RAD17 (RAD17 checkpoint clamp loader component)

2003-02-01  

Identity

HGNC
LOCATION
5q13.2
LOCUSID
ALIAS
CCYC,HRAD17,R24L,RAD17SP,RAD24
FUSION GENES

Other Information

Locus ID:

NCBI: 5884
MIM: 603139
HGNC: 9807
Ensembl: ENSG00000152942

Variants:

dbSNP: 5884
ClinVar: 5884
TCGA: ENSG00000152942
COSMIC: RAD17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152942ENST00000282891O75943
ENSG00000152942ENST00000305138O75943
ENSG00000152942ENST00000345306O75943
ENSG00000152942ENST00000354312O75943
ENSG00000152942ENST00000354868O75943
ENSG00000152942ENST00000358030O75943
ENSG00000152942ENST00000361732O75943
ENSG00000152942ENST00000380774O75943
ENSG00000152942ENST00000506564D6RAW6
ENSG00000152942ENST00000507927D6RA84
ENSG00000152942ENST00000508320H0Y9J8
ENSG00000152942ENST00000509734O75943
ENSG00000152942ENST00000512785D6RHU1
ENSG00000152942ENST00000513214H0Y9T7
ENSG00000152942ENST00000521422O75943
ENSG00000152942ENST00000616683O75943

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Activation of ATR in response to replication stressREACTOMER-HSA-176187
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Homologous DNA Pairing and Strand ExchangeREACTOMER-HSA-5693579
Presynaptic phase of homologous DNA pairing and strand exchangeREACTOMER-HSA-5693616
HDR through Single Strand Annealing (SSA)REACTOMER-HSA-5685938
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
146052142003Replication protein A-mediated recruitment and activation of Rad17 complexes.168
154858982004Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation.66
168850232006Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress.56
236846112013Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1.51
155383882004Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling.43
204245962010Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress.24
256506592015Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression.19
245340912014Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks.16
145008192003The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon.15
236873792013Depletion of RAD17 sensitizes pancreatic cancer cells to gemcitabine.14

Citation

Dessen P

RAD17 (RAD17 checkpoint clamp loader component)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42024/rad17