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RAD21 (RAD21 cohesin complex component)

Identity

Alias (NCBI)CDLS4
HR21
HRAD21
MCD1
MGS
NXP1
SCC1
hHR21
HGNC (Hugo) RAD21
HGNC Alias symbKIAA0078
hHR21
SCC1
HGNC Alias namesister chromatid cohesion 1
 kleisin
HGNC Previous nameRAD21 (S. pombe) homolog
 RAD21 homolog (S. pombe)
LocusID (NCBI) 5885
Atlas_Id 42026
Location 8q24.11  [Link to chromosome band 8q24]
Location_base_pair Starts at 116845934 and ends at 116874776 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABHD12 (20p11.21)::RAD21 (8q24.11)DSCR9 (21q22.13)::RAD21 (8q24.11)LOC100505806 ()::RAD21 (8q24.11)
RAD21 (8q24.11)::EIF3H (8q23.3)RAD21 (8q24.11)::EXT1 (8q24.11)RAD21 (8q24.11)::RAD21 (8q24.11)
RAD21 (8q24.11)::ZC4H2 (Xq11.2)TRPS1 (8q23.3)::RAD21 (8q24.11)TRPS1 8q23.3::RAD21 8q24.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  Chronic Myelomonocytic Leukemia (CMML)
Myeloid proliferations in Down syndrome


External links

 

