Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

RAD1 (RAD1 checkpoint DNA exonuclease)

Identity

Alias_namesRAD1 (S. pombe) homolog
RAD1 homolog (S. pombe)
Alias_symbol (synonym)HRAD1
REC1
Other alias
HGNC (Hugo) RAD1
LocusID (NCBI) 5810
Atlas_Id 42023
Location 5p13.2  [Link to chromosome band 5p13]
Location_base_pair Starts at 34905261 and ends at 34915675 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCDC6 (10q21.2) / RAD1 (5p13.2)RAD1 (5p13.2) / CA13 (8q21.2)RAD1 (5p13.2) / EHD2 (19q13.33)
TIAM2 (6q25.3) / RAD1 (5p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)RAD1   9806
Cards
Entrez_Gene (NCBI)RAD1  5810  RAD1 checkpoint DNA exonuclease
AliasesHRAD1; REC1
GeneCards (Weizmann)RAD1
Ensembl hg19 (Hinxton)ENSG00000113456 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113456 [Gene_View]  chr5:34905261-34915675 [Contig_View]  RAD1 [Vega]
ICGC DataPortalENSG00000113456
TCGA cBioPortalRAD1
AceView (NCBI)RAD1
Genatlas (Paris)RAD1
WikiGenes5810
SOURCE (Princeton)RAD1
Genetics Home Reference (NIH)RAD1
Genomic and cartography
GoldenPath hg38 (UCSC)RAD1  -     chr5:34905261-34915675 -  5p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAD1  -     5p13.2   [Description]    (hg19-Feb_2009)
EnsemblRAD1 - 5p13.2 [CytoView hg19]  RAD1 - 5p13.2 [CytoView hg38]
Mapping of homologs : NCBIRAD1 [Mapview hg19]  RAD1 [Mapview hg38]
OMIM603153   
Gene and transcription
Genbank (Entrez)AF011905 AF030933 AF058392 AF058393 AF073524
RefSeq transcript (Entrez)NM_001033673 NM_002853 NM_133282 NM_133377
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RAD1
Cluster EST : UnigeneHs.38114 [ NCBI ]
CGAP (NCI)Hs.38114
Alternative Splicing GalleryENSG00000113456
Gene ExpressionRAD1 [ NCBI-GEO ]   RAD1 [ EBI - ARRAY_EXPRESS ]   RAD1 [ SEEK ]   RAD1 [ MEM ]
Gene Expression Viewer (FireBrowse)RAD1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5810
GTEX Portal (Tissue expression)RAD1
Human Protein AtlasENSG00000113456-RAD1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60671   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60671  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60671
Splice isoforms : SwissVarO60671
Catalytic activity : Enzyme3.1.11.2 [ Enzyme-Expasy ]   3.1.11.23.1.11.2 [ IntEnz-EBI ]   3.1.11.2 [ BRENDA ]   3.1.11.2 [ KEGG ]   
PhosPhoSitePlusO60671
Domains : Interpro (EBI)Cell_cycle_checkpoint_Rad1    Rad1_Rec1_Rad17   
Domain families : Pfam (Sanger)Rad1 (PF02144)   
Domain families : Pfam (NCBI)pfam02144   
Conserved Domain (NCBI)RAD1
DMDM Disease mutations5810
Blocks (Seattle)RAD1
PDB (SRS)3A1J    3G65    3GGR   
PDB (PDBSum)3A1J    3G65    3GGR   
PDB (IMB)3A1J    3G65    3GGR   
PDB (RSDB)3A1J    3G65    3GGR   
Structural Biology KnowledgeBase3A1J    3G65    3GGR   
SCOP (Structural Classification of Proteins)3A1J    3G65    3GGR   
CATH (Classification of proteins structures)3A1J    3G65    3GGR   
SuperfamilyO60671
Human Protein Atlas [tissue]ENSG00000113456-RAD1 [tissue]
Peptide AtlasO60671
HPRD04400
IPIIPI00003647   IPI00107483   IPI00654688   IPI01009366   
Protein Interaction databases
DIP (DOE-UCLA)O60671
IntAct (EBI)O60671
FunCoupENSG00000113456
BioGRIDRAD1
STRING (EMBL)RAD1
ZODIACRAD1
Ontologies - Pathways
QuickGOO60671
Ontology : AmiGODNA damage checkpoint  damaged DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  chromosome  DNA replication  DNA repair  cellular response to DNA damage stimulus  3'-5' exonuclease activity  exodeoxyribonuclease III activity  substantia nigra development  checkpoint clamp complex  intracellular membrane-bounded organelle  meiotic recombination checkpoint  cellular response to ionizing radiation  nucleic acid phosphodiester bond hydrolysis  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIDNA damage checkpoint  damaged DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  chromosome  DNA replication  DNA repair  cellular response to DNA damage stimulus  3'-5' exonuclease activity  exodeoxyribonuclease III activity  substantia nigra development  checkpoint clamp complex  intracellular membrane-bounded organelle  meiotic recombination checkpoint  cellular response to ionizing radiation  nucleic acid phosphodiester bond hydrolysis  regulation of signal transduction by p53 class mediator  
Pathways : BIOCARTARole of BRCA1, BRCA2 and ATR in Cancer Susceptibility [Genes]   
NDEx NetworkRAD1
Atlas of Cancer Signalling NetworkRAD1
Wikipedia pathwaysRAD1
Orthology - Evolution
OrthoDB5810
GeneTree (enSembl)ENSG00000113456
Phylogenetic Trees/Animal Genes : TreeFamRAD1
HOVERGENO60671
HOGENOMO60671
Homologs : HomoloGeneRAD1
Homology/Alignments : Family Browser (UCSC)RAD1
Gene fusions - Rearrangements
Fusion : QuiverRAD1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAD1
dbVarRAD1
ClinVarRAD1
1000_GenomesRAD1 
Exome Variant ServerRAD1
ExAC (Exome Aggregation Consortium)ENSG00000113456
GNOMAD BrowserENSG00000113456
Genetic variants : HAPMAP5810
Genomic Variants (DGV)RAD1 [DGVbeta]
DECIPHERRAD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAD1 
Mutations
ICGC Data PortalRAD1 
TCGA Data PortalRAD1 
Broad Tumor PortalRAD1
OASIS PortalRAD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAD1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAD1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAD1
DgiDB (Drug Gene Interaction Database)RAD1
DoCM (Curated mutations)RAD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAD1 (select a term)
intoGenRAD1
Cancer3DRAD1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603153   
Orphanet
DisGeNETRAD1
MedgenRAD1
Genetic Testing Registry RAD1
NextProtO60671 [Medical]
TSGene5810
GENETestsRAD1
Target ValidationRAD1
Huge Navigator RAD1 [HugePedia]
snp3D : Map Gene to Disease5810
BioCentury BCIQRAD1
ClinGenRAD1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5810
Chemical/Pharm GKB GenePA34166
Clinical trialRAD1
Miscellaneous
canSAR (ICR)RAD1 (select the gene name)
Probes
Litterature
PubMed64 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAD1
EVEXRAD1
GoPubMedRAD1
iHOPRAD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jun 18 19:41:29 CEST 2018
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.