Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RAB6A (RAB6A, member RAS oncogene family)

Identity

Alias (NCBI)RAB6
HGNC (Hugo) RAB6A
HGNC Previous nameRAB6
LocusID (NCBI) 5870
Atlas_Id 42004
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 73675638 and ends at 73761074 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGEF2 (1q22) / RAB6A (11q13.4)FAM168A (11q13.4) / RAB6A (11q13.4)RAB6A (11q13.4) / MRPL48 (11q13.4)
RAB6A (11q13.4) / RAB6A (11q13.4)RAB6A (11q13.4) / USP43 (17p13.1)SIK2 (11q23.1) / RAB6A (11q13.4)
SLC8A1 (2p22.1) / RAB6A (11q13.4)ZFP91 (11q12.1) / RAB6A (11q13.4)FAM168A 11q13.4 / RAB6A 11q13.4
RAB6A 11q13.4 / MRPL48 11q13.4ZFP91 11q12.1 / RAB6A 11q13.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RAB6A   9786
Cards
Entrez_Gene (NCBI)RAB6A    RAB6A, member RAS oncogene family
AliasesRAB6
GeneCards (Weizmann)RAB6A
Ensembl hg19 (Hinxton)ENSG00000175582 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175582 [Gene_View]  ENSG00000175582 [Sequence]  chr11:73675638-73761074 [Contig_View]  RAB6A [Vega]
ICGC DataPortalENSG00000175582
TCGA cBioPortalRAB6A
AceView (NCBI)RAB6A
Genatlas (Paris)RAB6A
SOURCE (Princeton)RAB6A
Genetics Home Reference (NIH)RAB6A
Genomic and cartography
GoldenPath hg38 (UCSC)RAB6A  -     chr11:73675638-73761074 -  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAB6A  -     11q13.4   [Description]    (hg19-Feb_2009)
GoldenPathRAB6A - 11q13.4 [CytoView hg19]  RAB6A - 11q13.4 [CytoView hg38]
ImmunoBaseENSG00000175582
Genome Data Viewer NCBIRAB6A [Mapview hg19]  
OMIM179513   
Gene and transcription
Genbank (Entrez)AF052130 AF091030 AF119836 AF130122 AF130986
RefSeq transcript (Entrez)NM_001243718 NM_001243719 NM_002869 NM_198896
Consensus coding sequences : CCDS (NCBI)RAB6A
Gene ExpressionRAB6A [ NCBI-GEO ]   RAB6A [ EBI - ARRAY_EXPRESS ]   RAB6A [ SEEK ]   RAB6A [ MEM ]
Gene Expression Viewer (FireBrowse)RAB6A [ Firebrowse - Broad ]
GenevisibleExpression of RAB6A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5870
GTEX Portal (Tissue expression)RAB6A
Human Protein AtlasENSG00000175582-RAB6A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20340   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20340  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20340
PhosPhoSitePlusP20340
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)RAB6A
PDB (RSDB)1YZQ    2GIL    3BBP    3CWZ    4DKX    5LEF   
PDB Europe1YZQ    2GIL    3BBP    3CWZ    4DKX    5LEF   
PDB (PDBSum)1YZQ    2GIL    3BBP    3CWZ    4DKX    5LEF   
PDB (IMB)1YZQ    2GIL    3BBP    3CWZ    4DKX    5LEF   
Structural Biology KnowledgeBase1YZQ    2GIL    3BBP    3CWZ    4DKX    5LEF   
SCOP (Structural Classification of Proteins)1YZQ    2GIL    3BBP    3CWZ    4DKX    5LEF   
CATH (Classification of proteins structures)1YZQ    2GIL    3BBP    3CWZ    4DKX    5LEF   
SuperfamilyP20340
AlphaFold pdb e-kbP20340   
Human Protein Atlas [tissue]ENSG00000175582-RAB6A [tissue]
HPRD01543
Protein Interaction databases
DIP (DOE-UCLA)P20340
IntAct (EBI)P20340
BioGRIDRAB6A
STRING (EMBL)RAB6A
ZODIACRAB6A
Ontologies - Pathways
QuickGOP20340
