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RAB6A (RAB6A, member RAS oncogene family)

Identity

Alias_namesRAB6
Other alias
HGNC (Hugo) RAB6A
LocusID (NCBI) 5870
Atlas_Id 42004
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 73386683 and ends at 73472201 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARHGEF2 (1q22) / RAB6A (11q13.4)FAM168A (11q13.4) / RAB6A (11q13.4)RAB6A (11q13.4) / MRPL48 (11q13.4)
RAB6A (11q13.4) / RAB6A (11q13.4)RAB6A (11q13.4) / USP43 (17p13.1)SIK2 (11q23.1) / RAB6A (11q13.4)
SLC8A1 (2p22.1) / RAB6A (11q13.4)ZFP91 (11q12.1) / RAB6A (11q13.4)FAM168A 11q13.4 / RAB6A 11q13.4
RAB6A 11q13.4 / MRPL48 11q13.4ZFP91 11q12.1 / RAB6A 11q13.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RAB6A   9786
Cards
Entrez_Gene (NCBI)RAB6A  5870  RAB6A, member RAS oncogene family
AliasesRAB6
GeneCards (Weizmann)RAB6A
Ensembl hg19 (Hinxton)ENSG00000175582 [Gene_View]  chr11:73386683-73472201 [Contig_View]  RAB6A [Vega]
Ensembl hg38 (Hinxton)ENSG00000175582 [Gene_View]  chr11:73386683-73472201 [Contig_View]  RAB6A [Vega]
ICGC DataPortalENSG00000175582
TCGA cBioPortalRAB6A
AceView (NCBI)RAB6A
Genatlas (Paris)RAB6A
WikiGenes5870
SOURCE (Princeton)RAB6A
Genetics Home Reference (NIH)RAB6A
Genomic and cartography
GoldenPath hg19 (UCSC)RAB6A  -     chr11:73386683-73472201 -  11q13.4   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RAB6A  -     11q13.4   [Description]    (hg38-Dec_2013)
EnsemblRAB6A - 11q13.4 [CytoView hg19]  RAB6A - 11q13.4 [CytoView hg38]
Mapping of homologs : NCBIRAB6A [Mapview hg19]  RAB6A [Mapview hg38]
OMIM179513   
Gene and transcription
Genbank (Entrez)AF052130 AF091030 AF119836 AF130122 AF130986
RefSeq transcript (Entrez)NM_001243718 NM_001243719 NM_002869 NM_198896
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_029821 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)RAB6A
Cluster EST : UnigeneHs.591552 [ NCBI ]
CGAP (NCI)Hs.591552
Alternative Splicing GalleryENSG00000175582
Gene ExpressionRAB6A [ NCBI-GEO ]   RAB6A [ EBI - ARRAY_EXPRESS ]   RAB6A [ SEEK ]   RAB6A [ MEM ]
Gene Expression Viewer (FireBrowse)RAB6A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5870
GTEX Portal (Tissue expression)RAB6A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20340   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20340  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20340
Splice isoforms : SwissVarP20340
PhosPhoSitePlusP20340
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Rab_type   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Domain families : Smart (EMBL)RAB (SM00175)  
Conserved Domain (NCBI)RAB6A
DMDM Disease mutations5870
Blocks (Seattle)RAB6A
PDB (SRS)1YZQ    2GIL    3BBP    3CWZ    4DKX   
PDB (PDBSum)1YZQ    2GIL    3BBP    3CWZ    4DKX   
PDB (IMB)1YZQ    2GIL    3BBP    3CWZ    4DKX   
PDB (RSDB)1YZQ    2GIL    3BBP    3CWZ    4DKX   
Structural Biology KnowledgeBase1YZQ    2GIL    3BBP    3CWZ    4DKX   
SCOP (Structural Classification of Proteins)1YZQ    2GIL    3BBP    3CWZ    4DKX   
CATH (Classification of proteins structures)1YZQ    2GIL    3BBP    3CWZ    4DKX   
SuperfamilyP20340
Human Protein AtlasENSG00000175582
Peptide AtlasP20340
HPRD01543
IPIIPI00023526   IPI00217943   IPI01013015   IPI00883929   IPI01009243   IPI00748927   IPI01012277   IPI01009202   IPI00872108   IPI01011768   IPI01011000   
Protein Interaction databases
DIP (DOE-UCLA)P20340
IntAct (EBI)P20340
FunCoupENSG00000175582
BioGRIDRAB6A
STRING (EMBL)RAB6A
ZODIACRAB6A
Ontologies - Pathways
QuickGOP20340
