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RAC1 (Rac family small GTPase 1)

Identity

Alias_namesras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Alias_symbol (synonym)TC-25
p21-Rac1
Rac-1
Other aliasMIG5
MRD48
HGNC (Hugo) RAC1
LocusID (NCBI) 5879
Atlas_Id 42020
Location 7p22.1  [Link to chromosome band 7p22]
Location_base_pair Starts at 6374495 and ends at 6403967 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCT3 (1q22) / RAC1 (7p22.1)KIAA0040 (1q25.1) / RAC1 (7p22.1)LOC550643 () / RAC1 (7p22.1)
RAC1 (7p22.1) / AKT3 (1q43)RAC1 (7p22.1) / MRPS7 (17q25.1)RAC1 (7p22.1) / PROKR1 (2p13.3)
RAC1 (7p22.1) / PTPN11 (12q24.13)RAC1 (7p22.1) / RAC1 (7p22.1)RAC1 (7p22.1) / RAP1GAP2 (17p13.3)
RAC1 (7p22.1) / TRAF3IP2-AS1 (6q21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias TL_t0607q14p22ID3133 TL_t0709p22q34ID1114 TL_t0709p22q34ID3032

External links

Nomenclature
HGNC (Hugo)RAC1   9801
Cards
Entrez_Gene (NCBI)RAC1  5879  Rac family small GTPase 1
AliasesMIG5; MRD48; Rac-1; TC-25; 
p21-Rac1
GeneCards (Weizmann)RAC1
Ensembl hg19 (Hinxton)ENSG00000136238 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136238 [Gene_View]  ENSG00000136238 [Sequence]  chr7:6374495-6403967 [Contig_View]  RAC1 [Vega]
ICGC DataPortalENSG00000136238
TCGA cBioPortalRAC1
AceView (NCBI)RAC1
Genatlas (Paris)RAC1
WikiGenes5879
SOURCE (Princeton)RAC1
Genetics Home Reference (NIH)RAC1
Genomic and cartography
GoldenPath hg38 (UCSC)RAC1  -     chr7:6374495-6403967 +  7p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAC1  -     7p22.1   [Description]    (hg19-Feb_2009)
GoldenPathRAC1 - 7p22.1 [CytoView hg19]  RAC1 - 7p22.1 [CytoView hg38]
ImmunoBaseENSG00000136238
Mapping of homologs : NCBIRAC1 [Mapview hg19]  RAC1 [Mapview hg38]
OMIM602048   617751   
Gene and transcription
Genbank (Entrez)AB209410 AB451238 AB451363 AF136373 AF498964
RefSeq transcript (Entrez)NM_006908 NM_018890 NM_198829
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RAC1
Cluster EST : UnigeneHs.413812 [ NCBI ]
CGAP (NCI)Hs.413812
Alternative Splicing GalleryENSG00000136238
Gene ExpressionRAC1 [ NCBI-GEO ]   RAC1 [ EBI - ARRAY_EXPRESS ]   RAC1 [ SEEK ]   RAC1 [ MEM ]
Gene Expression Viewer (FireBrowse)RAC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5879
GTEX Portal (Tissue expression)RAC1
Human Protein AtlasENSG00000136238-RAC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63000   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63000  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63000
Splice isoforms : SwissVarP63000
PhosPhoSitePlusP63000
Domaine pattern : Prosite (Expaxy)RHO (PS51420)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Rho   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)RAC1
DMDM Disease mutations5879
Blocks (Seattle)RAC1
PDB (RSDB)1E96    1FOE    1G4U    1HE1    1HH4    1I4D    1I4L    1I4T    1MH1    1RYF    1RYH    2FJU    2H7V    2NZ8    2P2L    2RMK    2VRW    2WKP    2WKQ    2WKR    2YIN    3B13    3BJI    3RYT    3SBD    3SBE    3SU8    3SUA    3TH5    4GZL    4GZM    4YON    5FI0    5HZH    5N6O    5O33    6BC1   
PDB Europe1E96    1FOE    1G4U    1HE1    1HH4    1I4D    1I4L    1I4T    1MH1    1RYF    1RYH    2FJU    2H7V    2NZ8    2P2L    2RMK    2VRW    2WKP    2WKQ    2WKR    2YIN    3B13    3BJI    3RYT    3SBD    3SBE    3SU8    3SUA    3TH5    4GZL    4GZM    4YON    5FI0    5HZH    5N6O    5O33    6BC1   
PDB (PDBSum)1E96    1FOE    1G4U    1HE1    1HH4    1I4D    1I4L    1I4T    1MH1    1RYF    1RYH    2FJU    2H7V    2NZ8    2P2L    2RMK    2VRW    2WKP    2WKQ    2WKR    2YIN    3B13    3BJI    3RYT    3SBD    3SBE    3SU8    3SUA    3TH5    4GZL    4GZM    4YON    5FI0    5HZH    5N6O    5O33    6BC1   
