Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

RAB8A (RAB8A, member RAS oncogene family)

Identity

Other namesMEL
RAB8
HGNC (Hugo) RAB8A
LocusID (NCBI) 4218
Atlas_Id 42009
Location 19p13.12  [Link to chromosome band 19p13]
Location_base_pair Starts at 16222490 and ends at 16244445 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AP1M1 (19p13.11) / RAB8A (19p13.12)MPND (19p13.3) / RAB8A (19p13.12)RAB8A (19p13.12) / ADAM18 (8p11.22)
RAB8A (19p13.12) / AIM1 (6q21)RAB8A (19p13.12) / EIF4G2 (11p15.3)AP1M1 19p13.11 / RAB8A 19p13.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Skin: Melanoma

External links

Nomenclature
HGNC (Hugo)RAB8A   7007
Cards
Entrez_Gene (NCBI)RAB8A  4218  RAB8A, member RAS oncogene family
AliasesMEL; RAB8
GeneCards (Weizmann)RAB8A
Ensembl hg19 (Hinxton)ENSG00000167461 [Gene_View]  chr19:16222490-16244445 [Contig_View]  RAB8A [Vega]
Ensembl hg38 (Hinxton)ENSG00000167461 [Gene_View]  chr19:16222490-16244445 [Contig_View]  RAB8A [Vega]
ICGC DataPortalENSG00000167461
TCGA cBioPortalRAB8A
AceView (NCBI)RAB8A
Genatlas (Paris)RAB8A
WikiGenes4218
SOURCE (Princeton)RAB8A
Genomic and cartography
GoldenPath hg19 (UCSC)RAB8A  -     chr19:16222490-16244445 +  19p13.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RAB8A  -     19p13.12   [Description]    (hg38-Dec_2013)
EnsemblRAB8A - 19p13.12 [CytoView hg19]  RAB8A - 19p13.12 [CytoView hg38]
Mapping of homologs : NCBIRAB8A [Mapview hg19]  RAB8A [Mapview hg38]
OMIM165040   
Gene and transcription
Genbank (Entrez)AB209767 AF498943 AK025165 AK293676 BC002977
RefSeq transcript (Entrez)NM_005370
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011295 NW_004929414
Consensus coding sequences : CCDS (NCBI)RAB8A
Cluster EST : UnigeneHs.642874 [ NCBI ]
CGAP (NCI)Hs.642874
Alternative Splicing GalleryENSG00000167461
Gene ExpressionRAB8A [ NCBI-GEO ]   RAB8A [ EBI - ARRAY_EXPRESS ]   RAB8A [ SEEK ]   RAB8A [ MEM ]
Gene Expression Viewer (FireBrowse)RAB8A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4218
GTEX Portal (Tissue expression)RAB8A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61006 (Uniprot)
NextProtP61006  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61006
Splice isoforms : SwissVarP61006 (Swissvar)
PhosPhoSitePlusP61006
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Rab_type   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Domain families : Smart (EMBL)RAB (SM00175)  
DMDM Disease mutations4218
Blocks (Seattle)RAB8A
PDB (SRS)3QBT    3TNF    4LHV    4LHW    4LHX    4LHY    4LHZ    4LI0   
PDB (PDBSum)3QBT    3TNF    4LHV    4LHW    4LHX    4LHY    4LHZ    4LI0   
PDB (IMB)3QBT    3TNF    4LHV    4LHW    4LHX    4LHY    4LHZ    4LI0   
PDB (RSDB)3QBT    3TNF    4LHV    4LHW    4LHX    4LHY    4LHZ    4LI0   
Structural Biology KnowledgeBase3QBT    3TNF    4LHV    4LHW    4LHX    4LHY    4LHZ    4LI0   
SCOP (Structural Classification of Proteins)3QBT    3TNF    4LHV    4LHW    4LHX    4LHY    4LHZ    4LI0   
CATH (Classification of proteins structures)3QBT    3TNF    4LHV    4LHW    4LHX    4LHY    4LHZ    4LI0   
SuperfamilyP61006
Human Protein AtlasENSG00000167461
Peptide AtlasP61006
HPRD01296
IPIIPI00028481   IPI00556414   
Protein Interaction databases
DIP (DOE-UCLA)P61006
IntAct (EBI)P61006
FunCoupENSG00000167461
BioGRIDRAB8A
STRING (EMBL)RAB8A
ZODIACRAB8A
Ontologies - Pathways
QuickGOP61006
