RABL6 (RAB, member RAS oncogene family like 6)

2008-03-01  

Identity

HGNC
RABL6
LOCATION
9q34.3
LOCUSID
55684
ALIAS
C9orf86,PARF,RBEL1,pp8875
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55684
MIM: 610615
HGNC: 24703
Ensembl: ENSG00000196642

Variants:

dbSNP: 55684
ClinVar: 55684
TCGA: ENSG00000196642
COSMIC: RABL6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196642ENST00000311502Q3YEC7
ENSG00000196642ENST00000357466Q3YEC7
ENSG00000196642ENST00000371663Q3YEC7
ENSG00000196642ENST00000371671Q3YEC7
ENSG00000196642ENST00000436380H0Y7H6
ENSG00000196642ENST00000464941G3V154
ENSG00000196642ENST00000484471F2Z2T0
ENSG00000196642ENST00000629216G3V154

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
179621912007RBEL1 is a novel gene that encodes a nucleocytoplasmic Ras superfamily GTP-binding protein and is overexpressed in breast cancer.19
194335812009Identification and characterization of RBEL1 subfamily of GTPases in the Ras superfamily involved in cell growth regulation.19
235725122013Negative regulation of p53 by Ras superfamily protein RBEL1A.13
252730892014RABL6A promotes G1-S phase progression and pancreatic neuroendocrine tumor cell proliferation in an Rb1-dependent manner.12
239771392013Down-regulation of c9orf86 in human breast cancer cells inhibits cell proliferation, invasion and tumor growth and correlates with survival of breast cancer patients.11
266763802016RBEL1 is required for osteosarcoma cell proliferation via inhibiting retinoblastoma 1.7
307211562019RABL6A inhibits tumor-suppressive PP2A/AKT signaling to drive pancreatic neuroendocrine tumor growth.3

Citation

Dessen P

RABL6 (RAB, member RAS oncogene family like 6)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50069/rabl6