Nomenclature
HGNC (Hugo)RAD21   9811
LRG (Locus Reference Genomic)LRG_772
Cards
Entrez_Gene (NCBI)RAD21    RAD21 cohesin complex component
AliasesCDLS4; HR21; HRAD21; MCD1; 
MGS; NXP1; SCC1; hHR21
GeneCards (Weizmann)RAD21
Ensembl hg19 (Hinxton)ENSG00000164754 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164754 [Gene_View]  ENSG00000164754 [Sequence]  chr8:116845934-116874776 [Contig_View]  RAD21 [Vega]
ICGC DataPortalENSG00000164754
TCGA cBioPortalRAD21
AceView (NCBI)RAD21
Genatlas (Paris)RAD21
SOURCE (Princeton)RAD21
Genetics Home Reference (NIH)RAD21
Genomic and cartography
GoldenPath hg38 (UCSC)RAD21  -     chr8:116845934-116874776 -  8q24.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAD21  -     8q24.11   [Description]    (hg19-Feb_2009)
GoldenPathRAD21 - 8q24.11 [CytoView hg19]  RAD21 - 8q24.11 [CytoView hg38]
ImmunoBaseENSG00000164754
Genome Data Viewer NCBIRAD21 [Mapview hg19]  
OMIM606462   611376   614701   
Gene and transcription
Genbank (Entrez)AK097915 AK098521 AK125620 AK289505 BC001229
RefSeq transcript (Entrez)NM_006265
Consensus coding sequences : CCDS (NCBI)RAD21
Gene ExpressionRAD21 [ NCBI-GEO ]   RAD21 [ EBI - ARRAY_EXPRESS ]   RAD21 [ SEEK ]   RAD21 [ MEM ]
Gene Expression Viewer (FireBrowse)RAD21 [ Firebrowse - Broad ]
GenevisibleExpression of RAD21 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5885
GTEX Portal (Tissue expression)RAD21
Human Protein AtlasENSG00000164754-RAD21 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60216   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60216  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60216
PhosPhoSitePlusO60216
Domains : Interpro (EBI)Rad21/Rec8-like    Rad21/Rec8_C_eu    Rad21_Rec8_N    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)Rad21_Rec8 (PF04824)    Rad21_Rec8_N (PF04825)   
Domain families : Pfam (NCBI)pfam04824    pfam04825   
Conserved Domain (NCBI)RAD21
PDB (RSDB)4PJU    4PJW    4PK7    6QNX    6RRC    6RRK    6WG3    6WGE   
PDB Europe4PJU    4PJW    4PK7    6QNX    6RRC    6RRK    6WG3    6WGE   
PDB (PDBSum)4PJU    4PJW    4PK7    6QNX    6RRC    6RRK    6WG3    6WGE   
PDB (IMB)4PJU    4PJW    4PK7    6QNX    6RRC    6RRK    6WG3    6WGE   
Structural Biology KnowledgeBase4PJU    4PJW    4PK7    6QNX    6RRC    6RRK    6WG3    6WGE   
SCOP (Structural Classification of Proteins)4PJU    4PJW    4PK7    6QNX    6RRC    6RRK    6WG3    6WGE   
CATH (Classification of proteins structures)4PJU    4PJW    4PK7    6QNX    6RRC    6RRK    6WG3    6WGE   
SuperfamilyO60216
AlphaFold pdb e-kbO60216   
Human Protein Atlas [tissue]ENSG00000164754-RAD21 [tissue]
HPRD05924
Protein Interaction databases
DIP (DOE-UCLA)O60216
IntAct (EBI)O60216
BioGRIDRAD21
STRING (EMBL)RAD21
ZODIACRAD21
Ontologies - Pathways
QuickGOO60216
Ontology : AmiGOchromosome, centromeric region  chromatin  synaptonemal complex  spindle pole  DNA binding  chromatin binding  protein binding  nucleoplasm  nucleoplasm  chromosome  cytosol  double-strand break repair  DNA recombination  regulation of transcription by RNA polymerase II  apoptotic process  mitotic sister chromatid cohesion  synaptonemal complex assembly  reciprocal meiotic recombination  cohesin complex  cohesin complex  negative regulation of G2/M transition of mitotic cell cycle  membrane  nuclear matrix  nuclear mitotic cohesin complex  nuclear meiotic cohesin complex  nuclear meiotic cohesin complex  negative regulation of mitotic metaphase/anaphase transition  positive regulation of sister chromatid cohesion  cell division  protein localization to chromatin  replication-born double-strand break repair via sister chromatid exchange  
Ontology : EGO-EBIchromosome, centromeric region  chromatin  synaptonemal complex  spindle pole  DNA binding  chromatin binding  protein binding  nucleoplasm  nucleoplasm  chromosome  cytosol  double-strand break repair  DNA recombination  regulation of transcription by RNA polymerase II  apoptotic process  mitotic sister chromatid cohesion  synaptonemal complex assembly  reciprocal meiotic recombination  cohesin complex  cohesin complex  negative regulation of G2/M transition of mitotic cell cycle  membrane  nuclear matrix  nuclear mitotic cohesin complex  nuclear meiotic cohesin complex  nuclear meiotic cohesin complex  negative regulation of mitotic metaphase/anaphase transition  positive regulation of sister chromatid cohesion  cell division  protein localization to chromatin  replication-born double-strand break repair via sister chromatid exchange  
Pathways : KEGGKEGG_CELL_CYCLE   
NDEx NetworkRAD21
Atlas of Cancer Signalling NetworkRAD21
Wikipedia pathwaysRAD21
Orthology - Evolution
OrthoDB5885
GeneTree (enSembl)ENSG00000164754
Phylogenetic Trees/Animal Genes : TreeFamRAD21
Homologs : HomoloGeneRAD21
Homology/Alignments : Family Browser (UCSC)RAD21
Gene fusions - Rearrangements
Fusion : MitelmanTRPS1::RAD21 [8q23.3/8q24.11]  
Fusion : QuiverRAD21
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAD21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAD21
dbVarRAD21
ClinVarRAD21
MonarchRAD21
1000_GenomesRAD21 
Exome Variant ServerRAD21
GNOMAD BrowserENSG00000164754
Varsome BrowserRAD21
ACMGRAD21 variants
VarityO60216
Genomic Variants (DGV)RAD21 [DGVbeta]
DECIPHERRAD21 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAD21 
Mutations
ICGC Data PortalRAD21 
TCGA Data PortalRAD21 
Broad Tumor PortalRAD21
OASIS PortalRAD21 [ Somatic mutations - Copy number]
Cancer Gene: CensusRAD21 
Somatic Mutations in Cancer : COSMICRAD21  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRAD21
Mutations and Diseases : HGMDRAD21
intOGen PortalRAD21
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRAD21
DgiDB (Drug Gene Interaction Database)RAD21
DoCM (Curated mutations)RAD21
CIViC (Clinical Interpretations of Variants in Cancer)RAD21
Cancer3DRAD21
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606462    611376    614701   
Orphanet299   
DisGeNETRAD21
MedgenRAD21
Genetic Testing Registry RAD21
NextProtO60216 [Medical]
GENETestsRAD21
Target ValidationRAD21
Huge Navigator RAD21 [HugePedia]
ClinGenRAD21 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeRAD21
Protein Interactions : CTDRAD21
Pharm GKB GenePA34170
PharosO60216
Clinical trialRAD21
Miscellaneous
canSAR (ICR)RAD21
HarmonizomeRAD21
ARCHS4RAD21
DataMed IndexRAD21
Probes
Litterature
PubMed170 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRAD21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:55:11 CET 2022

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