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RAC1 (ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1))

Identity

Alias_symbol (synonym)TC-25
p21-Rac1
Rac-1
Other aliasMIG5
HGNC (Hugo) RAC1
LocusID (NCBI) 5879
Atlas_Id 42020
Location 7p22.1  [Link to chromosome band 7p22]
Location_base_pair Starts at 6414126 and ends at 6443598 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CCT3 (1q22) / RAC1 (7p22.1)KIAA0040 (1q25.1) / RAC1 (7p22.1)LOC550643 () / RAC1 (7p22.1)
RAC1 (7p22.1) / AKT3 (1q43)RAC1 (7p22.1) / MRPS7 (17q25.1)RAC1 (7p22.1) / PROKR1 (2p13.3)
RAC1 (7p22.1) / PTPN11 (12q24.13)RAC1 (7p22.1) / RAC1 (7p22.1)RAC1 (7p22.1) / RAP1GAP2 (17p13.3)
RAC1 (7p22.1) / TRAF3IP2-AS1 (6q21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  del(6q)
t(4;11)(q23;p15) NUP98/RAP1GDS1
t(5;12)(q33;q24) GIT2/PDGFRB


External links

Nomenclature
HGNC (Hugo)RAC1   9801
Cards
Entrez_Gene (NCBI)RAC1  5879  ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
AliasesMIG5; Rac-1; TC-25; p21-Rac1
GeneCards (Weizmann)RAC1
Ensembl hg19 (Hinxton)ENSG00000136238 [Gene_View]  chr7:6414126-6443598 [Contig_View]  RAC1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000136238 [Gene_View]  chr7:6414126-6443598 [Contig_View]  RAC1 [Vega]
ICGC DataPortalENSG00000136238
TCGA cBioPortalRAC1
AceView (NCBI)RAC1
Genatlas (Paris)RAC1
WikiGenes5879
SOURCE (Princeton)RAC1
Genetics Home Reference (NIH)RAC1
Genomic and cartography
GoldenPath hg19 (UCSC)RAC1  -     chr7:6414126-6443598 +  7p22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RAC1  -     7p22.1   [Description]    (hg38-Dec_2013)
EnsemblRAC1 - 7p22.1 [CytoView hg19]  RAC1 - 7p22.1 [CytoView hg38]
Mapping of homologs : NCBIRAC1 [Mapview hg19]  RAC1 [Mapview hg38]
OMIM602048   
Gene and transcription
Genbank (Entrez)AB209410 AB451238 AB451363 AF136373 AF498964
RefSeq transcript (Entrez)NM_006908 NM_018890 NM_198829
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_029431 NT_007819 NW_004929329
Consensus coding sequences : CCDS (NCBI)RAC1
Cluster EST : UnigeneHs.413812 [ NCBI ]
CGAP (NCI)Hs.413812
Alternative Splicing GalleryENSG00000136238
Gene ExpressionRAC1 [ NCBI-GEO ]   RAC1 [ EBI - ARRAY_EXPRESS ]   RAC1 [ SEEK ]   RAC1 [ MEM ]
Gene Expression Viewer (FireBrowse)RAC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5879
GTEX Portal (Tissue expression)RAC1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63000   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63000  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63000
Splice isoforms : SwissVarP63000
PhosPhoSitePlusP63000
Domaine pattern : Prosite (Expaxy)RHO (PS51420)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Rho   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Domain families : Smart (EMBL)RHO (SM00174)  
Conserved Domain (NCBI)RAC1
DMDM Disease mutations5879
Blocks (Seattle)RAC1
PDB (SRS)1E96    1FOE    1G4U    1HE1    1HH4    1I4D    1I4L    1I4T    1MH1    1RYF    1RYH    2FJU    2H7V    2NZ8    2P2L    2RMK    2VRW    2WKP    2WKQ    2WKR    2YIN    3B13    3BJI    3RYT    3SBD    3SBE    3SU8    3SUA    3TH5    4GZL    4GZM    4YON   
PDB (PDBSum)1E96    1FOE    1G4U    1HE1    1HH4    1I4D    1I4L    1I4T    1MH1    1RYF    1RYH    2FJU    2H7V    2NZ8    2P2L    2RMK    2VRW    2WKP    2WKQ    2WKR    2YIN    3B13    3BJI    3RYT    3SBD    3SBE    3SU8    3SUA    3TH5    4GZL    4GZM    4YON   
PDB (IMB)1E96    1FOE    1G4U    1HE1    1HH4    1I4D    1I4L    1I4T    1MH1    1RYF    1RYH    2FJU    2H7V    2NZ8    2P2L    2RMK    2VRW    2WKP    2WKQ    2WKR    2YIN    3B13    3BJI    3RYT    3SBD    3SBE    3SU8    3SUA    3TH5    4GZL    4GZM    4YON   
PDB (RSDB)1E96    1FOE    1G4U    1HE1    1HH4    1I4D    1I4L    1I4T    1MH1    1RYF    1RYH    2FJU    2H7V    2NZ8    2P2L    2RMK    2VRW    2WKP    2WKQ    2WKR    2YIN    3B13    3BJI    3RYT    3SBD    3SBE    3SU8    3SUA    3TH5    4GZL    4GZM    4YON   
