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RABL3 (RAB, member of RAS oncogene family like 3)

Identity

Alias_namesRAB, member of RAS oncogene family-like 3
Alias_symbol (synonym)MGC23920
Other aliasPNCA5
HGNC (Hugo) RABL3
LocusID (NCBI) 285282
Atlas_Id 42017
Location 3q13.33  [Link to chromosome band 3q13]
Location_base_pair Starts at 120684938 and ends at 120742516 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RYK (3q22.2) / RABL3 (3q13.33)RYK 3q22.2 / RABL3 3q13.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;3)(q13;q22) RYK/RABL3


External links

Nomenclature
HGNC (Hugo)RABL3   18072
Cards
Entrez_Gene (NCBI)RABL3  285282  RAB, member of RAS oncogene family like 3
AliasesPNCA5
GeneCards (Weizmann)RABL3
Ensembl hg19 (Hinxton)ENSG00000144840 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000144840 [Gene_View]  ENSG00000144840 [Sequence]  chr3:120684938-120742516 [Contig_View]  RABL3 [Vega]
ICGC DataPortalENSG00000144840
TCGA cBioPortalRABL3
AceView (NCBI)RABL3
Genatlas (Paris)RABL3
WikiGenes285282
SOURCE (Princeton)RABL3
Genetics Home Reference (NIH)RABL3
Genomic and cartography
GoldenPath hg38 (UCSC)RABL3  -     chr3:120684938-120742516 -  3q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RABL3  -     3q13.33   [Description]    (hg19-Feb_2009)
GoldenPathRABL3 - 3q13.33 [CytoView hg19]  RABL3 - 3q13.33 [CytoView hg38]
Genome Data Viewer NCBIRABL3 [Mapview hg19]  
OMIM618542   618680   
Gene and transcription
Genbank (Entrez)AK025772 AK293085 BC020832 BX647559 BX647593
RefSeq transcript (Entrez)NM_001363964 NM_001363965 NM_173825
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RABL3
Alternative Splicing GalleryENSG00000144840
Gene ExpressionRABL3 [ NCBI-GEO ]   RABL3 [ EBI - ARRAY_EXPRESS ]   RABL3 [ SEEK ]   RABL3 [ MEM ]
Gene Expression Viewer (FireBrowse)RABL3 [ Firebrowse - Broad ]
GenevisibleExpression of RABL3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)285282
GTEX Portal (Tissue expression)RABL3
Human Protein AtlasENSG00000144840-RABL3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5HYI8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5HYI8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5HYI8
Splice isoforms : SwissVarQ5HYI8
PhosPhoSitePlusQ5HYI8
Domaine pattern : Prosite (Expaxy)RAB (PS51419)   
Domains : Interpro (EBI)P-loop_NTPase   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)RABL3
DMDM Disease mutations285282
SuperfamilyQ5HYI8
Human Protein Atlas [tissue]ENSG00000144840-RABL3 [tissue]
Peptide AtlasQ5HYI8
HPRD15203
IPIIPI00102897   IPI00946386   IPI00946067   IPI00947222   IPI00946728   IPI00946230   
Protein Interaction databases
DIP (DOE-UCLA)Q5HYI8
IntAct (EBI)Q5HYI8
FunCoupENSG00000144840
BioGRIDRABL3
STRING (EMBL)RABL3
ZODIACRABL3
Ontologies - Pathways
QuickGOQ5HYI8
Ontology : AmiGOnatural killer cell differentiation  GTPase activity  protein binding  GTP binding  intracellular protein transport  endomembrane system  B cell differentiation  T cell differentiation in thymus  protein homodimerization activity  regulation of Ras protein signal transduction  regulation of protein lipidation  
Ontology : EGO-EBInatural killer cell differentiation  GTPase activity  protein binding  GTP binding  intracellular protein transport  endomembrane system  B cell differentiation  T cell differentiation in thymus  protein homodimerization activity  regulation of Ras protein signal transduction  regulation of protein lipidation  
NDEx NetworkRABL3
Atlas of Cancer Signalling NetworkRABL3
Wikipedia pathwaysRABL3
Orthology - Evolution
OrthoDB285282
GeneTree (enSembl)ENSG00000144840
Phylogenetic Trees/Animal Genes : TreeFamRABL3
HOGENOMQ5HYI8
Homologs : HomoloGeneRABL3
Homology/Alignments : Family Browser (UCSC)RABL3
Gene fusions - Rearrangements
Fusion : MitelmanRYK/RABL3 [3q22.2/3q13.33]  
Fusion PortalRYK 3q22.2 RABL3 3q13.33 BRCA
Fusion : QuiverRABL3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRABL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RABL3
dbVarRABL3
ClinVarRABL3
1000_GenomesRABL3 
Exome Variant ServerRABL3
GNOMAD BrowserENSG00000144840
Varsome BrowserRABL3
Genetic variants : HAPMAP285282
Genomic Variants (DGV)RABL3 [DGVbeta]
DECIPHERRABL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRABL3 
Mutations
ICGC Data PortalRABL3 
TCGA Data PortalRABL3 
Broad Tumor PortalRABL3
OASIS PortalRABL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRABL3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRABL3
Mutations and Diseases : HGMDRABL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect RABL3
DgiDB (Drug Gene Interaction Database)RABL3
DoCM (Curated mutations)RABL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RABL3 (select a term)
intoGenRABL3
Cancer3DRABL3 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618542    618680   
Orphanet
DisGeNETRABL3
MedgenRABL3
Genetic Testing Registry RABL3
NextProtQ5HYI8 [Medical]
TSGene285282
GENETestsRABL3
Open Targets GeneticsENSG00000144840  [validation]
snp3D : Map Gene to Disease285282
BioCentury BCIQRABL3
ClinGenRABL3
Clinical trials, drugs, therapy
Protein Interactions : CTD285282
Pharm GKB GenePA34161
Clinical trialRABL3
Miscellaneous
canSAR (ICR)RABL3 (select the gene name)
HarmonizomeRABL3
DataMed IndexRABL3
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRABL3
EVEXRABL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 20:08:00 CEST 2020

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