Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RAB5C (RAB5C, member RAS oncogene family)

Identity

Alias_namesRABL
Alias_symbol (synonym)RAB5CL
Other aliasL1880
RAB5L
HGNC (Hugo) RAB5C
LocusID (NCBI) 5878
Atlas_Id 42003
Location 17q21.2  [Link to chromosome band 17q21]
Location_base_pair Starts at 42124976 and ends at 42155044 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DNAJA3 (16p13.3) / RAB5C (17q21.2)PRR15L (17q21.32) / RAB5C (17q21.2)RAB5C (17q21.2) / RAB5C (17q21.2)
PRR15L 17q21.32 / RAB5C 17q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RAB5C   9785
Cards
Entrez_Gene (NCBI)RAB5C  5878  RAB5C, member RAS oncogene family
AliasesL1880; RAB5CL; RAB5L; RABL
GeneCards (Weizmann)RAB5C
Ensembl hg19 (Hinxton)ENSG00000108774 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108774 [Gene_View]  chr17:42124976-42155044 [Contig_View]  RAB5C [Vega]
ICGC DataPortalENSG00000108774
TCGA cBioPortalRAB5C
AceView (NCBI)RAB5C
Genatlas (Paris)RAB5C
WikiGenes5878
SOURCE (Princeton)RAB5C
Genetics Home Reference (NIH)RAB5C
Genomic and cartography
GoldenPath hg38 (UCSC)RAB5C  -     chr17:42124976-42155044 -  17q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAB5C  -     17q21.2   [Description]    (hg19-Feb_2009)
EnsemblRAB5C - 17q21.2 [CytoView hg19]  RAB5C - 17q21.2 [CytoView hg38]
Mapping of homologs : NCBIRAB5C [Mapview hg19]  RAB5C [Mapview hg38]
OMIM604037   
Gene and transcription
Genbank (Entrez)AF141304 AF498938 AK310234 AL553867 BC106039
RefSeq transcript (Entrez)NM_001252039 NM_004583 NM_201434
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RAB5C
Cluster EST : UnigeneHs.650382 [ NCBI ]
CGAP (NCI)Hs.650382
Alternative Splicing GalleryENSG00000108774
Gene ExpressionRAB5C [ NCBI-GEO ]   RAB5C [ EBI - ARRAY_EXPRESS ]   RAB5C [ SEEK ]   RAB5C [ MEM ]
Gene Expression Viewer (FireBrowse)RAB5C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5878
GTEX Portal (Tissue expression)RAB5C
Human Protein AtlasENSG00000108774-RAB5C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51148   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51148  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51148
Splice isoforms : SwissVarP51148
PhosPhoSitePlusP51148
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)RAB5C
DMDM Disease mutations5878
Blocks (Seattle)RAB5C
PDB (SRS)4KYI   
PDB (PDBSum)4KYI   
PDB (IMB)4KYI   
PDB (RSDB)4KYI   
Structural Biology KnowledgeBase4KYI   
SCOP (Structural Classification of Proteins)4KYI   
CATH (Classification of proteins structures)4KYI   
SuperfamilyP51148
Human Protein Atlas [tissue]ENSG00000108774-RAB5C [tissue]
Peptide AtlasP51148
HPRD04947
IPIIPI00016339   IPI01021644   IPI01022962   IPI01022484   IPI01022679   
Protein Interaction databases
DIP (DOE-UCLA)P51148
IntAct (EBI)P51148
FunCoupENSG00000108774
BioGRIDRAB5C
STRING (EMBL)RAB5C
ZODIACRAB5C
Ontologies - Pathways
QuickGOP51148
Ontology : AmiGOGTPase activity  protein binding  GTP binding  lysosomal membrane  early endosome  lipid particle  plasma membrane  plasma membrane  protein transport  GDP binding  regulation of endocytosis  endocytic vesicle  early endosome membrane  azurophil granule membrane  melanosome  neutrophil degranulation  plasma membrane to endosome transport  membrane organization  extracellular exosome  
Ontology : EGO-EBIGTPase activity  protein binding  GTP binding  lysosomal membrane  early endosome  lipid particle  plasma membrane  plasma membrane  protein transport  GDP binding  regulation of endocytosis  endocytic vesicle  early endosome membrane  azurophil granule membrane  melanosome  neutrophil degranulation  plasma membrane to endosome transport  membrane organization  extracellular exosome  
Pathways : KEGGRas signaling pathway    Endocytosis    Phagosome    Vasopressin-regulated water reabsorption    Amoebiasis    Tuberculosis   
NDEx NetworkRAB5C
Atlas of Cancer Signalling NetworkRAB5C
Wikipedia pathwaysRAB5C
Orthology - Evolution
OrthoDB5878
GeneTree (enSembl)ENSG00000108774
Phylogenetic Trees/Animal Genes : TreeFamRAB5C
HOVERGENP51148
HOGENOMP51148
Homologs : HomoloGeneRAB5C
Homology/Alignments : Family Browser (UCSC)RAB5C
Gene fusions - Rearrangements
Fusion : MitelmanPRR15L/RAB5C [17q21.32/17q21.2]  [t(17;17)(q21;q21)]  
Fusion: TCGA_MDACCPRR15L 17q21.32 RAB5C 17q21.2 PRAD
Tumor Fusion PortalRAB5C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAB5C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAB5C
dbVarRAB5C
ClinVarRAB5C
1000_GenomesRAB5C 
Exome Variant ServerRAB5C
ExAC (Exome Aggregation Consortium)ENSG00000108774
GNOMAD BrowserENSG00000108774
Genetic variants : HAPMAP5878
Genomic Variants (DGV)RAB5C [DGVbeta]
DECIPHERRAB5C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAB5C 
Mutations
ICGC Data PortalRAB5C 
TCGA Data PortalRAB5C 
Broad Tumor PortalRAB5C
OASIS PortalRAB5C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAB5C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAB5C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAB5C
DgiDB (Drug Gene Interaction Database)RAB5C
DoCM (Curated mutations)RAB5C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAB5C (select a term)
intoGenRAB5C
Cancer3DRAB5C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604037   
Orphanet
DisGeNETRAB5C
MedgenRAB5C
Genetic Testing Registry RAB5C
NextProtP51148 [Medical]
TSGene5878
GENETestsRAB5C
Target ValidationRAB5C
Huge Navigator RAB5C [HugePedia]
snp3D : Map Gene to Disease5878
BioCentury BCIQRAB5C
ClinGenRAB5C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5878
Chemical/Pharm GKB GenePA34145
Clinical trialRAB5C
Miscellaneous
canSAR (ICR)RAB5C (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAB5C
EVEXRAB5C
GoPubMedRAB5C
iHOPRAB5C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:31:26 CET 2017

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