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RAB7A (RAB7A, member RAS oncogene family)

Identity

Alias_namesRAB7
RAB7
HGNC (Hugo) RAB7A
LocusID (NCBI) 7879
Atlas_Id 42007
Location 3q21.3  [Link to chromosome band 3q21]
Location_base_pair Starts at 128444979 and ends at 128533641 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DDX6 (11q23.3) / RAB7A (3q21.3)LOC92249 () / RAB7A (3q21.3)MECOM (3q26.2) / RAB7A (3q21.3)
NID2 (14q22.1) / RAB7A (3q21.3)PFDN2 (1q23.3) / RAB7A (3q21.3)PNP (14q11.2) / RAB7A (3q21.3)
RAB7A (3q21.3) / CISD2 (4q24)RAB7A (3q21.3) / CSNK2A2 (16q21)RAB7A (3q21.3) / DICER1 (14q32.13)
RAB7A (3q21.3) / IL10RB (21q22.11)RAB7A (3q21.3) / LRCH3 (3q29)RAB7A (3q21.3) / LRRC47 (1p36.32)
RAB7A (3q21.3) / PKP2 (12p11.21)RAB7A (3q21.3) / RABEP1 (17p13.2)RAB7A (3q21.3) / SAMD12 (8q24.12)
SDCBP (8q12.1) / RAB7A (3q21.3)ZNF629 (16p11.2) / RAB7A (3q21.3)RAB7A 3q21.3 / RABEP1 17p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RAB7A   9788
LRG (Locus Reference Genomic)LRG_266
Cards
Entrez_Gene (NCBI)RAB7A  7879  RAB7A, member RAS oncogene family
AliasesPRO2706; RAB7
GeneCards (Weizmann)RAB7A
Ensembl hg19 (Hinxton)ENSG00000075785 [Gene_View]  chr3:128444979-128533641 [Contig_View]  RAB7A [Vega]
Ensembl hg38 (Hinxton)ENSG00000075785 [Gene_View]  chr3:128444979-128533641 [Contig_View]  RAB7A [Vega]
ICGC DataPortalENSG00000075785
TCGA cBioPortalRAB7A
AceView (NCBI)RAB7A
Genatlas (Paris)RAB7A
WikiGenes7879
SOURCE (Princeton)RAB7A
Genetics Home Reference (NIH)RAB7A
Genomic and cartography
GoldenPath hg19 (UCSC)RAB7A  -     chr3:128444979-128533641 +  3q21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RAB7A  -     3q21.3   [Description]    (hg38-Dec_2013)
EnsemblRAB7A - 3q21.3 [CytoView hg19]  RAB7A - 3q21.3 [CytoView hg38]
Mapping of homologs : NCBIRAB7A [Mapview hg19]  RAB7A [Mapview hg38]
OMIM600882   602298   
Gene and transcription
Genbank (Entrez)AF119891 AF498942 AK026136 AK094449 AK225177
RefSeq transcript (Entrez)NM_004637
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_008070 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)RAB7A
Cluster EST : UnigeneHs.744853 [ NCBI ]
CGAP (NCI)Hs.744853
Alternative Splicing GalleryENSG00000075785
Gene ExpressionRAB7A [ NCBI-GEO ]   RAB7A [ EBI - ARRAY_EXPRESS ]   RAB7A [ SEEK ]   RAB7A [ MEM ]
Gene Expression Viewer (FireBrowse)RAB7A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7879
GTEX Portal (Tissue expression)RAB7A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51149   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51149  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51149
Splice isoforms : SwissVarP51149
PhosPhoSitePlusP51149
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Rab_type   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Domain families : Smart (EMBL)RAB (SM00175)  
Conserved Domain (NCBI)RAB7A
DMDM Disease mutations7879
Blocks (Seattle)RAB7A
PDB (SRS)1T91    1YHN    3LAW   
PDB (PDBSum)1T91    1YHN    3LAW   
PDB (IMB)1T91    1YHN    3LAW   
PDB (RSDB)1T91    1YHN    3LAW   
Structural Biology KnowledgeBase1T91    1YHN    3LAW   
SCOP (Structural Classification of Proteins)1T91    1YHN    3LAW   
CATH (Classification of proteins structures)1T91    1YHN    3LAW   
SuperfamilyP51149
Human Protein AtlasENSG00000075785
Peptide AtlasP51149
HPRD03805
IPIIPI00016342   IPI00945574   IPI00945735   IPI00946911   IPI00946776   IPI00945337   IPI00945392   
Protein Interaction databases
DIP (DOE-UCLA)P51149
IntAct (EBI)P51149
FunCoupENSG00000075785
BioGRIDRAB7A
STRING (EMBL)RAB7A
ZODIACRAB7A
Ontologies - Pathways
QuickGOP51149
