RAB2A (RAB2A, member RAS oncogene family)

2003-11-01  

Identity

HGNC
LOCATION
8q12.1
LOCUSID
ALIAS
LHX,RAB2
FUSION GENES

Other Information

Locus ID:

NCBI: 5862
MIM: 179509
HGNC: 9763
Ensembl: ENSG00000104388

Variants:

dbSNP: 5862
ClinVar: 5862
TCGA: ENSG00000104388
COSMIC: RAB2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104388ENST00000262646P61019
ENSG00000104388ENST00000262646A0A024R7V6
ENSG00000104388ENST00000452437H7C125
ENSG00000104388ENST00000466595H0YD31
ENSG00000104388ENST00000529579E9PKL7
ENSG00000104388ENST00000531098A0A1D5RMT4
ENSG00000104388ENST00000531289P61019
ENSG00000104388ENST00000534260H0YDL5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Golgi Cisternae Pericentriolar Stack ReorganizationREACTOMER-HSA-162658
RAB geranylgeranylationREACTOMER-HSA-8873719

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
215013662011Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2.50
269384412016De Novo Synonymous Mutations in Regulatory Elements Contribute to the Genetic Etiology of Autism and Schizophrenia.41
258182972015The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.34
177168662007Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases.33
181872312008ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells.24
284839152017Rab2 promotes autophagic and endocytic lysosomal degradation.22
145708762003Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation.20
272550862016RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs.19
203089912011Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders.14
203089912011Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders.14

Citation

Dessen P

RAB2A (RAB2A, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41964/rab2a