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RAB38 (RAB38, member RAS oncogene family)

Identity

Alias_symbol (synonym)NY-MEL-1
Other aliasrrGTPbp
HGNC (Hugo) RAB38
LocusID (NCBI) 23682
Atlas_Id 41986
Location 11q14.2  [Link to chromosome band 11q14]
Location_base_pair Starts at 88113247 and ends at 88175467 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CTSC (11q14.2) / RAB38 (11q14.2)RAB38 (11q14.2) / CA10 (17q21.33)RAB38 11q14.2 / CA10 17q21.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias TL_t1111q14q14ID2638

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]

Solid Tumors TT_t1111q14q14ID100789 TT_t1111q14q14ID100790 TT_t1111q14q14ID100791 TT_t1111q14q14ID100792 TT_t1111q14q14ID100793
TT_t1117q14q22ID100998

External links

Nomenclature
HGNC (Hugo)RAB38   9776
Cards
Entrez_Gene (NCBI)RAB38  23682  RAB38, member RAS oncogene family
AliasesNY-MEL-1; rrGTPbp
GeneCards (Weizmann)RAB38
Ensembl hg19 (Hinxton)ENSG00000123892 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000123892 [Gene_View]  ENSG00000123892 [Sequence]  chr11:88113247-88175467 [Contig_View]  RAB38 [Vega]
ICGC DataPortalENSG00000123892
TCGA cBioPortalRAB38
AceView (NCBI)RAB38
Genatlas (Paris)RAB38
WikiGenes23682
SOURCE (Princeton)RAB38
Genetics Home Reference (NIH)RAB38
Genomic and cartography
GoldenPath hg38 (UCSC)RAB38  -     chr11:88113247-88175467 -  11q14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAB38  -     11q14.2   [Description]    (hg19-Feb_2009)
GoldenPathRAB38 - 11q14.2 [CytoView hg19]  RAB38 - 11q14.2 [CytoView hg38]
ImmunoBaseENSG00000123892
Mapping of homologs : NCBIRAB38 [Mapview hg19]  RAB38 [Mapview hg38]
OMIM606281   
Gene and transcription
Genbank (Entrez)AF136172 AF235022 AL546159 BC015808 BT009842
RefSeq transcript (Entrez)NM_022337
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RAB38
Cluster EST : UnigeneHs.591975 [ NCBI ]
CGAP (NCI)Hs.591975
Alternative Splicing GalleryENSG00000123892
Gene ExpressionRAB38 [ NCBI-GEO ]   RAB38 [ EBI - ARRAY_EXPRESS ]   RAB38 [ SEEK ]   RAB38 [ MEM ]
Gene Expression Viewer (FireBrowse)RAB38 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23682
GTEX Portal (Tissue expression)RAB38
Human Protein AtlasENSG00000123892-RAB38 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57729   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57729  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57729
Splice isoforms : SwissVarP57729
PhosPhoSitePlusP57729
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Rab29/Rab38/Rab32    Small_GTP-bd_dom    Small_GTPase   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)RAB38
DMDM Disease mutations23682
Blocks (Seattle)RAB38
SuperfamilyP57729
Human Protein Atlas [tissue]ENSG00000123892-RAB38 [tissue]
Peptide AtlasP57729
HPRD05889
IPIIPI00939888   IPI00983172   IPI00977387   
Protein Interaction databases
DIP (DOE-UCLA)P57729
IntAct (EBI)P57729
FunCoupENSG00000123892
BioGRIDRAB38
STRING (EMBL)RAB38
ZODIACRAB38
Ontologies - Pathways
QuickGOP57729
Ontology : AmiGOGTPase activity  GTPase activity  protein binding  GTP binding  mitochondrion  lysosome  early endosome  endoplasmic reticulum  trans-Golgi network  cytosol  plasma membrane  intracellular protein transport  mitochondrion organization  small GTPase mediated signal transduction  protein transport  membrane  vesicle-mediated transport  phagocytic vesicle membrane  GTP-dependent protein binding  early endosome lumen  Rab protein signal transduction  melanosome membrane  melanosome membrane  AP-2 adaptor complex binding  endosome to melanosome transport  AP-1 adaptor complex binding  AP-3 adaptor complex binding  BLOC-2 complex binding  melanosome  melanosome  post-translational protein modification  Mitochondria-associated ER Membrane  phagocytic vesicle  platelet dense granule organization  protein localization to membrane  phagosome acidification  melanosome assembly  melanosome assembly  positive regulation of phosphatidylcholine biosynthetic process  
