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RAD17 (RAD17 checkpoint clamp loader component)

Identity

Alias (NCBI)CCYC
HRAD17
R24L
RAD17SP
RAD24
HGNC (Hugo) RAD17
HGNC Alias symbRad24
RAD17Sp
CCYC
HGNC Previous nameRAD1 (S. pombe) homolog
 RAD17 homolog (S. pombe)
LocusID (NCBI) 5884
Atlas_Id 42024
Location 5q13.2  [Link to chromosome band 5q13]
Location_base_pair Starts at 69369818 and ends at 69414801 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C8orf44 (8q13.1) / RAD17 (5q13.2)RAD17 (5q13.2) / ASPH (8q12.3)RAD17 (5q13.2) / SEC24A (5q31.1)
RAD17 (5q13.2) / TRAPPC13 (5q12.3)RAD17 5q13.2 / SEC24A 5q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RAD17   9807
Cards
Entrez_Gene (NCBI)RAD17    RAD17 checkpoint clamp loader component
AliasesCCYC; HRAD17; R24L; RAD17SP; 
RAD24
GeneCards (Weizmann)RAD17
Ensembl hg19 (Hinxton)ENSG00000152942 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152942 [Gene_View]  ENSG00000152942 [Sequence]  chr5:69369818-69414801 [Contig_View]  RAD17 [Vega]
ICGC DataPortalENSG00000152942
TCGA cBioPortalRAD17
AceView (NCBI)RAD17
Genatlas (Paris)RAD17
SOURCE (Princeton)RAD17
Genetics Home Reference (NIH)RAD17
Genomic and cartography
GoldenPath hg38 (UCSC)RAD17  -     chr5:69369818-69414801 +  5q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAD17  -     5q13.2   [Description]    (hg19-Feb_2009)
GoldenPathRAD17 - 5q13.2 [CytoView hg19]  RAD17 - 5q13.2 [CytoView hg38]
ImmunoBaseENSG00000152942
Genome Data Viewer NCBIRAD17 [Mapview hg19]  
OMIM603139   
Gene and transcription
Genbank (Entrez)AF017748 AF076838 AF085736 AF098533 AF098534
RefSeq transcript (Entrez)NM_001278622 NM_002873 NM_133338 NM_133339 NM_133340 NM_133341 NM_133342 NM_133343 NM_133344
Consensus coding sequences : CCDS (NCBI)RAD17
Gene ExpressionRAD17 [ NCBI-GEO ]   RAD17 [ EBI - ARRAY_EXPRESS ]   RAD17 [ SEEK ]   RAD17 [ MEM ]
Gene Expression Viewer (FireBrowse)RAD17 [ Firebrowse - Broad ]
GenevisibleExpression of RAD17 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5884
GTEX Portal (Tissue expression)RAD17
Human Protein AtlasENSG00000152942-RAD17 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75943   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75943  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75943
PhosPhoSitePlusO75943
Domains : Interpro (EBI)Checkpoint_prot_Rad17_Rad24    P-loop_NTPase    Rad17/Rad24_fun/met   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)RAD17
SuperfamilyO75943
AlphaFold pdb e-kbO75943   
Human Protein Atlas [tissue]ENSG00000152942-RAD17 [tissue]
HPRD09124
Protein Interaction databases
DIP (DOE-UCLA)O75943
IntAct (EBI)O75943
BioGRIDRAD17
STRING (EMBL)RAD17
ZODIACRAD17
Ontologies - Pathways
QuickGOO75943
Ontology : AmiGODNA replication checkpoint signaling  DNA damage checkpoint signaling  chromosome, telomeric region  chromatin binding  DNA clamp loader activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  DNA replication  DNA repair  cellular response to DNA damage stimulus  negative regulation of DNA replication  Rad17 RFC-like complex  mitotic intra-S DNA damage checkpoint signaling  mitotic DNA replication checkpoint signaling  regulation of phosphorylation  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIDNA replication checkpoint signaling  DNA damage checkpoint signaling  chromosome, telomeric region  chromatin binding  DNA clamp loader activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  DNA replication  DNA repair  cellular response to DNA damage stimulus  negative regulation of DNA replication  Rad17 RFC-like complex  mitotic intra-S DNA damage checkpoint signaling  mitotic DNA replication checkpoint signaling  regulation of phosphorylation  regulation of signal transduction by p53 class mediator  
Pathways : BIOCARTARole of BRCA1, BRCA2 and ATR in Cancer Susceptibility [Genes]   
NDEx NetworkRAD17
Atlas of Cancer Signalling NetworkRAD17
Wikipedia pathwaysRAD17
Orthology - Evolution
OrthoDB5884
GeneTree (enSembl)ENSG00000152942
Phylogenetic Trees/Animal Genes : TreeFamRAD17
Homologs : HomoloGeneRAD17
Homology/Alignments : Family Browser (UCSC)RAD17
Gene fusions - Rearrangements
Fusion : MitelmanRAD17/SEC24A [5q13.2/5q31.1]  
Fusion Cancer (Beijing)RAD17 [5q13.2]  -  TRAPPC13 [5q12.3]  [FUSC002961]
Fusion : QuiverRAD17
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAD17 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAD17
dbVarRAD17
ClinVarRAD17
MonarchRAD17
1000_GenomesRAD17 
Exome Variant ServerRAD17
GNOMAD BrowserENSG00000152942
Varsome BrowserRAD17
ACMGRAD17 variants
VarityO75943
Genomic Variants (DGV)RAD17 [DGVbeta]
DECIPHERRAD17 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAD17 
Mutations
ICGC Data PortalRAD17 
TCGA Data PortalRAD17 
Broad Tumor PortalRAD17
OASIS PortalRAD17 [ Somatic mutations - Copy number]
Cancer Gene: CensusRAD17 
Somatic Mutations in Cancer : COSMICRAD17  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRAD17
Mutations and Diseases : HGMDRAD17
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRAD17
DgiDB (Drug Gene Interaction Database)RAD17
DoCM (Curated mutations)RAD17
CIViC (Clinical Interpretations of Variants in Cancer)RAD17
Cancer3DRAD17
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603139   
Orphanet
DisGeNETRAD17
MedgenRAD17
Genetic Testing Registry RAD17
NextProtO75943 [Medical]
GENETestsRAD17
Target ValidationRAD17
Huge Navigator RAD17 [HugePedia]
ClinGenRAD17
Clinical trials, drugs, therapy
MyCancerGenomeRAD17
Protein Interactions : CTDRAD17
Pharm GKB GenePA34167
PharosO75943
Clinical trialRAD17
Miscellaneous
canSAR (ICR)RAD17
HarmonizomeRAD17
DataMed IndexRAD17
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRAD17
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:28:03 CEST 2021

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