PDB (IMB)1E96    1FOE    1G4U    1HE1    1HH4    1I4D    1I4L    1I4T    1MH1    1RYF    1RYH    2FJU    2H7V    2NZ8    2P2L    2RMK    2VRW    2WKP    2WKQ    2WKR    2YIN    3B13    3BJI    3RYT    3SBD    3SBE    3SU8    3SUA    3TH5    4GZL    4GZM    4YON    5FI0    5HZH    5N6O    5O33    6BC1   
Structural Biology KnowledgeBase1E96    1FOE    1G4U    1HE1    1HH4    1I4D    1I4L    1I4T    1MH1    1RYF    1RYH    2FJU    2H7V    2NZ8    2P2L    2RMK    2VRW    2WKP    2WKQ    2WKR    2YIN    3B13    3BJI    3RYT    3SBD    3SBE    3SU8    3SUA    3TH5    4GZL    4GZM    4YON    5FI0    5HZH    5N6O    5O33    6BC1   
SCOP (Structural Classification of Proteins)1E96    1FOE    1G4U    1HE1    1HH4    1I4D    1I4L    1I4T    1MH1    1RYF    1RYH    2FJU    2H7V    2NZ8    2P2L    2RMK    2VRW    2WKP    2WKQ    2WKR    2YIN    3B13    3BJI    3RYT    3SBD    3SBE    3SU8    3SUA    3TH5    4GZL    4GZM    4YON    5FI0    5HZH    5N6O    5O33    6BC1   
CATH (Classification of proteins structures)1E96    1FOE    1G4U    1HE1    1HH4    1I4D    1I4L    1I4T    1MH1    1RYF    1RYH    2FJU    2H7V    2NZ8    2P2L    2RMK    2VRW    2WKP    2WKQ    2WKR    2YIN    3B13    3BJI    3RYT    3SBD    3SBE    3SU8    3SUA    3TH5    4GZL    4GZM    4YON    5FI0    5HZH    5N6O    5O33    6BC1   
SuperfamilyP63000
Human Protein Atlas [tissue]ENSG00000136238-RAC1 [tissue]
Peptide AtlasP63000
HPRD03627
IPIIPI00010271   IPI00219675   IPI00555566   
Protein Interaction databases
DIP (DOE-UCLA)P63000
IntAct (EBI)P63000
FunCoupENSG00000136238
BioGRIDRAC1
STRING (EMBL)RAC1
ZODIACRAC1
Ontologies - Pathways
QuickGOP63000
Ontology : AmiGOGolgi membrane  neuron migration  positive regulation of protein phosphorylation  mast cell chemotaxis  GTPase activity  GTPase activity  GTPase activity  protein binding  GTP binding  GTP binding  GTP binding  cytoplasm  cytoplasm  endoplasmic reticulum membrane  trans-Golgi network  cytosol  cytosol  actin filament  plasma membrane  plasma membrane  plasma membrane  focal adhesion  inflammatory response  cell adhesion  cell-matrix adhesion  Rho protein signal transduction  blood coagulation  motor neuron axon guidance  cell proliferation  regulation of cell size  regulation of cell size  response to wounding  anatomical structure morphogenesis  regulation of hydrogen peroxide metabolic process  regulation of lamellipodium assembly  positive regulation of lamellipodium assembly  positive regulation of lamellipodium assembly  positive regulation of cell-substrate adhesion  membrane  cell migration  Rac protein signal transduction  Rab GTPase binding  enzyme binding  protein kinase binding  protein kinase binding  lamellipodium  cell projection assembly  lamellipodium assembly  actin cytoskeleton organization  actin cytoskeleton organization  actin filament polymerization  regulation of cell migration  secretory granule membrane  positive regulation of microtubule polymerization  T cell costimulation  cytoplasmic vesicle  ruffle organization  ruffle organization  thioesterase binding  ruffle membrane  negative regulation of interleukin-23 production  substrate adhesion-dependent cell spreading  positive regulation of Rho protein signal transduction  intracellular signal transduction  positive regulation of insulin secretion involved in cellular response to glucose stimulus  cytoplasmic ribonucleoprotein granule  Fc-epsilon receptor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  melanosome  histone deacetylase binding  cell projection  dendritic spine  dendritic spine  neutrophil degranulation  protein-containing complex binding  regulation of nitric oxide biosynthetic