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RAB8A (RAB8A, member RAS oncogene family)

Identity

Other namesMEL
RAB8
HGNC (Hugo) RAB8A
LocusID (NCBI) 4218
Atlas_Id 42009
Location 19p13.12
Location_base_pair Starts at 16222490 and ends at 16244445 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)RAB8A   7007
Cards
Entrez_Gene (NCBI)RAB8A  4218  RAB8A, member RAS oncogene family
GeneCards (Weizmann)RAB8A
Ensembl hg19 (Hinxton) [Gene_View]  chr19:16222490-16244445 [Contig_View]  RAB8A [Vega]
Ensembl hg38 (Hinxton) [Gene_View]  chr19:16222490-16244445 [Contig_View]  RAB8A [Vega]
TCGA cBioPortalRAB8A
AceView (NCBI)RAB8A
Genatlas (Paris)RAB8A
WikiGenes4218
SOURCE (Princeton)RAB8A
Genomic and cartography
GoldenPath hg19 (UCSC)RAB8A  -     chr19:16222490-16244445 +  19p13.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RAB8A  -     19p13.12   [Description]    (hg38-Dec_2013)
EnsemblRAB8A - 19p13.12 [CytoView hg19]  RAB8A - 19p13.12 [CytoView hg38]
Mapping of homologs : NCBIRAB8A [Mapview hg19]  RAB8A [Mapview hg38]
OMIM165040   
Gene and transcription
Genbank (Entrez)AB209767 AF498943 AK025165 AK293676 BC002977
RefSeq transcript (Entrez)NM_005370
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011295 NW_004929414
Consensus coding sequences : CCDS (NCBI)RAB8A
Cluster EST : UnigeneHs.642874 [ NCBI ]
CGAP (NCI)Hs.642874
Alternative Splicing : Fast-db (Paris)GSHG0033328
Gene ExpressionRAB8A [ NCBI-GEO ]     RAB8A [ SEEK ]   RAB8A [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61006 (Uniprot)
NextProtP61006  [Medical]  [Publications]
With graphics : InterProP61006
Splice isoforms : SwissVarP61006 (Swissvar)
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Rab_type   
Related proteins : CluSTrP61006
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Domain families : Smart (EMBL)RAB (SM00175)  
DMDM Disease mutations4218
Blocks (Seattle)P61006
PDB (SRS)3QBT    3TNF    4LHV    4LHW    4LHX    4LHY    4LHZ    4LI0   
PDB (PDBSum)3QBT    3TNF    4LHV    4LHW    4LHX    4LHY    4LHZ    4LI0   
PDB (IMB)3QBT    3TNF    4LHV    4LHW    4LHX    4LHY    4LHZ    4LI0   
PDB (RSDB)3QBT    3TNF    4LHV    4LHW    4LHX    4LHY    4LHZ    4LI0   
Peptide AtlasP61006
HPRD01296
IPIIPI00028481   IPI00556414   
Protein Interaction databases
DIP (DOE-UCLA)P61006
IntAct (EBI)P61006
BioGRIDRAB8A
IntegromeDBRAB8A
STRING (EMBL)RAB8A
Ontologies - Pathways
QuickGOP61006
Ontology : AmiGOG2/M transition of mitotic cell cycle  Golgi membrane  mitotic cell cycle  GTPase activity  GTPase activity  protein binding  GTP binding  nucleus  nucleoplasm  nucleolus  endosome  centrosome  cytosol  plasma membrane  cilium  cilium  intracellular protein transport  vesicle docking involved in exocytosis  organelle organization  axonogenesis  synaptic vesicle  metabolic process  metabolic process  protein secretion  postsynaptic density  synaptic vesicle exocytosis  Rab GTPase binding  regulation of exocytosis  GDP binding  protein kinase binding  trans-Golgi network transport vesicle  dendrite  cytoplasmic vesicle membrane  secretory granule membrane  phagocytic vesicle membrane  myosin V binding  nonmotile primary cilium  Rab protein signal transduction  cellular response to insulin stimulus  cellular response to insulin stimulus  ciliary basal body  cilium assembly  cilium assembly  neuronal cell body  phagocytic vesicle  regulation of long-term neuronal synaptic plasticity  Golgi vesicle fusion to target membrane  regulation of protein transport  recycling endosome membrane  membrane organization  extracellular exosome  primary cilium  protein localization to plasma membrane  protein localization to plasma membrane  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  Golgi membrane  mitotic cell cycle  GTPase activity  GTPase activity  protein binding  GTP binding  nucleus  nucleoplasm  nucleolus  endosome  centrosome  cytosol  plasma membrane  cilium  cilium  intracellular protein transport  vesicle docking involved in exocytosis  organelle organization  axonogenesis  synaptic vesicle  metabolic process  metabolic process  protein secretion  postsynaptic density  synaptic vesicle exocytosis  Rab GTPase binding  regulation of exocytosis  GDP binding  protein kinase binding  trans-Golgi network transport vesicle  dendrite  cytoplasmic vesicle membrane  secretory granule membrane  phagocytic vesicle membrane  myosin V binding  nonmotile primary cilium  Rab protein signal transduction  cellular response to insulin stimulus  cellular response to insulin stimulus  ciliary basal body  cilium assembly  cilium assembly  neuronal cell body  phagocytic vesicle  regulation of long-term neuronal synaptic plasticity  Golgi vesicle fusion to target membrane  regulation of protein transport  recycling endosome membrane  membrane organization  extracellular exosome  primary cilium  protein localization to plasma membrane  protein localization to plasma membrane  
Pathways : BIOCARTARab GTPases Mark Targets In The Endocytotic Machinery [Genes]   
Pathways : KEGGPancreatic secretion   
Protein Interaction DatabaseRAB8A
DoCM (Curated mutations)RAB8A
Wikipedia pathwaysRAB8A
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerRAB8A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAB8A
dbVarRAB8A
ClinVarRAB8A
1000_GenomesRAB8A 
Exome Variant ServerRAB8A
SNP (GeneSNP Utah)RAB8A
SNP : HGBaseRAB8A
Genetic variants : HAPMAPRAB8A
Genomic Variants (DGV)RAB8A [DGVbeta]
Mutations
ICGC Data PortalRAB8A 
TCGA Data PortalRAB8A 
Tumor PortalRAB8A
Somatic Mutations in Cancer : COSMICRAB8A 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:16222490-16244445
CONAN: Copy Number AnalysisRAB8A 
Mutations and Diseases : HGMDRAB8A
OMIM165040   
MedgenRAB8A
NextProtP61006 [Medical]
GENETestsRAB8A
Disease Genetic AssociationRAB8A
Huge Navigator RAB8A [HugePedia]  RAB8A [HugeCancerGEM]
snp3D : Map Gene to Disease4218
DGIdb (Drug Gene Interaction db)RAB8A
BioCentury BCIQRAB8A
General knowledge
Homologs : HomoloGeneRAB8A
Homology/Alignments : Family Browser (UCSC)RAB8A
Phylogenetic Trees/Animal Genes : TreeFamRAB8A
Chemical/Protein Interactions : CTD4218
Chemical/Pharm GKB GenePA30743
Clinical trialRAB8A
Other databases
Probes
Litterature
PubMed90 Pubmed reference(s) in Entrez
CoreMineRAB8A
GoPubMedRAB8A
iHOPRAB8A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jun 27 12:10:17 CEST 2015

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