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RAD21 (RAD21 cohesin complex component)

Identity

Alias_namesRAD21 (S. pombe) homolog
RAD21 homolog (S. pombe)
Alias_symbol (synonym)KIAA0078
hHR21
SCC1
Other aliasCDLS4
HR21
HRAD21
MCD1
NXP1
HGNC (Hugo) RAD21
LocusID (NCBI) 5885
Atlas_Id 42026
Location 8q24.11  [Link to chromosome band 8q24]
Location_base_pair Starts at 117858173 and ends at 117887105 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ABHD12 (20p11.21) / RAD21 (8q24.11)DSCR9 (21q22.13) / RAD21 (8q24.11)LOC100505806 () / RAD21 (8q24.11)
RAD21 (8q24.11) / EIF3H (8q23.3)RAD21 (8q24.11) / EXT1 (8q24.11)RAD21 (8q24.11) / RAD21 (8q24.11)
RAD21 (8q24.11) / ZC4H2 (Xq11.2)TRPS1 (8q23.3) / RAD21 (8q24.11)TRPS1 8q23.3 / RAD21 8q24.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Chronic Myelomonocytic Leukemia (CMML)


External links

Nomenclature
HGNC (Hugo)RAD21   9811
LRG (Locus Reference Genomic)LRG_772
Cards
Entrez_Gene (NCBI)RAD21  5885  RAD21 cohesin complex component
AliasesCDLS4; HR21; HRAD21; MCD1; 
NXP1; SCC1; hHR21
GeneCards (Weizmann)RAD21
Ensembl hg19 (Hinxton)ENSG00000164754 [Gene_View]  chr8:117858173-117887105 [Contig_View]  RAD21 [Vega]
Ensembl hg38 (Hinxton)ENSG00000164754 [Gene_View]  chr8:117858173-117887105 [Contig_View]  RAD21 [Vega]
ICGC DataPortalENSG00000164754
TCGA cBioPortalRAD21
AceView (NCBI)RAD21
Genatlas (Paris)RAD21
WikiGenes5885
SOURCE (Princeton)RAD21
Genetics Home Reference (NIH)RAD21
Genomic and cartography
GoldenPath hg19 (UCSC)RAD21  -     chr8:117858173-117887105 -  8q24.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RAD21  -     8q24.11   [Description]    (hg38-Dec_2013)
EnsemblRAD21 - 8q24.11 [CytoView hg19]  RAD21 - 8q24.11 [CytoView hg38]
Mapping of homologs : NCBIRAD21 [Mapview hg19]  RAD21 [Mapview hg38]
OMIM606462   614701   
Gene and transcription
Genbank (Entrez)AK097915 AK098521 AK125620 AK289505 BC001229
RefSeq transcript (Entrez)NM_006265
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_032862 NT_008046 NW_004929340
Consensus coding sequences : CCDS (NCBI)RAD21
Cluster EST : UnigeneHs.81848 [ NCBI ]
CGAP (NCI)Hs.81848
Alternative Splicing GalleryENSG00000164754
Gene ExpressionRAD21 [ NCBI-GEO ]   RAD21 [ EBI - ARRAY_EXPRESS ]   RAD21 [ SEEK ]   RAD21 [ MEM ]
Gene Expression Viewer (FireBrowse)RAD21 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5885
GTEX Portal (Tissue expression)RAD21
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60216   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60216  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60216
Splice isoforms : SwissVarO60216
PhosPhoSitePlusO60216
Domains : Interpro (EBI)Rad21/Rec8_C    Rad21/Rec8_C_eu    Rad21_Rec8_N    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)Rad21_Rec8 (PF04824)    Rad21_Rec8_N (PF04825)   
Domain families : Pfam (NCBI)pfam04824    pfam04825   
Conserved Domain (NCBI)RAD21
DMDM Disease mutations5885
Blocks (Seattle)RAD21
PDB (SRS)4PJU    4PJW    4PK7   
PDB (PDBSum)4PJU    4PJW    4PK7   
PDB (IMB)4PJU    4PJW    4PK7   
PDB (RSDB)4PJU    4PJW    4PK7   
Structural Biology KnowledgeBase4PJU    4PJW    4PK7   
SCOP (Structural Classification of Proteins)4PJU    4PJW    4PK7   
CATH (Classification of proteins structures)4PJU    4PJW    4PK7   
SuperfamilyO60216
Human Protein AtlasENSG00000164754
Peptide AtlasO60216
HPRD05924
IPIIPI00006715   IPI00903016   IPI00982167   IPI00980849   IPI00982810   IPI00980208   IPI00984166   IPI00981513   
