RAC1 (Rac family small GTPase 1)

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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RAC1 (Rac family small GTPase 1)

Identity

Alias_names	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Alias_symbol (synonym)	TC-25
	p21-Rac1
	Rac-1
Other alias	MIG5
	MRD48
HGNC (Hugo)	RAC1
LocusID (NCBI)	5879
Atlas_Id	42020
Location	7p22.1 [Link to chromosome band 7p22]
Location_base_pair	Starts at 6374495 and ends at 6403967 bp from pter ( according to hg38-Dec_2013)

Fusion genes
(updated 2017)

Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

CCT3 (1q22) / RAC1 (7p22.1)	KIAA0040 (1q25.1) / RAC1 (7p22.1)	LOC550643 () / RAC1 (7p22.1)
RAC1 (7p22.1) / AKT3 (1q43)	RAC1 (7p22.1) / MRPS7 (17q25.1)	RAC1 (7p22.1) / PROKR1 (2p13.3)
RAC1 (7p22.1) / PTPN11 (12q24.13)	RAC1 (7p22.1) / RAC1 (7p22.1)	RAC1 (7p22.1) / RAP1GAP2 (17p13.3)
RAC1 (7p22.1) / TRAF3IP2-AS1 (6q21)

Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]

t(6;7)(q14;p22) RAC1/COL12A1
t(7;9)(p22;q34) NUP214/RAC1
t(7;9)(p22;q34) NUP214/RAC1