Ontology : AmiGOG2/M transition of mitotic cell cycle  Golgi membrane  GTPase activity  GTPase activity  protein binding  GTP binding  nucleus  nucleolus  centrosome  centriole  cytosol  plasma membrane  plasma membrane  cilium  cilium  intracellular protein transport  vesicle docking involved in exocytosis  nucleocytoplasmic transport  small GTPase mediated signal transduction  axonogenesis  synaptic vesicle  metabolic process  protein secretion  postsynaptic density  Rab GTPase binding  GDP binding  protein kinase binding  trans-Golgi network transport vesicle  dendrite  cytoplasmic vesicle membrane  phagocytic vesicle membrane  myosin V binding  nonmotile primary cilium  cellular response to insulin stimulus  cellular response to insulin stimulus  ciliary basal body  cilium assembly  cilium assembly  neuronal cell body  phagocytic vesicle  regulation of long-term neuronal synaptic plasticity  Golgi vesicle fusion to target membrane  regulation of protein transport  recycling endosome membrane  membrane organization  extracellular exosome  primary cilium  protein localization to plasma membrane  protein localization to plasma membrane  ciliary base  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  Golgi membrane  GTPase activity  GTPase activity  protein binding  GTP binding  nucleus  nucleolus  centrosome  centriole  cytosol  plasma membrane  plasma membrane  cilium  cilium  intracellular protein transport  vesicle docking involved in exocytosis  nucleocytoplasmic transport  small GTPase mediated signal transduction  axonogenesis  synaptic vesicle  metabolic process  protein secretion  postsynaptic density  Rab GTPase binding  GDP binding  protein kinase binding  trans-Golgi network transport vesicle  dendrite  cytoplasmic vesicle membrane  phagocytic vesicle membrane  myosin V binding  nonmotile primary cilium  cellular response to insulin stimulus  cellular response to insulin stimulus  ciliary basal body  cilium assembly  cilium assembly  neuronal cell body  phagocytic vesicle  regulation of long-term neuronal synaptic plasticity  Golgi vesicle fusion to target membrane  regulation of protein transport  recycling endosome membrane  membrane organization  extracellular exosome  primary cilium  protein localization to plasma membrane  protein localization to plasma membrane  ciliary base  
Pathways : BIOCARTARab GTPases Mark Targets In The Endocytotic Machinery [Genes]   
Pathways : KEGGPancreatic secretion   
NDEx Network
Atlas of Cancer Signalling NetworkRAB8A
Wikipedia pathwaysRAB8A
Orthology - Evolution
OrthoDB4218
GeneTree (enSembl)ENSG00000167461
Phylogenetic Trees/Animal Genes : TreeFamRAB8A
Homologs : HomoloGeneRAB8A
Homology/Alignments : Family Browser (UCSC)RAB8A
Gene fusions - Rearrangements
Fusion: TCGAAP1M1 19p13.11 RAB8A 19p13.12 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerRAB8A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAB8A
dbVarRAB8A
ClinVarRAB8A
1000_GenomesRAB8A 
Exome Variant ServerRAB8A
ExAC (Exome Aggregation Consortium)RAB8A (select the gene name)
Genetic variants : HAPMAP4218
Genomic Variants (DGV)RAB8A [DGVbeta]
Mutations
ICGC Data PortalRAB8A 
TCGA Data PortalRAB8A 
Broad Tumor PortalRAB8A
OASIS PortalRAB8A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAB8A 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAB8A
DgiDB (Drug Gene Interaction Database)RAB8A
DoCM (Curated mutations)RAB8A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAB8A (select a term)
intoGenRAB8A
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:16222490-16244445  ENSG00000167461
CONAN: Copy Number AnalysisRAB8A 
Mutations and Diseases : HGMDRAB8A
OMIM165040   
MedgenRAB8A
Genetic Testing Registry RAB8A
NextProtP61006 [Medical]
TSGene4218
GENETestsRAB8A
Huge Navigator RAB8A [HugePedia]
snp3D : Map Gene to Disease4218
BioCentury BCIQRAB8A
ClinGenRAB8A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4218
Chemical/Pharm GKB GenePA30743
Clinical trialRAB8A
Miscellaneous
canSAR (ICR)RAB8A (select the gene name)
Probes
Litterature
PubMed101 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAB8A
EVEXRAB8A
GoPubMedRAB8A
iHOPRAB8A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:05:37 CEST 2016

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.