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RAD17 (RAD17 checkpoint clamp loader component)

Identity

Alias_namesRAD1 (S. pombe) homolog
RAD17 homolog (S. pombe)
Alias_symbol (synonym)Rad24
RAD17Sp
CCYC
Other aliasHRAD17
R24L
RAD17SP
RAD24
HGNC (Hugo) RAD17
LocusID (NCBI) 5884
Atlas_Id 42024
Location 5q13.2  [Link to chromosome band 5q13]
Location_base_pair Starts at 68665887 and ends at 68710628 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
C8orf44 (8q13.1) / RAD17 (5q13.2)RAD17 (5q13.2) / ASPH (8q12.3)RAD17 (5q13.2) / SEC24A (5q31.1)
RAD17 (5q13.2) / TRAPPC13 (5q12.3)RAD17 5q13.2 / SEC24A 5q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RAD17   9807
Cards
Entrez_Gene (NCBI)RAD17  5884  RAD17 checkpoint clamp loader component
AliasesCCYC; HRAD17; R24L; RAD17SP; 
RAD24
GeneCards (Weizmann)RAD17
Ensembl hg19 (Hinxton)ENSG00000152942 [Gene_View]  chr5:68665887-68710628 [Contig_View]  RAD17 [Vega]
Ensembl hg38 (Hinxton)ENSG00000152942 [Gene_View]  chr5:68665887-68710628 [Contig_View]  RAD17 [Vega]
ICGC DataPortalENSG00000152942
TCGA cBioPortalRAD17
AceView (NCBI)RAD17
Genatlas (Paris)RAD17
WikiGenes5884
SOURCE (Princeton)RAD17
Genetics Home Reference (NIH)RAD17
Genomic and cartography
GoldenPath hg19 (UCSC)RAD17  -     chr5:68665887-68710628 +  5q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RAD17  -     5q13.2   [Description]    (hg38-Dec_2013)
EnsemblRAD17 - 5q13.2 [CytoView hg19]  RAD17 - 5q13.2 [CytoView hg38]
Mapping of homologs : NCBIRAD17 [Mapview hg19]  RAD17 [Mapview hg38]
OMIM603139   
Gene and transcription
Genbank (Entrez)AF017748 AF076838 AF085736 AF098533 AF098534
RefSeq transcript (Entrez)NM_001278622 NM_002873 NM_133338 NM_133339 NM_133340 NM_133341 NM_133342 NM_133343 NM_133344
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_034772 NW_003315917 NW_004929322
Consensus coding sequences : CCDS (NCBI)RAD17
Cluster EST : UnigeneHs.16184 [ NCBI ]
CGAP (NCI)Hs.16184
Alternative Splicing GalleryENSG00000152942
Gene ExpressionRAD17 [ NCBI-GEO ]   RAD17 [ EBI - ARRAY_EXPRESS ]   RAD17 [ SEEK ]   RAD17 [ MEM ]
Gene Expression Viewer (FireBrowse)RAD17 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5884
GTEX Portal (Tissue expression)RAD17
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75943   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75943  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75943
Splice isoforms : SwissVarO75943
PhosPhoSitePlusO75943
Domains : Interpro (EBI)AAA+_ATPase    Checkpoint_prot_Rad17_Rad24    P-loop_NTPase    Rad17/Rad24_fun/met   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)RAD17
DMDM Disease mutations5884
Blocks (Seattle)RAD17
SuperfamilyO75943
Human Protein AtlasENSG00000152942
Peptide AtlasO75943
HPRD09124
IPIIPI00395702   IPI00334267   IPI00107491   IPI00107492   IPI00968270   IPI00965268   IPI00965621   IPI00966403   IPI00965914   
Protein Interaction databases
DIP (DOE-UCLA)O75943
IntAct (EBI)O75943
FunCoupENSG00000152942
BioGRIDRAD17
STRING (EMBL)RAD17
ZODIACRAD17
Ontologies - Pathways
QuickGOO75943
Ontology : AmiGODNA replication checkpoint  DNA damage checkpoint  chromosome, telomeric region  DNA clamp loader activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA repair  cellular response to DNA damage stimulus  mitotic cell cycle checkpoint  negative regulation of DNA replication  Rad17 RFC-like complex  regulation of phosphorylation  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIDNA replication checkpoint  DNA damage checkpoint  chromosome, telomeric region  DNA clamp loader activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA repair  cellular response to DNA damage stimulus  mitotic cell cycle checkpoint  negative regulation of DNA replication  Rad17 RFC-like complex  regulation of phosphorylation  regulation of signal transduction by p53 class mediator  
Pathways : BIOCARTARole of BRCA1, BRCA2 and ATR in Cancer Susceptibility [Genes]   
NDEx NetworkRAD17
Atlas of Cancer Signalling NetworkRAD17
Wikipedia pathwaysRAD17
Orthology - Evolution
OrthoDB5884
GeneTree (enSembl)ENSG00000152942
Phylogenetic Trees/Animal Genes : TreeFamRAD17
HOVERGENO75943
HOGENOMO75943
Homologs : HomoloGeneRAD17
Homology/Alignments : Family Browser (UCSC)RAD17
Gene fusions - Rearrangements
Fusion : MitelmanRAD17/SEC24A [5q13.2/5q31.1]  
Fusion: TCGARAD17 5q13.2 SEC24A 5q31.1 PRAD
Fusion Cancer (Beijing)RAD17 [5q13.2]  -  TRAPPC13 [5q12.3]  [FUSC002961]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAD17 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAD17
dbVarRAD17
ClinVarRAD17
1000_GenomesRAD17 
Exome Variant ServerRAD17
ExAC (Exome Aggregation Consortium)RAD17 (select the gene name)
Genetic variants : HAPMAP5884
Genomic Variants (DGV)RAD17 [DGVbeta]
DECIPHER (Syndromes)5:68665887-68710628  ENSG00000152942
CONAN: Copy Number AnalysisRAD17 
Mutations
ICGC Data PortalRAD17 
TCGA Data PortalRAD17 
Broad Tumor PortalRAD17
OASIS PortalRAD17 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDRAD17
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAD17
DgiDB (Drug Gene Interaction Database)RAD17
DoCM (Curated mutations)RAD17 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAD17 (select a term)
intoGenRAD17
Cancer3DRAD17(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603139   
Orphanet
MedgenRAD17
Genetic Testing Registry RAD17
NextProtO75943 [Medical]
TSGene5884
GENETestsRAD17
Huge Navigator RAD17 [HugePedia]
snp3D : Map Gene to Disease5884
BioCentury BCIQRAD17
ClinGenRAD17
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5884
Chemical/Pharm GKB GenePA34167
Clinical trialRAD17
Miscellaneous
canSAR (ICR)RAD17 (select the gene name)
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAD17
EVEXRAD17
GoPubMedRAD17
iHOPRAD17
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:24:10 CET 2017

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