RAB3IP (RAB3A interacting protein)

2007-02-01 Affiliation

Identity

HGNC

RAB3IP

LOCATION

12q15

LOCUSID

117177

ALIAS

RABIN3,RABIN8

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 117177
MIM: 608686
HGNC: 16508
Ensembl: ENSG00000127328

Variants:

dbSNP: 117177
ClinVar: 117177
TCGA: ENSG00000127328
COSMIC: RAB3IP

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000127328	ENST00000247833	Q96QF0
ENSG00000127328	ENST00000362025	Q96QF0
ENSG00000127328	ENST00000378809	J3KPG1
ENSG00000127328	ENST00000378815	Q96QF0
ENSG00000127328	ENST00000417413	Q96QF0
ENSG00000127328	ENST00000483530	Q96QF0
ENSG00000127328	ENST00000526994	H0YD03
ENSG00000127328	ENST00000547055	H0YI66
ENSG00000127328	ENST00000547591	H0YHP4
ENSG00000127328	ENST00000549760	F8VNX9
ENSG00000127328	ENST00000550536	Q96QF0
ENSG00000127328	ENST00000550647	H0YI02
ENSG00000127328	ENST00000550847	F8VTR6
ENSG00000127328	ENST00000551641	Q96QF0
ENSG00000127328	ENST00000552199	Q96QF0
ENSG00000127328	ENST00000553099	Q96QF0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Organelle biogenesis and maintenance	REACTOME	R-HSA-1852241
Cilium Assembly	REACTOME	R-HSA-5617833
Anchoring of the basal body to the plasma membrane	REACTOME	R-HSA-5620912
Cargo trafficking to the periciliary membrane	REACTOME	R-HSA-5620920
VxPx cargo-targeting to cilium	REACTOME	R-HSA-5620916
BBSome-mediated cargo-targeting to cilium	REACTOME	R-HSA-5620922
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
RAB GEFs exchange GTP for GDP on RABs	REACTOME	R-HSA-8876198

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
12007189	2002	The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP.	22
25673879	2015	The Arf and Rab11 effector FIP3 acts synergistically with ASAP1 to direct Rabin8 in ciliary receptor targeting.	22
26258637	2015	Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11.	21
25535387	2015	Activation of Rab8 guanine nucleotide exchange factor Rabin8 by ERK1/2 in response to EGF signaling.	18
25787272	2015	Rabin8 suppresses autophagosome formation independently of its guanine nucleotide-exchange activity towards Rab8.	2
30005870	2018	Rab3IP interacts with SSX2 and enhances the invasiveness of gastric cancer cells.	1
29318657	2018	Crystal structure of tetrameric human Rabin8 GEF domain.	0
31467083	2019	The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis.	0

Citation

Dessen P

RAB3IP (RAB3A interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43670/rab3ip