Ontology : AmiGOGolgi membrane  Golgi membrane  GTPase activity  GTPase activity  protein binding  GTP binding  endoplasmic reticulum membrane  Golgi apparatus  Golgi apparatus  trans-Golgi network  cytosol  cytosol  plasma membrane  intracellular protein transport  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  intra-Golgi vesicle-mediated transport  endomembrane system  membrane  peptidyl-cysteine methylation  antigen processing and presentation  protein domain specific binding  secretory granule membrane  cytoplasmic vesicle  myosin V binding  trans-Golgi network membrane  protein localization to Golgi apparatus  early endosome to Golgi transport  retrograde transport, endosome to Golgi  neutrophil degranulation  extracellular exosome  endosome to plasma membrane transport vesicle  minus-end-directed organelle transport along microtubule  
Ontology : EGO-EBIGolgi membrane  Golgi membrane  GTPase activity  GTPase activity  protein binding  GTP binding  endoplasmic reticulum membrane  Golgi apparatus  Golgi apparatus  trans-Golgi network  cytosol  cytosol  plasma membrane  intracellular protein transport  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  intra-Golgi vesicle-mediated transport  endomembrane system  membrane  peptidyl-cysteine methylation  antigen processing and presentation  protein domain specific binding  secretory granule membrane  cytoplasmic vesicle  myosin V binding  trans-Golgi network membrane  protein localization to Golgi apparatus  early endosome to Golgi transport  retrograde transport, endosome to Golgi  neutrophil degranulation  extracellular exosome  endosome to plasma membrane transport vesicle  minus-end-directed organelle transport along microtubule  
Pathways : BIOCARTARab GTPases Mark Targets In The Endocytotic Machinery [Genes]   
NDEx NetworkRAB6A
Atlas of Cancer Signalling NetworkRAB6A
Wikipedia pathwaysRAB6A
Orthology - Evolution
OrthoDB5870
GeneTree (enSembl)ENSG00000175582
Phylogenetic Trees/Animal Genes : TreeFamRAB6A
Homologs : HomoloGeneRAB6A
Homology/Alignments : Family Browser (UCSC)RAB6A
Gene fusions - Rearrangements
Fusion : MitelmanFAM168A/RAB6A [11q13.4/11q13.4]  
Fusion : MitelmanRAB6A/MRPL48 [11q13.4/11q13.4]  
Fusion : MitelmanRAB6A/USP43 [11q13.4/17p13.1]  
Fusion : MitelmanZFP91/RAB6A [11q12.1/11q13.4]  
Fusion : QuiverRAB6A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAB6A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAB6A
dbVarRAB6A
ClinVarRAB6A
MonarchRAB6A
1000_GenomesRAB6A 
Exome Variant ServerRAB6A
GNOMAD BrowserENSG00000175582
Varsome BrowserRAB6A
ACMGRAB6A variants
VarityP20340
Genomic Variants (DGV)RAB6A [DGVbeta]
DECIPHERRAB6A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAB6A 
Mutations
ICGC Data PortalRAB6A 
TCGA Data PortalRAB6A 
Broad Tumor PortalRAB6A
OASIS PortalRAB6A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAB6A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRAB6A
Mutations and Diseases : HGMDRAB6A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRAB6A
DgiDB (Drug Gene Interaction Database)RAB6A
DoCM (Curated mutations)RAB6A
CIViC (Clinical Interpretations of Variants in Cancer)RAB6A
Cancer3DRAB6A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM179513   
Orphanet
DisGeNETRAB6A
MedgenRAB6A
Genetic Testing Registry RAB6A
NextProtP20340 [Medical]
GENETestsRAB6A
Target ValidationRAB6A
Huge Navigator RAB6A [HugePedia]
ClinGenRAB6A
Clinical trials, drugs, therapy
MyCancerGenomeRAB6A
Protein Interactions : CTDRAB6A
Pharm GKB GenePA34146
PharosP20340
Clinical trialRAB6A
Miscellaneous
canSAR (ICR)RAB6A
HarmonizomeRAB6A
DataMed IndexRAB6A
Probes
Litterature
PubMed128 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRAB6A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:27:57 CEST 2021

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