RAB5B (RAB5B, member RAS oncogene family)

2003-02-01  

Identity

HGNC
LOCATION
12q13.2
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 5869
MIM: 179514
HGNC: 9784
Ensembl: ENSG00000111540

Variants:

dbSNP: 5869
ClinVar: 5869
TCGA: ENSG00000111540
COSMIC: RAB5B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111540ENST00000360299P61020
ENSG00000111540ENST00000360299A0A024RB09
ENSG00000111540ENST00000548068F8VUA5
ENSG00000111540ENST00000549505F8VPW9
ENSG00000111540ENST00000549915F8VWZ7
ENSG00000111540ENST00000551459F8VVZ0
ENSG00000111540ENST00000553116P61020
ENSG00000111540ENST00000553116A0A024RB09
ENSG00000111540ENST00000628569F8VPW9

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Vasopressin-regulated water reabsorptionKEGGko04962
Vasopressin-regulated water reabsorptionKEGGhsa04962
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Ras signaling pathwayKEGGhsa04014
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Neutrophil degranulationREACTOMER-HSA-6798695
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198
TBC/RABGAPsREACTOMER-HSA-8854214
RAB geranylgeranylationREACTOMER-HSA-8873719

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
184454952008LRRK2 regulates synaptic vesicle endocytosis.145
197236332009Rab5 isoforms differentially regulate the trafficking and degradation of epidermal growth factor receptors.44
256057582015An early endosome regulator, Rab5b, is an LRRK2 kinase substrate.29
205263402010Common variants in FOXP1 are associated with generalized vitiligo.27
241062822013Cross-ethnic meta-analysis of genetic variants for polycystic ovary syndrome.27
179279602007A role for Rab5 activity in the biogenesis of endosomal and lysosomal compartments.21
297468652018MiR-130a-3p inhibits migration and invasion by regulating RAB5B in human breast cancer stem cell-like cells.12
311182602019Small Interfering RNA Screening for the Small GTPase Rab Proteins Identifies Rab5B as a Major Regulator of Hepatitis B Virus Production.3

Citation

Dessen P

RAB5B (RAB5B, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42002/rab5b