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RAB8A (RAB8A, member RAS oncogene family)

Identity

Other namesMEL
RAB8
HGNC (Hugo) RAB8A
LocusID (NCBI) 4218
Location 19p13.12
Location_base_pair Starts at 16222490 and ends at 16244445 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors ProstateOverviewID5041

External links

Nomenclature
HGNC (Hugo)RAB8A   7007
Cards
Entrez_Gene (NCBI)RAB8A  4218  RAB8A, member RAS oncogene family
GeneCards (Weizmann)RAB8A
Ensembl (Hinxton) [Gene_View]  chr19:16222490-16244445 [Contig_View]  RAB8A [Vega]
cBioPortalRAB8A
AceView (NCBI)RAB8A
Genatlas (Paris)RAB8A
WikiGenes4218
SOURCE (Princeton)NM_005370
Genomic and cartography
GoldenPath (UCSC)RAB8A  -  19p13.12   chr19:16222490-16244445 +  19p13.12   [Description]    (hg19-Feb_2009)
EnsemblRAB8A - 19p13.12 [CytoView]
Mapping of homologs : NCBIRAB8A [Mapview]
OMIM165040   
Gene and transcription
Genbank (Entrez)AB209767 AF498943 AK025165 AK293676 BC002977
RefSeq transcript (Entrez)NM_005370
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NT_011295 NW_001838484 NW_004929414
Consensus coding sequences : CCDS (NCBI)RAB8A
Cluster EST : UnigeneHs.642874 [ NCBI ]
CGAP (NCI)Hs.642874
Alternative Splicing : Fast-db (Paris)GSHG0033328
Gene ExpressionRAB8A [ NCBI-GEO ]     RAB8A [ SEEK ]   RAB8A [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61006 (Uniprot)
NextProtP61006  [Medical]
With graphics : InterProP61006
Splice isoforms : SwissVarP61006 (Swissvar)
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase [organisation]   Small_GTP-bd_dom [organisation]   Small_GTPase [organisation]   Small_GTPase_Rab_type [organisation]  
Related proteins : CluSTrP61006
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Domain families : Smart (EMBL)RAB (SM00175)  
DMDM Disease mutations4218
Blocks (Seattle)P61006
PDB (SRS)3QBT    3TNF    4LHV    4LHW    4LHX    4LHY    4LHZ    4LI0   
PDB (PDBSum)3QBT    3TNF    4LHV    4LHW    4LHX    4LHY    4LHZ    4LI0   
PDB (IMB)3QBT    3TNF    4LHV    4LHW    4LHX    4LHY    4LHZ    4LI0   
PDB (RSDB)3QBT    3TNF    4LHV    4LHW    4LHX    4LHY    4LHZ    4LI0   
Peptide AtlasP61006
HPRD01296
IPIIPI00028481   IPI00556414   
Protein Interaction databases
DIP (DOE-UCLA)P61006
IntAct (EBI)P61006
BioGRIDRAB8A
InParanoidP61006
Interologous Interaction database P61006
IntegromeDBRAB8A
STRING (EMBL)RAB8A
Ontologies - Pathways
Ontology : AmiGOG2/M transition of mitotic cell cycle  Golgi membrane  mitotic cell cycle  GTPase activity  protein binding  GTP binding  centrosome  plasma membrane  cilium  cilium  GTP catabolic process  vesicle docking involved in exocytosis  small GTPase mediated signal transduction  axonogenesis  postsynaptic density  protein transport  Rab GTPase binding  GDP binding  protein kinase binding  dendrite  cytoplasmic vesicle membrane  phagocytic vesicle membrane  nonmotile primary cilium  cellular response to insulin stimulus  cilium assembly  cilium assembly  neuronal cell body  phagocytic vesicle  regulation of long-term neuronal synaptic plasticity  Golgi vesicle fusion to target membrane  regulation of protein transport  recycling endosome membrane  membrane organization  extracellular vesicular exosome  protein localization to plasma membrane  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  Golgi membrane  mitotic cell cycle  GTPase activity  protein binding  GTP binding  centrosome  plasma membrane  cilium  cilium  GTP catabolic process  vesicle docking involved in exocytosis  small GTPase mediated signal transduction  axonogenesis  postsynaptic density  protein transport  Rab GTPase binding  GDP binding  protein kinase binding  dendrite  cytoplasmic vesicle membrane  phagocytic vesicle membrane  nonmotile primary cilium  cellular response to insulin stimulus  cilium assembly  cilium assembly  neuronal cell body  phagocytic vesicle  regulation of long-term neuronal synaptic plasticity  Golgi vesicle fusion to target membrane  regulation of protein transport  recycling endosome membrane  membrane organization  extracellular vesicular exosome  protein localization to plasma membrane  
Pathways : BIOCARTARab GTPases Mark Targets In The Endocytotic Machinery [Genes]   
Pathways : KEGGPancreatic secretion   
Protein Interaction DatabaseRAB8A
Wikipedia pathwaysRAB8A
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)RAB8A
snp3D : Map Gene to Disease4218
SNP (GeneSNP Utah)RAB8A
SNP : HGBaseRAB8A
Genetic variants : HAPMAPRAB8A
Exome VariantRAB8A
1000_GenomesRAB8A 
Somatic Mutations in Cancer : COSMICRAB8A 
CONAN: Copy Number AnalysisRAB8A 
Mutations and Diseases : HGMDRAB8A
Genomic VariantsRAB8A  RAB8A [DGVbeta]
dbVarRAB8A
ClinVarRAB8A
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM165040   
MedgenRAB8A
GENETestsRAB8A
Disease Genetic AssociationRAB8A
Huge Navigator RAB8A [HugePedia]  RAB8A [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneRAB8A
Homology/Alignments : Family Browser (UCSC)RAB8A
Phylogenetic Trees/Animal Genes : TreeFamRAB8A
Chemical/Protein Interactions : CTD4218
Chemical/Pharm GKB GenePA30743
Clinical trialRAB8A
Other databases
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
CoreMineRAB8A
iHOPRAB8A
OncoSearchRAB8A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 14:12:15 CEST 2014

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