RAB23 (RAB23, member RAS oncogene family)

2003-12-01  

Identity

HGNC
RAB23
LOCATION
6p12.1
LOCUSID
51715
ALIAS
HSPC137
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51715
MIM: 606144
HGNC: 14263
Ensembl: ENSG00000112210

Variants:

dbSNP: 51715
ClinVar: 51715
TCGA: ENSG00000112210
COSMIC: RAB23

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112210ENST00000317483Q9ULC3
ENSG00000112210ENST00000317483A0A024RD41
ENSG00000112210ENST00000468148Q9ULC3
ENSG00000112210ENST00000468148A0A024RD41

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
RAB geranylgeranylationREACTOMER-HSA-8873719

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
175033332007RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity.68
184854832008Rab GTPases and their roles in brain neurons and glia.49
185595072008Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer.41
224523362012The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection.32
173737342007Rab23 is a potential biological target for treating hepatocellular carcinoma.16
223659722012Rab23 negatively regulates Gli1 transcriptional factor in a Su(Fu)-dependent manner.15
254899842015The microRNA-367 inhibits the invasion and metastasis of gastric cancer by directly repressing Rab23.15
267152722016Rab23 is overexpressed in human bladder cancer and promotes cancer cell proliferation and invasion.15
203586132010RAB23 mutation in a large family from Comoros Islands with Carpenter syndrome.12
262381432015Effect of Rab23 on the proliferation and apoptosis in breast cancer.10

Citation

Dessen P

RAB23 (RAB23, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41968/rab23