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RAB5B (RAB5B, member RAS oncogene family)

Identity

Other alias-
HGNC (Hugo) RAB5B
LocusID (NCBI) 5869
Atlas_Id 42002
Location 12q13.2  [Link to chromosome band 12q13]
Location_base_pair Starts at 55973913 and ends at 55996683 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DCAF5 (14q24.1) / RAB5B (12q13.2)GPR108 (19p13.3) / RAB5B (12q13.2)MALAT1 (11q13.1) / RAB5B (12q13.2)
PLXNA2 (1q32.2) / RAB5B (12q13.2)RAB5B (12q13.2) / CCNL1 (3q25.31)RAB5B (12q13.2) / CDH23 (10q22.1)
RAB5B (12q13.2) / RAB5B (12q13.2)RAB5B (12q13.2) / SRRM2 (16p13.3)ZC3H7B (22q13.2) / RAB5B (12q13.2)
DCAF5 14q24.1 / RAB5B 12q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RAB5B   9784
Cards
Entrez_Gene (NCBI)RAB5B  5869  RAB5B, member RAS oncogene family
Aliases
GeneCards (Weizmann)RAB5B
Ensembl hg19 (Hinxton)ENSG00000111540 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111540 [Gene_View]  chr12:55973913-55996683 [Contig_View]  RAB5B [Vega]
ICGC DataPortalENSG00000111540
TCGA cBioPortalRAB5B
AceView (NCBI)RAB5B
Genatlas (Paris)RAB5B
WikiGenes5869
SOURCE (Princeton)RAB5B
Genetics Home Reference (NIH)RAB5B
Genomic and cartography
GoldenPath hg38 (UCSC)RAB5B  -     chr12:55973913-55996683 +  12q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAB5B  -     12q13.2   [Description]    (hg19-Feb_2009)
EnsemblRAB5B - 12q13.2 [CytoView hg19]  RAB5B - 12q13.2 [CytoView hg38]
Mapping of homologs : NCBIRAB5B [Mapview hg19]  RAB5B [Mapview hg38]
OMIM179514   
Gene and transcription
Genbank (Entrez)AF267863 AF498937 AK292597 AK296517 AK307468
RefSeq transcript (Entrez)NM_001252036 NM_001252037 NM_002868
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RAB5B
Cluster EST : UnigeneHs.157659 [ NCBI ]
CGAP (NCI)Hs.157659
Alternative Splicing GalleryENSG00000111540
Gene ExpressionRAB5B [ NCBI-GEO ]   RAB5B [ EBI - ARRAY_EXPRESS ]   RAB5B [ SEEK ]   RAB5B [ MEM ]
Gene Expression Viewer (FireBrowse)RAB5B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5869
GTEX Portal (Tissue expression)RAB5B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61020   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61020  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61020
Splice isoforms : SwissVarP61020
PhosPhoSitePlusP61020
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)RAB5B
DMDM Disease mutations5869
Blocks (Seattle)RAB5B
PDB (SRS)2HEI   
PDB (PDBSum)2HEI   
PDB (IMB)2HEI   
PDB (RSDB)2HEI   
Structural Biology KnowledgeBase2HEI   
SCOP (Structural Classification of Proteins)2HEI   
CATH (Classification of proteins structures)2HEI   
SuperfamilyP61020
Human Protein AtlasENSG00000111540
Peptide AtlasP61020
HPRD01544
IPIIPI00017344   IPI00908835   IPI00022858   IPI01021826   IPI01021993   IPI01022148   IPI01021040   IPI01021338   
Protein Interaction databases
DIP (DOE-UCLA)P61020
IntAct (EBI)P61020
FunCoupENSG00000111540
BioGRIDRAB5B
STRING (EMBL)RAB5B
ZODIACRAB5B
Ontologies - Pathways
QuickGOP61020
Ontology : AmiGOGTPase activity  protein binding  GTP binding  intracellular  endosome  early endosome  plasma membrane  plasma membrane  endosome organization  protein transport  membrane  GDP binding  antigen processing and presentation  regulation of endocytosis  endocytic vesicle  secretory granule membrane  GTP-dependent protein binding  early endosome membrane  melanosome  intracellular membrane-bounded organelle  neutrophil degranulation  plasma membrane to endosome transport  membrane organization  extracellular exosome  
Ontology : EGO-EBIGTPase activity  protein binding  GTP binding  intracellular  endosome  early endosome  plasma membrane  plasma membrane  endosome organization  protein transport  membrane  GDP binding  antigen processing and presentation  regulation of endocytosis  endocytic vesicle  secretory granule membrane  GTP-dependent protein binding  early endosome membrane  melanosome  intracellular membrane-bounded organelle  neutrophil degranulation  plasma membrane to endosome transport  membrane organization  extracellular exosome  
Pathways : KEGGRas signaling pathway    Endocytosis    Phagosome    Vasopressin-regulated water reabsorption    Amoebiasis    Tuberculosis   
NDEx NetworkRAB5B
Atlas of Cancer Signalling NetworkRAB5B
Wikipedia pathwaysRAB5B
Orthology - Evolution
OrthoDB5869
GeneTree (enSembl)ENSG00000111540
Phylogenetic Trees/Animal Genes : TreeFamRAB5B
HOVERGENP61020
HOGENOMP61020
Homologs : HomoloGeneRAB5B
Homology/Alignments : Family Browser (UCSC)RAB5B
Gene fusions - Rearrangements
Fusion : MitelmanDCAF5/RAB5B [14q24.1/12q13.2]  [t(12;14)(q13;q24)]  
Fusion: TCGADCAF5 14q24.1 RAB5B 12q13.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAB5B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAB5B
dbVarRAB5B
ClinVarRAB5B
1000_GenomesRAB5B 
Exome Variant ServerRAB5B
ExAC (Exome Aggregation Consortium)RAB5B (select the gene name)
Genetic variants : HAPMAP5869
Genomic Variants (DGV)RAB5B [DGVbeta]
DECIPHERRAB5B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAB5B 
Mutations
ICGC Data PortalRAB5B 
TCGA Data PortalRAB5B 
Broad Tumor PortalRAB5B
OASIS PortalRAB5B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAB5B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAB5B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAB5B
DgiDB (Drug Gene Interaction Database)RAB5B
DoCM (Curated mutations)RAB5B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAB5B (select a term)
intoGenRAB5B
Cancer3DRAB5B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM179514   
Orphanet
MedgenRAB5B
Genetic Testing Registry RAB5B
NextProtP61020 [Medical]
TSGene5869
GENETestsRAB5B
Huge Navigator RAB5B [HugePedia]
snp3D : Map Gene to Disease5869
BioCentury BCIQRAB5B
ClinGenRAB5B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5869
Chemical/Pharm GKB GenePA34144
Clinical trialRAB5B
Miscellaneous
canSAR (ICR)RAB5B (select the gene name)
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAB5B
EVEXRAB5B
GoPubMedRAB5B
iHOPRAB5B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:33:56 CEST 2017

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