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RAB4A (RAB4A, member RAS oncogene family)

Identity

Alias_namesRAB4
Alias_symbol (synonym)HRES-1/RAB4
Other aliasHRES-1
HRES1
HGNC (Hugo) RAB4A
LocusID (NCBI) 5867
Atlas_Id 41999
Location 1q42.13  [Link to chromosome band 1q42]
Location_base_pair Starts at 229271062 and ends at 229305893 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NPM1 (5q35.1) / RAB4A (1q42.13)RAB4A (1q42.13) / RMI2 (16p13.13)RAB4A (1q42.13) / SNRPB (20p13)
RAB4A (1q42.13) / WDR47 (1p13.3)NPM1 5q35.1 / RAB4A 1q42.13RAB4A 1q42.13 / SNRPB 20p13
RAB4A 1q42.13 / WDR47 1p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RAB4A   9781
Cards
Entrez_Gene (NCBI)RAB4A  5867  RAB4A, member RAS oncogene family
AliasesHRES-1; HRES-1/RAB4; HRES1; RAB4
GeneCards (Weizmann)RAB4A
Ensembl hg19 (Hinxton)ENSG00000168118 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168118 [Gene_View]  chr1:229271062-229305893 [Contig_View]  RAB4A [Vega]
ICGC DataPortalENSG00000168118
TCGA cBioPortalRAB4A
AceView (NCBI)RAB4A
Genatlas (Paris)RAB4A
WikiGenes5867
SOURCE (Princeton)RAB4A
Genetics Home Reference (NIH)RAB4A
Genomic and cartography
GoldenPath hg38 (UCSC)RAB4A  -     chr1:229271062-229305893 +  1q42.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAB4A  -     1q42.13   [Description]    (hg19-Feb_2009)
EnsemblRAB4A - 1q42.13 [CytoView hg19]  RAB4A - 1q42.13 [CytoView hg38]
Mapping of homologs : NCBIRAB4A [Mapview hg19]  RAB4A [Mapview hg38]
OMIM179511   
Gene and transcription
Genbank (Entrez)AF498934 AK223009 AK313807 AM392940 AM393585
RefSeq transcript (Entrez)NM_001271998 NM_004578
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RAB4A
Cluster EST : UnigeneHs.296169 [ NCBI ]
CGAP (NCI)Hs.296169
Alternative Splicing GalleryENSG00000168118
Gene ExpressionRAB4A [ NCBI-GEO ]   RAB4A [ EBI - ARRAY_EXPRESS ]   RAB4A [ SEEK ]   RAB4A [ MEM ]
Gene Expression Viewer (FireBrowse)RAB4A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5867
GTEX Portal (Tissue expression)RAB4A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20338   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20338  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20338
Splice isoforms : SwissVarP20338
PhosPhoSitePlusP20338
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)RAB4A
DMDM Disease mutations5867
Blocks (Seattle)RAB4A
PDB (SRS)1YU9    1Z0K    2BMD    2BME   
PDB (PDBSum)1YU9    1Z0K    2BMD    2BME   
PDB (IMB)1YU9    1Z0K    2BMD    2BME   
PDB (RSDB)1YU9    1Z0K    2BMD    2BME   
Structural Biology KnowledgeBase1YU9    1Z0K    2BMD    2BME   
SCOP (Structural Classification of Proteins)1YU9    1Z0K    2BMD    2BME   
CATH (Classification of proteins structures)1YU9    1Z0K    2BMD    2BME   
SuperfamilyP20338
Human Protein AtlasENSG00000168118
Peptide AtlasP20338
HPRD01541
IPIIPI00480056   
Protein Interaction databases
DIP (DOE-UCLA)P20338
IntAct (EBI)P20338
FunCoupENSG00000168118
BioGRIDRAB4A
STRING (EMBL)RAB4A
ZODIACRAB4A
Ontologies - Pathways
QuickGOP20338