Protein Interaction databases
DIP (DOE-UCLA)O60216
IntAct (EBI)O60216
FunCoupENSG00000164754
BioGRIDRAD21
STRING (EMBL)RAD21
ZODIACRAD21
Ontologies - Pathways
QuickGOO60216
Ontology : AmiGOchromosome, centromeric region  chromatin  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  protein binding  nucleoplasm  nucleoplasm  chromosome  cytosol  double-strand break repair  DNA recombination  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  apoptotic process  sister chromatid cohesion  mitotic nuclear division  reciprocal meiotic recombination  cohesin complex  membrane  protein sumoylation  nuclear meiotic cohesin complex  positive regulation of transcription from RNA polymerase II promoter  cell division  protein localization to chromatin  
Ontology : EGO-EBIchromosome, centromeric region  chromatin  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  protein binding  nucleoplasm  nucleoplasm  chromosome  cytosol  double-strand break repair  DNA recombination  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  apoptotic process  sister chromatid cohesion  mitotic nuclear division  reciprocal meiotic recombination  cohesin complex  membrane  protein sumoylation  nuclear meiotic cohesin complex  positive regulation of transcription from RNA polymerase II promoter  cell division  protein localization to chromatin  
Pathways : KEGGCell cycle   
NDEx NetworkRAD21
Atlas of Cancer Signalling NetworkRAD21
Wikipedia pathwaysRAD21
Orthology - Evolution
OrthoDB5885
GeneTree (enSembl)ENSG00000164754
Phylogenetic Trees/Animal Genes : TreeFamRAD21
HOVERGENO60216
HOGENOMO60216
Homologs : HomoloGeneRAD21
Homology/Alignments : Family Browser (UCSC)RAD21
Gene fusions - Rearrangements
Fusion : MitelmanTRPS1/RAD21 [8q23.3/8q24.11]  [t(8;8)(q23;q24)]  
Fusion: TCGATRPS1 8q23.3 RAD21 8q24.11 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAD21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAD21
dbVarRAD21
ClinVarRAD21
1000_GenomesRAD21 
Exome Variant ServerRAD21
ExAC (Exome Aggregation Consortium)RAD21 (select the gene name)
Genetic variants : HAPMAP5885
Genomic Variants (DGV)RAD21 [DGVbeta]
DECIPHER (Syndromes)8:117858173-117887105  ENSG00000164754
CONAN: Copy Number AnalysisRAD21 
Mutations
ICGC Data PortalRAD21 
TCGA Data PortalRAD21 
Broad Tumor PortalRAD21
OASIS PortalRAD21 [ Somatic mutations - Copy number]
Cancer Gene: CensusRAD21 
Somatic Mutations in Cancer : COSMICRAD21  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAD21
intOGen PortalRAD21
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAD21
DgiDB (Drug Gene Interaction Database)RAD21
DoCM (Curated mutations)RAD21 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAD21 (select a term)
intoGenRAD21
Cancer3DRAD21(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606462    614701   
Orphanet299   
MedgenRAD21
Genetic Testing Registry RAD21
NextProtO60216 [Medical]
TSGene5885
GENETestsRAD21
Huge Navigator RAD21 [HugePedia]
snp3D : Map Gene to Disease5885
BioCentury BCIQRAD21
ClinGenRAD21 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5885
Chemical/Pharm GKB GenePA34170
Clinical trialRAD21
Miscellaneous
canSAR (ICR)RAD21 (select the gene name)
Probes
Litterature
PubMed100 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAD21
EVEXRAD21
GoPubMedRAD21
iHOPRAD21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:16:43 CEST 2017

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