [Mapview hg38]
OMIM179508   
Gene and transcription
Genbank (Entrez)AF498929 AI768809 AK055927 AK303678 AK315495
RefSeq transcript (Entrez)NM_004161 NM_015543
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RAB1A
Cluster EST : UnigeneHs.310645 [ NCBI ]
CGAP (NCI)Hs.310645
Alternative Splicing GalleryENSG00000138069
Gene ExpressionRAB1A [ NCBI-GEO ]   RAB1A [ EBI - ARRAY_EXPRESS ]   RAB1A [ SEEK ]   RAB1A [ MEM ]
Gene Expression Viewer (FireBrowse)RAB1A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5861
GTEX Portal (Tissue expression)RAB1A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62820   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62820  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62820
Splice isoforms : SwissVarP62820
PhosPhoSitePlusP62820
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)RAB1A
DMDM Disease mutations5861
Blocks (Seattle)RAB1A
PDB (SRS)2FOL    2WWX    3L0I    3SFV    3TKL    4FMB    4FMC    4FMD    4FME    4IRU    4JVS   
PDB (PDBSum)2FOL    2WWX    3L0I    3SFV    3TKL    4FMB    4FMC    4FMD    4FME    4IRU    4JVS   
PDB (IMB)2FOL    2WWX    3L0I    3SFV    3TKL    4FMB    4FMC    4FMD    4FME    4IRU    4JVS   
PDB (RSDB)2FOL    2WWX    3L0I    3SFV    3TKL    4FMB    4FMC    4FMD    4FME    4IRU    4JVS   
Structural Biology KnowledgeBase2FOL    2WWX    3L0I    3SFV    3TKL    4FMB    4FMC    4FMD    4FME    4IRU    4JVS   
SCOP (Structural Classification of Proteins)2FOL    2WWX    3L0I    3SFV    3TKL    4FMB    4FMC    4FMD    4FME    4IRU    4JVS   
CATH (Classification of proteins structures)2FOL    2WWX    3L0I    3SFV    3TKL    4FMB    4FMC    4FMD    4FME    4IRU    4JVS   
SuperfamilyP62820
Human Protein AtlasENSG00000138069
Peptide AtlasP62820
HPRD01538
IPIIPI00005719   IPI00334174   IPI00185217   IPI00937805   IPI00917079   
Protein Interaction databases
DIP (DOE-UCLA)P62820
IntAct (EBI)P62820
FunCoupENSG00000138069
BioGRIDRAB1A
STRING (EMBL)RAB1A
ZODIACRAB1A
Ontologies - Pathways
QuickGOP62820
Ontology : AmiGOautophagosome assembly  Golgi membrane  Golgi membrane  GTPase activity  protein binding  GTP binding  early endosome  endoplasmic reticulum membrane  Golgi apparatus  cytosol  ER to Golgi vesicle-mediated transport  ER to Golgi vesicle-mediated transport  ER to Golgi vesicle-mediated transport  retrograde vesicle-mediated transport, Golgi to ER  endocytosis  autophagy  Golgi organization  vesicle-mediated transport  cell migration  virion assembly  virion assembly  growth hormone secretion  transport vesicle membrane  melanosome transport  substrate adhesion-dependent cell spreading  melanosome  defense response to bacterium  cadherin binding  vesicle transport along microtubule  COPII vesicle coating  cilium assembly  membrane organization  extracellular exosome  interleukin-8 secretion  cargo loading into COPII-coated vesicle  establishment of endothelial intestinal barrier  positive regulation of glycoprotein metabolic process  positive regulation of ubiquitin protein ligase activity  
Ontology : EGO-EBIautophagosome assembly  Golgi membrane  Golgi membrane  GTPase activity  protein binding  GTP binding  early endosome  endoplasmic reticulum membrane  Golgi apparatus  cytosol  ER to Golgi vesicle-mediated transport  ER to Golgi vesicle-mediated transport  ER to Golgi vesicle-mediated transport  retrograde vesicle-mediated transport, Golgi to ER  endocytosis  autophagy  Golgi organization  vesicle-mediated transport  cell migration  virion assembly  virion assembly  growth hormone secretion  transport vesicle membrane  melanosome transport  substrate adhesion-dependent cell spreading  melanosome  defense response to bacterium  cadherin binding  vesicle transport along microtubule  COPII vesicle coating  cilium assembly  membrane organization  extracellular exosome  interleukin-8 secretion  cargo loading into COPII-coated vesicle  establishment of endothelial intestinal barrier  positive regulation of glycoprotein metabolic process  positive regulation of ubiquitin protein ligase activity  
Pathways : BIOCARTARab GTPases Mark Targets In The Endocytotic Machinery [Genes]   
Pathways : KEGGLegionellosis   
NDEx NetworkRAB1A
Atlas of Cancer Signalling NetworkRAB1A
Wikipedia pathwaysRAB1A
Orthology - Evolution
OrthoDB5861
GeneTree (enSembl)ENSG00000138069
Phylogenetic Trees/Animal Genes : TreeFamRAB1A
HOVERGENP62820
HOGENOMP62820
Homologs : HomoloGeneRAB1A
Homology/Alignments : Family Browser (UCSC)RAB1A
Gene fusions - Rearrangements
Fusion : MitelmanPHTF2/RAB1A [7q11.23/2p14]  [t(2;7)(p14;q11)]  
Fusion : MitelmanRAB1A/PHTF2 [2p14/7q11.23]  [t(2;7)(p14;q11)]  
Fusion: TCGAPHTF2 7q11.23 RAB1A 2p14 BRCA
Fusion: TCGARAB1A 2p14 PHTF2 7q11.23 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAB1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAB1A
dbVarRAB1A
ClinVarRAB1A
1000_GenomesRAB1A 
Exome Variant ServerRAB1A
ExAC (Exome Aggregation Consortium)RAB1A (select the gene name)
Genetic variants : HAPMAP5861
Genomic Variants (DGV)RAB1A [DGVbeta]
DECIPHERRAB1A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAB1A 
Mutations
ICGC Data PortalRAB1A 
TCGA Data PortalRAB1A 
Broad Tumor PortalRAB1A
OASIS PortalRAB1A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAB1A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAB1A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAB1A
DgiDB (Drug Gene Interaction Database)RAB1A
DoCM (Curated mutations)RAB1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAB1A (select a term)
intoGenRAB1A
Cancer3DRAB1A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM179508   
Orphanet
MedgenRAB1A
Genetic Testing Registry RAB1A
NextProtP62820 [Medical]
TSGene5861
GENETestsRAB1A
Target ValidationRAB1A
Huge Navigator RAB1A [HugePedia]
snp3D : Map Gene to Disease5861
BioCentury BCIQRAB1A
ClinGenRAB1A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5861
Chemical/Pharm GKB GenePA34107
Clinical trialRAB1A
Miscellaneous
canSAR (ICR)RAB1A (select the gene name)
Probes
Litterature
PubMed94 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAB1A
EVEXRAB1A
GoPubMedRAB1A
iHOPRAB1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:12:16 CEST 2017

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