External links

	Nomenclature
HGNC (Hugo)	RAC1 9801
	Cards
Entrez_Gene (NCBI)	RAC1 5879 Rac family small GTPase 1
Aliases	MIG5; MRD48; Rac-1; TC-25;
	p21-Rac1
GeneCards (Weizmann)	RAC1
Ensembl hg19 (Hinxton)	ENSG00000136238 [Gene_View]
Ensembl hg38 (Hinxton)	ENSG00000136238 [Gene_View] ENSG00000136238 [Sequence] chr7:6374495-6403967 [Contig_View] RAC1 [Vega]
ICGC DataPortal	ENSG00000136238
TCGA cBioPortal	RAC1
AceView (NCBI)	RAC1
Genatlas (Paris)	RAC1
WikiGenes	5879
SOURCE (Princeton)	RAC1
Genetics Home Reference (NIH)	RAC1
	Genomic and cartography
GoldenPath hg38 (UCSC)	RAC1 - chr7:6374495-6403967 + 7p22.1 [Description] (hg38-Dec_2013)
GoldenPath hg19 (UCSC)	RAC1 - 7p22.1 [Description] (hg19-Feb_2009)
GoldenPath	RAC1 - 7p22.1 [CytoView hg19] RAC1 - 7p22.1 [CytoView hg38]
ImmunoBase	ENSG00000136238
Mapping of homologs : NCBI	RAC1 [Mapview hg19] RAC1 [Mapview hg38]
OMIM	602048 617751
	Gene and transcription
Genbank (Entrez)	AB209410 AB451238 AB451363 AF136373 AF498964
RefSeq transcript (Entrez)	NM_006908 NM_018890 NM_198829
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)	RAC1
Cluster EST : Unigene	Hs.413812 [ NCBI ]
CGAP (NCI)	Hs.413812
Alternative Splicing Gallery	ENSG00000136238
Gene Expression	RAC1 [ NCBI-GEO ] RAC1 [ EBI - ARRAY_EXPRESS ] RAC1 [ SEEK ] RAC1 [ MEM ]
Gene Expression Viewer (FireBrowse)	RAC1 [ Firebrowse - Broad ]
SOURCE (Princeton)	Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
Genevestigator	Expression in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	5879
GTEX Portal (Tissue expression)	RAC1
Human Protein Atlas	ENSG00000136238-RAC1 [pathology] [cell] [tissue]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P63000 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction]
NextProt	P63000 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	P63000
Splice isoforms : SwissVar	P63000
PhosPhoSitePlus	P63000
Domaine pattern : Prosite (Expaxy)	RHO (PS51420)
Domains : Interpro (EBI)	P-loop_NTPase Small_GTP-bd_dom Small_GTPase Small_GTPase_Rho
Domain families : Pfam (Sanger)	Ras (PF00071)
Domain families : Pfam (NCBI)	pfam00071
Conserved Domain (NCBI)	RAC1
DMDM Disease mutations	5879
Blocks (Seattle)	RAC1
PDB (RSDB)	1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2RMK 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD 3SBE 3SU8 3SUA 3TH5 4GZL 4GZM 4YON 5FI0 5HZH 5N6O 5O33 6BC1
PDB Europe	1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2RMK 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD 3SBE 3SU8 3SUA 3TH5 4GZL 4GZM 4YON 5FI0 5HZH 5N6O 5O33 6BC1
PDB (PDBSum)	1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2RMK 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD 3SBE 3SU8 3SUA 3TH5 4GZL 4GZM 4YON 5FI0 5HZH 5N6O 5O33 6BC1
PDB (IMB)	1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2RMK 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD 3SBE 3SU8 3SUA 3TH5 4GZL 4GZM 4YON 5FI0 5HZH 5N6O 5O33 6BC1
Structural Biology KnowledgeBase	1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2RMK 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD 3SBE 3SU8 3SUA 3TH5 4GZL 4GZM 4YON 5FI0 5HZH 5N6O 5O33 6BC1
SCOP (Structural Classification of Proteins)	1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2RMK 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD 3SBE 3SU8 3SUA 3TH5 4GZL 4GZM 4YON 5FI0 5HZH 5N6O 5O33 6BC1
CATH (Classification of proteins structures)	1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2RMK 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD 3SBE 3SU8 3SUA 3TH5 4GZL 4GZM 4YON 5FI0 5HZH 5N6O 5O33 6BC1
Superfamily	P63000
Human Protein Atlas [tissue]	ENSG00000136238-RAC1 [tissue]
Peptide Atlas	P63000
HPRD	03627
IPI	IPI00010271 IPI00219675 IPI00555566
	Protein Interaction databases
DIP (DOE-UCLA)	P63000
IntAct (EBI)	P63000
FunCoup	ENSG00000136238
BioGRID	RAC1
STRING (EMBL)	RAC1
ZODIAC	RAC1
	Ontologies - Pathways
QuickGO	P63000
