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RAB7A (RAB7A, member RAS oncogene family)

Identity

Other namesPRO2706
RAB7
HGNC (Hugo) RAB7A
LocusID (NCBI) 7879
Location 3q21.3
Location_base_pair Starts at 128444979 and ends at 128533641 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)RAB7A   9788
Cards
Entrez_Gene (NCBI)RAB7A  7879  RAB7A, member RAS oncogene family
GeneCards (Weizmann)RAB7A
Ensembl hg19 (Hinxton)ENSG00000075785 [Gene_View]  chr3:128444979-128533641 [Contig_View]  RAB7A [Vega]
Ensembl hg38 (Hinxton)ENSG00000075785 [Gene_View]  chr3:128444979-128533641 [Contig_View]  RAB7A [Vega]
ICGC DataPortalENSG00000075785
cBioPortalRAB7A
AceView (NCBI)RAB7A
Genatlas (Paris)RAB7A
WikiGenes7879
SOURCE (Princeton)RAB7A
Genomic and cartography
GoldenPath hg19 (UCSC)RAB7A  -     chr3:128444979-128533641 +  3q21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RAB7A  -     3q21.3   [Description]    (hg38-Dec_2013)
EnsemblRAB7A - 3q21.3 [CytoView hg19]  RAB7A - 3q21.3 [CytoView hg38]
Mapping of homologs : NCBIRAB7A [Mapview hg19]  RAB7A [Mapview hg38]
OMIM600882   602298   
Gene and transcription
Genbank (Entrez)AF119891 AF498942 AK026136 AK094449 AK225177
RefSeq transcript (Entrez)NM_004637
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NG_008070 NT_005612 NW_001838883 NW_004929311
Consensus coding sequences : CCDS (NCBI)RAB7A
Cluster EST : UnigeneHs.744853 [ NCBI ]
CGAP (NCI)Hs.744853
Alternative Splicing : Fast-db (Paris)GSHG0021132
Alternative Splicing GalleryENSG00000075785
Gene ExpressionRAB7A [ NCBI-GEO ]     RAB7A [ SEEK ]   RAB7A [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51149 (Uniprot)
NextProtP51149  [Medical]
With graphics : InterProP51149
Splice isoforms : SwissVarP51149 (Swissvar)
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Rab_type   
Related proteins : CluSTrP51149
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Domain families : Smart (EMBL)RAB (SM00175)  
DMDM Disease mutations7879
Blocks (Seattle)P51149
PDB (SRS)1T91    1YHN    3LAW   
PDB (PDBSum)1T91    1YHN    3LAW   
PDB (IMB)1T91    1YHN    3LAW   
PDB (RSDB)1T91    1YHN    3LAW   
Human Protein AtlasENSG00000075785
Peptide AtlasP51149
HPRD03805
IPIIPI00016342   IPI00945574   IPI00945735   IPI00946911   IPI00946776   IPI00945337   IPI00945392   
Protein Interaction databases
DIP (DOE-UCLA)P51149
IntAct (EBI)P51149
FunCoupENSG00000075785
BioGRIDRAB7A
IntegromeDBRAB7A
STRING (EMBL)RAB7A
Ontologies - Pathways
QuickGOP51149
Ontology : AmiGOGTPase activity  protein binding  GTP binding  lysosome  lysosome  lysosomal membrane  late endosome  late endosome  Golgi apparatus  GTP catabolic process  GTP catabolic process  protein targeting to lysosome  endocytosis  epidermal growth factor catabolic process  small GTPase mediated signal transduction  cell death  endosome to lysosome transport  protein transport  GDP binding  antigen processing and presentation of exogenous peptide antigen via MHC class II  phagocytic vesicle membrane  melanosome  intracellular membrane-bounded organelle  early endosome to late endosome transport  phagocytic vesicle  bone resorption  Rac GTPase binding  extracellular vesicular exosome  phagosome maturation  phagosome acidification  phagosome-lysosome fusion  alveolar lamellar body  
Ontology : EGO-EBIGTPase activity  protein binding  GTP binding  lysosome  lysosome  lysosomal membrane  late endosome  late endosome  Golgi apparatus  GTP catabolic process  GTP catabolic process  protein targeting to lysosome  endocytosis  epidermal growth factor catabolic process  small GTPase mediated signal transduction  cell death  endosome to lysosome transport  protein transport  GDP binding  antigen processing and presentation of exogenous peptide antigen via MHC class II  phagocytic vesicle membrane  melanosome  intracellular membrane-bounded organelle  early endosome to late endosome transport  phagocytic vesicle  bone resorption  Rac GTPase binding  extracellular vesicular exosome  phagosome maturation  phagosome acidification  phagosome-lysosome fusion  alveolar lamellar body  
Pathways : BIOCARTARab GTPases Mark Targets In The Endocytotic Machinery [Genes]   
Pathways : KEGGEndocytosis    Phagosome    Salmonella infection    Amoebiasis    Tuberculosis   
Protein Interaction DatabaseRAB7A
DoCM (Curated mutations)RAB7A
Wikipedia pathwaysRAB7A
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerRAB7A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAB7A
dbVarRAB7A
ClinVarRAB7A
1000_GenomesRAB7A 
Exome Variant ServerRAB7A
SNP (GeneSNP Utah)RAB7A
SNP : HGBaseRAB7A
Genetic variants : HAPMAPRAB7A
Genomic VariantsRAB7A  RAB7A [DGVbeta]
Mutations
ICGC Data PortalENSG00000075785 
Somatic Mutations in Cancer : COSMICRAB7A 
CONAN: Copy Number AnalysisRAB7A 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)3:128444979-128533641
Mutations and Diseases : HGMDRAB7A
OMIM600882    602298   
MedgenRAB7A
NextProtP51149 [Medical]
GENETestsRAB7A
Disease Genetic AssociationRAB7A
Huge Navigator RAB7A [HugePedia]  RAB7A [HugeCancerGEM]
snp3D : Map Gene to Disease7879
DGIdb (Drug Gene Interaction db)RAB7A
General knowledge
Homologs : HomoloGeneRAB7A
Homology/Alignments : Family Browser (UCSC)RAB7A
Phylogenetic Trees/Animal Genes : TreeFamRAB7A
Chemical/Protein Interactions : CTD7879
Chemical/Pharm GKB GenePA162400619
Clinical trialRAB7A
Cancer Resource (Charite)ENSG00000075785
Other databases
Probes
Litterature
PubMed122 Pubmed reference(s) in Entrez
CoreMineRAB7A
GoPubMedRAB7A
iHOPRAB7A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Dec 21 01:05:19 CET 2014

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