Ontology : AmiGOATPase activator activity  GTPase activity  GTPase activity  protein binding  GTP binding  endosome  cytosol  plasma membrane  phosphatidylinositol biosynthetic process  protein transporter activity  protein transport  GDP binding  antigen processing and presentation  syntaxin binding  regulation of endocytosis  cytoplasmic vesicle membrane  early endosome membrane  vesicle  Rab protein signal transduction  insulin-responsive compartment  positive regulation of ATPase activity  ionotropic glutamate receptor binding  intracellular membrane-bounded organelle  perinuclear region of cytoplasm  ATPase binding  membrane organization  extracellular exosome  postsynaptic recycling endosome  
Ontology : EGO-EBIATPase activator activity  GTPase activity  GTPase activity  protein binding  GTP binding  endosome  cytosol  plasma membrane  phosphatidylinositol biosynthetic process  protein transporter activity  protein transport  GDP binding  antigen processing and presentation  syntaxin binding  regulation of endocytosis  cytoplasmic vesicle membrane  early endosome membrane  vesicle  Rab protein signal transduction  insulin-responsive compartment  positive regulation of ATPase activity  ionotropic glutamate receptor binding  intracellular membrane-bounded organelle  perinuclear region of cytoplasm  ATPase binding  membrane organization  extracellular exosome  postsynaptic recycling endosome  
Pathways : BIOCARTARab GTPases Mark Targets In The Endocytotic Machinery [Genes]   
Pathways : KEGGEndocytosis   
NDEx NetworkRAB4A
Atlas of Cancer Signalling NetworkRAB4A
Wikipedia pathwaysRAB4A
Orthology - Evolution
OrthoDB5867
GeneTree (enSembl)ENSG00000168118
Phylogenetic Trees/Animal Genes : TreeFamRAB4A
HOVERGENP20338
HOGENOMP20338
Homologs : HomoloGeneRAB4A
Homology/Alignments : Family Browser (UCSC)RAB4A
Gene fusions - Rearrangements
Fusion : MitelmanNPM1/RAB4A [5q35.1/1q42.13]  [t(1;5)(q42;q35)]  
Fusion : MitelmanRAB4A/SNRPB [1q42.13/20p13]  [t(1;20)(q42;p13)]  
Fusion : MitelmanRAB4A/WDR47 [1q42.13/1p13.3]  [t(1;1)(p13;q42)]  
Fusion: TCGANPM1 5q35.1 RAB4A 1q42.13 BRCA
Fusion: TCGARAB4A 1q42.13 SNRPB 20p13 BLCA
Fusion: TCGARAB4A 1q42.13 WDR47 1p13.3 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAB4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAB4A
dbVarRAB4A
ClinVarRAB4A
1000_GenomesRAB4A 
Exome Variant ServerRAB4A
ExAC (Exome Aggregation Consortium)RAB4A (select the gene name)
Genetic variants : HAPMAP5867
Genomic Variants (DGV)RAB4A [DGVbeta]
DECIPHERRAB4A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAB4A 
Mutations
ICGC Data PortalRAB4A 
TCGA Data PortalRAB4A 
Broad Tumor PortalRAB4A
OASIS PortalRAB4A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAB4A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAB4A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAB4A
DgiDB (Drug Gene Interaction Database)RAB4A
DoCM (Curated mutations)RAB4A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAB4A (select a term)
intoGenRAB4A
Cancer3DRAB4A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM179511   
Orphanet
MedgenRAB4A
Genetic Testing Registry RAB4A
NextProtP20338 [Medical]
TSGene5867
GENETestsRAB4A
Target ValidationRAB4A
Huge Navigator RAB4A [HugePedia]
snp3D : Map Gene to Disease5867
BioCentury BCIQRAB4A
ClinGenRAB4A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5867
Chemical/Pharm GKB GenePA34141
Clinical trialRAB4A
Miscellaneous
canSAR (ICR)RAB4A (select the gene name)
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAB4A
EVEXRAB4A
GoPubMedRAB4A
iHOPRAB4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:12:22 CEST 2017

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