RAD21 (RAD21 cohesin complex component)

2003-05-01  

Identity

HGNC
LOCATION
8q24.11
LOCUSID
ALIAS
CDLS4,HR21,HRAD21,MCD1,MGS,NXP1,SCC1,hHR21
FUSION GENES

Other Information

Locus ID:

NCBI: 5885
MIM: 606462
HGNC: 9811
Ensembl: ENSG00000164754

Variants:

dbSNP: 5885
ClinVar: 5885
TCGA: ENSG00000164754
COSMIC: RAD21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164754ENST00000297338O60216
ENSG00000164754ENST00000297338A0A024R9J0
ENSG00000164754ENST00000517485E5RFV8
ENSG00000164754ENST00000517749E5RG18
ENSG00000164754ENST00000518055E5RFZ5
ENSG00000164754ENST00000519837E5RJK5
ENSG00000164754ENST00000520992E5RIN7
ENSG00000164754ENST00000522699E5RJW1
ENSG00000164754ENST00000523986E5RI01

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Establishment of Sister Chromatid CohesionREACTOMER-HSA-2468052
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Mitotic Telophase/CytokinesisREACTOMER-HSA-68884
Cohesin Loading onto ChromatinREACTOMER-HSA-2470946
MeiosisREACTOMER-HSA-1500620
Meiotic synapsisREACTOMER-HSA-1221632

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
157370632005Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2.190
121985502002A chromatin remodelling complex that loads cohesin onto human chromosomes.104
193221932009Architectural roles of multiple chromatin insulators at the human apolipoprotein gene cluster.103
226333992012RAD21 mutations cause a human cohesinopathy.87
254143062014Characterization of a DNA exit gate in the human cohesin ring.67
250061312014Genetic alterations of the cohesin complex genes in myeloid malignancies.56
157675452005Suppression of RAD21 gene expression decreases cell growth and enhances cytotoxicity of etoposide and bleomycin in human breast cancer cells.42
227515012012Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.40
212553982011Enhanced RAD21 cohesin expression confers poor prognosis and resistance to chemotherapy in high grade luminal, basal and HER2 breast cancers.35
244159412014CTCF and Rad21 act as host cell restriction factors for Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication by modulating viral gene transcription.34

Citation

Dessen P

RAD21 (RAD21 cohesin complex component)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42026/rad21