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RAB2A (RAB2A, member RAS oncogene family)

Identity

Alias_namesRAB2
RAB2
Other aliasLHX
HGNC (Hugo) RAB2A
LocusID (NCBI) 5862
Atlas_Id 41964
Location 8q12.1  [Link to chromosome band 8q12]
Location_base_pair Starts at 60516910 and ends at 60623644 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ATP6V1C1 (8q22.3) / RAB2A (8q12.1)KIF3A (5q31.1) / RAB2A (8q12.1)MYH11 (16p13.11) / RAB2A (8q12.1)
RAB2A (8q12.1) / ASPH (8q12.3)RAB2A (8q12.1) / CHD7 (8q12.2)RAB2A (8q12.1) / MYH9 (22q12.3)
RAB2A (8q12.1) / PLAG1 (8q12.1)RAB2A (8q12.1) / RAB2A (8q12.1)RAB2A (8q12.1) / TRAPPC9 (8q24.3)
RAB2A 8q12.1 / TRAPPC9 8q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;12)(q27;p13) GAPDH/BCL6


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Soft Tissues: Lipoblastoma with t(8;8)(q12;q12) RAB2A/PLAG1


External links

Nomenclature
HGNC (Hugo)RAB2A   9763
Cards
Entrez_Gene (NCBI)RAB2A  5862  RAB2A, member RAS oncogene family
AliasesLHX; RAB2
GeneCards (Weizmann)RAB2A
Ensembl hg19 (Hinxton)ENSG00000104388 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104388 [Gene_View]  chr8:60516910-60623644 [Contig_View]  RAB2A [Vega]
ICGC DataPortalENSG00000104388
TCGA cBioPortalRAB2A
AceView (NCBI)RAB2A
Genatlas (Paris)RAB2A
WikiGenes5862
SOURCE (Princeton)RAB2A
Genetics Home Reference (NIH)RAB2A
Genomic and cartography
GoldenPath hg38 (UCSC)RAB2A  -     chr8:60516910-60623644 +  8q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAB2A  -     8q12.1   [Description]    (hg19-Feb_2009)
EnsemblRAB2A - 8q12.1 [CytoView hg19]  RAB2A - 8q12.1 [CytoView hg38]
Mapping of homologs : NCBIRAB2A [Mapview hg19]  RAB2A [Mapview hg38]
OMIM179509   
Gene and transcription
Genbank (Entrez)AF070629 AF498930 AK297576 AK312344 AL137321
RefSeq transcript (Entrez)NM_001242644 NM_002865
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RAB2A
Cluster EST : UnigeneHs.369017 [ NCBI ]
CGAP (NCI)Hs.369017
Alternative Splicing GalleryENSG00000104388
Gene ExpressionRAB2A [ NCBI-GEO ]   RAB2A [ EBI - ARRAY_EXPRESS ]   RAB2A [ SEEK ]   RAB2A [ MEM ]
Gene Expression Viewer (FireBrowse)RAB2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5862
GTEX Portal (Tissue expression)RAB2A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61019   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61019  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61019
Splice isoforms : SwissVarP61019
PhosPhoSitePlusP61019
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)RAB2A
DMDM Disease mutations5862
Blocks (Seattle)RAB2A
PDB (SRS)1Z0A   
PDB (PDBSum)1Z0A   
PDB (IMB)1Z0A   
PDB (RSDB)1Z0A   
Structural Biology KnowledgeBase1Z0A   
SCOP (Structural Classification of Proteins)1Z0A   
CATH (Classification of proteins structures)1Z0A   
SuperfamilyP61019
Human Protein AtlasENSG00000104388
Peptide AtlasP61019
HPRD01539
IPIIPI00031169   IPI01014788   IPI00790570   IPI00794561   IPI00798089   IPI00980772   IPI00983442   IPI00981364   
Protein Interaction databases
DIP (DOE-UCLA)P61019
IntAct (EBI)P61019
FunCoupENSG00000104388
BioGRIDRAB2A
STRING (EMBL)RAB2A
ZODIACRAB2A
Ontologies - Pathways
QuickGOP61019
Ontology : AmiGOGolgi membrane  GTPase activity  protein binding  GTP binding  nucleus  lysosomal membrane  endoplasmic reticulum membrane  Golgi apparatus  cytosol  ER to Golgi vesicle-mediated transport  Golgi organization  protein transport  GDP binding  endoplasmic reticulum-Golgi intermediate compartment membrane  melanosome  extracellular exosome  
Ontology : EGO-EBIGolgi membrane  GTPase activity  protein binding  GTP binding  nucleus  lysosomal membrane  endoplasmic reticulum membrane  Golgi apparatus  cytosol  ER to Golgi vesicle-mediated transport  Golgi organization  protein transport  GDP binding  endoplasmic reticulum-Golgi intermediate compartment membrane  melanosome  extracellular exosome  
Pathways : BIOCARTARab GTPases Mark Targets In The Endocytotic Machinery [Genes]   
NDEx NetworkRAB2A
Atlas of Cancer Signalling NetworkRAB2A
Wikipedia pathwaysRAB2A
Orthology - Evolution
OrthoDB5862
GeneTree (enSembl)ENSG00000104388
Phylogenetic Trees/Animal Genes : TreeFamRAB2A
HOVERGENP61019
HOGENOMP61019
Homologs : HomoloGeneRAB2A
Homology/Alignments : Family Browser (UCSC)RAB2A
Gene fusions - Rearrangements
Fusion : MitelmanRAB2A/PLAG1 [8q12.1/8q12.1]  
Fusion : MitelmanRAB2A/TRAPPC9 [8q12.1/8q24.3]  [t(8;8)(q12;q24)]  
Fusion: TCGARAB2A 8q12.1 TRAPPC9 8q24.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAB2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAB2A
dbVarRAB2A
ClinVarRAB2A
1000_GenomesRAB2A 
Exome Variant ServerRAB2A
ExAC (Exome Aggregation Consortium)RAB2A (select the gene name)
Genetic variants : HAPMAP5862
Genomic Variants (DGV)RAB2A [DGVbeta]
DECIPHERRAB2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAB2A 
Mutations
ICGC Data PortalRAB2A 
TCGA Data PortalRAB2A 
Broad Tumor PortalRAB2A
OASIS PortalRAB2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAB2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAB2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAB2A
DgiDB (Drug Gene Interaction Database)RAB2A
DoCM (Curated mutations)RAB2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAB2A (select a term)
intoGenRAB2A
Cancer3DRAB2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM179509   
Orphanet
MedgenRAB2A
Genetic Testing Registry RAB2A
NextProtP61019 [Medical]
TSGene5862
GENETestsRAB2A
Target ValidationRAB2A
Huge Navigator RAB2A [HugePedia]
snp3D : Map Gene to Disease5862
BioCentury BCIQRAB2A
ClinGenRAB2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5862
Chemical/Pharm GKB GenePA162400618
Clinical trialRAB2A
Miscellaneous
canSAR (ICR)RAB2A (select the gene name)
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAB2A
EVEXRAB2A
GoPubMedRAB2A
iHOPRAB2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:52:07 CEST 2017

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