Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RAB6B (RAB6B, member RAS oncogene family)

Identity

Other alias-
HGNC (Hugo) RAB6B
LocusID (NCBI) 51560
Atlas_Id 42005
Location 3q22.1  [Link to chromosome band 3q22]
Location_base_pair Starts at 133543080 and ends at 133614691 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CPLX2 (5q35.2) / RAB6B (3q22.1)DGKZ (11p11.2) / RAB6B (3q22.1)NCK1 (3q22.3) / RAB6B (3q22.1)
RAB6B (3q22.1) / RAB6B (3q22.1)NCK1 3q22.3 / RAB6B 3q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RAB6B   14902
Cards
Entrez_Gene (NCBI)RAB6B  51560  RAB6B, member RAS oncogene family
Aliases
GeneCards (Weizmann)RAB6B
Ensembl hg19 (Hinxton)ENSG00000154917 [Gene_View]  chr3:133543080-133614691 [Contig_View]  RAB6B [Vega]
Ensembl hg38 (Hinxton)ENSG00000154917 [Gene_View]  chr3:133543080-133614691 [Contig_View]  RAB6B [Vega]
ICGC DataPortalENSG00000154917
TCGA cBioPortalRAB6B
AceView (NCBI)RAB6B
Genatlas (Paris)RAB6B
WikiGenes51560
SOURCE (Princeton)RAB6B
Genetics Home Reference (NIH)RAB6B
Genomic and cartography
GoldenPath hg19 (UCSC)RAB6B  -     chr3:133543080-133614691 -  3q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RAB6B  -     3q22.1   [Description]    (hg38-Dec_2013)
EnsemblRAB6B - 3q22.1 [CytoView hg19]  RAB6B - 3q22.1 [CytoView hg38]
Mapping of homologs : NCBIRAB6B [Mapview hg19]  RAB6B [Mapview hg38]
OMIM615852   
Gene and transcription
Genbank (Entrez)AB073348 AF091031 AF166492 AF498940 AK055102
RefSeq transcript (Entrez)NM_016577
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)RAB6B
Cluster EST : UnigeneHs.715344 [ NCBI ]
CGAP (NCI)Hs.715344
Alternative Splicing GalleryENSG00000154917
Gene ExpressionRAB6B [ NCBI-GEO ]   RAB6B [ EBI - ARRAY_EXPRESS ]   RAB6B [ SEEK ]   RAB6B [ MEM ]
Gene Expression Viewer (FireBrowse)RAB6B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51560
GTEX Portal (Tissue expression)RAB6B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRW1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NRW1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NRW1
Splice isoforms : SwissVarQ9NRW1
PhosPhoSitePlusQ9NRW1
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Rab_type   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Domain families : Smart (EMBL)RAB (SM00175)  
Conserved Domain (NCBI)RAB6B
DMDM Disease mutations51560
Blocks (Seattle)RAB6B
PDB (SRS)2E9S    2FE4    2FFQ   
PDB (PDBSum)2E9S    2FE4    2FFQ   
PDB (IMB)2E9S    2FE4    2FFQ   
PDB (RSDB)2E9S    2FE4    2FFQ   
Structural Biology KnowledgeBase2E9S    2FE4    2FFQ   
SCOP (Structural Classification of Proteins)2E9S    2FE4    2FFQ   
CATH (Classification of proteins structures)2E9S    2FE4    2FFQ   
SuperfamilyQ9NRW1
Human Protein AtlasENSG00000154917
Peptide AtlasQ9NRW1
HPRD11474
IPIIPI00946358   
Protein Interaction databases
DIP (DOE-UCLA)Q9NRW1
IntAct (EBI)Q9NRW1
FunCoupENSG00000154917
BioGRIDRAB6B
STRING (EMBL)RAB6B
ZODIACRAB6B
Ontologies - Pathways
QuickGOQ9NRW1
Ontology : AmiGOGolgi membrane  GTPase activity  protein binding  GTP binding  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  Golgi apparatus  cytosol  intracellular protein transport  retrograde vesicle-mediated transport, Golgi to ER  retrograde vesicle-mediated transport, Golgi to ER  intra-Golgi vesicle-mediated transport  nucleocytoplasmic transport  small GTPase mediated signal transduction  metabolic process  cytoplasmic, membrane-bounded vesicle  myosin V binding  retrograde transport, endosome to Golgi  
Ontology : EGO-EBIGolgi membrane  GTPase activity  protein binding  GTP binding  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  Golgi apparatus  cytosol  intracellular protein transport  retrograde vesicle-mediated transport, Golgi to ER  retrograde vesicle-mediated transport, Golgi to ER  intra-Golgi vesicle-mediated transport  nucleocytoplasmic transport  small GTPase mediated signal transduction  metabolic process  cytoplasmic, membrane-bounded vesicle  myosin V binding  retrograde transport, endosome to Golgi  
NDEx NetworkRAB6B
Atlas of Cancer Signalling NetworkRAB6B
Wikipedia pathwaysRAB6B
Orthology - Evolution
OrthoDB51560
GeneTree (enSembl)ENSG00000154917
Phylogenetic Trees/Animal Genes : TreeFamRAB6B
HOVERGENQ9NRW1
HOGENOMQ9NRW1
Homologs : HomoloGeneRAB6B
Homology/Alignments : Family Browser (UCSC)RAB6B
Gene fusions - Rearrangements
Fusion : MitelmanNCK1/RAB6B [3q22.3/3q22.1]  [t(3;3)(q22;q22)]  
Fusion: TCGANCK1 3q22.3 RAB6B 3q22.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAB6B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAB6B
dbVarRAB6B
ClinVarRAB6B
1000_GenomesRAB6B 
Exome Variant ServerRAB6B
ExAC (Exome Aggregation Consortium)RAB6B (select the gene name)
Genetic variants : HAPMAP51560
Genomic Variants (DGV)RAB6B [DGVbeta]
DECIPHER (Syndromes)3:133543080-133614691  ENSG00000154917
CONAN: Copy Number AnalysisRAB6B 
Mutations
ICGC Data PortalRAB6B 
TCGA Data PortalRAB6B 
Broad Tumor PortalRAB6B
OASIS PortalRAB6B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAB6B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAB6B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAB6B
DgiDB (Drug Gene Interaction Database)RAB6B
DoCM (Curated mutations)RAB6B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAB6B (select a term)
intoGenRAB6B
Cancer3DRAB6B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615852   
Orphanet
MedgenRAB6B
Genetic Testing Registry RAB6B
NextProtQ9NRW1 [Medical]
TSGene51560
GENETestsRAB6B
Huge Navigator RAB6B [HugePedia]
snp3D : Map Gene to Disease51560
BioCentury BCIQRAB6B
ClinGenRAB6B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51560
Chemical/Pharm GKB GenePA34147
Clinical trialRAB6B
Miscellaneous
canSAR (ICR)RAB6B (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAB6B
EVEXRAB6B
GoPubMedRAB6B
iHOPRAB6B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:24:04 CET 2017

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