Ontology : EGO-EBIGTPase activity  GTPase activity  protein binding  GTP binding  mitochondrion  lysosome  early endosome  endoplasmic reticulum  trans-Golgi network  cytosol  plasma membrane  intracellular protein transport  mitochondrion organization  small GTPase mediated signal transduction  protein transport  membrane  vesicle-mediated transport  phagocytic vesicle membrane  GTP-dependent protein binding  early endosome lumen  Rab protein signal transduction  melanosome membrane  melanosome membrane  AP-2 adaptor complex binding  endosome to melanosome transport  AP-1 adaptor complex binding  AP-3 adaptor complex binding  BLOC-2 complex binding  melanosome  melanosome  post-translational protein modification  Mitochondria-associated ER Membrane  phagocytic vesicle  platelet dense granule organization  protein localization to membrane  phagosome acidification  melanosome assembly  melanosome assembly  positive regulation of phosphatidylcholine biosynthetic process  
NDEx NetworkRAB38
Atlas of Cancer Signalling NetworkRAB38
Wikipedia pathwaysRAB38
Orthology - Evolution
OrthoDB23682
GeneTree (enSembl)ENSG00000123892
Phylogenetic Trees/Animal Genes : TreeFamRAB38
HOGENOMP57729
Homologs : HomoloGeneRAB38
Homology/Alignments : Family Browser (UCSC)RAB38
Gene fusions - Rearrangements
Fusion : MitelmanCTSC/RAB38 [11q14.2/11q14.2]  [t(11;11)(q14;q14)]  
Fusion : MitelmanRAB38/CA10 [11q14.2/17q21.33]  [t(11;17)(q14;q22)]  
Fusion PortalRAB38 11q14.2 CA10 17q21.33 BRCA
Fusion : QuiverRAB38
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAB38 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAB38
dbVarRAB38
ClinVarRAB38
1000_GenomesRAB38 
Exome Variant ServerRAB38
ExAC (Exome Aggregation Consortium)ENSG00000123892
GNOMAD BrowserENSG00000123892
Varsome BrowserRAB38
Genetic variants : HAPMAP23682
Genomic Variants (DGV)RAB38 [DGVbeta]
DECIPHERRAB38 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAB38 
Mutations
ICGC Data PortalRAB38 
TCGA Data PortalRAB38 
Broad Tumor PortalRAB38
OASIS PortalRAB38 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAB38  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRAB38
Mutations and Diseases : HGMDRAB38
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAB38
DgiDB (Drug Gene Interaction Database)RAB38
DoCM (Curated mutations)RAB38 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAB38 (select a term)
intoGenRAB38
Cancer3DRAB38(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606281   
Orphanet
DisGeNETRAB38
MedgenRAB38
Genetic Testing Registry RAB38
NextProtP57729 [Medical]
TSGene23682
GENETestsRAB38
Target ValidationRAB38
Huge Navigator RAB38 [HugePedia]
snp3D : Map Gene to Disease23682
BioCentury BCIQRAB38
ClinGenRAB38
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23682
Chemical/Pharm GKB GenePA34129
Clinical trialRAB38
Miscellaneous
canSAR (ICR)RAB38 (select the gene name)
DataMed IndexRAB38
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAB38
EVEXRAB38
GoPubMedRAB38
iHOPRAB38
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jan 27 15:02:18 CET 2020
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