Ontology : AmiGOprotein targeting to Golgi  Golgi membrane  GTPase activity  protein binding  GTP binding  endoplasmic reticulum membrane  Golgi apparatus  trans-Golgi network  cytosol  cytosol  retrograde vesicle-mediated transport, Golgi to ER  nucleocytoplasmic transport  small GTPase mediated signal transduction  membrane  viral process  peptidyl-cysteine methylation  antigen processing and presentation  protein domain specific binding  cytoplasmic vesicle  myosin V binding  trans-Golgi network membrane  protein localization to Golgi apparatus  early endosome to Golgi transport  extracellular exosome  endosome to plasma membrane transport vesicle  minus-end-directed organelle transport along microtubule  
Ontology : EGO-EBIprotein targeting to Golgi  Golgi membrane  GTPase activity  protein binding  GTP binding  endoplasmic reticulum membrane  Golgi apparatus  trans-Golgi network  cytosol  cytosol  retrograde vesicle-mediated transport, Golgi to ER  nucleocytoplasmic transport  small GTPase mediated signal transduction  membrane  viral process  peptidyl-cysteine methylation  antigen processing and presentation  protein domain specific binding  cytoplasmic vesicle  myosin V binding  trans-Golgi network membrane  protein localization to Golgi apparatus  early endosome to Golgi transport  extracellular exosome  endosome to plasma membrane transport vesicle  minus-end-directed organelle transport along microtubule  
Pathways : BIOCARTARab GTPases Mark Targets In The Endocytotic Machinery [Genes]   
NDEx NetworkRAB6A
Atlas of Cancer Signalling NetworkRAB6A
Wikipedia pathwaysRAB6A
Orthology - Evolution
OrthoDB5870
GeneTree (enSembl)ENSG00000175582
Phylogenetic Trees/Animal Genes : TreeFamRAB6A
HOVERGENP20340
HOGENOMP20340
Homologs : HomoloGeneRAB6A
Homology/Alignments : Family Browser (UCSC)RAB6A
Gene fusions - Rearrangements
Fusion : MitelmanFAM168A/RAB6A [11q13.4/11q13.4]  [t(11;11)(q13;q13)]  
Fusion : MitelmanRAB6A/MRPL48 [11q13.4/11q13.4]  [t(11;11)(q13;q13)]  
Fusion : MitelmanRAB6A/USP43 [11q13.4/17p13.1]  [t(11;17)(q13;p13)]  
Fusion : MitelmanZFP91/RAB6A [11q12.1/11q13.4]  [t(11;11)(q12;q13)]  
Fusion: TCGAFAM168A 11q13.4 RAB6A 11q13.4 LUAD
Fusion: TCGARAB6A 11q13.4 MRPL48 11q13.4 BRCA
Fusion: TCGAZFP91 11q12.1 RAB6A 11q13.4 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAB6A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAB6A
dbVarRAB6A
ClinVarRAB6A
1000_GenomesRAB6A 
Exome Variant ServerRAB6A
ExAC (Exome Aggregation Consortium)RAB6A (select the gene name)
Genetic variants : HAPMAP5870
Genomic Variants (DGV)RAB6A [DGVbeta]
DECIPHER (Syndromes)11:73386683-73472201  ENSG00000175582
CONAN: Copy Number AnalysisRAB6A 
Mutations
ICGC Data PortalRAB6A 
TCGA Data PortalRAB6A 
Broad Tumor PortalRAB6A
OASIS PortalRAB6A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAB6A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAB6A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAB6A
DgiDB (Drug Gene Interaction Database)RAB6A
DoCM (Curated mutations)RAB6A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAB6A (select a term)
intoGenRAB6A
Cancer3DRAB6A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM179513   
Orphanet
MedgenRAB6A
Genetic Testing Registry RAB6A
NextProtP20340 [Medical]
TSGene5870
GENETestsRAB6A
Huge Navigator RAB6A [HugePedia]
snp3D : Map Gene to Disease5870
BioCentury BCIQRAB6A
ClinGenRAB6A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5870
Chemical/Pharm GKB GenePA34146
Clinical trialRAB6A
Miscellaneous
canSAR (ICR)RAB6A (select the gene name)
Probes
Litterature
PubMed91 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAB6A
EVEXRAB6A
GoPubMedRAB6A
iHOPRAB6A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:24:04 CET 2017

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