Ontology : AmiGO	Golgi membrane neuron migration positive regulation of protein phosphorylation mast cell chemotaxis GTPase activity GTPase activity GTPase activity protein binding GTP binding GTP binding GTP binding cytoplasm cytoplasm endoplasmic reticulum membrane trans-Golgi network cytosol cytosol actin filament plasma membrane plasma membrane plasma membrane focal adhesion inflammatory response cell adhesion cell-matrix adhesion Rho protein signal transduction blood coagulation motor neuron axon guidance cell proliferation regulation of cell size regulation of cell size response to wounding anatomical structure morphogenesis regulation of hydrogen peroxide metabolic process regulation of lamellipodium assembly positive regulation of lamellipodium assembly positive regulation of lamellipodium assembly positive regulation of cell-substrate adhesion membrane cell migration Rac protein signal transduction Rab GTPase binding enzyme binding protein kinase binding protein kinase binding lamellipodium cell projection assembly lamellipodium assembly actin cytoskeleton organization actin cytoskeleton organization actin filament polymerization regulation of cell migration secretory granule membrane positive regulation of microtubule polymerization T cell costimulation cytoplasmic vesicle ruffle organization ruffle organization thioesterase binding ruffle membrane negative regulation of interleukin-23 production substrate adhesion-dependent cell spreading positive regulation of Rho protein signal transduction intracellular signal transduction positive regulation of insulin secretion involved in cellular response to glucose stimulus cytoplasmic ribonucleoprotein granule Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis melanosome histone deacetylase binding cell projection dendritic spine dendritic spine neutrophil degranulation protein-containing complex binding regulation of nitric oxide biosynthetic process bone resorption positive regulation of DNA replication vascular endothelial growth factor receptor signaling pathway hepatocyte growth factor receptor signaling pathway ephrin receptor signaling pathway negative regulation of receptor-mediated endocytosis cell motility regulation of defense response to virus by virus Rho GDP-dissociation inhibitor binding regulation of small GTPase mediated signal transduction ATPase binding regulation of stress fiber assembly positive regulation of stress fiber assembly positive regulation of stress fiber assembly localization within membrane positive regulation of focal adhesion assembly positive regulation of protein kinase B signaling recycling endosome membrane Wnt signaling pathway, planar cell polarity pathway Wnt signaling pathway, planar cell polarity pathway regulation of respiratory burst extracellular exosome cellular response to mechanical stimulus semaphorin-plexin signaling pathway positive regulation of neutrophil chemotaxis ruffle assembly postsynapse postsynapse glutamatergic synapse glutamatergic synapse ficolin-1-rich granule membrane positive regulation of substrate adhesion-dependent cell spreading regulation of neutrophil migration
Ontology : EGO-EBI	Golgi membrane neuron migration positive regulation of protein phosphorylation mast cell chemotaxis GTPase activity GTPase activity GTPase activity protein binding GTP binding GTP binding GTP binding cytoplasm cytoplasm endoplasmic reticulum membrane trans-Golgi network cytosol cytosol actin filament plasma membrane plasma membrane plasma membrane focal adhesion inflammatory response cell adhesion cell-matrix adhesion Rho protein signal transduction blood coagulation motor neuron axon guidance cell proliferation regulation of cell size regulation of cell size response to wounding anatomical structure morphogenesis regulation of hydrogen peroxide metabolic process regulation of lamellipodium assembly positive regulation of lamellipodium assembly positive regulation of lamellipodium assembly positive regulation of cell-substrate adhesion membrane cell migration Rac protein signal transduction Rab GTPase binding enzyme binding protein kinase binding protein kinase binding lamellipodium cell projection assembly lamellipodium assembly actin cytoskeleton organization actin cytoskeleton organization actin filament polymerization regulation of cell migration secretory granule membrane positive regulation of microtubule polymerization T cell costimulation cytoplasmic vesicle ruffle organization ruffle organization thioesterase binding ruffle membrane negative regulation of interleukin-23 production substrate adhesion-dependent cell spreading positive regulation of Rho protein signal transduction intracellular signal transduction positive regulation of insulin secretion involved in cellular response to glucose stimulus cytoplasmic ribonucleoprotein granule Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis melanosome histone deacetylase binding cell projection dendritic spine dendritic spine neutrophil degranulation protein-containing complex binding regulation of nitric oxide biosynthetic process bone resorption