RAD1 (RAD1 checkpoint DNA exonuclease)

2003-02-01  

Identity

HGNC
LOCATION
5p13.2
LOCUSID
ALIAS
HRAD1,REC1
FUSION GENES

Other Information

Locus ID:

NCBI: 5810
MIM: 603153
HGNC: 9806
Ensembl: ENSG00000113456

Variants:

dbSNP: 5810
ClinVar: 5810
TCGA: ENSG00000113456
COSMIC: RAD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113456ENST00000325577O60671
ENSG00000113456ENST00000341754O60671
ENSG00000113456ENST00000341754A0A024R045
ENSG00000113456ENST00000382038O60671
ENSG00000113456ENST00000382038A0A024R045
ENSG00000113456ENST00000511456D6R9A1
ENSG00000113456ENST00000513914D6R9A1
ENSG00000113456ENST00000628399D6R9A1

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Activation of ATR in response to replication stressREACTOMER-HSA-176187
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Homologous DNA Pairing and Strand ExchangeREACTOMER-HSA-5693579
Presynaptic phase of homologous DNA pairing and strand exchangeREACTOMER-HSA-5693616
HDR through Single Strand Annealing (SSA)REACTOMER-HSA-5685938
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
153141872004The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair.57
155569962004The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1.51
158716982005The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery.37
162162732005The two DNA clamps Rad9/Rad1/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity.36
195353282009Structure and functional implications of the human rad9-hus1-rad1 cell cycle checkpoint complex.36
178554022007The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase.34
173956412007The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates NEIL1 glycosylase.32
167315262006Mechanism of stimulation of human DNA ligase I by the Rad9-rad1-Hus1 checkpoint complex.30
225861022012Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability.27
190748852008Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.25

Citation

Dessen P

RAD1 (RAD1 checkpoint DNA exonuclease)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42023/rad1