Structural Biology KnowledgeBase1E96    1FOE    1G4U    1HE1    1HH4    1I4D    1I4L    1I4T    1MH1    1RYF    1RYH    2FJU    2H7V    2NZ8    2P2L    2RMK    2VRW    2WKP    2WKQ    2WKR    2YIN    3B13    3BJI    3RYT    3SBD    3SBE    3SU8    3SUA    3TH5    4GZL    4GZM    4YON   
SCOP (Structural Classification of Proteins)1E96    1FOE    1G4U    1HE1    1HH4    1I4D    1I4L    1I4T    1MH1    1RYF    1RYH    2FJU    2H7V    2NZ8    2P2L    2RMK    2VRW    2WKP    2WKQ    2WKR    2YIN    3B13    3BJI    3RYT    3SBD    3SBE    3SU8    3SUA    3TH5    4GZL    4GZM    4YON   
CATH (Classification of proteins structures)1E96    1FOE    1G4U    1HE1    1HH4    1I4D    1I4L    1I4T    1MH1    1RYF    1RYH    2FJU    2H7V    2NZ8    2P2L    2RMK    2VRW    2WKP    2WKQ    2WKR    2YIN    3B13    3BJI    3RYT    3SBD    3SBE    3SU8    3SUA    3TH5    4GZL    4GZM    4YON   
SuperfamilyP63000
Human Protein AtlasENSG00000136238
Peptide AtlasP63000
HPRD03627
IPIIPI00010271   IPI00219675   IPI00555566   
Protein Interaction databases
DIP (DOE-UCLA)P63000
IntAct (EBI)P63000
FunCoupENSG00000136238
BioGRIDRAC1
STRING (EMBL)RAC1
ZODIACRAC1
Ontologies - Pathways
QuickGOP63000
Ontology : AmiGOGolgi membrane  phagocytic cup  positive regulation of protein phosphorylation  auditory receptor cell morphogenesis  mast cell chemotaxis  epithelial cell morphogenesis  GTPase activity  protein binding  GTP binding  GTP binding  nucleus  cytoplasm  endoplasmic reticulum membrane  trans-Golgi network  cytosol  cytosol  actin filament  plasma membrane  focal adhesion  movement of cell or subcellular component  inflammatory response  hyperosmotic response  cell adhesion  cell-matrix adhesion  G-protein coupled receptor signaling pathway  small GTPase mediated signal transduction  axon guidance  blood coagulation  metabolic process  cell proliferation  regulation of cell size  regulation of cell size  response to wounding  anatomical structure morphogenesis  regulation of hydrogen peroxide metabolic process  positive regulation of lamellipodium assembly  positive regulation of lamellipodium assembly  regulation of fibroblast migration  positive regulation of cell-substrate adhesion  regulation of neuron maturation  protein transport  membrane  Rab GTPase binding  extrinsic component of plasma membrane  enzyme binding  protein kinase binding  cerebral cortex radially oriented cell migration  embryonic olfactory bulb interneuron precursor migration  cerebral cortex GABAergic interneuron development  lamellipodium  lamellipodium assembly  actin cytoskeleton organization  actin filament polymerization  platelet activation  regulation of cell migration  GTP-dependent protein binding  positive regulation of actin filament polymerization  T cell costimulation  ruffle organization  ruffle organization  early endosome membrane  thioesterase binding  ruffle membrane  negative regulation of interleukin-23 production  substrate adhesion-dependent cell spreading  positive regulation of Rho protein signal transduction  intracellular signal transduction  cytoplasmic ribonucleoprotein granule  Fc-epsilon receptor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  melanosome  histone deacetylase binding  positive regulation of apoptotic process  positive regulation of phosphatidylinositol 3-kinase activity  engulfment of apoptotic cell  cell-cell junction organization  bone resorption  positive regulation of DNA replication  vascular endothelial growth factor receptor signaling pathway  ephrin receptor signaling pathway  negative regulation of receptor-mediated endocytosis  anatomical structure arrangement  dendrite morphogenesis  cell motility  homeostasis of number of cells within a tissue  regulation of defense response to virus by virus  Rho GDP-dissociation inhibitor binding  regulation of small GTPase