process  bone resorption  positive regulation of DNA replication  vascular endothelial growth factor receptor signaling pathway  hepatocyte growth factor receptor signaling pathway  ephrin receptor signaling pathway  negative regulation of receptor-mediated endocytosis  cell motility  regulation of defense response to virus by virus  Rho GDP-dissociation inhibitor binding  regulation of small GTPase mediated signal transduction  ATPase binding  regulation of stress fiber assembly  positive regulation of stress fiber assembly  positive regulation of stress fiber assembly  localization within membrane  positive regulation of focal adhesion assembly  positive regulation of protein kinase B signaling  recycling endosome membrane  Wnt signaling pathway, planar cell polarity pathway  Wnt signaling pathway, planar cell polarity pathway  regulation of respiratory burst  extracellular exosome  cellular response to mechanical stimulus  semaphorin-plexin signaling pathway  positive regulation of neutrophil chemotaxis  ruffle assembly  postsynapse  postsynapse  glutamatergic synapse  glutamatergic synapse  ficolin-1-rich granule membrane  positive regulation of substrate adhesion-dependent cell spreading  regulation of neutrophil migration  
Ontology : EGO-EBIGolgi membrane  neuron migration  positive regulation of protein phosphorylation  mast cell chemotaxis  GTPase activity  GTPase activity  GTPase activity  protein binding  GTP binding  GTP binding  GTP binding  cytoplasm  cytoplasm  endoplasmic reticulum membrane  trans-Golgi network  cytosol  cytosol  actin filament  plasma membrane  plasma membrane  plasma membrane  focal adhesion  inflammatory response  cell adhesion  cell-matrix adhesion  Rho protein signal transduction  blood coagulation  motor neuron axon guidance  cell proliferation  regulation of cell size  regulation of cell size  response to wounding  anatomical structure morphogenesis  regulation of hydrogen peroxide metabolic process  regulation of lamellipodium assembly  positive regulation of lamellipodium assembly  positive regulation of lamellipodium assembly  positive regulation of cell-substrate adhesion  membrane  cell migration  Rac protein signal transduction  Rab GTPase binding  enzyme binding  protein kinase binding  protein kinase binding  lamellipodium  cell projection assembly  lamellipodium assembly  actin cytoskeleton organization  actin cytoskeleton organization  actin filament polymerization  regulation of cell migration  secretory granule membrane  positive regulation of microtubule polymerization  T cell costimulation  cytoplasmic vesicle  ruffle organization  ruffle organization  thioesterase binding  ruffle membrane  negative regulation of interleukin-23 production  substrate adhesion-dependent cell spreading  positive regulation of Rho protein signal transduction  intracellular signal transduction  positive regulation of insulin secretion involved in cellular response to glucose stimulus  cytoplasmic ribonucleoprotein granule  Fc-epsilon receptor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  melanosome  histone deacetylase binding  cell projection  dendritic spine  dendritic spine  neutrophil degranulation  protein-containing complex binding  regulation of nitric oxide biosynthetic process  bone resorption  positive regulation of DNA replication  vascular endothelial growth factor receptor signaling pathway  hepatocyte growth factor receptor signaling pathway  ephrin receptor signaling pathway  negative regulation of receptor-mediated endocytosis  cell motility  regulation of defense response to virus by virus  Rho GDP-dissociation inhibitor binding  regulation of small GTPase mediated