RAB1B (RAB1B, member RAS oncogene family)

2003-12-01 Affiliation

Identity

HGNC

RAB1B

LOCATION

11q13.2

LOCUSID

81876

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 81876
MIM: 612565
HGNC: 18370
Ensembl: ENSG00000174903

Variants:

dbSNP: 81876
ClinVar: 81876
TCGA: ENSG00000174903
COSMIC: RAB1B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000174903	ENST00000311481	Q9H0U4
ENSG00000174903	ENST00000527397	E9PLD0

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Legionellosis	KEGG	ko05134
Legionellosis	KEGG	hsa05134
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
Transport to the Golgi and subsequent modification	REACTOME	R-HSA-948021
ER to Golgi Anterograde Transport	REACTOME	R-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle Transport	REACTOME	R-HSA-204005
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prophase	REACTOME	R-HSA-68875
Golgi Cisternae Pericentriolar Stack Reorganization	REACTOME	R-HSA-162658
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
COPI-mediated anterograde transport	REACTOME	R-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER traffic	REACTOME	R-HSA-6811442
Golgi-to-ER retrograde transport	REACTOME	R-HSA-8856688
COPI-dependent Golgi-to-ER retrograde traffic	REACTOME	R-HSA-6811434
RAB GEFs exchange GTP for GDP on RABs	REACTOME	R-HSA-8876198
RAB geranylgeranylation	REACTOME	R-HSA-8873719

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17947549	2007	A bifunctional bacterial protein links GDI displacement to Rab1 activation.	108
17429068	2007	Rab1b interacts with GBF1 and modulates both ARF1 dynamics and COPI association.	60
20980813	2011	Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase.	52
26977884	2016	PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion.	32
21680502	2011	Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envelopment.	30
23236136	2012	Catalytic mechanism of a mammalian Rab·RabGAP complex in atomic detail.	24
23288104	2013	Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB.	23
23188820	2013	Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways.	21
25970785	2015	Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-β/SMAD signaling.	20
28316326	2017	Overexpression of Rab1B and MMP9 predicts poor survival and good response to chemotherapy in patients with colorectal cancer.	14

Citation

Dessen P

RAB1B (RAB1B, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41963/rab1b