mediated signal transduction  positive regulation of stress fiber assembly  localization within membrane  positive regulation of focal adhesion assembly  synaptic transmission, GABAergic  Wnt signaling pathway, planar cell polarity pathway  Wnt signaling pathway, planar cell polarity pathway  regulation of respiratory burst  extracellular exosome  cellular response to mechanical stimulus  semaphorin-plexin signaling pathway  dopaminergic neuron differentiation  protein localization to plasma membrane  positive regulation of neutrophil chemotaxis  cochlea morphogenesis  ruffle assembly  positive regulation of substrate adhesion-dependent cell spreading  
Ontology : EGO-EBIGolgi membrane  phagocytic cup  positive regulation of protein phosphorylation  auditory receptor cell morphogenesis  mast cell chemotaxis  epithelial cell morphogenesis  GTPase activity  protein binding  GTP binding  GTP binding  nucleus  cytoplasm  endoplasmic reticulum membrane  trans-Golgi network  cytosol  cytosol  actin filament  plasma membrane  focal adhesion  movement of cell or subcellular component  inflammatory response  hyperosmotic response  cell adhesion  cell-matrix adhesion  G-protein coupled receptor signaling pathway  small GTPase mediated signal transduction  axon guidance  blood coagulation  metabolic process  cell proliferation  regulation of cell size  regulation of cell size  response to wounding  anatomical structure morphogenesis  regulation of hydrogen peroxide metabolic process  positive regulation of lamellipodium assembly  positive regulation of lamellipodium assembly  regulation of fibroblast migration  positive regulation of cell-substrate adhesion  regulation of neuron maturation  protein transport  membrane  Rab GTPase binding  extrinsic component of plasma membrane  enzyme binding  protein kinase binding  cerebral cortex radially oriented cell migration  embryonic olfactory bulb interneuron precursor migration  cerebral cortex GABAergic interneuron development  lamellipodium  lamellipodium assembly  actin cytoskeleton organization  actin filament polymerization  platelet activation  regulation of cell migration  GTP-dependent protein binding  positive regulation of actin filament polymerization  T cell costimulation  ruffle organization  ruffle organization  early endosome membrane  thioesterase binding  ruffle membrane  negative regulation of interleukin-23 production  substrate adhesion-dependent cell spreading  positive regulation of Rho protein signal transduction  intracellular signal transduction  cytoplasmic ribonucleoprotein granule  Fc-epsilon receptor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  melanosome  histone deacetylase binding  positive regulation of apoptotic process  positive regulation of phosphatidylinositol 3-kinase activity  engulfment of apoptotic cell  cell-cell junction organization  bone resorption  positive regulation of DNA replication  vascular endothelial growth factor receptor signaling pathway  ephrin receptor signaling pathway  negative regulation of receptor-mediated endocytosis  anatomical structure arrangement  dendrite morphogenesis  cell motility  homeostasis of number of cells within a tissue  regulation of defense response to virus by virus  Rho GDP-dissociation inhibitor binding  regulation of small GTPase mediated signal transduction  positive regulation of stress fiber assembly  localization within membrane  positive regulation of focal adhesion assembly  synaptic transmission, GABAergic  Wnt signaling pathway, planar cell polarity pathway  Wnt signaling pathway, planar cell polarity pathway  regulation of respiratory burst  extracellular exosome  cellular response to mechanical stimulus  semaphorin-plexin signaling pathway  dopaminergic neuron differentiation  protein localization to plasma membrane  positive regulation of neutrophil chemotaxis  cochlea morphogenesis  ruffle assembly  positive regulation of substrate adhesion-dependent cell spreading  