signal transduction  ATPase binding  regulation of stress fiber assembly  positive regulation of stress fiber assembly  positive regulation of stress fiber assembly  localization within membrane  positive regulation of focal adhesion assembly  positive regulation of protein kinase B signaling  recycling endosome membrane  Wnt signaling pathway, planar cell polarity pathway  Wnt signaling pathway, planar cell polarity pathway  regulation of respiratory burst  extracellular exosome  cellular response to mechanical stimulus  semaphorin-plexin signaling pathway  positive regulation of neutrophil chemotaxis  ruffle assembly  postsynapse  postsynapse  glutamatergic synapse  glutamatergic synapse  ficolin-1-rich granule membrane  positive regulation of substrate adhesion-dependent cell spreading  regulation of neutrophil migration  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    Chemokine signaling pathway    Phagosome    PI3K-Akt signaling pathway    Wnt signaling pathway    Axon guidance    VEGF signaling pathway    Osteoclast differentiation    Focal adhesion    Adherens junction    Toll-like receptor signaling pathway    Natural killer cell mediated cytotoxicity    B cell receptor signaling pathway    Fc epsilon RI signaling pathway    Fc gamma R-mediated phagocytosis    Leukocyte transendothelial migration    Neurotrophin signaling pathway    Regulation of actin cytoskeleton    Non-alcoholic fatty liver disease (NAFLD)    Pancreatic secretion    Amyotrophic lateral sclerosis (ALS)    Bacterial invasion of epithelial cells    Epithelial cell signaling in Helicobacter pylori infection    Shigellosis    Salmonella infection    Pathways in cancer    Viral carcinogenesis    Proteoglycans in cancer    Colorectal cancer    Renal cell carcinoma    Pancreatic cancer    Viral myocarditis   
NDEx NetworkRAC1
Atlas of Cancer Signalling NetworkRAC1
Wikipedia pathwaysRAC1
Orthology - Evolution
OrthoDB5879
GeneTree (enSembl)ENSG00000136238
Phylogenetic Trees/Animal Genes : TreeFamRAC1
HOGENOMP63000
Homologs : HomoloGeneRAC1
Homology/Alignments : Family Browser (UCSC)RAC1
Gene fusions - Rearrangements
Fusion : QuiverRAC1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAC1
dbVarRAC1
ClinVarRAC1
1000_GenomesRAC1 
Exome Variant ServerRAC1
ExAC (Exome Aggregation Consortium)ENSG00000136238
GNOMAD BrowserENSG00000136238
Varsome BrowserRAC1
Genetic variants : HAPMAP5879
Genomic Variants (DGV)RAC1 [DGVbeta]
DECIPHERRAC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAC1 
Mutations
ICGC Data PortalRAC1 
TCGA Data PortalRAC1 
Broad Tumor PortalRAC1
OASIS PortalRAC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAC1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRAC1
Mutations and Diseases : HGMDRAC1
intOGen PortalRAC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAC1
DgiDB (Drug Gene Interaction Database)RAC1
DoCM (Curated mutations)RAC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAC1 (select a term)
intoGenRAC1
Cancer3DRAC1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602048    617751   
Orphanet
DisGeNETRAC1
MedgenRAC1
Genetic Testing Registry RAC1
NextProtP63000 [Medical]
TSGene5879
GENETestsRAC1
Target ValidationRAC1
Huge Navigator RAC1 [HugePedia]
snp3D : Map Gene to Disease5879
BioCentury BCIQRAC1
ClinGenRAC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5879
Chemical/Pharm GKB GenePA34162
Clinical trialRAC1
Miscellaneous
canSAR (ICR)RAC1 (select the gene name)
DataMed IndexRAC1
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAC1
EVEXRAC1
GoPubMedRAC1
iHOPRAC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 26 18:25:45 CEST 2019
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