Ontology : AmiGOautophagosome membrane  GTPase activity  protein binding  GTP binding  lysosome  lysosome  lysosomal membrane  late endosome  late endosome  vacuolar membrane  Golgi apparatus  lipid particle  cytosol  protein targeting to lysosome  endocytosis  nucleocytoplasmic transport  epidermal growth factor catabolic process  small GTPase mediated signal transduction  endosome to lysosome transport  protein transport  GDP binding  viral release from host cell  antigen processing and presentation of exogenous peptide antigen via MHC class II  protein to membrane docking  phagocytic vesicle membrane  retromer complex  late endosome membrane  extrinsic component of lysosome membrane  melanosome membrane  pre-autophagosomal structure membrane  retrograde transport, endosome to Golgi  terminal bouton  intracellular membrane-bounded organelle  early endosome to late endosome transport  phagocytic vesicle  bone resorption  positive regulation of protein catabolic process  Rac GTPase binding  positive regulation of viral process  lipophagy  extracellular exosome  phagosome maturation  phagosome acidification  phagosome-lysosome fusion  alveolar lamellar body  positive regulation of exosomal secretion  regulation of autophagosome assembly  
Ontology : EGO-EBIautophagosome membrane  GTPase activity  protein binding  GTP binding  lysosome  lysosome  lysosomal membrane  late endosome  late endosome  vacuolar membrane  Golgi apparatus  lipid particle  cytosol  protein targeting to lysosome  endocytosis  nucleocytoplasmic transport  epidermal growth factor catabolic process  small GTPase mediated signal transduction  endosome to lysosome transport  protein transport  GDP binding  viral release from host cell  antigen processing and presentation of exogenous peptide antigen via MHC class II  protein to membrane docking  phagocytic vesicle membrane  retromer complex  late endosome membrane  extrinsic component of lysosome membrane  melanosome membrane  pre-autophagosomal structure membrane  retrograde transport, endosome to Golgi  terminal bouton  intracellular membrane-bounded organelle  early endosome to late endosome transport  phagocytic vesicle  bone resorption  positive regulation of protein catabolic process  Rac GTPase binding  positive regulation of viral process  lipophagy  extracellular exosome  phagosome maturation  phagosome acidification  phagosome-lysosome fusion  alveolar lamellar body  positive regulation of exosomal secretion  regulation of autophagosome assembly  
Pathways : BIOCARTARab GTPases Mark Targets In The Endocytotic Machinery [Genes]   
Pathways : KEGGEndocytosis    Phagosome    Salmonella infection    Amoebiasis    Tuberculosis   
NDEx NetworkRAB7A
Atlas of Cancer Signalling NetworkRAB7A
Wikipedia pathwaysRAB7A
Orthology - Evolution
OrthoDB7879
GeneTree (enSembl)ENSG00000075785
Phylogenetic Trees/Animal Genes : TreeFamRAB7A
HOVERGENP51149
HOGENOMP51149
Homologs : HomoloGeneRAB7A
Homology/Alignments : Family Browser (UCSC)RAB7A
Gene fusions - Rearrangements
Fusion : MitelmanRAB7A/LRCH3 [3q21.3/3q29]  
Fusion : MitelmanRAB7A/RABEP1 [3q21.3/17p13.2]  [t(3;17)(q21;p13)]  
Fusion: TCGARAB7A 3q21.3 RABEP1 17p13.2 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAB7A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAB7A
dbVarRAB7A
ClinVarRAB7A
1000_GenomesRAB7A 
Exome Variant ServerRAB7A
ExAC (Exome Aggregation Consortium)RAB7A (select the gene name)
Genetic variants : HAPMAP7879
Genomic Variants (DGV)RAB7A [DGVbeta]
DECIPHER (Syndromes)3:128444979-128533641  ENSG00000075785
CONAN: Copy Number AnalysisRAB7A 
Mutations
ICGC Data PortalRAB7A 
TCGA Data PortalRAB7A 
Broad Tumor PortalRAB7A
OASIS PortalRAB7A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAB7A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAB7A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAB7A
DgiDB (Drug Gene Interaction Database)RAB7A
DoCM (Curated mutations)RAB7A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAB7A (select a term)
intoGenRAB7A
Cancer3DRAB7A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600882    602298   
Orphanet14509   
MedgenRAB7A
Genetic Testing Registry RAB7A
NextProtP51149 [Medical]
TSGene7879
GENETestsRAB7A
Huge Navigator RAB7A [HugePedia]
snp3D : Map Gene to Disease7879
BioCentury BCIQRAB7A
ClinGenRAB7A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7879
Chemical/Pharm GKB GenePA162400619
Clinical trialRAB7A
Miscellaneous
canSAR (ICR)RAB7A (select the gene name)
Probes
Litterature
PubMed143 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAB7A
EVEXRAB7A
GoPubMedRAB7A
iHOPRAB7A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:49:17 CET 2016

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