Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

RAB21 (RAB21, member RAS oncogene family)

Identity

Alias_symbol (synonym)KIAA0118
Other alias-
HGNC (Hugo) RAB21
LocusID (NCBI) 23011
Atlas_Id 41966
Location 12q21.1  [Link to chromosome band 12q21]
Location_base_pair Starts at 71754863 and ends at 71793476 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AKIRIN1 (1p34.3) / RAB21 (12q21.1)LOC100507412 (-) / RAB21 (12q21.1)MORF4L1 (15q25.1) / RAB21 (12q21.1)
RAB21 (12q21.1) / FRS2 (12q15)RAB21 (12q21.1) / LOC100128714 (15q12)RAB21 (12q21.1) / MDM1 (12q15)
RAB21 (12q21.1) / TBC1D15 (12q21.1)RAB21 12q21.1 / MDM1 12q15

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)RAB21   18263
Cards
Entrez_Gene (NCBI)RAB21  23011  RAB21, member RAS oncogene family
Aliases
GeneCards (Weizmann)RAB21
Ensembl hg19 (Hinxton)ENSG00000080371 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000080371 [Gene_View]  chr12:71754863-71793476 [Contig_View]  RAB21 [Vega]
ICGC DataPortalENSG00000080371
TCGA cBioPortalRAB21
AceView (NCBI)RAB21
Genatlas (Paris)RAB21
WikiGenes23011
SOURCE (Princeton)RAB21
Genetics Home Reference (NIH)RAB21
Genomic and cartography
GoldenPath hg38 (UCSC)RAB21  -     chr12:71754863-71793476 +  12q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAB21  -     12q21.1   [Description]    (hg19-Feb_2009)
EnsemblRAB21 - 12q21.1 [CytoView hg19]  RAB21 - 12q21.1 [CytoView hg38]
Mapping of homologs : NCBIRAB21 [Mapview hg19]  RAB21 [Mapview hg38]
OMIM612398   
Gene and transcription
Genbank (Entrez)AF091035 AM393692 BC009109 BC021901 BC092475
RefSeq transcript (Entrez)NM_014999
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RAB21
Cluster EST : UnigeneHs.524590 [ NCBI ]
CGAP (NCI)Hs.524590
Alternative Splicing GalleryENSG00000080371
Gene ExpressionRAB21 [ NCBI-GEO ]   RAB21 [ EBI - ARRAY_EXPRESS ]   RAB21 [ SEEK ]   RAB21 [ MEM ]
Gene Expression Viewer (FireBrowse)RAB21 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23011
GTEX Portal (Tissue expression)RAB21
Human Protein AtlasENSG00000080371-RAB21 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UL25   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UL25  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UL25
Splice isoforms : SwissVarQ9UL25
PhosPhoSitePlusQ9UL25
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)RAB21
DMDM Disease mutations23011
Blocks (Seattle)RAB21
PDB (SRS)1YZT    1YZU    1Z08    1Z0I    2OT3   
PDB (PDBSum)1YZT    1YZU    1Z08    1Z0I    2OT3   
PDB (IMB)1YZT    1YZU    1Z08    1Z0I    2OT3   
PDB (RSDB)1YZT    1YZU    1Z08    1Z0I    2OT3   
Structural Biology KnowledgeBase1YZT    1YZU    1Z08    1Z0I    2OT3   
SCOP (Structural Classification of Proteins)1YZT    1YZU    1Z08    1Z0I    2OT3   
CATH (Classification of proteins structures)1YZT    1YZU    1Z08    1Z0I    2OT3   
SuperfamilyQ9UL25
Human Protein Atlas [tissue]ENSG00000080371-RAB21 [tissue]
Peptide AtlasQ9UL25
HPRD06695
IPIIPI00007755   
Protein Interaction databases
DIP (DOE-UCLA)Q9UL25
IntAct (EBI)Q9UL25
FunCoupENSG00000080371
BioGRIDRAB21
STRING (EMBL)RAB21
ZODIACRAB21
Ontologies - Pathways
QuickGOQ9UL25
