Atlas of Genetics and Cytogenetics in Oncology and Haematology


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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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RAB27A (RAB27A, member RAS oncogene family)

Identity

Other namesGS2
HsT18676
RAB27
RAM
HGNC (Hugo) RAB27A
LocusID (NCBI) 5873
Location 15q21.3
Location_base_pair Starts at 55495164 and ends at 55562592 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)RAB27A   9766
Cards
Entrez_Gene (NCBI)RAB27A  5873  RAB27A, member RAS oncogene family
GeneCards (Weizmann)RAB27A
Ensembl hg19 (Hinxton)ENSG00000069974 [Gene_View]  chr15:55495164-55562592 [Contig_View]  RAB27A [Vega]
Ensembl hg38 (Hinxton)ENSG00000069974 [Gene_View]  chr15:55495164-55562592 [Contig_View]  RAB27A [Vega]
ICGC DataPortalENSG00000069974
cBioPortalRAB27A
AceView (NCBI)RAB27A
Genatlas (Paris)RAB27A
WikiGenes5873
SOURCE (Princeton)RAB27A
Genomic and cartography
GoldenPath hg19 (UCSC)RAB27A  -     chr15:55495164-55562592 -  15q21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RAB27A  -     15q21.3   [Description]    (hg38-Dec_2013)
EnsemblRAB27A - 15q21.3 [CytoView hg19]  RAB27A - 15q21.3 [CytoView hg38]
Mapping of homologs : NCBIRAB27A [Mapview hg19]  RAB27A [Mapview hg38]
OMIM603868   607624   
Gene and transcription
Genbank (Entrez)AF125393 AF498953 AK312836 AV661679 BC107680
RefSeq transcript (Entrez)NM_004580 NM_183234 NM_183235 NM_183236
RefSeq genomic (Entrez)NC_000015 NC_018926 NG_009103 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)RAB27A
Cluster EST : UnigeneHs.735555 [ NCBI ]
CGAP (NCI)Hs.735555
Alternative Splicing : Fast-db (Paris)GSHG0010438
Alternative Splicing GalleryENSG00000069974
Gene ExpressionRAB27A [ NCBI-GEO ]     RAB27A [ SEEK ]   RAB27A [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51159 (Uniprot)
NextProtP51159  [Medical]
With graphics : InterProP51159
Splice isoforms : SwissVarP51159 (Swissvar)
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Rab_type   
Related proteins : CluSTrP51159
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Domain families : Smart (EMBL)RAB (SM00175)  
DMDM Disease mutations5873
Blocks (Seattle)P51159
Human Protein AtlasENSG00000069974
Peptide AtlasP51159
HPRD04845
IPIIPI00016381   IPI00219858   
Protein Interaction databases
DIP (DOE-UCLA)P51159
IntAct (EBI)P51159
FunCoupENSG00000069974
BioGRIDRAB27A
IntegromeDBRAB27A
STRING (EMBL)RAB27A
Ontologies - Pathways
QuickGOP51159
Ontology : AmiGOphotoreceptor outer segment  GTPase activity  GTPase activity  protein binding  GTP binding  GTP binding  lysosome  late endosome  Golgi apparatus  protein targeting  intracellular protein transport  exocytosis  vesicle docking involved in exocytosis  blood coagulation  protein secretion  positive regulation of gene expression  apical plasma membrane  GDP binding  antigen processing and presentation  protein domain specific binding  secretory granule  melanocyte differentiation  dendrite  secretory granule membrane  myosin V binding  melanosome localization  melanosome transport  Rab protein signal transduction  multivesicular body membrane  multivesicular body organization  melanosome  cytotoxic T cell degranulation  natural killer cell degranulation  cellular protein metabolic process  positive regulation of exocytosis  synaptic vesicle transport  positive regulation of phagocytosis  extracellular exosome  exocytic vesicle  multivesicular body sorting pathway  complement-dependent cytotoxicity  positive regulation of regulated secretory pathway  positive regulation of regulated secretory pathway  positive regulation of reactive oxygen species biosynthetic process  positive regulation of constitutive secretory pathway  exosomal secretion  
Ontology : EGO-EBIphotoreceptor outer segment  GTPase activity  GTPase activity  protein binding  GTP binding  GTP binding  lysosome  late endosome  Golgi apparatus  protein targeting  intracellular protein transport  exocytosis  vesicle docking involved in exocytosis  blood coagulation  protein secretion  positive regulation of gene expression  apical plasma membrane  GDP binding  antigen processing and presentation  protein domain specific binding  secretory granule  melanocyte differentiation  dendrite  secretory granule membrane  myosin V binding  melanosome localization  melanosome transport  Rab protein signal transduction  multivesicular body membrane  multivesicular body organization  melanosome  cytotoxic T cell degranulation  natural killer cell degranulation  cellular protein metabolic process  positive regulation of exocytosis  synaptic vesicle transport  positive regulation of phagocytosis  extracellular exosome  exocytic vesicle  multivesicular body sorting pathway  complement-dependent cytotoxicity  positive regulation of regulated secretory pathway  positive regulation of regulated secretory pathway  positive regulation of reactive oxygen species biosynthetic process  positive regulation of constitutive secretory pathway  exosomal secretion  
Pathways : BIOCARTARab GTPases Mark Targets In The Endocytotic Machinery [Genes]   
Protein Interaction DatabaseRAB27A
DoCM (Curated mutations)RAB27A
Wikipedia pathwaysRAB27A
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerRAB27A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAB27A
dbVarRAB27A
ClinVarRAB27A
1000_GenomesRAB27A 
Exome Variant ServerRAB27A
SNP (GeneSNP Utah)RAB27A
SNP : HGBaseRAB27A
Genetic variants : HAPMAPRAB27A
Genomic Variants (DGV)RAB27A [DGVbeta]
Mutations
ICGC Data PortalENSG00000069974 
Somatic Mutations in Cancer : COSMICRAB27A 
CONAN: Copy Number AnalysisRAB27A 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)15:55495164-55562592
Mutations and Diseases : HGMDRAB27A
OMIM603868    607624   
MedgenRAB27A
NextProtP51159 [Medical]
GENETestsRAB27A
Disease Genetic AssociationRAB27A
Huge Navigator RAB27A [HugePedia]  RAB27A [HugeCancerGEM]
snp3D : Map Gene to Disease5873
DGIdb (Drug Gene Interaction db)RAB27A
General knowledge
Homologs : HomoloGeneRAB27A
Homology/Alignments : Family Browser (UCSC)RAB27A
Phylogenetic Trees/Animal Genes : TreeFamRAB27A
Chemical/Protein Interactions : CTD5873
Chemical/Pharm GKB GenePA34117
Clinical trialRAB27A
Cancer Resource (Charite)ENSG00000069974
Other databases
Probes
Litterature
PubMed111 Pubmed reference(s) in Entrez
CoreMineRAB27A
GoPubMedRAB27A
iHOPRAB27A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 17:04:39 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.