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RAB4B (RAB4B, member RAS oncogene family)

Identity

Alias_symbol (synonym)FLJ78649
MGC52123
Other alias-
HGNC (Hugo) RAB4B
LocusID (NCBI) 53916
Atlas_Id 42000
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 40778219 and ends at 40796944 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LMNA (1q22) / RAB4B (19q13.2)LMNA 1q22 / RAB4B 19q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;19)(q22;q13) LMNA/RAB4B


External links

Nomenclature
HGNC (Hugo)RAB4B   9782
Cards
Entrez_Gene (NCBI)RAB4B  53916  RAB4B, member RAS oncogene family
Aliases
GeneCards (Weizmann)RAB4B
Ensembl hg19 (Hinxton)ENSG00000167578 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167578 [Gene_View]  ENSG00000167578 [Sequence]  chr19:40778219-40796944 [Contig_View]  RAB4B [Vega]
ICGC DataPortalENSG00000167578
TCGA cBioPortalRAB4B
AceView (NCBI)RAB4B
Genatlas (Paris)RAB4B
WikiGenes53916
SOURCE (Princeton)RAB4B
Genetics Home Reference (NIH)RAB4B
Genomic and cartography
GoldenPath hg38 (UCSC)RAB4B  -     chr19:40778219-40796944 +  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAB4B  -     19q13.2   [Description]    (hg19-Feb_2009)
RAB4B - 19q13.2 [CytoView hg19]  RAB4B - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIRAB4B [Mapview hg19]  RAB4B [Mapview hg38]
OMIM612945   
Gene and transcription
Genbank (Entrez)AF165522 AF217985 AF498935 AI083750 AK024845
RefSeq transcript (Entrez)NM_016154
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RAB4B
Cluster EST : UnigeneHs.730737 [ NCBI ]
CGAP (NCI)Hs.730737
Alternative Splicing GalleryENSG00000167578
Gene ExpressionRAB4B [ NCBI-GEO ]   RAB4B [ EBI - ARRAY_EXPRESS ]   RAB4B [ SEEK ]   RAB4B [ MEM ]
Gene Expression Viewer (FireBrowse)RAB4B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)53916
GTEX Portal (Tissue expression)RAB4B
Human Protein AtlasENSG00000167578-RAB4B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61018   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61018  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61018
Splice isoforms : SwissVarP61018
PhosPhoSitePlusP61018
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)RAB4B
DMDM Disease mutations53916
Blocks (Seattle)RAB4B
PDB (RSDB)2O52   
PDB Europe2O52   
PDB (PDBSum)2O52   
PDB (IMB)2O52   
Structural Biology KnowledgeBase2O52   
SCOP (Structural Classification of Proteins)2O52   
CATH (Classification of proteins structures)2O52   
SuperfamilyP61018
Human Protein Atlas [tissue]ENSG00000167578-RAB4B [tissue]
Peptide AtlasP61018
HPRD11473
IPIIPI00477489   IPI00448725   
Protein Interaction databases
DIP (DOE-UCLA)P61018
IntAct (EBI)P61018
FunCoupENSG00000167578
BioGRIDRAB4B
STRING (EMBL)RAB4B
ZODIACRAB4B
Ontologies - Pathways
QuickGOP61018
Ontology : AmiGOmolecular_function  GTPase activity  protein binding  GTP binding  endosome  plasma membrane  intracellular protein transport  regulation of endocytosis  secretory granule membrane  Rab protein signal transduction  insulin-responsive compartment  insulin-responsive compartment  neutrophil degranulation  glucose import  perinuclear region of cytoplasm  recycling endosome  
Ontology : EGO-EBImolecular_function  GTPase activity  protein binding  GTP binding  endosome  plasma membrane  intracellular protein transport  regulation of endocytosis  secretory granule membrane  Rab protein signal transduction  insulin-responsive compartment  insulin-responsive compartment  neutrophil degranulation  glucose import  perinuclear region of cytoplasm  recycling endosome  
NDEx NetworkRAB4B
Atlas of Cancer Signalling NetworkRAB4B
Wikipedia pathwaysRAB4B
Orthology - Evolution
OrthoDB53916
GeneTree (enSembl)ENSG00000167578
Phylogenetic Trees/Animal Genes : TreeFamRAB4B
HOGENOMP61018
Homologs : HomoloGeneRAB4B
Homology/Alignments : Family Browser (UCSC)RAB4B
Gene fusions - Rearrangements
Fusion : MitelmanLMNA/RAB4B [1q22/19q13.2]  [t(1;19)(q22;q13)]  
Fusion PortalLMNA 1q22 RAB4B 19q13.2 SKCM
Fusion : QuiverRAB4B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAB4B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAB4B
dbVarRAB4B
ClinVarRAB4B
1000_GenomesRAB4B 
Exome Variant ServerRAB4B
ExAC (Exome Aggregation Consortium)ENSG00000167578
GNOMAD BrowserENSG00000167578
Varsome BrowserRAB4B
Genetic variants : HAPMAP53916
Genomic Variants (DGV)RAB4B [DGVbeta]
DECIPHERRAB4B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAB4B 
Mutations
ICGC Data PortalRAB4B 
TCGA Data PortalRAB4B 
Broad Tumor PortalRAB4B
OASIS PortalRAB4B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAB4B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAB4B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch RAB4B
DgiDB (Drug Gene Interaction Database)RAB4B
DoCM (Curated mutations)RAB4B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAB4B (select a term)
intoGenRAB4B
Cancer3DRAB4B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612945   
Orphanet
DisGeNETRAB4B
MedgenRAB4B
Genetic Testing Registry RAB4B
NextProtP61018 [Medical]
TSGene53916
GENETestsRAB4B
Target ValidationRAB4B
Huge Navigator RAB4B [HugePedia]
snp3D : Map Gene to Disease53916
BioCentury BCIQRAB4B
ClinGenRAB4B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD53916
Chemical/Pharm GKB GenePA34142
Clinical trialRAB4B
Miscellaneous
canSAR (ICR)RAB4B (select the gene name)
DataMed IndexRAB4B
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAB4B
EVEXRAB4B
GoPubMedRAB4B
iHOPRAB4B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu May 2 13:07:01 CEST 2019

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