Ontology : AmiGOGTPase activity  protein binding  GTP binding  GTP binding  endosome  endoplasmic reticulum membrane  trans-Golgi network  cytosol  focal adhesion  anterograde axonal transport  cytoplasmic side of plasma membrane  vesicle membrane  protein transport  regulation of exocytosis  GDP binding  regulation of axon extension  cytoplasmic vesicle membrane  early endosome membrane  cleavage furrow  Golgi cisterna membrane  positive regulation of receptor-mediated endocytosis  positive regulation of dendrite morphogenesis  membrane organization  extracellular exosome  cytoplasmic side of early endosome membrane  axon cytoplasm  positive regulation of early endosome to late endosome transport  
Ontology : EGO-EBIGTPase activity  protein binding  GTP binding  GTP binding  endosome  endoplasmic reticulum membrane  trans-Golgi network  cytosol  focal adhesion  anterograde axonal transport  cytoplasmic side of plasma membrane  vesicle membrane  protein transport  regulation of exocytosis  GDP binding  regulation of axon extension  cytoplasmic vesicle membrane  early endosome membrane  cleavage furrow  Golgi cisterna membrane  positive regulation of receptor-mediated endocytosis  positive regulation of dendrite morphogenesis  membrane organization  extracellular exosome  cytoplasmic side of early endosome membrane  axon cytoplasm  positive regulation of early endosome to late endosome transport  
NDEx NetworkRAB21
Atlas of Cancer Signalling NetworkRAB21
Wikipedia pathwaysRAB21
Orthology - Evolution
OrthoDB23011
GeneTree (enSembl)ENSG00000080371
Phylogenetic Trees/Animal Genes : TreeFamRAB21
HOVERGENQ9UL25
HOGENOMQ9UL25
Homologs : HomoloGeneRAB21
Homology/Alignments : Family Browser (UCSC)RAB21
Gene fusions - Rearrangements
Fusion : MitelmanRAB21/FRS2 [12q21.1/12q15]  
Fusion : MitelmanRAB21/MDM1 [12q21.1/12q15]  [t(12;12)(q15;q21)]  
Fusion : MitelmanRAB21/TBC1D15 [12q21.1/12q21.1]  [dup(12)(q21q21)]  
Fusion: TCGARAB21 12q21.1 MDM1 12q15 BRCA
Fusion: Tumor Portal RAB21
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAB21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAB21
dbVarRAB21
ClinVarRAB21
1000_GenomesRAB21 
Exome Variant ServerRAB21
ExAC (Exome Aggregation Consortium)ENSG00000080371
GNOMAD BrowserENSG00000080371
Genetic variants : HAPMAP23011
Genomic Variants (DGV)RAB21 [DGVbeta]
DECIPHERRAB21 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAB21 
Mutations
ICGC Data PortalRAB21 
TCGA Data PortalRAB21 
Broad Tumor PortalRAB21
OASIS PortalRAB21 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAB21  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAB21
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAB21
DgiDB (Drug Gene Interaction Database)RAB21
DoCM (Curated mutations)RAB21 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAB21 (select a term)
intoGenRAB21
Cancer3DRAB21(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612398   
Orphanet
MedgenRAB21
Genetic Testing Registry RAB21
NextProtQ9UL25 [Medical]
TSGene23011
GENETestsRAB21
Target ValidationRAB21
Huge Navigator RAB21 [HugePedia]
snp3D : Map Gene to Disease23011
BioCentury BCIQRAB21
ClinGenRAB21
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23011
Chemical/Pharm GKB GenePA34111
Clinical trialRAB21
Miscellaneous
canSAR (ICR)RAB21 (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAB21
EVEXRAB21
GoPubMedRAB21
iHOPRAB21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 13:07:34 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.