Pathways : BIOCARTAY branching of actin filaments [Genes]    Tumor Suppressor Arf Inhibits Ribosomal Biogenesis [Genes]    Links between Pyk2 and Map Kinases [Genes]    BCR Signaling Pathway [Genes]    Transcription factor CREB and its extracellular signals [Genes]    fMLP induced chemokine gene expression in HMC-1 cells [Genes]    Rac 1 cell motility signaling pathway [Genes]    Ras Signaling Pathway [Genes]    T Cell Receptor Signaling Pathway [Genes]    Phosphoinositides and their downstream targets. [Genes]    Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration [Genes]    How does salmonella hijack a cell [Genes]    Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]    Role of MAL in Rho-Mediated Activation of SRF [Genes]    Ras-Independent pathway in NK cell-mediated cytotoxicity [Genes]    uCalpain and friends in Cell spread [Genes]    Agrin in Postsynaptic Differentiation [Genes]    Phospholipids as signalling intermediaries [Genes]    Influence of Ras and Rho proteins on G1 to S Transition [Genes]    MAPKinase Signaling Pathway [Genes]    p38 MAPK Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    Chemokine signaling pathway    Phagosome    PI3K-Akt signaling pathway    Wnt signaling pathway    Axon guidance    VEGF signaling pathway    Osteoclast differentiation    Focal adhesion    Adherens junction    Toll-like receptor signaling pathway    Natural killer cell mediated cytotoxicity    B cell receptor signaling pathway    Fc epsilon RI signaling pathway    Fc gamma R-mediated phagocytosis    Leukocyte transendothelial migration    Neurotrophin signaling pathway    Regulation of actin cytoskeleton    Non-alcoholic fatty liver disease (NAFLD)    Pancreatic secretion    Amyotrophic lateral sclerosis (ALS)    Bacterial invasion of epithelial cells    Epithelial cell signaling in Helicobacter pylori infection    Shigellosis    Salmonella infection    Pathways in cancer    Viral carcinogenesis    Proteoglycans in cancer    Colorectal cancer    Renal cell carcinoma    Pancreatic cancer    Viral myocarditis   
NDEx NetworkRAC1
Atlas of Cancer Signalling NetworkRAC1
Wikipedia pathwaysRAC1
Orthology - Evolution
OrthoDB5879
GeneTree (enSembl)ENSG00000136238
Phylogenetic Trees/Animal Genes : TreeFamRAC1
HOVERGENP63000
HOGENOMP63000
Homologs : HomoloGeneRAC1
Homology/Alignments : Family Browser (UCSC)RAC1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAC1
dbVarRAC1
ClinVarRAC1
1000_GenomesRAC1 
Exome Variant ServerRAC1
ExAC (Exome Aggregation Consortium)RAC1 (select the gene name)
Genetic variants : HAPMAP5879
Genomic Variants (DGV)RAC1 [DGVbeta]
DECIPHER (Syndromes)7:6414126-6443598  ENSG00000136238
CONAN: Copy Number AnalysisRAC1 
Mutations
ICGC Data PortalRAC1 
TCGA Data PortalRAC1 
Broad Tumor PortalRAC1
OASIS PortalRAC1 [ Somatic mutations - Copy number]
Cancer Gene: CensusRAC1 
Somatic Mutations in Cancer : COSMICRAC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAC1
intOGen PortalRAC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAC1
DgiDB (Drug Gene Interaction Database)RAC1
DoCM (Curated mutations)RAC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAC1 (select a term)
intoGenRAC1
Cancer3DRAC1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602048   
Orphanet
MedgenRAC1
Genetic Testing Registry RAC1
NextProtP63000 [Medical]
TSGene5879
GENETestsRAC1
Huge Navigator RAC1 [HugePedia]
snp3D : Map Gene to Disease5879
BioCentury BCIQRAC1
ClinGenRAC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5879
Chemical/Pharm GKB GenePA34162
Clinical trialRAC1
Miscellaneous
canSAR (ICR)RAC1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAC1
EVEXRAC1
GoPubMedRAC1
iHOPRAC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:24:10 CET 2017

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