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RABGAP1 (RAB GTPase activating protein 1)

Identity

Alias_symbol (synonym)GAPCenA
TBC1D11
Other aliasGAPCENA
HGNC (Hugo) RABGAP1
LocusID (NCBI) 23637
Atlas_Id 56372
Location 9q33.2  [Link to chromosome band 9q33]
Location_base_pair Starts at 122941009 and ends at 123104868 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ERBB2 (17q12) / RABGAP1 (9q33.2)MDK (11p11.2) / RABGAP1 (9q33.2)RABGAP1 (9q33.2) / MLPH (2q37.3)
RABGAP1 (9q33.2) / NIPSNAP3B (9q31.1)RABGAP1 (9q33.2) / RABGAP1 (9q33.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RABGAP1   17155
Cards
Entrez_Gene (NCBI)RABGAP1  23637  RAB GTPase activating protein 1
AliasesGAPCENA; TBC1D11
GeneCards (Weizmann)RABGAP1
Ensembl hg19 (Hinxton)ENSG00000011454 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000011454 [Gene_View]  chr9:122941009-123104868 [Contig_View]  RABGAP1 [Vega]
ICGC DataPortalENSG00000011454
TCGA cBioPortalRABGAP1
AceView (NCBI)RABGAP1
Genatlas (Paris)RABGAP1
WikiGenes23637
SOURCE (Princeton)RABGAP1
Genetics Home Reference (NIH)RABGAP1
Genomic and cartography
GoldenPath hg38 (UCSC)RABGAP1  -     chr9:122941009-123104868 +  9q33.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RABGAP1  -     9q33.2   [Description]    (hg19-Feb_2009)
EnsemblRABGAP1 - 9q33.2 [CytoView hg19]  RABGAP1 - 9q33.2 [CytoView hg38]
Mapping of homologs : NCBIRABGAP1 [Mapview hg19]  RABGAP1 [Mapview hg38]
OMIM615882   
Gene and transcription
Genbank (Entrez)AA948302 AB449897 AF088073 AF161357 AJ011679
RefSeq transcript (Entrez)NM_012197
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RABGAP1
Cluster EST : UnigeneHs.271341 [ NCBI ]
CGAP (NCI)Hs.271341
Alternative Splicing GalleryENSG00000011454
Gene ExpressionRABGAP1 [ NCBI-GEO ]   RABGAP1 [ EBI - ARRAY_EXPRESS ]   RABGAP1 [ SEEK ]   RABGAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)RABGAP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23637
GTEX Portal (Tissue expression)RABGAP1
Human Protein AtlasENSG00000011454-RABGAP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y3P9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y3P9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y3P9
Splice isoforms : SwissVarQ9Y3P9
PhosPhoSitePlusQ9Y3P9
Domaine pattern : Prosite (Expaxy)PID (PS01179)    TBC_RABGAP (PS50086)   
Domains : Interpro (EBI)Homeobox-like    Kinesin-like    PH_dom-like    PTB/PI_dom    Rab-GTPase-TBC_dom    RabGAP1   
Domain families : Pfam (Sanger)DUF3694 (PF12473)    PID (PF00640)    RabGAP-TBC (PF00566)   
Domain families : Pfam (NCBI)pfam12473    pfam00640    pfam00566   
Domain families : Smart (EMBL)PTB (SM00462)  TBC (SM00164)  
Conserved Domain (NCBI)RABGAP1
DMDM Disease mutations23637
Blocks (Seattle)RABGAP1
PDB (SRS)4NC6   
PDB (PDBSum)4NC6   
PDB (IMB)4NC6   
PDB (RSDB)4NC6   
Structural Biology KnowledgeBase4NC6   
SCOP (Structural Classification of Proteins)4NC6   
CATH (Classification of proteins structures)4NC6   
SuperfamilyQ9Y3P9
Human Protein Atlas [tissue]ENSG00000011454-RABGAP1 [tissue]
Peptide AtlasQ9Y3P9
HPRD06575
IPIIPI00016702   IPI00856033   IPI00855799   IPI00386898   IPI00942440   IPI00893657   IPI00953348   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y3P9
IntAct (EBI)Q9Y3P9
FunCoupENSG00000011454
BioGRIDRABGAP1
STRING (EMBL)RABGAP1
ZODIACRABGAP1
Ontologies - Pathways
QuickGOQ9Y3P9
Ontology : AmiGOGTPase activator activity  protein binding  centrosome  cytosol  cytosol  microtubule associated complex  intracellular protein transport  cell cycle  endomembrane system  tubulin binding  Rab GTPase binding  regulation of vesicle fusion  regulation of GTPase activity  membrane organization  activation of GTPase activity  regulation of cilium assembly  
Ontology : EGO-EBIGTPase activator activity  protein binding  centrosome  cytosol  cytosol  microtubule associated complex  intracellular protein transport  cell cycle  endomembrane system  tubulin binding  Rab GTPase binding  regulation of vesicle fusion  regulation of GTPase activity  membrane organization  activation of GTPase activity  regulation of cilium assembly  
NDEx NetworkRABGAP1
Atlas of Cancer Signalling NetworkRABGAP1
Wikipedia pathwaysRABGAP1
Orthology - Evolution
OrthoDB23637
GeneTree (enSembl)ENSG00000011454
Phylogenetic Trees/Animal Genes : TreeFamRABGAP1
HOVERGENQ9Y3P9
HOGENOMQ9Y3P9
Homologs : HomoloGeneRABGAP1
Homology/Alignments : Family Browser (UCSC)RABGAP1
Gene fusions - Rearrangements
Tumor Fusion PortalRABGAP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRABGAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RABGAP1
dbVarRABGAP1
ClinVarRABGAP1
1000_GenomesRABGAP1 
Exome Variant ServerRABGAP1
ExAC (Exome Aggregation Consortium)ENSG00000011454
GNOMAD BrowserENSG00000011454
Genetic variants : HAPMAP23637
Genomic Variants (DGV)RABGAP1 [DGVbeta]
DECIPHERRABGAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRABGAP1 
Mutations
ICGC Data PortalRABGAP1 
TCGA Data PortalRABGAP1 
Broad Tumor PortalRABGAP1
OASIS PortalRABGAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRABGAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRABGAP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RABGAP1
DgiDB (Drug Gene Interaction Database)RABGAP1
DoCM (Curated mutations)RABGAP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RABGAP1 (select a term)
intoGenRABGAP1
Cancer3DRABGAP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615882   
Orphanet
DisGeNETRABGAP1
MedgenRABGAP1
Genetic Testing Registry RABGAP1
NextProtQ9Y3P9 [Medical]
TSGene23637
GENETestsRABGAP1
Target ValidationRABGAP1
Huge Navigator RABGAP1 [HugePedia]
snp3D : Map Gene to Disease23637
BioCentury BCIQRABGAP1
ClinGenRABGAP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23637
Chemical/Pharm GKB GenePA134977298
Clinical trialRABGAP1
Miscellaneous
canSAR (ICR)RABGAP1 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRABGAP1
EVEXRABGAP1
GoPubMedRABGAP1
iHOPRABGAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:31:30 CET 2017

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