positive regulation of DNA replication vascular endothelial growth factor receptor signaling pathway hepatocyte growth factor receptor signaling pathway ephrin receptor signaling pathway negative regulation of receptor-mediated endocytosis cell motility regulation of defense response to virus by virus Rho GDP-dissociation inhibitor binding regulation of small GTPase mediated signal transduction ATPase binding regulation of stress fiber assembly positive regulation of stress fiber assembly positive regulation of stress fiber assembly localization within membrane positive regulation of focal adhesion assembly positive regulation of protein kinase B signaling recycling endosome membrane Wnt signaling pathway, planar cell polarity pathway Wnt signaling pathway, planar cell polarity pathway regulation of respiratory burst extracellular exosome cellular response to mechanical stimulus semaphorin-plexin signaling pathway positive regulation of neutrophil chemotaxis ruffle assembly postsynapse postsynapse glutamatergic synapse glutamatergic synapse ficolin-1-rich granule membrane positive regulation of substrate adhesion-dependent cell spreading regulation of neutrophil migration
Pathways : KEGG	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Chemokine signaling pathway Phagosome PI3K-Akt signaling pathway Wnt signaling pathway Axon guidance VEGF signaling pathway Osteoclast differentiation Focal adhesion Adherens junction Toll-like receptor signaling pathway Natural killer cell mediated cytotoxicity B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Neurotrophin signaling pathway Regulation of actin cytoskeleton Non-alcoholic fatty liver disease (NAFLD) Pancreatic secretion Amyotrophic lateral sclerosis (ALS) Bacterial invasion of epithelial cells Epithelial cell signaling in Helicobacter pylori infection Shigellosis Salmonella infection Pathways in cancer Viral carcinogenesis Proteoglycans in cancer Colorectal cancer Renal cell carcinoma Pancreatic cancer Viral myocarditis
NDEx Network	RAC1
Atlas of Cancer Signalling Network	RAC1
Wikipedia pathways	RAC1
	Orthology - Evolution
OrthoDB	5879
GeneTree (enSembl)	ENSG00000136238
Phylogenetic Trees/Animal Genes : TreeFam	RAC1
HOGENOM	P63000
Homologs : HomoloGene	RAC1
Homology/Alignments : Family Browser (UCSC)	RAC1
	Gene fusions - Rearrangements
Fusion : Quiver	RAC1
	Polymorphisms : SNP and Copy number variants
NCBI Variation Viewer	RAC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	RAC1
dbVar	RAC1
ClinVar	RAC1
1000_Genomes	RAC1
Exome Variant Server	RAC1
ExAC (Exome Aggregation Consortium)	ENSG00000136238
GNOMAD Browser	ENSG00000136238
Varsome Browser	RAC1
Genetic variants : HAPMAP	5879
Genomic Variants (DGV)	RAC1 [DGVbeta]
DECIPHER	RAC1 [patients] [syndromes] [variants] [genes]
CONAN: Copy Number Analysis	RAC1
	Mutations
ICGC Data Portal	RAC1
TCGA Data Portal	RAC1
Broad Tumor Portal	RAC1
OASIS Portal	RAC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMIC	RAC1 [overview] [genome browser] [tissue] [distribution]
Somatic Mutations in Cancer : COSMIC3D	RAC1
Mutations and Diseases : HGMD	RAC1
intOGen Portal	RAC1
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
BioMuta	search RAC1
DgiDB (Drug Gene Interaction Database)	RAC1
DoCM (Curated mutations)	RAC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)	RAC1 (select a term)
intoGen	RAC1
Cancer3D	RAC1(select the gene name)
Impact of mutations	[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
	Diseases
OMIM	602048 617751
Orphanet
DisGeNET	RAC1
Medgen	RAC1
Genetic Testing Registry	RAC1
NextProt	P63000 [Medical]
TSGene	5879
GENETests	RAC1
Target Validation	RAC1
Huge Navigator	RAC1 [HugePedia]
snp3D : Map Gene to Disease	5879
BioCentury BCIQ	RAC1
ClinGen	RAC1
	Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD	5879
Chemical/Pharm GKB Gene	PA34162
Clinical trial	RAC1
	Miscellaneous
canSAR (ICR)	RAC1 (select the gene name)
DataMed Index	RAC1
	Probes
	Litterature
PubMed	499 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
CoreMine	RAC1
EVEX	RAC1
GoPubMed	RAC1
iHOP	RAC1

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

indexed on : Wed Nov 13 18:03:56 CET 2019

Home Genes Leukemias Solid Tumors Cancer-Prone Deep Insight Case Reports Journals Portal Teaching

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jlhuret@AtlasGeneticsOncology.org.

Atlas of Genetics and Cytogenetics in Oncology and Haematology

RAC1 (Rac family small GTPase 1)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute